About the project
Growing evidence demonstrates the contribution of the neuropeptide oxytocin in the observed differences between autistic and non-autistic people. While some preliminary findings have demonstrated promising evidence that oxytocin may provide a support for autistic people, who would benefit from such an intervention, a complete understanding of the effects of long-term oxytocin administration in autism remains elusive, as participant numbers in oxytocin administration studies in autism have been small, most studies exclusively recruit males, and reproducibility has been inconsistent.
Objectives
To address this critical knowledge gap, this project will include a double-blind, placebo-controlled, randomized controlled crossover study of a four-week intranasal oxytocin administration in 128 male and female autistic youth aged 12-21. We predict that intranasal oxytocin treatments will provide support for social behavior and routinized behaviors and improve overall quality of life.
Along with the investigation of oxytocin’s effects over four-weeks, we will also assess the impact of a single administration of oxytocin on precise computer-based laboratory tasks that can evaluate differences in social behavior and routined behaviors. In addition, an electrocardiogram will track predicted positive changes in the cardiac autonomic system.
Outcomes
While some autistic people are thriving due to their differences, others have expressed their need for additional support options that can improve interpersonal relationships and their educational and vocational opportunities. This project has the potential to reduce the improve the day-to-day lives of autistic individuals, who desire such support, via a cost-effective intervention.
