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Genetic and phenotypic architecture of the ontogenetic determinants of severe mental illness (completed)

Mental illness is the largest contributor to years lived with disability worldwide.

About the project

Causal models implementing cognitive, biological, and genetic mechanisms are lacking, and identifying mechanisms is crucial to improve mental health care. Psychotic disorders are heritable, involving aberrant development of brain networks.

Objectives

In this large-scale multi-disciplinary and translational effort, we combine advanced multimodal fusion of brain imaging data, clinical information and genetics to (1) characterize the hierarchy of the structural and functional neuronal breakdown in psychosis, its developmental profiles and genetic modifiers, (2) develop multimodal classifiers to identify clinically predictive genotype-phenotype patterns, and (3) describe the genetic mapping and hierarchical clustering of the discriminative brain patterns based on phenotypic and genetic correlations to identify genetic pleiotropy between risk and sustainment of disease and brain networks in a lifespan perspective.

Outcomes

Our unique approach includes state-of-the art technology and tools for data integration, and builds on the joint efforts of a cross-disciplinary international team. Anecdotal observations and statistical evidence have suggested overlap between a range of traits and disorders. Novel biostatistical tools have finally enabled us to quantify the genetic correlations between traits using high-density genotype data, which have created an avenue for genetic dissection of complex traits, allowing for new discoveries and hypotheses. These methods provide a biostatistical platform for challenging historical conventions, paving the way toward a new nosology of complex disorders. We leverage these exciting new developments to propose a genetically informed hierarchical clustering of brain imaging and clinical traits, with a particular emphasis on neurodevelopmental markers. In addition to improving current brain-based models of mental illness, our genetic dissection provides novel clues about the fundamental architecture of the brain, the dynamic lifespan alterations, and the perturbations underlying neurodevelopmental disorders.

Financing

The project is financed by the Research Council of Norway (FRIMEDBIO - Young Researcher Talents) 2016 - 2020.

Cooperation

Department of Psychology and Norwegian Centre for Mental Disorders Research (NORMENT).

