Lars Tjelta Westlye

Førsteamanuensis - Psykologisk institutt

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E-post l.t.westlye@psykologi.uio.no

Mobiltelefon +4797163221

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Besøksadresse Forskningsveien 3A Harald Schjelderups hus 0373 OSLO

Postadresse Postboks 1094 Blindern 0317 OSLO

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Academic interests

I am an associate professor at the Department of Psychology, University of Oslo and Core Researcher and group leader at the Norwegian Center for Mental Disorders Research (NORMENT), Oslo University Hospital/University of Oslo.

Identifying mechanisms of disease is of vital importance to increase patient care and develop safe and effective treatment approaches. The heterogeneity and complexity of mental illnesses and other disorders of brain biology can only be fully appreciated by employing a cross-disciplinary and translational effort, preferably combined with a lifespan perspective.

Advanced neuroimaging techniques including MRI have revolutionized the understanding of the structural and functional makeup of the human brain. Structural and functional brain features are highly heritable, and our current research aims at characterizing the cognitive, brain and genetic mechanisms of severe neuropsychiatric disorders, in particular schizophrenia and bipolar spectrum disorders. In addition, in order to address questions pertaining to the clinical sensitivity and specificity of our results, we are aiming to compare and validate our findings across a range of brain disorders through a close collaboration with several clinical research groups. In addition, using brain network modeling approaches we are approaching the cognitive neuroscience of attention and memory functions, and questions related to the potential and mechanisms of neuroplasticity, both in clinical and non-clinical populations.

My research group utilizes various advanced MRI neuroimaging data and analysis approaches, with a particular emphasis on measures of structural (diffusion tensor imaging, DTI) and functional connectivity (functional magnetic resonance imaging, fMRI), and its integration using multimodal analysis approaches. In particular, by applying machine learning algorithms, we are investigating the clinical and cognitive sensitivity and specificity of various brain network-modeling approaches, including principles from graph theory.

In addition to the extended inter-disciplinary network of researchers at NORMENT and other clinical research groups at Oslo University Hospital, we are working closely with world-class international research groups, including the FMRIB Centre, Oxford University, and MMIL, UCSD.

Students interested in pursuing a cand psychol, MA or PhD within any of these areas of research are encouraged to contact me.

Please see my Google scholar profile for an updated publication list and citation metrics:

https://scholar.google.no/citations?user=zm7OAxsAAAAJ&hl=en

Higher education and employment history

Education

2011 PhD, University of Oslo
2007 Cand. Psychol. (professionally oriented degree in psychology), University of Oslo, accredited psychologist 2008

Employment history

2011 - 2012 Postdoctoral research fellow, Department of Psychology, University of Oslo
2011 Visiting Researcher, Multimodal Imaging Laboratory (MMIL), University of California San Diego, USA
2011 - Postdoctoral Research Fellow (research council of Norway), Center for the Study of Human Cognition, University of Oslo
2010 - 2011 Visiting Researcher, Oxford Centre for functional MRI of the Brain (FMRIB), University of Oxford, UK
2008 - 2011 PhD Research Fellow (The Research Council of Norway), Center for the Study of Human Cognition, Institute of Psychology, University of Oslo
2006 - 2007 Student Research Fellow (part time) (The Research Council of Norway), Department of Psychology, University of Oslo
2005 Student Research Fellow (full time) (The Research Council of Norway), Department of Psychology, University of Oslo

Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia; Djurovic, Srdjan; Melle, Ingrid; van der Meer, Dennis; Martin-Ruiz, Carmen; Steen, Nils Eiel; Agartz, Ingrid & Andreassen, Ole Andreas (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational psychiatry. ISSN 2158-3188. 9 . doi: 10.1038/s41398-019-0432-7
Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav; Moberget, Torgeir; Bettella, Francesco; Agartz, Ingrid; Brandt, Christine Lycke; Djurovic, Srdjan; Haatveit, Beathe; Lund, Martina Jonette; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk. JAMA psychiatry. ISSN 2168-6238. 76(7), s 739 . doi: 10.1001/jamapsychiatry.2019.0257
Bjørnebekk, Astrid; Westlye, Lars Tjelta; Walhovd, Kristine B; Jørstad, Marie Lindvik; Sundset, Øyvind & Fjell, Anders Martin (2019). Cognitive Performance and Structural Brain Correlates in Long-Term Anabolic-Androgenic Steroid Exposed and Nonexposed Weightlifters. Neuropsychology. ISSN 0894-4105. 33(4), s 547- 559 . doi: 10.1037/neu0000537
Grydeland, Håkon; Vértes, Petra; Váša, František; Romero-Garcia, Rafael; Whitaker, Kirstie; Aaron F., Alexander-Bloch; Bjørnerud, Atle; Patel, Ameera X.; Sederevicius, Donatas; Tamnes, Christian Krog; Westlye, Lars Tjelta; White, Simon; Walhovd, Kristine B; Fjell, Anders Martin & Bullmore, Edward T. (2019). Waves of Maturation and Senescence in Microstructural MRI Markers of Human Cortical Myelination over the Lifespan. Cerebral Cortex. ISSN 1047-3211. 29(3), s 1369- 1381 . doi: 10.1093/cercor/bhy330
Hauger, Lisa Evju; Westlye, Lars Tjelta; Fjell, Anders Martin; Walhovd, Kristine B & Bjørnebekk, Astrid (2019). Structural brain characteristics of anabolic-androgenic steroid dependence in men. Addiction. ISSN 0965-2140. s 1- 11 . doi: 10.1111/add.14629
Høgestøl, Einar August; Kaufmann, Tobias; Nygaard, Gro Owren; Beyer, Mona K.; Sowa, Piotr; Nordvik, Jan Egil; Kolskår, Knut-Kristian; Richard, Geneviève; Andreassen, Ole Andreas; Harbo, Hanne Flinstad & Westlye, Lars Tjelta (2019). Cross-sectional and longitudinal MRI brain scans reveal accelerated brain aging in multiple sclerosis. Frontiers in Neurology. ISSN 1664-2295. 10:450, s 1- 9 . doi: 10.3389/fneur.2019.00450
Høgestøl, Einar August; Nygaard, Gro Owren; Alnæs, Dag; Beyer, Mona K.; Westlye, Lars Tjelta & Harbo, Hanne Flinstad (2019). Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis. PLOS ONE. ISSN 1932-6203. 14(4) . doi: 10.1371/journal.pone.0210375
Jiang, Wenhao; Andreassen, Ole Andreas; Agartz, Ingrid; Lagerberg, Trine Vik; Westlye, Lars Tjelta; Calhoun, Vince D & Turner, Jessica A (2019). Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder.. NeuroImage: Clinical. ISSN 2213-1582. . doi: doi: 10.1016/j.nicl.2019.101989.
Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Dietrichs, Espen; Thorsby, Per Medbøe; Westlye, Lars Tjelta & Knudsen, Stine (2019). Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing. Sleep. ISSN 0161-8105. 42:zsz082(7), s 1- 12 . doi: 10.1093/sleep/zsz082
Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Córdova-Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, S.; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Karolinska Schizophrenia Pro, KaSP; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22, s 1617- 1623 . doi: 10.1038/s41593-019-0471-7 Vis sammendrag
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
Maglanoc, Luigi Angelo; Kaufmann, Tobias; Jonassen, Rune; Hilland, Eva; Beck, Dani; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis. Human Brain Mapping. ISSN 1065-9471. . doi: 10.1002/hbm.24802
Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan; Westlye, Lars Tjelta; Linne, Marja-Leena; Rietschel, Marcella; Schubert, Dirk; Borgwardt, Stefan; Efrim-Budisteanu, Magdalena; Bettella, Francesco; Halnes, Geir; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Metzner, Christoph; Edwards, Andrew G.; Fyhn, Marianne; Dale, Anders M.; Einevoll, Gaute T. & Andreassen, Ole Andreas (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.. Frontiers in Psychiatry. ISSN 1664-0640. 10(534) . doi: doi: 10.3389/fpsyt.2019.00534
Maximov, Ivan; Alnæs, Dag & Westlye, Lars Tjelta (2019). Towards an optimised processing pipeline for diffusion magnetic resonance imaging data: Effects of artefact corrections on diffusion metrics and their age associations in UK Biobank. Human Brain Mapping. ISSN 1065-9471. 40, s 4146- 4162 . doi: https://doi.org/10.1002/hbm.24691
Moberget, Torgeir; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence. Biological Psychiatry. ISSN 0006-3223. 86(1), s 65- 75 . doi: 10.1016/j.biopsych.2019.01.019
Quintana, Daniel; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Kaufmann, Tobias; Córdova-Palomera, Aldo; Dieset, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Oxytocin pathway gene networks in the human brain. Nature Communications. ISSN 2041-1723. 10(1) . doi: 10.1038/s41467-019-08503-8
Schwarz, Emanuel; Doan, Nhat Trung; Pergola, Giulio; Westlye, Lars Tjelta; Kaufmann, Tobias; Wolfers, Thomas; Brecheisen, Ralph; Quarto, Tiziana; Ing, Alex J.; di Carlo, Pasquale; Gurholt, Tiril Pedersen; Harms, Robbert L.; Noirhomme, Quentin; Moberget, Torgeir; Agartz, Ingrid; Andreassen, Ole Andreas; Bellani, Marcella; Bertolino, Alessandro; Blasi, Giuseppe; Brambilla, Paolo; Buitelaar, Jan K.; Cervenka, Simon; Flyckt, Lena; Frangou, Sophia; Franke, Barbara; Hall, Jeremy; Heslenfeld, Dirk J.; Kirsch, Peter; McIntosh, Andrew M.; Nöthen, Markus M.; Papassotiropoulos, Andreas; de Quervain, Dominique J.F.; Rietschel, Marcella; Schumann, Gunter; Tost, Heike; Witt, Stephanie H.; Zink, Mathias & Meyer-Lindenberg, Andreas (2019). Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder. Translational psychiatry. ISSN 2158-3188. 9(12) . doi: 10.1038/s41398-018-0225-4
Smith, Steve; Duff, Eugene; Groves, Adrian; Nichols, Thomas E; Jbabdi, Saad; Westlye, Lars Tjelta; Tamnes, Christian Krog; Engvig, Andreas; Walhovd, Kristine B; Fjell, Anders Martin; Johansen-Berg, Heidi & Douaud, Gwenaëlle (2019). Structural Variability in the Human Brain Reflects Fine-Grained Functional Architecture at the Population Level. Journal of Neuroscience. ISSN 0270-6474. 39, s 6136- 6149
Tesli, Natalia; Westlye, Lars Tjelta; Storvestre, Guttorm Breivik; Gurholt, Tiril Pedersen; Agartz, Ingrid; Melle, Ingrid; Andreassen, Ole Andreas & Haukvik, Unn Kristin H. (2019). White matter microstructure in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. . doi: 10.1007/s00406-019-00988-0
Zak, Nathalia; Bøen, Erlend; Boye, Birgitte; Andreassen, Ole Andreas; Doan, Nhat Trung; Malt, Ulrik Fredrik; Westlye, Lars Tjelta & Elvsåshagen, Torbjørn (2019). Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II. Bipolar Disorders. ISSN 1398-5647. . doi: 10.1111/bdi.12771
Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Wang, Yunpeng; Bettella, Francesco; Moberget, Torgeir; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents. JAMA psychiatry. ISSN 2168-6238. 75(3), s 287- 295 . doi: 10.1001/jamapsychiatry.2017.4277
Chen, Jiayu; Calhoun, Vince D.; Lin, Dongdong; Perrone-Bizzozero, Nora I.; Bustillo, Juan R.; Pearlson, Godfrey D.; Potkin, Steven G.; Van Erp, Theo G.M.; Macciardi, Fabio; Ehrlich, Stefan; Ho, Beng-Choon; Sponheim, Scott R.; Wang, Lei; Stephen, Julia M.; Mayer, Julia M.; Hanlon, Faith M.; Jung, Rex E.; Clementz, Brett A.; Keshavan, Matcheri S.; Gershon, Elliot S.; Sweeney, John A.; Tamminga, Carol A.; Andreassen, Ole Andreas; Agartz, Ingrid; Westlye, Lars Tjelta; Sui, Jing; Du, Yuhui; Turner, Jessica A. & Liu, Jingyuan (2018). Shared genetic risk of schizophrenia and gray matter reduction in 6p22.1. Schizophrenia Bulletin. ISSN 0586-7614. 45(1), s 222- 232 . doi: 10.1093/schbul/sby010
Còrdova Palomera, Aldo; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; van der Meer, Dennis; Alnæs, Dag; Rokicki, Jaroslav; Moberget, Torgeir; Sønderby, Ida Elken; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics. ISSN 1018-4813. 26(7), s 1049- 1059 . doi: 10.1038/s41431-018-0134-2
Elvsåshagen, Torbjørn; Mutsaerts, Henri J.M.M; Zak, Nathalia; Norbom, Linn Christin Bonaventure; Quiraishi, Sophia; Pedersen, Per Øystein Heiberg; Malt, Ulrik Fredrik; Westlye, Lars Tjelta; van Someren, Eus; Bjørnerud, Atle & Groote, Inge Rasmus (2018). Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation. NeuroImage. ISSN 1053-8119. 186, s 497- 509 . doi: 10.1016/j.neuroimage.2018.11.032 Vis sammendrag
Elucidating the neurobiological effects of sleep and wake is an important goal of the neurosciences. Whether and how human cerebral blood flow (CBF) changes during the sleep-wake cycle remain to be clarified. Based on the synaptic homeostasis hypothesis of sleep and wake, we hypothesized that a day of wake and a night of sleep deprivation would be associated with gray matter resting CBF (rCBF) increases and that sleep would be associated with rCBF decreases. Thirty-eight healthy adult males (age 22.1 ± 2.5 years) underwent arterial spin labeling perfusion magnetic resonance imaging at three time points: in the morning after a regular night's sleep, the evening of the same day, and the next morning, either after total sleep deprivation (n = 19) or a night of sleep (n = 19). All analyses were adjusted for hematocrit and head motion. rCBF increased from morning to evening and decreased after a night of sleep. These effects were most prominent in bilateral hippocampus, amygdala, thalamus, and in the occipital and sensorimotor cortices. Group × time interaction analyses for evening versus next morning revealed significant interaction in bilateral lateral and medial occipital cortices and in bilateral insula, driven by rCBF increases in the sleep deprived individuals and decreases in the sleepers, respectively. Furthermore, group × time interaction analyses for first morning versus next morning showed significant effects in medial and lateral occipital cortices, in anterior cingulate gyrus, and in the insula, in both hemispheres. These effects were mainly driven by CBF increases from TP1 to TP3 in the sleep deprived individuals. There were no associations between the rCBF changes and sleep characteristics, vigilant attention, or subjective sleepiness that remained significant after adjustments for multiple analyses. Altogether, these results encourage future studies to clarify mechanisms underlying sleep-related rCBF changes.
