Thomas Espeseth

• Bøen, Rune; Kaufmann, Tobias Herbert; van der Meer, Dennis; Frei, Oleksandr; Agartz, Ingrid & Ames, David [Vis alle 53 forfattere av denne artikkelen] (2023). Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers. Biological Psychiatry. ISSN 0006-3223. 95(2), s. 147–160. doi: 10.1016/j.biopsych.2023.08.018. Fulltekst i vitenarkiv
• Korbmacher, Max; Wang, Mengyun; Eikeland, Rune; Buchert, Ralph; Andreassen, Ole & Espeseth, Thomas [Vis alle 10 forfattere av denne artikkelen] (2023). Considerations on brain age predictions from repeatedly sampled data across time. Brain and Behavior. ISSN 2162-3279. doi: 10.1002/brb3.3219. Fulltekst i vitenarkiv
• Herrebrøden, Henrik; Espeseth, Thomas & Bishop, Laura (2023). Mental Effort in Elite and Nonelite Rowers. Journal of Sport & Exercise Psychology (JSEP). ISSN 0895-2779. 45(4), s. 208–223. doi: 10.1123/jsep.2022-0164. Fulltekst i vitenarkiv
• Herrebrøden, Henrik; Jensenius, Alexander Refsum; Espeseth, Thomas; Bishop, Laura & Vuoskoski, Jonna Katariina (2023). Cognitive load causes kinematic changes in both elite and non-elite rowers. Human Movement Science. ISSN 0167-9457. 90. doi: 10.1016/j.humov.2023.103113. Fulltekst i vitenarkiv
• Brouwer, Rachel M.; Klein, Marieke; Grasby, Katrina L.; Schnack, Hugo G.; Jahanshad, Neda & Teeuw, Jalmar [Vis alle 200 forfattere av denne artikkelen] (2022). Genetic variants associated with longitudinal changes in brain structure across the lifespan. Nature Neuroscience. ISSN 1097-6256. 25(4), s. 421–432. doi: 10.1038/s41593-022-01042-4.
• Kraft, Pål; Kraft, Brage; Hagen, Thomas & Espeseth, Thomas (2022). Subjective Socioeconomic Status, Cognitive Abilities, and Personal Control: Associations With Health Behaviours. Frontiers in Psychology. ISSN 1664-1078. 12. doi: 10.3389/fpsyg.2021.784758.
• Leonardsen, Esten Høyland; Peng, Han; Kaufmann, Tobias; Agartz, Ingrid; Andreassen, Ole & Celius, Elisabeth Gulowsen [Vis alle 19 forfattere av denne artikkelen] (2022). Deep neural networks learn general and clinically relevant representations of the ageing brain. NeuroImage. ISSN 1053-8119. 256. doi: 10.1016/j.neuroimage.2022.119210. Fulltekst i vitenarkiv Vis sammendrag

  The discrepancy between chronological age and the apparent age of the brain based on neuroimaging data — the brain age delta — has emerged as a reliable marker of brain health. With an increasing wealth of data, approaches to tackle heterogeneity in data acquisition are vital. To this end, we compiled raw structural magnetic resonance images into one of the largest and most diverse datasets assembled (n=53542), and trained convolutional neural networks (CNNs) to predict age. We achieved state-of-the-art performance on unseen data from unknown scanners (n=2553), and showed that higher brain age delta is associated with diabetes, alcohol intake and smoking. Using transfer learning, the intermediate representations learned by our model complemented and partly outperformed brain age delta in predicting common brain disorders. Our work shows we can achieve generalizable and biologically plausible brain age predictions using CNNs trained on heterogeneous datasets, and transfer them to clinical use cases.