Publications

  • Irene Voldsbekk; Inge Rasmus Groote; Nathalia Zak; Daniël Thomas Heimen Roelfs; Oliver Geier; Paulina Due-Tønnessen; Lise Linn Løkken; Marie Strømstad; Taran Y Blakstvedt; Yvonne S Kuiper; Torbjørn Elvsåshagen; Lars Tjelta Westlye; Atle Bjørnerud & Ivan Maximov (2021). Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling. NeuroImage.  ISSN 1053-8119.  226
  • Eduard Pogosbekian; Igor N Pronin; Natalia Zakharova; A.I. Batalov; A.M. Turkin; T.A. Konakova & Ivan Maximov (2021). Feasibility of generalised diffusion kurtosis imaging approach for brain glioma grading. Neuroradiology.  ISSN 0028-3940.
  • Daniel Roelfs; Dag Alnæs; Oleksandr Frei; Dennis van der Meer; Olav Bjerkehagen Smeland; Ole Andreas Andreassen; Lars Tjelta Westlye & Tobias Kaufmann (2021). Phenotypically independent profiles relevant to mental health are genetically correlated. Translational Psychiatry.  ISSN 2158-3188.  11
  • Natalia Tesli; Dennis van der Meer; Jaroslav Rokicki; Guttorm Breivik Storvestre; Cato Røsæg; Arvid Jensen; Gabriela Hjell; Christina Bell; Thomas Fischer-Vieler; Martin Steen Tesli; Ole Andreas Andreassen; Ingrid Melle; Ingrid Agartz & Unn Kristin H. Haukvik (2020). Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience.  ISSN 0940-1334.
  • Irene Voldsbekk; Ivan Maximov; Nathalia Zak; Daniël Thomas Heimen Roelfs; Oliver Geier; Paulina Due-Tønnessen; Torbjørn Elvsåshagen; Marie Strømstad; Atle Bjørnerud & Inge Rasmus Groote (2020). Evidence for wakefulness-related changes to extracellular space in human brain white matter from diffusion-weighted MRI.. NeuroImage.  ISSN 1053-8119.  212, s 116682
  • Dennis van der Meer; Oleksandr Frei; Tobias Kaufmann; Chi-Hua Chen; Wesley K. Thompson; Kevin S. O'Connell; Jennifer Monereo Sanchez; David E.J. Linden; Lars Tjelta Westlye; Anders M Dale & Ole Andreas Andreassen (2020). Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area. Cerebral Cortex.  ISSN 1047-3211.  30, s 5597- 5603
  • Martina Jonette Lund; Dag Alnæs; Simon Schwab; Dennis van der Meer; Ole Andreas Andreassen; Lars Tjelta Westlye & Tobias Kaufmann (2020). Differences in directed functional brain connectivity related to age, sex and mental health. Human Brain Mapping.  ISSN 1065-9471.  41, s 4173- 4186
  • Siren Tønnesen; Tobias Kaufmann; Ann-Marie Glasø de Lange; Geneviève Richard; Nhat Trung Doan; Dag Alnæs; Dennis van der Meer; Jaroslav Rokicki; Torgeir Moberget; Ivan Maximov; Ingrid Agartz; Sofie Ragnhild Aminoff; Dani Beck; Deanna M. Barch; Justyna Beresniewicz; Simon Cervenka; Helena Fatouros-Bergman; Alexander R. Craven; Lena Flyckt; Tiril Pedersen Gurholt; Unn Kristin H. Haukvik; Kenneth Hugdahl; Erik Johnsen; Erik Gunnar Jönsson; Knut-Kristian Kolskår; Rune Andreas Kroken; Trine Vik Lagerberg; Else-Marie Løberg; Jan Egil Nordvik; Anne-Marthe Sanders; Kristine Moe Ulrichsen; Ole Andreas Andreassen & Lars Tjelta Westlye (2020). Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.  ISSN 2451-9022.  5, s 1095- 1103
  • Ann-Marie Glasø de Lange; Claudia Barth; Tobias Kaufmann; Ivan Maximov; Dennis van der Meer; Ingrid Agartz & Lars Tjelta Westlye (2020). Women's brain aging: effects of sex-hormone exposure, pregnancies, and genetic risk for Alzheimer's disease. Human Brain Mapping.  ISSN 1065-9471.  s 1- 10
  • Linn Christin Bonaventure Norbom; Jaroslav Rokicki; Dag Alnæs; Tobias Kaufmann; Nhat Trung Doan; Ole Andreas Andreassen; Lars Tjelta Westlye & Christian Krog Tamnes (2020). Maturation of cortical microstructure and cognitive development in childhood and adolescence: A T1w/T2w ratio MRI study. Human Brain Mapping.  ISSN 1065-9471.  41, s 4676- 4690
  • Linn Christin Bonaventure Norbom; Jaroslav Rokicki; Dennis van der Meer; Dag Alnæs; Nhat Trung Doan; Torgeir Moberget; Tobias Kaufmann; Ole Andreas Andreassen; Lars Tjelta Westlye & Christian Krog Tamnes (2020). Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents. Translational Psychiatry.  ISSN 2158-3188.  10
  • Ann-Marie Glasø de Lange; Melis Anatürk; Sana Suri; Tobias Kaufmann; James H. Cole; Ludovica Griffanti; Enikő Zsoldos; Daria E.A. Jensen; Nicola Filippini; Archana Singh-Manoux; Mika Kivimäki; Lars Tjelta Westlye & Klaus Ebmeier (2020). Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study. NeuroImage.  ISSN 1053-8119.  222
  • Dennis van der Meer; Oleksandr Frei; Tobias Kaufmann; Alexey A. Shadrin; Anna Devor; Olav Bjerkehagen Smeland; Wesley Kurt Thompson; Chun Chieh Fan; Dominic Holland; Lars Tjelta Westlye; Ole Andreas Andreassen & Anders Dale (2020). Understanding the genetic determinants of the brain with MOSTest. Nature Communications.  ISSN 2041-1723.  11:3512, s 1- 9
  • Aldo Còrdova Palomera; Dennis van der Meer; Tobias Kaufmann; Francesco Bettella; Yunpeng Wang; Dag Alnæs; Nhat Trung Doan; Ingrid Agartz; Alessandro Bertolino; Jan Buitelaar; David Coynel; Srdjan Djurovic; Erlend Solberg Dørum; Thomas Espeseth; Leonardo Fazio; Barbara Franke; Oleksandr Frei; Asta Håberg; Stephanie Le Hellard; Erik Gunnar Jönsson; Knut-Kristian Kolskår; Martina Jonette Lund; Torgeir Moberget; Jan Nordvik; Lars Nyberg; Andreas Papassotiropoulos; Giulio Pergola; Dominique de Quervain; Antonio Rampino; Geneviève Richard; Jaroslav Rokicki; Anne-Marthe Sanders; Emanuel Schwarz; Olav Bjerkehagen Smeland; Vidar Martin Steen; Jostein Starrfelt; Ida Elken Sønderby; Kristine Moe Ulrichsen; Ole Andreas Andreassen & Lars Tjelta Westlye (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 8