Hibar, Derrek; Westlye, Lars Tjelta; Doan, Nhat Trung; Jahanshad, Neda; Cheung, J. W.; Ching, Christopher R K; Versace, Amelia; Bilderbeck, A; Uhlmann, Anne; Mwangi, B; Krämer, B; Overs, B; Hartberg, Cecilie Bhandari; Abé, Christoph; Dima, Danai; Grotegerd, Dominik; Sprooten, Emma; Bøen, Erlend; Jimenez, Enrique; Howells, Fleur M.; Delvecchio, G; Temmingh, H; Starke, J; Almeida, JRC; Goikolea, JM; Houenou, J; Beard, Lauren M.; Rauer, L; Abramovic, Lucija; Bonnin, M.; Ponteduro, MF; Keil, M; Rive, MM; Yao, N; Yalin, N; Najt, P; Rosa, PG; Redlich, Ronny; Trost, S; Hagenaars, Saskia; Fears, SC; Alonso-Lana, S; Van Erp, TGM; Nickson, Thomas; Chaim-Avancini, TM; Meier, TB; Elvsåshagen, Torbjørn; Haukvik, Unn Kristin H.; Lee, Who-Seung; Schene, AH; Lloyd, AJ; Young, AH; Nugent, Allison C; Dale, AM; Pfennig, Andrea; McIntosh, AM; Lafer, Beny; Baune, BT; Ekman, CJ; Zarate, CA; Bearden, CE; Henry, C; Simhandl, Christian; McDonald, C; Bourne, C; Stein, DJ; Wolf, DH; Cannon, DM; Glahn, DC; Veltman, DJ; Pomarol-Clotet, E; Vieta, E; Canales-Rodriguez, EJ; Nery, FG; Duran, FLS; Busatto, GF; Roberts, G; Pearlson, GD; Goodwin, GM; Kugel, H; Whalley, HC; Ruhe, HG; Soares, JC; Fullerton, JM; Rybakowski, JK; Savitz, Jonathan; Chaim, KT; Fatjo-Vilas, Mar; Soeiro-de-Souza, MG; Boks, MP; Zanetti, MV; Otaduy, MCG; Schaufelberger, MS; Alda, Martin; Ingvar, Martin; Phillips, ML; Kempton, MJ; Bauer, M; Landén, M; Lawrence, NS; Van Haren, NEM; Horn, NR; Freimer, NB; Gruber, Oliver; Schofield, PR; Mitchell, PB; Kahn, RS; Lenroot, R; Machado-Vieira, R; Ophoff, RA; Sarró, S; Frangou, Sophia; Satterthwaite, TD; Hajek, Tomas; Dannlowski, Udo; Malt, Ulrik Fredrik; Arolt, Volker; Gattaz, WF; Drevets, WC; Caseras, Xavier; Agartz, Ingrid; Thompson, PM & Andreassen, Ole Andreas (2018). Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, s 932- 942 . doi: 10.1038/mp.2017.73 Fulltekst i vitenarkiv.
Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Agartz, Ingrid; Andreassen, Ole Andreas; Dietrichs, Espen; Thorsby, Per Medbøe; Westlye, Lars Tjelta & Knudsen, Stine (2018). Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives. Sleep. ISSN 0161-8105. 41(10) . doi: 10.1093/sleep/zsy145
Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Bettella, Francesco; Djurovic, Srdjan; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia. JAMA psychiatry. ISSN 2168-6238.
Kelly, S; Jahanshad, Neda; Zalesky, A; P, Kochunov; Agartz, Ingrid; Alloza, C; Andreassen, Ole Andreas; Arango, C; Banaj, Nerisa; Bouix, S; Bousman, CA; Brouwer, RM; Bruggemann, J; Bustillo, Juan R; Cahn, Wiepke; Calhoun, Vince; Cannon, Dara M; Carr, Vaughan J.; Catts, Stanley V.; Chen, J; Chen, JX; Chen, X; Chiapponi, C; Cho, KK; Ciullo, Valentina; Corvin, A; Crespo-Facorro, Benedicto; Cropley, V; De Rossi, Pietro; Diaz-Caneja, CM; Dickie, EW; Ehrlich, S; Fan, FM; Faskowitz, Joshua; Fatouros-Bergman, Helena; Flyckt, Lena; Ford, JM; Fouche, JP; Fukunaga, Masaki; Gill, M; Glahn, DC; Gollub, Randy L; Goudzwaard, ED; Guo, H; Gur, RE; Gur, RC; Gurholt, Tiril Pedersen; Hashimoto, Ryota; Hatton, SN; Henskens, FA; Hibar, DP; Hickie, IB; Hong, LE; Horacek, Jan; Howells, FM; Hulshoff Pol, Hilleke E; Hyde, CL; Isaev, D; Jablensky, Assen; Jansen, PR; Janssen, J; Jönsson, Erik Gunnar; Jung, LA; Kahn, RS; Kikinis, Z; Liu, K; Klauser, Paul; Knöchel, C; Kubicki, M; Lagopoulos, Jim; Langen, C; Lawrie, Stephen M; Lenroot, R; Lim, KO; Lopez-Jaramillo, Carlos; Lyall, A; Magnotta, V; Mandl, RCW; Mathalon, DH; McCarley, RW; McCarthy-Jones, Simon; McDonald, C; McEwen, S; McIntosh, A; Melicher, T; Mesholam-Gately, RI; Michie, PT; Mowry, Bryan J.; Mueller, BA; Newell, DT; O'donnell, P; Oertel-Knöchel, V; Oestreich, L; Paciga, SA; Pantelis, Christos; Pasternak, O; Pearlson, Godfrey D; Pellicano, GR; Pereira, A; Pineda Zapata, J; Piras, Fabrizio; Potkin, SG; Preda, Adrian; Rasser, PE; Roalf, DR; Roiz, R; Roos, A; Rotenberg, D; Satterthwaite, TD; Savadjiev, P; Schall, Ulrich; Scott, RJ; Seal, ML; Seidman, LJ; Shannon Weickert, C; Whelan, CD; Shenton, ME; Kwon, JS; Spalletta, Gianfranco; Spaniel, F; Sprooten, Emma; Stäblein, M; Stein, DJ; Sundram, S; Tan, Y; Tan, S; Tang, S; Temmingh, HS; Westlye, Lars Tjelta; Tønnesen, Siren; Tordesillas-Gutierrez, Diana; Doan, Nhat Trung; Vaidya, Jatin G.; Van Haren, NEM; Vargas, CD; Vecchio, D; Velakoulis, D; Voineskos, Aristotle N.; Voyvodic, JQ; Wang, Z; Wan, P; Wei, D; Weickert, TW; Whalley, Heather Clare; White, T; Whitford, TJ; Wojcik, JD; XIANG, HUA; Xie, Z; Yamamori, Hidenaga; Yang, F; Yao, N; Zhang, G.; Zhao, J; Van Erp, Theo G M; Turner, J; Thompson, PM & Donohoe, Gary (2018). Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, s 1261- 1269 . doi: 10.1038/mp.2017.170 Fulltekst i vitenarkiv.
Kolskår, Knut-Kristian; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Moberget, Torgeir; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2018). Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence. eNeuro. ISSN 2373-2822. 5(4), s 1- 13 . doi: 10.1523/ENEURO.0092-18.2018
Kong, Xiang-Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Agartz, Ingrid; Andreassen, Ole Andreas; Bøen, Erlend; Còrdova Palomera, Aldo; Dale, Anders; Doan, Nhat Trung; Elvsåshagen, Torbjørn; Faraone, Stephen V.; Gurholt, Tiril Pedersen; Haavik, Jan; Høvik, Marie Farstad; Hugdahl, Kenneth; Jönsson, Erik Gunnar; Lundervold, Astri; Malt, Ulrik Fredrik; Nerland, Stener; Nordvik, Jan Egil; Plessen, Kerstin J.; Smelror, Runar; van den Heuvel, Odile A; van der Meer, Dennis; Lønning, Kjersti; Westlye, Lars Tjelta; Glahn, David C.; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E.; Thompson, Paul M. & Francks, Clyde (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(22), s E5154- E5163 . doi: 10.1073/pnas.1718418115
Kuhn, Taylor; Kaufmann, Tobias; Doan, Nhat Trung; Westlye, Lars Tjelta; Jones, Jacob L.; Nunez, Rodolfo A; Bookheimer, Susan Y; Singer, Elyse J; Hinkin, Charles H & Thames, April D (2018). An augmented aging process in brain white matter in HIV. Human Brain Mapping. ISSN 1065-9471. 39(6), s 2532- 2540 . doi: 10.1002/hbm.24019
Liew, Sook-Lei; Anglin, Julia M.; Banks, Nick W.; Sondag, Matt; Ito, Kaori L.; Kim, Hosung; Chan, Jennifer; Ito, Joyce; Jung, Connie; Khoshab, Nima; Lefebvre, Stephanie; Nakamura, William; Saldaña, David; Schmiesing, Allie; Tran, Cathy; Vo, Danny; Ard, Tyler; Heydari, Panthea; Kim, Bokkyu; Aziz-Zadeh, Lisa; Cramer, Steven C.; Liu, Jingchun; Soekadar, Surjo; Nordvik, Jan Egil; Westlye, Lars Tjelta; Wang, Junping; Winstein, Carolee; Yu, Chunshui; Ai, Lei; Koo, Bonhwang; Craddock, R. Cameron; Milham, Michael Peter; Lakich, Matthew; Pienta, Amy & Stroud, Alison (2018). A large, open source dataset of stroke anatomical brain images and manual lesion segmentations. Scientific Data. ISSN 2052-4463. 5 . doi: 10.1038/sdata.2018.11 Fulltekst i vitenarkiv.
Maglanoc, Luigi Angelo; Landrø, Nils Inge; Jonassen, Rune; Kaufmann, Tobias; Còrdova Palomera, Aldo; Hilland, Eva & Westlye, Lars Tjelta (2018). Data-driven clustering reveals a link between symptoms and functional brain connectivity in depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 4(1), s 16- 26 . doi: 10.1016/j.bpsc.2018.05.005 Fulltekst i vitenarkiv.
Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Moberget, Torgeir; Rokicki, Jaroslav; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2018). Probing brain developmental patterns of myelination and associations with psychopathology in youths using gray/white matter contrast. Biological Psychiatry. ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.09.027
Nunes, Abraham; Schnack, Hugo G.; Ching, Christopher R.K.; Agartz, Ingrid; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T; Bøen, Erlend; Bonnin, Caterina del Mar; Busatto, Geraldo F.; Canales-Rodriguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Chaim-Avancini, Tiffany M.; Dannlowski, Udo; Díaz-Zuluaga, Ana M.; Dietsche, Bruno; Doan, Nhat Trung; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Emden, Daniel; Eyler, Lisa T.; Fatjó-Vilas, Mar; Favre, Pauline; Foley, Sonya F.; Fullerton, Janice M.; Glahn, David C.; Goikolea, Jose M.; Grotegerd, Dominik; Hahn, Tim; Henry, Chantal; Hibar, Derrek; Houenou, Josselin; Howells, Fleur M.; Jahanshad, Neda; Kaufmann, Tobias; Kenney, Joanne; Kircher, Tilo T.J.; Krug, Axel; Lagerberg, Trine Vik; Lenroot, Rhoshel K.; López-Jaramillo, Carlos; Machado-Vieira, Rodrigo; Malt, Ulrik Fredrik; McDonald, Colm; Mitchell, Philip B.; Mwangi, Benson; Nabulsi, Leila; Opel, Nils; Overs, Bronwyn J.; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Redlich, Ronny; Roberts, Gloria; Rosa, Pedro G.; Salvador, Raymond; Satterthwaite, Theodore D.; Soares, Jair C.; Stein, Dan J.; Temmingh, Henk S.; Trappenberg, Thomas; Uhlmann, Anne; van Haren, Neeltje E.M.; Vieta, Eduard; Westlye, Lars Tjelta; Wolf, Daniel H.; Yüksel, Dilara; Zanetti, Marcus V.; Andreassen, Ole Andreas; Thompson, Paul M. & Hájek, Tomás (2018). Using structural MRI to identify bipolar disorders ? 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Molecular Psychiatry. ISSN 1359-4184. . doi: 10.1038/s41380-018-0228-9
Quintana, Daniel; Westlye, Lars Tjelta; Alnæs, Dag; Kaufmann, Tobias; Mahmoud, Ramy A.; Smerud, Knut Terje; Djupesland, Per G. & Andreassen, Ole Andreas (2018). Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study. Neuropsychopharmacology. ISSN 0893-133X. 44, s 306- 313 . doi: 10.1038/s41386-018-0241-3