• Frangou, Sophia; Modabbernia, Amirhossein; Williams, Steven C. R.; Papachristou, Efstathios; Doucet, Gaëlle E. & Agartz, Ingrid [Vis alle 63 forfattere av denne artikkelen] (2022). Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Human Brain Mapping. ISSN 1065-9471. 43(1), s. 431–451. doi: 10.1002/hbm.25364. Fulltekst i vitenarkiv
• Dima, Danai; Modabbernia, Amirhossein; Papachristou, Efstathios; Doucet, Gaëlle E.; Agartz, Ingrid & Aghajani, Moji [Vis alle 52 forfattere av denne artikkelen] (2022). Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping. ISSN 1065-9471. 43(1), s. 452–469. doi: 10.1002/hbm.25320. Fulltekst i vitenarkiv
• Lam, Max; Chen, Chia-Yen; Ge, Tian; Xia, Yan; Hill, David W. & Trampush, Joey W. [Vis alle 71 forfattere av denne artikkelen] (2021). Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics. Neuropsychopharmacology. ISSN 0893-133X. 46(10), s. 1788–1801. doi: 10.1038/s41386-021-01023-4. Fulltekst i vitenarkiv
• Bølstad, Evalill; Havighurst, Sophie S.; Tamnes, Christian K.; Nygaard, Egil; Bjørk, Rune Flaaten & Stavrinou, Maria [Vis alle 7 forfattere av denne artikkelen] (2021). A Pilot Study of a Parent Emotion Socialization Intervention: Impact on Parent Behavior, Child Self-Regulation, and Adjustment. Frontiers in Psychology. ISSN 1664-1078. 12, s. 1–15. doi: 10.3389/fpsyg.2021.730278. Fulltekst i vitenarkiv
• Sønderby, Ida Elken; Ching, Christopher R. K.; Thomopoulos, Sophia I.; van der Meer, Dennis; Sun, Daqiang & Villalon-Reina, Julio E. [Vis alle 52 forfattere av denne artikkelen] (2021). Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Human Brain Mapping. ISSN 1065-9471. 43, s. 470–499. doi: 10.1002/hbm.25354. Fulltekst i vitenarkiv
• Polushina, Tatiana; Banerjee, Niladri; Giddaluru, Sudheer; Bettella, Francesco; Espeseth, Thomas & Lundervold, Astri J. [Vis alle 13 forfattere av denne artikkelen] (2021). Identification of pleiotropy at the gene level between psychiatric disorders and related traits. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-021-01530-4. Fulltekst i vitenarkiv
• Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi & Ellegaard, Maria [Vis alle 76 forfattere av denne artikkelen] (2021). 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01213-0. Fulltekst i vitenarkiv
• Høgestøl, Einar August; Ghezzo, Samuele; Nygaard, Gro Owren; Espeseth, Thomas; Sowa, Piotr & Beyer, Mona K. [Vis alle 10 forfattere av denne artikkelen] (2021). Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study. Multiple Sclerosis. ISSN 1352-4585. s. 1–9. doi: 10.1177/13524585211030212. Fulltekst i vitenarkiv
• Bøen, Rune; Ferschmann, Lia; Vijayakumar, Nandita; Øverbye, Knut; Fjell, Anders Martin & Espeseth, Thomas [Vis alle 7 forfattere av denne artikkelen] (2021). Development of attention networks from childhood to young adulthood: A study of performance, intraindividual variability and cortical thickness. Cortex. ISSN 0010-9452. 138, s. 138–151. doi: 10.1016/j.cortex.2021.01.018. Fulltekst i vitenarkiv
• Mäki-Marttunen, Verónica & Espeseth, Thomas (2021). Uncovering the locus coeruleus: Comparison of localization methods for functional analysis. NeuroImage. ISSN 1053-8119. 224:117409, s. 1–15. doi: 10.1016/j.neuroimage.2020.117409.
• Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang & Li, Shuo [Vis alle 51 forfattere av denne artikkelen] (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-18367-y. Fulltekst i vitenarkiv
• Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita & Hibar, DP [Vis alle 50 forfattere av denne artikkelen] (2020). The genetic architecture of the human cerebral cortex. Science. ISSN 0036-8075. 367(6484). doi: 10.1126/science.aay6690. Fulltekst i vitenarkiv Vis sammendrag

  INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.

• Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag & Barch, Deanna M. [Vis alle 76 forfattere av denne artikkelen] (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-17376-1. Fulltekst i vitenarkiv Vis sammendrag

  Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.

• Mäki-Marttunen, Verónica; Andreassen, Ole Andreas & Espeseth, Thomas (2020). The role of norepinephrine in the pathophysiology of schizophrenia. Neuroscience and Biobehavioral Reviews. ISSN 0149-7634. 118, s. 298–314. doi: 10.1016/j.neubiorev.2020.07.038. Fulltekst i vitenarkiv
• Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng & Alnæs, Dag [Vis alle 40 forfattere av denne artikkelen] (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry. ISSN 1359-4184. s. 1–8. doi: 10.1038/s41380-020-0664-1. Fulltekst i vitenarkiv
• Aminihajibashi, Samira; Hagen, Thomas; Andreassen, Ole Andreas; Laeng, Bruno & Espeseth, Thomas (2020). The effects of cognitive abilities and task demands on tonic and phasic pupil sizes. Biological Psychology. ISSN 0301-0511. 156. doi: 10.1016/j.biopsycho.2020.107945. Fulltekst i vitenarkiv
• Aminihajibashi, Samira; Hagen, Thomas; Laeng, Bruno & Espeseth, Thomas (2020). Pupillary and behavioral markers of alerting and orienting: An individual difference approach. Brain and Cognition. ISSN 0278-2626. 143. doi: 10.1016/j.bandc.2020.105597. Fulltekst i vitenarkiv
• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob & Zhu, Zhaozhong [Vis alle 66 forfattere av denne artikkelen] (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. ISSN 0092-8674. 179(7), s. 1469–1482. doi: 10.1016/j.cell.2019.11.020. Fulltekst i vitenarkiv
• Mäki-Marttunen, Verónica; Hagen, Thomas; Laeng, Bruno & Espeseth, Thomas (2019). Distinct Neural Mechanisms Meet Challenges in Dynamic Visual Attention due to Either Load or Object Spacing. Journal of Cognitive Neuroscience. ISSN 0898-929X. 32(1), s. 65–84. doi: 10.1162/jocn_a_01469.
• Richards, Alexander L.; Pardiñas, Antonio F.; Frizzati, Aura; Tansey, Katherine E.; Lynham, Amy J. & Holmans, Peter [Vis alle 48 forfattere av denne artikkelen] (2019). The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia. Schizophrenia Bulletin. ISSN 0586-7614. doi: 10.1093/schbul/sbz061. Vis sammendrag

  BACKGROUND: Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. METHODS: We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results were then meta-analyzed across all samples. A genome-wide association studies (GWAS) of cognition was conducted in schizophrenia cases. RESULTS: PRS for both population IQ (P = 4.39 x 10-28) and EA (P = 1.27 x 10-26) were positively correlated with cognition in those with schizophrenia. In contrast, there was no association between cognition in schizophrenia cases and PRS for schizophrenia (P = .39), BD (P = .51), or MDD (P = .49). No individual variant approached genome-wide significance in the GWAS. CONCLUSIONS: Cognition in schizophrenia cases is more strongly associated with PRS that index cognitive traits in the general population than PRS for neuropsychiatric disorders. This suggests the mechanisms of cognitive variation within schizophrenia are at least partly independent from those that predispose to schizophrenia diagnosis itself. Our findings indicate that this cognitive variation arises at least in part due to genetic factors shared with cognitive performance in populations and is not solely due to illness or treatment-related factors, although our findings are consistent with important contributions from these factors.

• Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J. & Stein, Jason L. [Vis alle 289 forfattere av denne artikkelen] (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics. ISSN 1061-4036. 51, s. 1624–1636. doi: 10.1038/s41588-019-0511-y. Fulltekst i vitenarkiv Vis sammendrag

  Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

• Mäki-Marttunen, Verónica; Hagen, Thomas & Espeseth, Thomas (2019). Proactive and reactive modes of cognitive control can operate independently and simultaneously. Acta Psychologica. ISSN 0001-6918. 199. doi: 10.1016/j.actpsy.2019.102891.
• van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel & Ames, David [Vis alle 132 forfattere av denne artikkelen] (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2019.3779. Vis sammendrag

  IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders

• Lam, Max; Hill, W. David; Trampush, Joey W.; Yu, Jin; Knowles, Emma & Davies, Gail [Vis alle 68 forfattere av denne artikkelen] (2019). Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways. American Journal of Human Genetics. ISSN 0002-9297. 105(2), s. 334–350. doi: 10.1016/j.ajhg.2019.06.012. Fulltekst i vitenarkiv
• Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette & Agartz, Ingrid [Vis alle 84 forfattere av denne artikkelen] (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22(10), s. 1617–1623. doi: 10.1038/s41593-019-0471-7. Fulltekst i vitenarkiv
• Aminihajibashi, Samira; Hagen, Thomas; Foldal, Maja Dyhre; Laeng, Bruno & Espeseth, Thomas (2019). Individual differences in resting-state pupil size: Evidence for association between working memory capacity and pupil size variability. International Journal of Psychophysiology. ISSN 0167-8760. 140, s. 1–7. doi: 10.1016/j.ijpsycho.2019.03.007. Fulltekst i vitenarkiv
• Mäki-Marttunen, Verónica; Hagen, Thomas & Espeseth, Thomas (2019). Task context load induces reactive cognitive control: An fMRI study on cortical and brain stem activity. Cognitive, Affective, & Behavioral Neuroscience. ISSN 1530-7026. s. 1–21. doi: 10.3758/s13415-019-00691-6. Fulltekst i vitenarkiv Vis sammendrag

  When solving dynamic visuo-spatial tasks, the brain copes with perceptual and cognitive processing challenges. In the multiple-object tracking (MOT) task, the number of objects to be tracked (i.e. load) imposes attentional demands, but so does spatial interference from irrelevant objects (i.e. crowding). Presently, it is not clear whether load and crowding activate separate cognitive and physiological mechanisms. Such knowledge would be important to understand the neurophysiology of visual attention. Furthermore, it would help resolve conflicting views between theories of visual cognition, particularly concerning sources of capacity limitations. To address this problem, we varied the degree of processing challenge in the MOT task in two ways: First, the number of objects to track, and second, the spatial proximity between targets and distractors. We first measured task-induced pupil dilations and saccades during MOT. In a separate cohort we measured fMRI brain activity during MOT. The behavioral results in both cohorts revealed that increased load and crowding led to reduced accuracy in an additive manner. Load was associated with pupil dilations, whereas crowding was not. Activity in dorsal attentional areas and frequency of saccades were proportionally larger both with higher levels of load and crowding. Higher crowding recruited additionally ventral attentional areas that may reflect orienting mechanisms. The activity in the brainstem nuclei ventral tegmental area/substantia nigra and locus coeruleus showed clearly dissociated patterns. Our results constitute convergent evidence from independent samples that processing challenges due to load and object spacing may rely on different mechanisms.

