Brain function in early-onset psychosis (completed)

About the project

We are studying a group of patients with psychosis, aged 12-18 years. The patient group and a group of healthy controls have been assessed at three time points at one-year intervals (longitudinal study - “The early onset study”).

Objectives

The aim of this study is to generate knowledge relevant for the discussion of whether schizophrenia is a degenerative disorder. Present neuropsychological and morphological data have not been able to provide conclusive answers to this question.

A further aim is to find out if the early-onset and adult-onset psychoses are characterized by different neurocognitive impairments. This also pertains to the longitudinal development of these neurocognitive impairments.

Outcomes

The patients undergo a clinical interview and are assessed with a comprehensive neuropsychological battery (the MCCB).  Structural and functional MR studies are performed at Oslo University Hospital, in collaboration with TOP/NORMENT.

Cooperation

Three Ph.D. candidates, financed by the University of Oslo and Helse Sør Øst, have been part of this study. All three have defended their thesis (Holmen, Thormodsen and Juuhl-Langseth).

Publication

Holmen, Juuhl-Langseth, Thormodsen, Melle & Rund: Neuropsychological Profile in Early-Onset Schizophrenia-Spectrum Disorders: Measured With the MATRICS Battery

Published Apr. 4, 2014 9:00 AM - Last modified Oct. 20, 2016 9:58 AM