Quintana, Daniel; Westlye, Lars Tjelta; Smerud, Knut Terje; Mahmoud, Ramy A.; Andreassen, Ole Andreas & Djupesland, Per G. (2018). Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men. Hormones and Behavior. ISSN 0018-506X. 102, s 85- 92 . doi: 10.1016/j.yhbeh.2018.05.004
Richard, Geneviève; Kolskår, Knut-Kristian; Sanders, Anne-Marthe; Kaufmann, Tobias; Petersen, Anders; Doan, Nhat Trung; Monereo Sanchez, Jennifer; Alnæs, Dag; Ulrichsen, Kristine Moe; Dørum, Erlend Solberg; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2018). Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry. PeerJ. ISSN 2167-8359. . doi: 10.7717/peerj.5908 Vis sammendrag
Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and interpretations. Multivariate age prediction reduces the dimensionality to one biologically informative summary measure with potential for assessing deviations from normal lifespan trajectories. A number of studies documented remarkably accurate age prediction, but the differential age trajectories and the cognitive sensitivity of distinct brain tissue classes have yet to be adequately characterized. Exploring differential brain age models driven by tissue- specific classifiers provides a hitherto unexplored opportunity to disentangle indepen- dent sources of heterogeneity in brain biology. We trained machine-learning models to estimate brain age using various combinations of FreeSurfer based morphometry and diffusion tensor imaging based indices of white matter microstructure in 612 healthy controls aged 18–87 years. To compare the tissue-specific brain ages and their cognitive sensitivity, we applied each of the 11 models in an independent and cognitively well- characterized sample ( n = 265, 20–88 years). Correlations between true and estimated age and mean absolute error (MAE) in our test sample were highest for the most comprehensive brain morphometry ( r = 0 . 83, CI:0.78–0.86, MAE = 6.76 years) and white matter microstructure ( r = 0 . 79, CI:0.74–0.83, MAE = 7.28 years) models, confirming sensitivity and generalizability. The deviance from the chronological age were sensitive to performance on several cognitive tests for various models, including spatial Stroop and symbol coding, indicating poorer performance in individuals with an over-estimated age. Tissue-specific brain age models provide sensitive measures of brain integrity, with implications for the study of a range of brain disorders.
Sowa, Piotr; Harbo, Hanne Flinstad; White, Nathan S.; Celius, Elisabeth Gulowsen; Bartsch, Hauke; Berg-Hansen, Pål; Moen, Stine Marit; Bjørnerud, Atle; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Dale, Anders & Beyer, Mona K. (2018). Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. s 1- 12 . doi: 10.1177/1352458518765671
Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra; Espeseth, Thomas; Vaskinn, Anja; Wang, Yunpeng; Westlye, Lars Tjelta; Jacquemont, Sébastien; Djurovic, Srdjan; Stefánsson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry. ISSN 1359-4184. s 1- 16 . doi: 10.1038/s41380-018-0118-1
Tønnesen, Siren; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Ueland, Torill; Lagerberg, Trine Vik; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging. Scientific Reports. ISSN 2045-2322. 8 . doi: 10.1038/s41598-018-32355-9 Fulltekst i vitenarkiv.
van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. ISSN 1359-4184. s 1- 13 . doi: 10.1038/s41380-018-0262-7 Fulltekst i vitenarkiv.
Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao; Glahn, David C.; Pearlson, Godfrey D.; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Bustillo, Juan R.; Clark, Vincent P.; Agartz, Ingrid; Mueller, Bryon A.; Cahn, Wiepke; de Zwarte, Sonja M.C.; Hulshoff Pol, Hilleke E.; Kahn, René S.; Ophoff, Roel A.; van Haren, Neeltje E.M.; Andreassen, Ole Andreas; Dale, Anders; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Jørgensen, Kjetil Nordbø; Lagerberg, Trine Vik; Melle, Ingrid; Westlye, Lars Tjelta; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Zilles, David; Calhoun, Vince D.; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; Tordesillas-Gutiérrez, Diana; Loughland, Carmel; Carr, Vaughan J.; Catts, Stanley; Cropley, Vanessa L.; Fullerton, Janice M.; Green, Melissa J.; Henskens, Frans A.; Jablensky, Assen; Lenroot, Rhoshel K.; Mowry, Bryan J.; Michie, Patricia T.; Pantelis, Christos; Quide, Yann; Schall, Ulrich; Scott, Rodney J.; Cairns, Murray J.; Seal, Marc; Tooney, Paul A.; Rasser, Paul E.; Cooper, Gavin; Shannon Weickert, Cynthia; Weickert, Thomas W.; Morris, Derek W.; Hong, Elliot; Kochunov, Peter; Beard, Lauren M.; Gur, Raquel E.; Gur, Ruben C.; Satterthwaite, Theodore D; Wolf, Daniel H.; Belger, Aysenil; Brown, Gregory G.; Ford, Judith M.; Macciardi, Fabio; Mathalon, Daniel H.; O'Leary, Daniel S.; Potkin, Steven G.; Preda, Adrian; Voyvodic, James; Lim, Kelvin O.; McEwen, Sarah; Yang, Fude; Tan, Yunlong; Tan, Shuping; Wang, Zhiren; Fan, Fengmei; Chen, Jingxu; Xiang, Hong; Tang, Shiyou; Guo, Hua; Wan, Ping; Wei, Dong; Bockholt, Henry J.; Ehrlich, Stefan; Wolthusen, Rick P.F.; King, Margaret D.; Shoemaker, Jody M.; Sponheim, Scott R.; De Haan, Lieuwe; Koenders, Laura; Machielsen, Marise W.; van Amelsvoort, Therese; Veltman, Dick J.; Assogna, Francesca; Banaj, Nerisa; de Rossi, Pietro; Iorio, Mariangela; Piras, Fabrizio; Spalletta, Gianfranco; McKenna, Peter J.; Pomarol-Clotet, Edith; Salvador, Raymond; Corvin, Aiden; Donohoe, Gary; Kelly, Sinead; Whelan, Christopher D.; Dickie, Erin W.; Rotenberg, David; Voineskos, Aristotle N.; Ciufolini, Simone; Radua, Joaquim; Dazzan, Paola; Murray, Robin; Reis Marques, Tiago; Simmons, Andrew; Borgwardt, Stefan; Egloff, Laura; Harrisberger, Fabienne; Riecher-Rössler, Anita; Smieskova, Renata; Alpert, Kathryn I.; Wang, Lei; Jönsson, Erik Gunnar; Koops, Sanne; Sommer, Iris Else Clara; Bertolino, Alessandro; Bonvino, Aurora; Di Giorgio, Annabella; Neilson, Emma; Mayer, Andrew R.; Stephen, Julia M.; Kwon, Jun Soo; Yun, Je-Yeon; Cannon, Dara M.; McDonald, Colm; Lebedeva, Irina; Tomyshev, Alexander S.; Akhadov, Tolibjohn; Kaleda, Vasily; Fatouros-Bergman, Helena & Flyckt, Lena (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.04.023 Fulltekst i vitenarkiv.
Walton, E; Hibar, Derrek; Van Erp, Theo G M; Potkin, Steven G; Roiz-Santiañez, Roberto; Crespo-Facorro, B; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn Egeland; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Jahanshad, Neda; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Spalletta, Gianfranco; Gur, Raquel E; Gur, Ruben C; Wolf, Daniel H.; Satterthwaite, TD; Beard, Lauren M.; Sommer, Iris E; Koops, Sanne; Gruber, Oliver; Richter, A; Krämer, Bernhard; Kelly, S; Donohoe, G; McDonald, C; Cannon, Dara M; Corvin, Aiden; Gill, M; Di Giorgio, Annabella; Bertolino, A; Lawrie, Stephen M; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, J A & Ehrlich, S (2018). Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychological Medicine. ISSN 0033-2917. 48(1), s 82- 94 . doi: 10.1017/S0033291717001283 Fulltekst i vitenarkiv.
Wolfers, Thomas; Doan, Nhat Trung; Kaufmann, Tobias; Alnæs, Dag; Moberget, Torgeir; Agartz, Ingrid; Buitelaar, Jan K.; Ueland, Torill; Melle, Ingrid; Franke, Barbara; Andreassen, Ole Andreas; Beckmann, Christian F.; Westlye, Lars Tjelta & Marquand, André F. (2018). Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models. JAMA psychiatry. ISSN 2168-6238. 75(11), s 1146- 1155 . doi: 10.1001/jamapsychiatry.2018.2467
Zak, Nathalia; Moberget, Torgeir; Bøen, Erlend; Boye, Birgitte; Waage, Trine Rygvold; Dietrichs, Espen; Harkestad, Nina; Malt, Ulrik Fredrik; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Andersson, Stein & Elvsåshagen, Torbjørn (2018). Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals. Translational psychiatry. ISSN 2158-3188. 8(103) . doi: 10.1038/s41398-018-0151-5 Fulltekst i vitenarkiv.
Aas, Monica; Kauppi, Karolina; Brandt, Christine Lycke; Tesli, Martin Steen; Kaufmann, Tobias; Steen, Nils Eiel; Agartz, Ingrid; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. Psychological Medicine. ISSN 0033-2917. 47(4), s 669- 679 . doi: 10.1017/S0033291716002762
Còrdova Palomera, Aldo; Kaufmann, Tobias; Persson, Karin; Alnæs, Dag; Doan, Nhat Trung; Moberget, Torgeir; Lund, Martina Jonette; Barca, Maria Lage; Engvig, Andreas; Brækhus, Anne; Engedal, Knut; Andreassen, Ole Andreas; Selbæk, Geir & Westlye, Lars Tjelta (2017). Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum. Scientific Reports. ISSN 2045-2322. 7(40268), s 1- 14 . doi: 10.1038/srep40268 Fulltekst i vitenarkiv. Vis sammendrag
As findings on the neuropathological and behavioral components of Alzheimer’s disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent developments on theoretical neuroscience indicate that instantaneous patterns of brain connectivity and metastability may be a key mechanism in neural communication underlying cognitive performance. However, the potential significance of these patterns across the AD spectrum remains virtually unexplored. We assessed the clinical sensitivity of static and dynamic functional brain disruptions across the AD spectrum using resting-state fMRI in a sample consisting of AD patients (n = 80) and subjects with either mild (n = 44) or subjective (n = 26) cognitive impairment (MCI, SCI). Spatial maps constituting the nodes in the functional brain network and their associated time-series were estimated using spatial group independent component analysis and dual regression, and whole-brain oscillatory activity was analyzed both globally (metastability) and locally (static and dynamic connectivity). Instantaneous phase metrics showed functional coupling alterations in AD compared to MCI and SCI, both static (putamen, dorsal and default-mode) and dynamic (temporal, frontal-superior and default-mode), along with decreased global metastability. The results suggest that brains of AD patients display altered oscillatory patterns, in agreement with theoretical premises on cognitive dynamics.