• Mæhlum Walle, Kjersti; Nordvik, Jan Egil; Becker, Frank; Espeseth, Thomas; Sneve, Markus Handal & Laeng, Bruno (2019). Unilateral neglect post stroke: Eye movement frequencies indicate directional hypokinesia while fixation distributions suggest compensational mechanism. Brain and Behavior. ISSN 2162-3279. 9:e01170(1). doi: 10.1002/brb3.1170. Fulltekst i vitenarkiv
• Mæhlum Walle, Kjersti; Nordvik, Jan Egil; Espeseth, Thomas; Becker, Frank & Laeng, Bruno (2018). Multiple object tracking and pupillometry reveal deficits in both selective and intensive attention in unilateral spatial neglect. Journal of Clinical and Experimental Neuropsychology. ISSN 1380-3395. 49(3), s. 270–289. doi: 10.1080/13803395.2018.1536735.
• Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra & Espeseth, Thomas [Vis alle 15 forfattere av denne artikkelen] (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry. ISSN 1359-4184. s. 1–16. doi: 10.1038/s41380-019-0358-8. Fulltekst i vitenarkiv
• van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir & Alnæs, Dag [Vis alle 54 forfattere av denne artikkelen] (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. ISSN 1359-4184. s. 1–13. doi: 10.1038/s41380-018-0262-7. Fulltekst i vitenarkiv
• Hagen, Thomas; Espeseth, Thomas & Laeng, Bruno (2018). Chasing Animals With Split Attention: Are Animals Prioritized in Visual Tracking? i-Perception. ISSN 2041-6695. 9(5), s. 1–35. doi: 10.1177/2041669518795932. Fulltekst i vitenarkiv
• Mäki-Marttunen, Verónica; Hagen, Thomas; Aminihajibashi, Samira; Foldal, Maja Dyhre; Stavrinou, Maria & Halvorsen, Jens [Vis alle 8 forfattere av denne artikkelen] (2018). Ocular signatures of proactive versus reactive cognitive control in young adults. Cognitive, Affective, & Behavioral Neuroscience. ISSN 1530-7026. s. 1–15. doi: 10.3758/s13415-018-0621-5.
• Savage, Jeanne E.; Jansen, Philip R.; Stringer, Sven; Watanabe, Kyoko; Bryois, Julien & de Leeuw, Christiaan A. [Vis alle 117 forfattere av denne artikkelen] (2018). Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nature Genetics. ISSN 1061-4036. 50, s. 912–919. doi: 10.1038/s41588-018-0152-6.
• Fan, Chun Chieh; Schork, Andrew J.; Brown, Timothy T.; Spencer, Barbara E.; Akshoomoff, Natacha & Chen, Chi-Hua [Vis alle 16 forfattere av denne artikkelen] (2018). Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes. Translational Psychiatry. ISSN 2158-3188. 8:114(1), s. 1–8. doi: 10.1038/s41398-018-0166-y. Fulltekst i vitenarkiv
• Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose & Duncan, Laramie [Vis alle 571 forfattere av denne artikkelen] (2018). Analysis of shared heritability in common disorders of the brain. Science. ISSN 0036-8075. 360(6395). doi: 10.1126/science.aap8757. Fulltekst i vitenarkiv
• Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle & Hill, W. David [Vis alle 221 forfattere av denne artikkelen] (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. ISSN 2041-1723. 9(2098), s. 1–16. doi: 10.1038/s41467-018-04362-x. Fulltekst i vitenarkiv
• Polushina, Tatiana; Giddaluru, Sudheer; Bettella, Francesco; Espeseth, Thomas; Lundervold, Astri & Djurovic, Srdjan [Vis alle 12 forfattere av denne artikkelen] (2017). Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data. Translational Psychiatry. ISSN 2158-3188. 7(12). doi: 10.1038/s41398-017-0033-2.
• Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail & Liewald, David C. [Vis alle 65 forfattere av denne artikkelen] (2017). Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets. Cell reports. ISSN 2211-1247. 21(9), s. 2597–2613. doi: 10.1016/j.celrep.2017.11.028.
• Jensen, Jacob Malte; Villesen, Palle; Friborg, Rune Møllegaard; Espeseth, Thomas; Le Hellard, Stephanie & Mailund, Thomas [Vis alle 8 forfattere av denne artikkelen] (2017). Assembly and analysis of 100 full MHC haplotypes from the Danish population. Genome Research. ISSN 1088-9051. 27(9), s. 1597–1607. doi: 10.1101/gr.218891.116.
• Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent; Sibbesen, Jonas Andreas; Liu, Siyang & Villesen, Palle [Vis alle 59 forfattere av denne artikkelen] (2017). Sequencing and de novo assembly of 150 genomes from Denmark as a population reference. Nature. ISSN 0028-0836. 548(7665), s. 87–91. doi: 10.1038/nature23264.
• Li, Dong; Chang, Xiao; Connolly, John J.; Tian, Lifeng; Liu, Yichuan & Bhoj, Elizabeth J. [Vis alle 199 forfattere av denne artikkelen] (2017). A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling. Scientific Reports. ISSN 2045-2322. 7:3847, s. 1–9. doi: 10.1038/s41598-017-01674-8.
• Hibar, Derrek; Adams, Hieab H.H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L. & Hofer, Edith [Vis alle 332 forfattere av denne artikkelen] (2017). Novel genetic loci associated with hippocampal volume. Nature Communications. ISSN 2041-1723. 8:13624, s. 1–12. doi: 10.1038/ncomms13624. Fulltekst i vitenarkiv
• Trampush, Joey W.; Yang, M.L.Z.; Yu, Jin; Knowles, Emma; Davies, Gail & Liewald, David C.M. [Vis alle 66 forfattere av denne artikkelen] (2017). GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report form the COGENT consortium. Molecular Psychiatry. ISSN 1359-4184. 22(3), s. 336–345. doi: 10.1038/mp.2016.244. Fulltekst i vitenarkiv
• Le Hellard, Stephanie; Wang, Yunpeng; Witoelar, Aree; Zuber, Verena; Bettella, Francesco & Hugdahl, Kenneth [Vis alle 15 forfattere av denne artikkelen] (2017). Identification of gene loci that overlap between schizophrenia and educational attainment. Schizophrenia Bulletin. ISSN 0586-7614. 43(3), s. 654–664. doi: 10.1093/schbul/sbw085.
• Lillenes, Meryl Sønderby; Støen, Mari; Günther, Clara-Cecilie; Selnes, Per; Stenset, Vidar & Espeseth, Thomas [Vis alle 9 forfattere av denne artikkelen] (2017). Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance. Neuroscience Letters. ISSN 0304-3940. 645, s. 46–52. doi: 10.1016/j.neulet.2017.02.062. Vis sammendrag

  Mitochondrial dysfunction and DNA damage is intimately connected to ageing and neurodegeneration, including Alzheimer’s disease (AD). A particular culprit in this context is oxidative stress, which is a result of increased reactive oxygen species (ROS) due to hyperactive or dysfunctional mitochondria and/or reduced DNA repair capacity. Base excision repair (BER) is the major pathway for repairing oxidative damage events in chromosomal and mitochondrial DNA. Defects in BER have been detected in ageing and neurodegeneration. Mitochondrial transcription factor A (TFAM) plays an important role in the maintenance of mitochondrial DNA integrity. The present study investigated single nucleotide polymorphisms (SNPs) in the genes encoding the BER components MutYH, OGG1, APE1, PolB and PolG and the gene encoding mitochondrial TFAM in a cohort of 161 AD patients, 96 non-AD patient controls (PC) and 192 healthy controls (HC). Notably, the minor allele carriers of APE1 rs1130409 and the common allele carriers of TFAM rs1937 were associated with reduced mini-mental state examination score in AD patients, PC and HC, with no distinction of SNP frequencies in either of these sub-groups. Collectively, the results suggest an association between DNA maintenance and decline in cognitive function. These studies enlighten the normal brain aging process and point to potential new biomarkers for cognitive function and impairment.

