AgeConsolidate: The Missing Link of Episodic Memory Decline in Aging
The Role of Inefficient Systems Consolidation.
About the project
Which brain mechanisms are responsible for the faith of the memories we make with age, whether they wither or stay, and in what form? Episodic memory function does decline with age. While this decline can have multiple causes, research has focused almost entirely on encoding and retrieval processes, largely ignoring a third critical process– consolidation.
The objective of this project is to provide this missing link, by combining novel experimental cognitive paradigms with neuroimaging in a longitudinal large-scale attempt to directly test how age-related changes in consolidation processes in the brain impact episodic memory decline. The ambitious aims of the present proposal are two-fold:
(1) Use recent advances in memory consolidation theory to achieve an elaborate model of episodic memory deficits in aging
(2) Use aging as a model to uncover how structural and functional brain changes affect episodic memory consolidation in general
The novelty of the project lies in the synthesis of recent methodological advances and theoretical models for episodic memory consolidation to explain age-related decline, by employing a unique combination of a range of different techniques and approaches. This is ground-breaking, in that it aims at taking our understanding of the brain processes underlying episodic memory decline in aging to a new level, while at the same time advancing our theoretical understanding of how episodic memories are consolidated in the human brain.
Project full title: AgeConsolidate – The Missing Link of Episodic Memory Decline in Aging: The Role of Inefficient Systems Consolidation.
This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 725025).