Doan, Nhat Trung; Engvig, Andreas; Persson, Karin; Alnæs, Dag; Kaufmann, Tobias; Rokicki, Jaroslav; Còrdova Palomera, Aldo; Moberget, Torgeir; Brækhus, Anne; Barca, Maria Lage; Engedal, Knut; Andreassen, Ole Andreas; Selbæk, Geir & Westlye, Lars Tjelta (2017). Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum. Scientific Reports. ISSN 2045-2322. 7:45131 . doi: 10.1038/srep45131 Vis sammendrag
Recent efforts using diffusion tensor imaging (DTI) have documented white matter (WM) alterations in Alzheimer’s disease (AD). The full potential of whole-brain DTI, however, has not been fully exploited as studies have focused on individual microstructural indices independently. In patients with AD (n = 79), mild (MCI, n = 55) and subjective (SCI, n = 30) cognitive impairment, we applied linked independent component analysis (LICA) to model inter-subject variability across five complementary DTI measures (fractional anisotropy (FA), axial/radial/mean diffusivity, diffusion tensor mode), two crossing fiber measures estimated using a multi-compartment crossing-fiber model reflecting the volume fraction of the dominant (f1) and non-dominant (f2) diffusion orientation, and finally, connectivity density obtained from full-brain probabilistic tractography. The LICA component explaining the largest data variance was highly sensitive to disease severity (AD < MCI < SCI) and revealed widespread coordinated decreases in FA and f1 with increases in all diffusivity measures in AD. Additionally, it reflected regional coordinated decreases and increases in f2, mode and connectivity density, implicating bidirectional alterations of crossing fibers in the fornix, uncinate fasciculi, corpus callosum and major sensorimotor pathways. LICA yielded improved diagnostic classification performance compared to univariate region-of-interest features. Our results document coordinated WM microstructural and connectivity alterations in line with disease severity across the AD continuum.
Doan, Nhat Trung; Engvig, Andreas; Zaske, Krystal; Persson, Karin; Lund, Martina Jonette; Kaufmann, Tobias; Còrdova Palomera, Aldo; Alnæs, Dag; Moberget, Torgeir; Brækhus, Anne; Barca, Maria Lage; Nordvik, Jan Egil; Engedal, Knut; Agartz, Ingrid; Selbæk, Geir; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Distinguishing early and late brain aging from the Alzheimer's disease spectrum: Consistent morphological patterns across independent samples. NeuroImage. ISSN 1053-8119. 158, s 282- 295 . doi: 10.1016/j.neuroimage.2017.06.070 Fulltekst i vitenarkiv.
Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders. NeuroImage: Clinical. ISSN 2213-1582. 15, s 719- 731 . doi: 10.1016/j.nicl.2017.06.014 Fulltekst i vitenarkiv.
Dørum, Erlend Solberg; Kaufmann, Tobias; Alnæs, Dag; Andreassen, Ole Andreas; Richard, Geneviéve´; Kolskår, Knut-Kristian; Nordvik, Jan Egil & Westlye, Lars Tjelta (2017). Increased sensitivity to age-related differences in brain functional connectivity during continuous multiple object tracking compared to resting-state. NeuroImage. ISSN 1053-8119. 148, s 364- 372 . doi: 10.1016/j.neuroimage.2017.01.048
Elvsåshagen, Torbjørn; Zak, Nathalia; Norbom, Linn Christin Bonaventure; Pedersen, Per Øystein Heiberg; Quraishi, Sophia H.; Bjørnerud, Atle; Alnæs, Dag; Doan, Nhat Trung; Malt, Ulrik Fredrik; Groote, Inge Rasmus & Westlye, Lars Tjelta (2017). Evidence for cortical structural plasticity in humans after a day of waking and sleep deprivation. NeuroImage. ISSN 1053-8119. 156, s 214- 223 . doi: 10.1016/j.neuroimage.2017.05.027 Fulltekst i vitenarkiv.
Hellstrøm, Torgeir; Kaufmann, Tobias; Andelic, Nada; Søberg, Helene L.; Sigurdardottir, Solrun; Helseth, Eirik; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Predicting outcome 12 months after mild traumatic brain injury in patients admitted to a neurosurgery service. Frontiers in Neurology. ISSN 1664-2295. 8:125, s 1- 12 . doi: 10.3389/fneur.2017.00125 Fulltekst i vitenarkiv.
Hellstrøm, Torgeir; Westlye, Lars Tjelta; Kaufmann, Tobias; Doan, Nhat Trung; Søberg, Helene L.; Sigurdardottir, Solrun; Nordhøy, Wibeke; Helseth, Eirik; Andreassen, Ole Andreas & Andelic, Nada (2017). White matter microstructure is associated with functional, cognitive and emotional symptoms 12 months after mild traumatic brain injury. Scientific Reports. ISSN 2045-2322. 7(1) . doi: 10.1038/s41598-017-13628-1 Fulltekst i vitenarkiv.
Hellstrøm, Torgeir; Westlye, Lars Tjelta; Sigurdardottir, Solrun; Brunborg, Cathrine; Søberg, Helene L.; Holthe, Øyvor; SERVER, ANDRES; Lund, Martina Jonette; Andreassen, Ole Andreas & Andelic, Nada (2017). Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables. Brain Injury. ISSN 0269-9052. 31(5), s 674- 685 . doi: 10.1080/02699052.2017.1283537 Fulltekst i vitenarkiv.
Hibar, Derrek; Adams, Hieab H.H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteriá, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivières, Sylvane; Vernooij, Meike W; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Armstrong, Nicola J.; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H.; Beiser, Alexa; Bernard, Manon; Blanton, Susan H.; Bohlken, Marc M.; Boks, Marco P.; Bralten, Janita; Brickman, Adam M.; Carmichael, Owen; Chakravarty, M. Mallar; Chen, Qiang; Ching, Christopher R.K.; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F.; Grimm, Oliver; Griswold, Michael E.; Guadalupe, Tulio; Gutman, Boris A.; Hass, Johanna; Haukvik, Unn Kristin H.; Hoehn, David; Holmes, Avram J.; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jørgensen, Kjetil Nordbø; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H.; Liewald, David C.M.; Lopez, Lorna M.; Luciano, Michelle; MacAre, Christine; Marquand, André F.; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; McKay, David R.; Milaneschi, Yuri; Muñoz Maniega, Susana; Nho, Kwangsik; Nugent, Allison C.; Nyquist, Paul; Loohuis, Loes M. 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Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R. & Andreassen, Ole Andreas (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin. ISSN 0586-7614. 43(4), s 881- 890 . doi: 10.1093/schbul/sbw183 Fulltekst i vitenarkiv.
Jørgensen, Kjetil Nordbø; Nesvåg, Ragnar; Nerland, Stener; Mørch-Johnsen, Lynn; Westlye, Lars Tjelta; Lange, Elisabeth; Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2017). Brain volume change in first-episode psychosis: an effect of antipsychotic medication independent of BMI change. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 135(2), s 117- 126 . doi: 10.1111/acps.12677
Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Doan, Nhat Trung; Kauppi, Karolina; Bettella, Francesco; Lagerberg, Trine Vik; Berg, Akiah Ottesen; Djurovic, Srdjan; Agartz, Ingrid; Melle, Ingrid; Ueland, Torill; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Task modulations and clinical manifestations in the brain functional connectome in 1615 fMRI datasets. NeuroImage. ISSN 1053-8119. 147, s 243- 252 . doi: 10.1016/j.neuroimage.2016.11.073
Kaufmann, Tobias; Alnæs, Dag; Doan, Nhat Trung; Brandt, Christine Lycke; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Delayed stabilization and individualization in connectome development are related to psychiatric disorders. Nature Neuroscience. ISSN 1097-6256. 20(4), s 513- 515 . doi: 10.1038/nn.4511
Moberget, Torgeir; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Còrdova Palomera, Aldo; Lagerberg, Trine Vik; Diedrichsen, Jörn; Schwarz, E.; Zink, M; Eisenacher, S.; Kirsch, Peter; Jönsson, Erik Gunnar; Fatouros-Bergman, Helena; Flyckt, Lena; Pergola, G; Quarto, T; Bertolino, A; Barch, D; Meyer-Lindenberg, Andreas; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls. Molecular Psychiatry. ISSN 1359-4184. 23(6), s 1512- 1520 . doi: 10.1038/mp.2017.106
Mowinckel, Athanasia Monika; Alnæs, Dag; Pedersen, Mads Lund; Ziegler, Sigurd; Fredriksen, Mats; Kaufmann, Tobias; Sonuga-Barke, Edmund J.S.; Endestad, Tor; Westlye, Lars Tjelta & Biele, Guido (2017). Increased default-mode variability is related to reduced task-performance and is evident in adults with ADHD. NeuroImage: Clinical. ISSN 2213-1582. 16, s 369- 382 . doi: 10.1016/j.nicl.2017.03.008 Fulltekst i vitenarkiv.
Quintana, Daniel; Dieset, Ingrid; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2017). Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders. Frontiers in neuroendocrinology (Print). ISSN 0091-3022. 45, s 1- 10 . doi: 10.1016/j.yfrne.2016.12.004 Fulltekst i vitenarkiv.
Quintana, Daniel; Elvsåshagen, Torbjørn; Zak, Nathalia; Norbom, Linn Christin Bonaventure; Pedersen, Per Øystein Heiberg; Quraishi, Sophia H.; Bjørnerud, Atle; Malt, Ulrik Fredrik; Groote, Inge Rasmus; Kaufmann, Tobias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Diurnal Variation and twenty-four hour sleep deprivation do not alter supine heart rate variability in healthy male young adults. PLOS ONE. ISSN 1932-6203. 12:e0170921(2), s 1- 16 . doi: 10.1371/journal.pone.0170921 Fulltekst i vitenarkiv.
Quintana, Daniel; Westlye, Lars Tjelta; Hope, Sigrun; Nærland, Terje; Elvsåshagen, Torbjørn; Dørum, Erlend Solberg; Rustan, Øyvind; Valstad, Mathias; Rezvaya, Liudmila; Lishaugen, Hanna; Stensønes, Elise; Yaqub, Sheraz; Smerud, Knut Terje; Mahmoud, Ramy; Djupesland, Per G. & Andreassen, Ole Andreas (2017). Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial. Translational psychiatry. ISSN 2158-3188. e1136(7), s 1- 9 . doi: 10.1038/tp.2017.103 Fulltekst i vitenarkiv.