• Athanasiu, Lavinia; Giddaluru, Sudheer; Neto, Carla Patricia Duarte Fernande; Christoforou, Andrea; Reinvang, Ivar & Lundervold, Astri [Vis alle 17 forfattere av denne artikkelen] (2017). A genetic association study of CSMD1 and CSMD2 with cognitive function. Brain, Behavior, and Immunity. ISSN 0889-1591. 61, s. 209–216. doi: 10.1016/j.bbi.2016.11.026.
• Adams, Hieab H.H.; Hibar, Derrek; Chouraki, Vincent; Stein, Jason L.; Nyquist, Paul A. & Renteriá, Miguel E. [Vis alle 342 forfattere av denne artikkelen] (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience. ISSN 1097-6256. 19(12), s. 1569–1582. doi: 10.1038/nn.4398.
• Gunnarsson, Bjarni; Jonsdottir, Gudrun A; Bjornsdottir, Gyda; Konte, Bettina; Sulem, Patrick & Kristmundsdottir, Snædis [Vis alle 31 forfattere av denne artikkelen] (2016). A sequence variant associating with educational attainment also affects childhood cognition. Scientific Reports. ISSN 2045-2322. 6. doi: 10.1038/srep36189.
• Guadalupe, Tulio; Mathias, Samuel R.; VanErp, Theo G.M.; Whelan, Christopher D.; Zwiers, Marcel P. & Abe, Yoshinari [Vis alle 161 forfattere av denne artikkelen] (2016). Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behavior. ISSN 1931-7557. Published ahead of print, s. 1–18. doi: 10.1007/s11682-016-9629-z.
• Athanasiadis, Georgios; Cheng, Jade Y.; Vilhjálmsson, Bjarni J.; Jørgensen, Frank G.; Als, Thomas D. & Le Hellard, Stephanie [Vis alle 12 forfattere av denne artikkelen] (2016). Nationwide genomic study in Denmark reveals remarkable population homogeneity. Genetics. ISSN 0016-6731. 204(2), s. 711–722. doi: 10.1534/genetics.116.189241.
• Qian, Peng; Schork, Andrew J.; Bartsch, Hauke; Lo, Min-Tzu; Panizzon, Matthew S. & Westlye, Lars Tjelta [Vis alle 20 forfattere av denne artikkelen] (2016). Conservation of Distinct Genetically-Mediated Human Cortical Pattern. PLoS Genetics. ISSN 1553-7390. 12:e1006143(7). doi: 10.1371/journal.pgen.1006143. Fulltekst i vitenarkiv
• Giddaluru, Sudheer; Espeseth, Thomas; Salami, Alireza; Westlye, Lars Tjelta; Lundquist, Anders & Christoforou, Andrea [Vis alle 13 forfattere av denne artikkelen] (2016). Genetics of structural connectivity and information processing in the brain. Brain Structure and Function. ISSN 1863-2653. 221(9), s. 4643–4661. doi: 10.1007/s00429-016-1194-0.
• Howrigan, Dave; Simonson, M.A.; Davies, Gail; Harris, SE; Tenesa, A. & Starr, JM [Vis alle 47 forfattere av denne artikkelen] (2016). Genome-wide autozygosity is associated with lower general cognitive ability. Molecular Psychiatry. ISSN 1359-4184. 21(6), s. 837–843. doi: 10.1038/mp.2015.120.
• Espeseth, Thomas (2015). Visuell oppmerksomhet sett fra et matematisk og genetisk perspektiv. Nevropsykologi : Medlemsblad for Norsk Nevropsykologisk Forening. ISSN 1500-8347. 17(1), s. 14–23.
• Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars & Lundervold, Astri [Vis alle 14 forfattere av denne artikkelen] (2015). Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior. ISSN 2162-3279. 5(10). doi: 10.1002/brb3.376. Fulltekst i vitenarkiv
• Chen, Chi-Hua; Peng, Qian; Schork, Andrew J.; Lo, Min-Tzu; Fan, Chun-Chieh & Wang, Yunpeng [Vis alle 22 forfattere av denne artikkelen] (2015). Large-scale genomics unveil polygenic architecture of human cortical surface area. Nature Communications. ISSN 2041-1723. 6:7549. doi: 10.1038/ncomms8549. Fulltekst i vitenarkiv
• Davies, Gail; Armstrong, N; Bis, JC; Bressler, J; Chouraki, V & Giddaluru, Sudheer [Vis alle 129 forfattere av denne artikkelen] (2015). Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949). Molecular Psychiatry. ISSN 1359-4184. 20(2), s. 183–192. doi: 10.1038/mp.2014.188. Fulltekst i vitenarkiv
• Tesli, Martin Steen; Kauppi, Karolina; Bettella, Franscesco; Brandt, Christine Lycke; Kaufmann, Tobias & Espeseth, Thomas [Vis alle 12 forfattere av denne artikkelen] (2015). Altered brain activation during emotional face processing in relation to both diagnosis and polygenic risk of bipolar disorder. PLOS ONE. ISSN 1932-6203. 10:e0134202(7). doi: 10.1371/journal.pone.0134202. Fulltekst i vitenarkiv
• Trampush, Joey W.; Lencz, Todd; Knowles, Emma; Davies, Gail; Guha, Saurav & Pe'er, Itsik [Vis alle 53 forfattere av denne artikkelen] (2015). Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-4841. 168(5), s. 363–373. doi: 10.1002/ajmg.b.32319.
• Hansell, Narelle K.; Halford, Graeme S.; Andrews, Glenda; Shum, David H.K.; Harris, Sarah E. & Davies, Gail [Vis alle 25 forfattere av denne artikkelen] (2015). Genetic basis of a cognitive complexity metric. PLOS ONE. ISSN 1932-6203. 10:e0123886(4). doi: 10.1371/journal.pone.0123886.
• Wehling, Eike; Lundervold, Astri; Espeseth, Thomas; Reinvang, Ivar; Brämerson, Annika & Nordin, Steven (2015). Even cognitively well-functioning adults are unaware of their olfactory dysfunction: Implications for ENT clinicians and researchers. Rhinology. ISSN 0300-0729. 53(1), s. 89–94. doi: 10.4193/Rhino14.081.
• Hibar, Derrek; Stein, Jason L; Renteria, Miguel E; Arias-Vasquez, Alejandro; Desrivieres, Sylvane & Jahanshad, Neda [Vis alle 287 forfattere av denne artikkelen] (2015). Common genetic variants influence human subcortical brain structures. Nature. ISSN 0028-0836. 520(7546), s. 224–229. doi: 10.1038/nature14101.
• Kauppi, Karolina; Westlye, Lars Tjelta; Tesli, Martin Steen; Bettella, Franscesco; Brandt, Christine Lycke & Mattingsdal, Morten [Vis alle 12 forfattere av denne artikkelen] (2015). Polygenic risk for schizophrenia associated with working memory-related prefrontal brain activation in patients with schizophrenia and healthy controls. Schizophrenia Bulletin. ISSN 0586-7614. 41(3), s. 736–743. doi: 10.1093/schbul/sbu152. Vis sammendrag