Skåtun, Kristina Cecilie; Kaufmann, Tobias; Brandt, Christine Lycke; Doan, Nhat Trung; Alnæs, Dag; Tønnesen, Siren; Biele, Guido; Vaskinn, Anja; Melle, Ingrid; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Thalamo-cortical functional connectivity in schizophrenia and bipolar disorder. Brain Imaging and Behavior. ISSN 1931-7557. . doi: 10.1007/s11682-017-9714-y
Valstad, Mathias; Alvares, Gail A.; Egknud, Maiken; Matziorinis, Anna Maria; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Quintana, Daniel (2017). The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews. ISSN 0149-7634. 78, s 117- 124 . doi: 10.1016/j.neubiorev.2017.04.017 Fulltekst i vitenarkiv.
Walton, Esther Fintan; Hibar, Derrek; Van Erp, Theo G.M.; Potkin, Steven G.; Roiz-Santiáñez, Roberto; Crespo-Facorro, Benedicto; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S.; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Preda, Adrian; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Ciullo, Valentina; Spalletta, Gianfranco; Gur, Raquel E.; Gur, Ruben C.; Wolf, Daniel H.; Satterthwaite, Theaodore D.; Beard, Lauren M.; Sommer, Iris E.; Koops, Sanne; Gruber, Oliver; Richter, Anja; Krämer, B.; Kelly, Sinéad; Donohoe, Gary J.; McDonald, Colm; Cannon, Dara M.; Corvin, Aiden; Gill, Michael; Di Giorgio, Annabella; Bertolino, Alessandro; Lawrie, Stephen M.; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, Jessica A. & Ehrlich, Stefan (2017). Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 135(5), s 439- 447 . doi: 10.1111/acps.12718
Westlye, Lars Tjelta; Kaufmann, Tobias; Alnæs, Dag; Hullstein, Ingunn Riise & Bjørnebekk, Astrid (2017). Brain connectivity aberrations in anabolic-androgenic steroid users. NeuroImage: Clinical. ISSN 2213-1582. 13, s 62- 69 . doi: 10.1016/j.nicl.2016.11.014
Adams, Hieab H.H.; Hibar, Derrek; Chouraki, Vincent; Stein, Jason L.; Nyquist, Paul A.; Renteriá, Miguel E.; Trompet, Stella; Arias-Vasquez, Alejandro; Seshadri, Sudha; Desrivieres, Sylvane; Beecham, Ashley H.; Jahanshad, Neda; Wittfeld, Katharina; Van Der Lee, Sven J.; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Armstrong, Nicola J.; Athanasiu, Lavinia; Axelsson, Tomas; Beiser, Alexa; Bernard, Manon; Bis, Joshua C.; Blanken, Laura M.E.; Blanton, Susan H.; Bohlken, Marc M.; Boks, Marco P.; Bralten, Janita; Brickman, Adam M.; Carmichael, Owen; Chakravarty, M. Mallar; Chauhan, Ganesh; Chen, Qiang; Ching, Christopher R.K.; Cuellar-Partida, Gabriel; Braber, Anouk Den; Doan, Nhat Trung; Ehrlich, Stefan; Filippi, Irina; Ge, Tian; Giddaluru, Sudheer; Goldman, Aaron L.; Gottesman, Rebecca F.; Greven, Corina U.; Grimm, Oliver; Griswold, Michael E.; Guadalupe, Tulio; Hass, Johanna; Haukvik, Unn Kristin H.; Hilal, Saima; Hofer, Edith; Hoehn, David; Holmes, Avram J.; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H.; Liao, Jiemin; Liewald, David C.M.; Lopez, Lorna M.; Luciano, Michelle; Macare, Christine; Marquand, Andre; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; Mazoyer, Bernard; McKay, David R.; McWhirter, Rebekah; Milaneschi, Yuri; Mirza-Schreiber, Nazanin; Muetzel, Ryan L.; Maniega, Susana Munoz; Nho, Kwangsik; Nugent, Allison C.; Loohuis, Loes M. 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Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience. ISSN 1097-6256. 19(12), s 1569- 1582 . doi: 10.1038/nn.4398
Dørum, Erlend Solberg; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Lund, Martina Jonette; Tønnesen, Siren; Sneve, Markus Handal; Mathiesen, Nina Christine; Rustan, Øyvind; Gjertsen, Øivind; Vatn, Sigurd; Fure, Brynjar; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2016). Age-related differences in brain network activation and co-activation during multiple object tracking. Brain and Behavior. ISSN 2162-3279. 6(11) . doi: 10.1002/brb3.533 Fulltekst i vitenarkiv.
Elvsåshagen, Torbjørn; Zuzarte, Pedro; Westlye, Lars Tjelta; Bøen, Erlend; Josefsen, Dag; Boye, Birgitte; Hol, Per Kristian; Malt, Ulrik Fredrik; Young, L Trevor & Andreazza, Ana C (2016). Dentate gyrus-cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross-sectional analyses. Bipolar Disorders. ISSN 1398-5647. 18(8), s 657- 668 . doi: 10.1111/bdi.12457
Giddaluru, Sudheer; Espeseth, Thomas; Salami, Alireza; Westlye, Lars Tjelta; Lundquist, Anders; Christoforou, Andrea; Cichon, Sven; Adolfsson, Rolf; Steen, Vidar Martin; Reinvang, Ivar; Nilsson, Lars Göran; Le Hellard, Stephanie & Nyberg, Lars Erik (2016). Genetics of structural connectivity and information processing in the brain. Brain Structure and Function. ISSN 1863-2653. 221(9), s 4643- 4661 . doi: 10.1007/s00429-016-1194-0
Grellmann, Claudia; Neumann, Jane; Bitzer, Sebastian; Kovacs, Peter; Tönjes, Anke; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Stumvoll, Michael; Villringer, Arno & Horstmann, Annette (2016). Random Projection for fast and efficient multivariate correlation analysis of high-dimensional data: A new approach. Frontiers in Genetics. ISSN 1664-8021. 7 . doi: 10.3389/fgene.2016.00102
Grydeland, Håkon; Westlye, Lars Tjelta; Walhovd, Kristine B & Fjell, Anders Martin (2016). Intracortical Posterior Cingulate Myelin Content Relates to Error Processing – Results From T1- and T2-weighted MRI Myelin Mapping and Electrophysiology in Healthy Adults. Cerebral Cortex. ISSN 1047-3211. 26(6), s 2402- 2410 . doi: 10.1093/cercor/bhv065 Fulltekst i vitenarkiv.
Guadalupe, Tulio; Mathias, Samuel R.; VanErp, Theo G.M.; Whelan, Christopher D.; Zwiers, Marcel P.; Abe, Yoshinari; Abramovic, Lucija; Agartz, Ingrid; Andreassen, Ole Andreas; Arias-Vásquez, Alejandro; Aribisala, Benjamin S.; Armstrong, Nicola J.; Arolt, Volker; Artiges, Eric; Ayesa-Arriola, Rosa; Baboyan, Vatche G.; Banaschewski, Tobias; Barker, Gareth; Bastin, Mark E.; Baune, Bernhard T.; Blangero, John; Bokde, Arun L.W.; Boedhoe, Premika S.W.; Bose, Anushree; Brem, Silvia; Brodaty, Henry; Bromberg, Uli; Brooks, Samantha; Büchel, Christian; Buitelaar, Jan; Calhoun, Vince D.; Cannon, Dara M.; Cattrell, Anna; Cheng, Yuqi; Conrod, Patricia J.; Conzelmann, Annette; Corvin, Aiden; Crespo-Facorro, Benedicto; Crivello, Fabrice; Dannlowski, Udo; de Zubicaray, Greig I.; de Zwarte, Sonja M.C.; Deary, Ian J.; Desrivieres, Sylvane; Doan, Nhat Trung; Donohoe, Gary; Dørum, Erlend Solberg; Ehrlich, Stefan; Espeseth, Thomas; Fernandéz, Guillén; Flor, Herta; Fouche, Jean-Paul; Frouin, Vincent; Fukunaga, Masaki; Gallinat, Jurgen; Garavan, Hugh; Gill, Michael; Suarez, Andrea Gonzalez; Gowland, Penny; Grabe, Hans J.; Grotegerd, Dominik; Gruber, Oliver; Hagenaars, Saskia; Hashimoto, Ryota; Hauser, Tobias U.; Heinz, Andreas; Hibar, Derrek; Hoekstra, Pieter J.; Hoogman, Martine; Howells, Fleur M.; Hu, Hao; Hulshoff Pol, Hilleke E.; Huyser, Chaim; Ittermann, Bernd; Jahanshad, Neda; Jönsson, Erik Gunnar; Jurk, Sarah; Kahn, René S.; Kelly, Sinead; Kraemer, Bernd; Kugel, Harald; Kwon, Jun Soo; Lemaitre, Herve; Lesch, Klaus-Peter; Lochner, Christine; Luciano, Michelle; Marquand, André F.; Martin, Nicholas G.; Martinez-Zalacain, Ignacio; Martinot, Jean-Luc; Mataix-Cols, David; Mather, Karen; McDonald, Colm; McMahon, Katie L.; Medland, Sarah E.; Menchon, José M.; Morris, Derek W.; Mothersill, Omar; Maniega, Susana Munoz; Mwangi, Benson; Nakamae, Takashi; Nakao, Tomohiro; Narayanaswaamy, Janardhanan C.; Nees, Frauke; Nordvik, Jan Egil; Onnink, A. Marten H.; Opel, Nils; Ophoff, Roel; Paillere Martinot, Marie-Laure; Papadopoulos Orfanos, Dimitri; Pauli, Paul; Paus, Tomáš; Poustka, Luise; Reddy, Janardhan Y.C.; Renteriá, Miguel E.; Roiz-Santiañez, Roberto; Roos, Annerine; Royle, Natalie A.; Sachdev, Perminder; Sánchez-Juan, Pascual; Schmaal, Lianne; Schumann, Gunter; Shumskaya, Elena; Smolka, Michael N.; Soares, Jair C.; Soriano-Mas, Carles; Stein, Dan J.; Strike, Lachlan T.; Toro, Roberto; Turner, Jessica A.; Tzourio-Mazoyer, Nathalie; Uhlmann, Anne; Hernández, Maria Valdés; van den Heuvel, Odile A.; van der Meer, Dennis; van Haren, Neeltje E.M.; Veltman, Dick J.; Venkatasubramanian, Ganesan; Vetter, Nora C.; Vuletic, Daniella; Walitza, Susanne; Walter, Henrik; Walton, Esther; Wang, Zhen; Wardlaw, Joanna; Wen, Wei; Westlye, Lars Tjelta; Whelan, Robert; Wittfeld, Katharina; Wolfers, Thomas; Wright, Margaret J.; Xu, Jian; Xu, Xiufeng; Yun, Je-Yeon; Zhao, JingJing; Franke, Barbara; Thompson, Paul M.; Glahn, David C.; Mazoyer, Bernard; Fisher, Simon E. & Francks, Clyde (2016). Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behavior. ISSN 1931-7557. Published ahead of print, s 1- 18 . doi: 10.1007/s11682-016-9629-z
Haatveit, Beathe Christin; Jensen, Jimmy; Alnæs, Dag; Kaufmann, Tobias; Brandt, Christine Lycke; Thoresen, Christian; Andreassen, Ole Andreas; Melle, Ingrid; Ueland, Torill & Westlye, Lars Tjelta (2016). Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders. NeuroImage: Clinical. ISSN 2213-1582. 12, s 389- 396 . doi: 10.1016/j.nicl.2016.08.012
Haram, Marit; Bettella, Francesco; Brandt, Christine Lycke; Quintana, Daniel; Nerhus, Mari; Bjella, Thomas; Djurovic, Srdjan; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Melle, Ingrid & Tesli, Martin Steen (2016). Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders. BJPsych Open. ISSN 2056-4724. 2(6), s 353- 358 . doi: 10.1192/bjpo.bp.116.003376
Hellstrøm, Torgeir; Westlye, Lars Tjelta; SERVER, ANDRES; Løvstad, Marianne; Brunborg, Cathrine; Lund, Martina Jonette; Nordhøy, Wibeke; Andreassen, Ole Andreas & Andelic, Nada (2016). Volumetric and morphometric MRI findings in patients with mild traumatic brain injury. Brain Injury. ISSN 0269-9052. 30(13-14), s 1683- 1691 . doi: 10.1080/02699052.2016.1199905 Vis sammendrag
Objective: This study compared cortical and sub-cortical volumes between patients with complicated (i.e. presence of intracranial abnormality on the day-of-injury CT) and uncomplicated (i.e. absence of intracranial abnormality) mild traumatic brain injury (MTBI) 4 weeks post-injury. The study hypothesized regionally decreased brain volumes and reduced cortical thickness in patients with complicated MTBIs compared with uncomplicated MTBI. Methods: This study was part of a larger 2 years cohort study on MTBI. Baseline clinical and magnetic resonance imaging (MRI) data were compared for those with complicated and uncomplicated MTBI. It identified 168 patients with MTBI (90 uncomplicated and 78 complicated), aged 16–65 years. 3T MRI-system (Signa HDxt, GE Medical Systems, Milwaukee, WI) and cortical reconstruction and volumetric segmentation by FreeSurfer software have been used. Results: No significant differences between uncomplicated and complicated MTBIs were found in neuroanatomic volumes and cortical thickness after controlling for age, gender and education. The complicated MTBI group showed larger ventricles compared with the uncomplicated group, but this effect diluted when adjusting for potential confounders. Conclusion: The study findings suggest that the classification of complicated and uncomplicated MTBI may be too broad to differentiate volumetric and morphometric effects of injury in the early post-injury phase.
Hibar, Derrek; Westlye, Lars Tjelta; Van Erp, TGM; Rasmussen, J; Leonardo, CD; Faskowitz, J; Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Doan, Nhat Trung; Agartz, Ingrid; Dale, AM; Gruber, O; Krämer, B; Trost, S; Liberg, B; Abe, C; Ekman, CJ; Ingvar, M; Landen, M; Fears, SC; Freimer, NB; Bearden, CE; Sprooten, E; Glahn, DC; Pearlson, GD; Emsell, L; Kenney, J; Scanlon, C; McDonald, C; Cannon, DM; Almeida, J; Versace, A; Caseras, X; Lawrence, NS; Phillips, ML; Dima, D; Delvecchio, G; Frangou, S; Satterthwaite, TD; Wolf, D; Houenou, J; Henry, C; Malt, Ulrik Fredrik; Bøen, Erlend; Elvsåshagen, Torbjørn; Young, AH; Lloyd, AJ; Goodwin, GM; Mackay, CE; Bourne, C; Bilderbeck, A; Abramovic, L; Boks, MP; Van Haren, NEM; Ophoff, RA; Kahn, RS; Bauer, M; Pfennig, A; Alda, M; Hajek, T; Mwangi, B; Soares, JC; Nickson, T; Dimitrova, R; Sussmann, JE; Hagenaars, S; Whalley, HC; McIntosh, AM; Thompson, PM & Andreassen, Ole Andreas (2016). Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry. ISSN 1359-4184. 21(12), s 1710- 1716 . doi: 10.1038/mp.2015.227 Vis sammendrag
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case–control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen’s d=−0.232; P=3.50 × 10−7) and thalamus (d=−0.148; P=4.27 × 10−3) and enlarged lateral ventricles (d=−0.260; P=3.93 × 10−5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.
Jørgensen, Kjetil Nordbø; Nerland, Stener; Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Nesvåg, Ragnar; Mørch-Johnsen, Lynn; Haukvik, Unn Kristin H.; Melle, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Agartz, Ingrid (2016). Increased MRI-based cortical grey/white-matter contrast in sensory and motor regions in schizophrenia and bipolar disorder. Psychological Medicine. ISSN 0033-2917. 46(9), s 1971- 1985 . doi: 10.1017/S0033291716000593
Qian, Peng; Schork, Andrew J.; Bartsch, Hauke; Lo, Min-Tzu; Panizzon, Matthew S.; Westlye, Lars Tjelta; Kremen, William S.; Jernigan, Terry L.; Le Hellard, Stephanie; Steen, Vidar Martin; Espeseth, Thomas; Huentelman, Matt; Håberg, Asta; Agartz, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas; Dale, Anders; Schork, Nicholas J.; Chen, Chi-Hua & Schork, Nicholas J (2016). Conservation of Distinct Genetically-Mediated Human Cortical Pattern. PLoS Genetics. ISSN 1553-7390. 12:e1006143(7) . doi: 10.1371/journal.pgen.1006143 Fulltekst i vitenarkiv.
Quintana, Daniel; Elstad, Maja; Kaufmann, Tobias; Brandt, Christine Lycke; Haatveit, Beathe Christin; Haram, Marit; Nerhus, Mari; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2016). Resting-state heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls. Scientific Reports. ISSN 2045-2322. 6:37212, s 1- 8 . doi: 10.1038/srep37212 Fulltekst i vitenarkiv.
Quintana, Daniel; Guastella, Adam J.; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2016). The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders. Molecular Psychiatry. ISSN 1359-4184. 21(1), s 29- 38 . doi: 10.1038/mp.2015.166
Quintana, Daniel; Outhred, Tim; Westlye, Lars Tjelta; Malhi, Gin & Andreassen, Ole Andreas (2016). The impact of oxytocin administration on brain activity: a systematic review and meta-analysis protocol. Systematic Reviews. ISSN 2046-4053. 5(1) . doi: 10.1186/s13643-016-0386-2
Quintana, Daniel; Westlye, Lars Tjelta; Alnæs, Dag; Rustan, Øyvind; Kaufmann, Tobias; Smerud, Knut Terje; Mahmoud, Ramy; Djupesland, Per G. & Andreassen, Ole Andreas (2016). Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within- subjects randomized dose-response fMRI trial. Psychoneuroendocrinology. ISSN 0306-4530. 69, s 180- 188 . doi: 10.1016/j.psyneuen.2016.04.010 Fulltekst i vitenarkiv.
Quintana, Daniel; Westlye, Lars Tjelta; Smerud, Knut T.; Mahmoud, Ramy; Djupesland, Per G. & Andreassen, Ole Andreas (2016). Reliability of basal plasma vasopressin concentrations in healthy male adults. Acta Neuropsychiatrica. ISSN 0924-2708. . doi: 10.1017/neu.2016.67
Skåtun, Kristina Cecilie; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; Jönsson, Erik Gunnar; Fatouros-Bergman, Helena; Flyckt, Lena; Melle, Ingrid; Andreassen, Ole Andreas; Agartz, Ingrid & Westlye, Lars Tjelta (2016). Consistent functional connectivity alterations in schizophrenia spectrum disorder: a multisite study. Schizophrenia Bulletin. ISSN 0586-7614. 43(4), s 914- 924 . doi: 10.1093/schbul/sbw145
Skåtun, Kristina Cecilie; Kaufmann, Tobias; Tønnesen, Siren; Biele, Guido; Melle, Ingrid; Agartz, Ingrid; Alnæs, Dag; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2016). Global brain connectivity alterations in persons with schizophrenia and bipolar spectrum disorders. Journal of Psychiatry & Neuroscience. ISSN 1180-4882. 41(5), s 331- 341 . doi: 10.1503/jpn.150159 Fulltekst i vitenarkiv.
Ulrichsen, Kristine Moe; Kaufmann, Tobias; Dørum, Erlend Solberg; Kolskår, Knut-Kristian; Richard, Geneviéve´; Alnæs, Dag; Arneberg, Tone Johanne; Westlye, Lars Tjelta & Nordvik, Jan Egil (2016). Clinical utility of mindfulness training in the treatment of fatigue after stroke, traumatic brain injury and multiple sclerosis: A systematic literature review and meta-analysis. Frontiers in Psychology. ISSN 1664-1078. 7 . doi: 10.3389/fpsyg.2016.00912 Fulltekst i vitenarkiv.
Valstad, Mathias; Alvares, Gail A.; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Quintana, Daniel (2016). The relationship between central and peripheral oxytocin concentrations: a systematic review and meta-analysis protocol. Systematic Reviews. ISSN 2046-4053. 5(49) . doi: 10.1186/s13643-016-0225-5 Fulltekst i vitenarkiv.
Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Duff, Eugene; Sneve, Markus Handal; Endestad, Tor; Nordvik, Jan Egil; Andreassen, Ole Andreas; Smith, Stephen M. & Westlye, Lars Tjelta (2015). Attentional load modulates large-scale functional brain connectivity beyond the core attention networks. NeuroImage. ISSN 1053-8119. 109, s 260- 272 . doi: 10.1016/j.neuroimage.2015.01.026 Vis sammendrag
In line with the notion of a continuously active and dynamic brain, functional networks identified during rest correspond with those revealed by task-fMRI. Characterizing the dynamic cross-talk between these network nodes is key to understanding the successful implementation of effortful cognitive processing in healthy individuals and its breakdown in a variety of conditions involving aberrant brain biology and cognitive dysfunction. We employed advanced network modeling on fMRI data collected during a task involving sustained attentive tracking of objects at two load levels and during rest. Using multivariate techniques, we demonstrate that attentional load levels can be significantly discriminated, and from a resting-state condition, the accuracy approaches 100%, by means of estimates of between-node functional connectivity. Several network edges were modulated during task engagement: The dorsal attention network increased connectivity with a visual node, while decreasing connectivity with motor and sensory nodes. Also, we observed a decoupling between left and right hemisphere dorsal visual streams. These results support the notion of dynamic network reconfigurations based on attentional effort. No simple correspondence between node signal amplitude change and node connectivity modulations was found, thus network modeling provides novel information beyond what is revealed by conventional task-fMRI analysis. The current decoding of attentional states confirms that edge connectivity contains highly predictive information about the mental state of the individual, and the approach shows promise for the utilization in clinical contexts.
Alnæs, Dag; Sneve, Markus Handal; Richard, Geneviéve´; Skåtun, Kristina Cecilie; Kaufmann, Tobias; Nordvik, Jan Egil; Andreassen, Ole Andreas; Endestad, Tor; Laeng, Bruno & Westlye, Lars Tjelta (2015). Functional connectivity indicates differential roles for the intraparietal sulcus and the superior parietal lobule in multiple object tracking. NeuroImage. ISSN 1053-8119. 123, s 129- 137 . doi: 10.1016/j.neuroimage.2015.08.029
Brandt, Christine Lycke; Doan, Nhat Trung; Tønnesen, Siren; Agartz, Ingrid; Hugdahl, Kenneth; Melle, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2015). Assessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis. NeuroImage: Clinical. ISSN 2213-1582. 9, s 253- 263 . doi: 10.1016/j.nicl.2015.08.010 Fulltekst i vitenarkiv.
Brandt, Christine Lycke; Kaufmann, Tobias; Agartz, Ingrid; Hugdahl, Kenneth; Jensen, Jimmy Kristian; Ueland, Toril; Haatveit, Beathe Christin; Skåtun, Kristina Cecilie; Doan, Nhat Trung; Melle, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2015). Cognitive effort and schizophrenia modulate large-scale functional brain connectivity. Schizophrenia Bulletin. ISSN 0586-7614. 41(6), s 1360- 1369 . doi: 10.1093/schbul/sbv013