  Schizophrenia is a highly heritable and polygenic disease, and identified common genetic variants have shown weak individual effects. Many studies have reported altered working memory (WM)-related brain activation in schizophrenia, preferentially in the frontal lobe. Such differences in brain activations could reflect inherited alterations possibly involved in the disease etiology, or rather secondary disease-related mechanisms. The use of polygenic risk scores (PGRS) based on a large number of risk polymorphisms with small effects is a valuable approach to examine the effect of cumulative genetic risk on brain functioning. This study examined the impact of cumulative genetic risk for schizophrenia on WM-related brain activations, assessed with functional magnetic resonance imaging. For each participant (63 schizophrenia patients and 118 healthy controls), we calculated a PGRS for schizophrenia based on 18 862 single-nucleotide polymorphism in a large multicenter genome-wide association study including 9146 schizophrenia patients and 12 111 controls, performed by the Psychiatric Genomics Consortium. As expected, the PGRS was significantly higher in patients compared with healthy controls. Further, the PGRS was related to differences in frontal lobe brain activation between high and low WM demand. Specifically, even in absence of main effects of diagnosis, increased PGRS was associated with decreased activation difference in the right middle-superior prefrontal cortex (BA 10/11) and the right inferior frontal gyrus (BA 45). This effect was seen in both cases and controls, and was not influenced by sex, age, or task performance. The findings support the notion of dysregulation of frontal lobe functioning as an inherited vulnerability factor in schizophrenia.

• Fjell, Anders Martin; Westlye, Lars Tjelta; Amlien, Inge; Tamnes, Christian Krog; Grydeland, Håkon & Engvig, Andreas [Vis alle 11 forfattere av denne artikkelen] (2015). High-expanding cortical regions in human development and evolution are related to higher intellectual abilities. Cerebral Cortex. ISSN 1047-3211. 25, s. 26–34. doi: 10.1093/cercor/bht201. Fulltekst i vitenarkiv
• Christoforou, Andrea; Espeseth, Thomas; Davies, Gail L.; Duarte Fernandes, Carla; Giddaluru, Sudheer & Mattheisen, Manuel [Vis alle 24 forfattere av denne artikkelen] (2014). GWAS-based pathway analysis differentiates between fluid and crystallized intelligence. Genes, Brain and Behavior. ISSN 1601-1848. 13(7). doi: 10.1111/gbb.12152. Fulltekst i vitenarkiv
• Reichborn-Kjennerud, Ted; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Espeseth, Thomas; Lundervold, Astri & Reinvang, Ivar [Vis alle 50 forfattere av denne artikkelen] (2014). A genome-wide association study of anorexia nervosa. Molecular Psychiatry. ISSN 1359-4184. 19(10), s. 1085–1094. doi: 10.1038/mp.2013.187. Fulltekst i vitenarkiv
• Walhovd, Kristine B; Fjell, Anders Martin & Espeseth, Thomas (2014). Cognitive decline and brain pathology in aging - need for a dimensional, lifespan and systems vulnerability view. Scandinavian Journal of Psychology. ISSN 0036-5564. 55(3), s. 244–254. doi: 10.1111/sjop.12120. Fulltekst i vitenarkiv
• Espeseth, Thomas; Vangkilde, Signe A; Petersen, Anders; Dyrholm, Mads & Westlye, Lars Tjelta (2014). TVA-based assessment of attentional capacities-associations with age and indices of brain white matter microstructure. Frontiers in Psychology. ISSN 1664-1078. 5. doi: 10.3389/fpsyg.2014.01177. Vis sammendrag