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Maximov, Ivan; Alnæs, Dag & Westlye, Lars Tjelta (2019). Influence of diffusion pipeline on data analysis: UK Biobank example for age-diffusion dependences.
Maximov, Ivan & Westlye, Lars Tjelta (2019). Variability of NODDI metrics between AMICO and original NODDI in UK Biobank data.
Ousdal, Olga Therese; Lundervold, Astri; Westlye, Lars Tjelta & Lundervold, Arvid (2018). Longitudinal stability of the brain functional connectome is associated with episodic memory performance.
Córdova-Palomera, Aldo; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; Alnæs, Dag; Moberget, Torgeir; Kaufmann, Tobias; Sønderby, Ida Elken; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2016). POTENTIAL BRAIN MORPHOLOGY INSTABILITY FEATURES MEDIATING THE ASSOCIATION BETWEEN GENOME-WIDE HOMOZYGOSITY AND ALTERED NEUROCOGNITION.
Hellstrøm, Torgeir; Westlye, Lars Tjelta; Røe, Cecilie; SERVER, ANDRES & Andelic, Nada (2016). Longitudinal changes in brain volume and cortical thickness and functional outcomes during the first year after mild traumatic brain injury. Brain Injury. ISSN 0269-9052. 30(5-6), s 646- 646 . doi: 10.3109/02699052.2016.1162060

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Publisert 20. sep. 2010 11:30 - Sist endret 17. juni 2019 11:53

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