  In this study the primary aims were to characterize the effects of age on basic components of visual attention derived from assessments based on a theory of visual attention (TVA) in 325 healthy volunteers covering the adult lifespan (19-81 years). Furthermore, we aimed to investigate how age-related differences on TVA parameters are associated with white matter (WM) microstructure as indexed by diffusion tensor imaging (DTI). Finally, we explored how TVA parameter estimates were associated with complex, or multicomponent indices of processing speed (Digit-symbol substitution, DSS) and fluid intelligence (gF). The results indicated that the TVA parameters for visual short-term memory capacity, K, and for attentional selectivity, α, were most strongly associated with age before the age of 50. However, in this age range, it was the parameter for processing speed, C, that was most clearly associated with DTI indices, in this case fractional anisotropy (FA), particularly in the genu and body of the corpus callosum. Furthermore, differences in the C parameter partially mediated differences in DSS within this age range. After the age of 50, the TVA parameter for the perceptual threshold, t 0, as well as K, were most strongly related to participant age. Both parameters, but t 0 more strongly so than K, were associated WM diffusivity, particularly in projection fibers such as the internal capsule, the sagittal stratum, and the corona radiata. Within this age range, t 0 partially mediated age-related differences in gF. The results are consistent with, and provide novel empirical support for the neuroanatomical localization of TVA computations as outlined in the neuronal interpretation of TVA (NTVA). Furthermore, the results indicate that to understand the biological sources of age-related changes in processing speed and fluid cognition, it may be useful to employ methods that allow for computational fractionation of these multicomponent measures.

• Tesli, Martin Steen; Espeseth, Thomas; Bettella, Franscesco; Mattingsdal, Morten; Aas, Monica & Melle, Ingrid [Vis alle 8 forfattere av denne artikkelen] (2014). Polygenic risk score and the psychosis continuum model. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 130(4), s. 311–317. doi: 10.1111/acps.12307.
• Thompson, Paul M; Stein, Jason L; Medland, Sarah E; Hibar, Derrek P; Vasquez, Alejandro Arias & Renteria, Miguel E [Vis alle 289 forfattere av denne artikkelen] (2014). The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior. ISSN 1931-7557. 8(2), s. 153–182. doi: 10.1007/s11682-013-9269-5. Fulltekst i vitenarkiv
• Hill, Wayne David; Davies, Gail; Van De Lagemaat, Louie N.; Christoforou, Andrea; Marioni, Riccardo R. & Duarte Fernandes, Carla [Vis alle 27 forfattere av denne artikkelen] (2014). Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins. Translational Psychiatry. ISSN 2158-3188. 4:e341. doi: 10.1038/tp.2013.114. Fulltekst i vitenarkiv
• Greenwood, Pamela M.; Espeseth, Thomas; Lin, Ming-Kuan; Reinvang, Ivar & Parasuraman, Raja (2014). Longitudinal change in working memory as a function of APOE genotype in midlife and old age. Scandinavian Journal of Psychology. ISSN 0036-5564. 55(3), s. 268–277. doi: 10.1111/sjop.12123.
• Fjell, Anders Martin; Westlye, Lars Tjelta; Grydeland, Håkon; Amlien, Inge; Espeseth, Thomas & Reinvang, Ivar [Vis alle 9 forfattere av denne artikkelen] (2014). Accelerating cortical thinning: Unique to dementia or universal in aging? Cerebral Cortex. ISSN 1047-3211. 24(4), s. 919–934. doi: 10.1093/cercor/bhs379.
• Duarte Fernandes, Carla; Westlye, Lars Tjelta; Giddaluru, Sudheer; Christoforou, Andrea; Kauppi, Karolina & Adolfsson, Rolf [Vis alle 13 forfattere av denne artikkelen] (2014). Lack of association of the rs1344706 ZNF804A variant with cognitive functions and DTI indices of white matter microstructure in two independent healthy populations. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 222(1-2), s. 60–66. doi: 10.1016/j.pscychresns.2014.02.009.
• Alnæs, Dag; Sneve, Markus Handal; Espeseth, Thomas; Endestad, Tor; van de Pavert, Steven & Laeng, Bruno (2014). Pupil size signals mental effort deployed during multiple object tracking and predicts brain activity in the dorsal attention network and the locus coeruleus. Journal of Vision. ISSN 1534-7362. 14(4), s. 1–20. doi: 10.1167/14.4.1.
• Lencz, T; Knowles, Emily; Davies, G; Guha, S; Liewald, DC & Starr, JM [Vis alle 46 forfattere av denne artikkelen] (2014). Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: A report from the Cognitive Genomics consorTium (COGENT). Molecular Psychiatry. ISSN 1359-4184. 19(2), s. 168–174. doi: 10.1038/mp.2013.166. Fulltekst i vitenarkiv
• Sivertsen, Børge; Hysing, Mari; Wehling, Eike; Pallesen, Ståle; Nordhus, Inger Hilde & Espeseth, Thomas [Vis alle 7 forfattere av denne artikkelen] (2013). Neuropsychological performance in older insomniacs. Aging, Neuropsychology and Cognition. ISSN 1382-5585. 20(1), s. 34–48. doi: 10.1080/13825585.2012.672947.
• Duarte Fernandes, Carla; Christoforou, Andrea; Giddaluru, Sudheer; Ersland, Kari Merete; Djurovic, Srdjan & Mattheisen, Manuel [Vis alle 19 forfattere av denne artikkelen] (2013). A genetic deconstruction of neurocognitive traits in schizophrenia and bipolar disorder. PLOS ONE. ISSN 1932-6203. 8(12:e81052). doi: 10.1371/journal.pone.0081052.
• Haász, Judit; Westlye, Erling Tjelta; Fjær, Sveinung; Espeseth, Thomas; Lundervold, Arvid & Lundervold, Astri (2013). General fluid-type intelligence is related to indices of white matter structure in middle-aged and old adults. NeuroImage. ISSN 1053-8119. 83, s. 372–383. doi: 10.1016/j.neuroimage.2013.06.040.
• Fjell, Anders Martin; Westlye, Lars Tjelta; Grydeland, Håkon; Amlien, Inge; Espeseth, Thomas & Reinvang, Ivar [Vis alle 10 forfattere av denne artikkelen] (2013). Critical ages in the life course of the adult brain: nonlinear subcortical aging. Neurobiology of Aging. ISSN 0197-4580. 34(10), s. 2239–2247. doi: 10.1016/j.neurobiolaging.2013.04.006. Fulltekst i vitenarkiv
• Reinvang, Ivar; Espeseth, Thomas & Westlye, Lars Tjelta (2013). APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's Disease. Neuroscience and Biobehavioral Reviews. ISSN 0149-7634. 37(8), s. 1322–1335. doi: 10.1016/j.neubiorev.2013.05.006.
• Westlye, Erling Tjelta; Hodneland, Erlend; Haász, Judit; Espeseth, Thomas; Lundervold, Arvid & Lundervold, Astri (2012). Episodic memory of APOE epsilon 4 carriers is correlated with fractional anisotropy, but not cortical thickness, in the medial temporal lobe. NeuroImage. ISSN 1053-8119. 63(1), s. 507–516. doi: 10.1016/j.neuroimage.2012.06.072.

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• Korbmacher, Max; Wang, Meng-yun; Eikeland, Rune; Buchert, Ralph; Andreassen, Ole & Espeseth, Thomas [Vis alle 10 forfattere av denne artikkelen] (2023). Field strength and potentially scan quality influence brain age estimates. Fulltekst i vitenarkiv
• Herrebrøden, Henrik; Espeseth, Thomas & Bishop, Laura (2023). Cognitive load affects effort, performance, and kinematics in elite and non-elite rowers. Journal of Sport & Exercise Psychology (JSEP). ISSN 0895-2779. 45(S1), s. S83–S83. doi: 10.1123/jsep.2023-0077. Vis sammendrag

  The extent to which elite athletes depend on mental effort and attention to task execution has been a debated topic. Some studies have suggested that motor experts might be relatively unaffected in the face of distraction and that they might even perform better when they attend to extraneous cognitive stimuli (for example in a dual-task paradigm), as compared to single-task conditions where they concentrate fully on a sports task. However, task complexity and participants’ skill levels have so far been relatively modest in most dual-task studies. To address gaps in past research, a multi-method study was conducted using a rowing ergometer task. Participants were nine male elite rowers from the Norwegian national rowing team, preparing for the 2020 Olympic Games in Tokyo, as well as nine male recreational rowers. Participants engaged in three-minute rowing trials of varying task demands, including single-task conditions (focusing on rowing only) and dual-task conditions (focusing on rowing and solving arithmetic problems). Performance and mental effort were measured via ergometer data (i.e., rowing speed values) and eye-tracking measures (i.e., blink rates and pupil size measurements), respectively. Movement kinematics was measured by motion capture technology. The results suggested that adding extraneous cognitive load led to performance decline and increased mental effort across all participants. Both elites and non-elites demonstrated kinematic changes when going from single-task to dual-task performance. That is, kinematic events in participants’ lower-body and upper-body segments became more temporally coupled, and more in line with movement patterns associated with novice athletes when the extraneous cognitive load was added. This study contradicts several past findings and suggests that elite athletes rely on attentional resources to execute fundamental aspects of their performance. Funding source: Research Council of Norway.

• Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette & Agartz, Ingrid [Vis alle 97 forfattere av denne artikkelen] (2020). Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain (Nature Neuroscience, (2019), 22, 10, (1617-1623), 10.1038/s41593-019-0471-7). Nature Neuroscience. ISSN 1097-6256. 23(2). doi: 10.1038/s41593-019-0553-6.
• Foster, Philip P; Baldwin, Carryl L.; Thompson, James Campbell; Espeseth, Thomas; Jiang, Xiong & Greenwood, Pamela M. (2019). Editorial: Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age. Frontiers in Aging Neuroscience. ISSN 1663-4365. 11. doi: 10.3389/fnagi.2019.00268.
• Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle & Hill, W. David [Vis alle 222 forfattere av denne artikkelen] (2019). Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x). Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-10160-w.
• Mäki-Marttunen, Verónica; Hagen, Thomas & Espeseth, Thomas (2019). Correction to: Task context load induces reactive cognitive control: An fMRI study on cortical and brain stem activity (Cognitive, Affective, & Behavioral Neuroscience, (2019), 19, 4, (945-965), 10.3758/s13415-019-00691-6). Cognitive, Affective, & Behavioral Neuroscience. ISSN 1530-7026. 19(4). doi: 10.3758/s13415-019-00701-7.
• Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Djurovic, Srdjan & Melle, Ingrid [Vis alle 61 forfattere av denne artikkelen] (2018). Multi-Trait analysis of gwas and biological insights into cognition: A response to Hill (2018). Twin Research and Human Genetics. ISSN 1832-4274. 21(5), s. 394–397. doi: 10.1017/thg.2018.46.
• Stavrinou, Maria; Asko, Olgerta; Hagen, Thomas; Foldal, Maja Dyhre & Espeseth, Thomas (2017). The long term effects of reward on spatial priority maps studied with Electroencephalography and Pupillometry.
• Haász, Judit; Lundervold, Arvid; Espeseth, Thomas; Thomassen, Lars & Specht, Karsten (2014). Longitudinal changes in visual working memory performance and frontoparietal intrinsic connectivity network synchronization non-cortical stroke.
• Steen, Vidar; Le Hellard, Stephanie; Espeseth, Thomas; Lundervold, Astri & Reinvang, Ivar (2013). Human cognitive ability is influenced by genetic variation in components of postsynaptic signaling complexes assembled by MAGUK proteins. Behavior Genetics. ISSN 0001-8244. 43(6), s. 521–522.

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