  • Dani Beck; Ann-Marie Glasø de Lange; Ivan Maximov; Geneviève Richard; Ole Andreas Andreassen; Jan E. Nordvik & Lars Tjelta Westlye (2020). White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction. NeuroImage.  ISSN 1053-8119.  224:117441, s 1- 14
  • Geneviève Richard; Anders Petersen; Kristine Moe Ulrichsen; Knut-Kristian Kolskår; Dag Alnæs; Anne-Marthe Sanders; Erlend Solberg Dørum; Hege Ihle-Hansen; Jan Egil Nordvik & Lars Tjelta Westlye (2020). TVA-based modeling of short-term memory capacity, speed of processing and perceptual threshold in chronic stroke patients undergoing cognitive training: Case-control differences, reliability, and associations with cognitive performance. PeerJ.  ISSN 2167-8359.  8:e9948, s 1- 21
  • Kristine Moe Ulrichsen; Dag Alnæs; Knut-Kristian Kolskår; Geneviève Richard; Anne-Marthe Sanders; Erlend Solberg Dørum; Hege Ihle-Hansen; Mads Lund Pedersen; Sveinung Tornås; Jan Egil Nordvik & Lars Tjelta Westlye (2020). Dissecting the cognitive phenotype of post-stroke fatigue using computerized assessment and computational modeling of sustained attention. European Journal of Neuroscience.  ISSN 0953-816X.  52, s 3828- 3845
  • Melis Anatürk; Tobias Kaufmann; James H. Cole; Sana Suri; Ludovica Griffanti; Enikő Zsoldos; Nicola Filippini; Archana Singh-Manoux; Mika Kivimäki; Lars Tjelta Westlye; Klaus Ebmeier & Ann-Marie Glasø de Lange (2020). Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging. Human Brain Mapping.  ISSN 1065-9471.
  • Torbjørn Elvsåshagen; Shahram Bahrami; Dennis van der Meer; Ingrid Agartz; Dag Alnæs; Deanna M. Barch; Ramona Baur-Streubel; Alessandro Bertolino; Mona K. Beyer; Giuseppe Blasi; Stefan Borgwardt; Birgitte Boye; Jan Buitelaar; Erlend Bøen; Elisabeth Gulowsen Celius; Simon Cervenka; Annette Conzelmann; David Coynel; Pasquale di Carlo; Srdjan Djurovic; Sarah Eisenacher; Thomas Espeseth; Helena Fatouros-Bergman; Lena Flyckt; Barbara Franke; Oleksandr Frei; Barbara Gelao; Hanne Flinstad Harbo; Catharina A. Hartman; Asta Håberg; Dirk Heslenfeld; Pieter J. Hoekstra; Einar August Høgestøl; Rune Jonassen; Erik Gunnar Jönsson; Peter Kirsch; Iwona Kloszewska; Trine Vik Lagerberg; Nils Inge Landrø; Stephanie Le Hellard; Klaus-Peter Lesch; Luigi Angelo Maglanoc; Ulrik Fredrik Malt; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Torgeir Moberget; Jan Egil Nordvik; Lars Nyberg; Kevin O`Connell; Jaap Oosterlaan; Marco Papalino; Andreas Papassotiropoulos; Paul Pauli; Giulio Pergola; Karin Ester Torun Persson; Dominique de Quervain; Andreas Reif; Jaroslav Rokicki; Daan Van Rooij; Alexey A. Shadrin; André Schmidt; Emanuel Schwarz; Geir Selbæk; Piotr Sowa; Hilkka Soininen; Vidar Martin Steen; Bruno Vellas; Magda Tsolaki; Lei Wang; Eric Westman; Georg C. Ziegler; Mathias Zink; Ole Andreas Andreassen; Lars Tjelta Westlye & Tobias Kaufmann (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications.  ISSN 2041-1723.  11
  • Jaroslav Rokicki; Thomas Wolfers; Wibeke Nordhøy; Natalia Tesli; Daniel Quintana; Dag Alnæs; Geneviève Richard; Ann-Marie Glasø de Lange; Martina Jonette Lund; Linn Christin Bonaventure Norbom; Ingrid Agartz; Ingrid Melle; Terje Nærland; Geir Selbæk; Karin Ester Torun Persson; Jan Egil Nordvik; Emanuel Schwarz; Ole Andreas Andreassen; Tobias Kaufmann & Lars Tjelta Westlye (2020). Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders. Human Brain Mapping.  ISSN 1065-9471.  s 1- 13
  • Ivan Maximov & Sebastian Vellmer (2019). Isotropically weighted intravoxel incoherent motion brain imaging at 7T.. Magnetic Resonance Imaging.  ISSN 0730-725X.  57, s 124- 132
  • Emanuel Schwarz; Nhat Trung Doan; Giulio Pergola; Lars Tjelta Westlye; Tobias Kaufmann; Thomas Wolfers; Ralph Brecheisen; Tiziana Quarto; Alex J. Ing; Pasquale di Carlo; Tiril Pedersen Gurholt; Robbert L. Harms; Quentin Noirhomme; Torgeir Moberget; Ingrid Agartz; Ole Andreas Andreassen; Marcella Bellani; Alessandro Bertolino; Giuseppe Blasi; Paolo Brambilla; Jan K. Buitelaar; Simon Cervenka; Lena Flyckt; Sophia Frangou; Barbara Franke; Jeremy Hall; Dirk J. Heslenfeld; Peter Kirsch; Andrew M. McIntosh; Markus M. Nöthen; Andreas Papassotiropoulos; Dominique J.F. de Quervain; Marcella Rietschel; Gunter Schumann; Heike Tost; Stephanie H. Witt; Mathias Zink & Andreas Meyer-Lindenberg (2019). Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder. Translational Psychiatry.  ISSN 2158-3188.  9
  • Nathalia Zak; Erlend Bøen; Birgitte Boye; Ole Andreas Andreassen; Nhat Trung Doan; Ulrik Fredrik Malt; Lars Tjelta Westlye & Torbjørn Elvsåshagen (2019). Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II. Bipolar Disorders.  ISSN 1398-5647.  21, s 525- 538
  • Ivan Maximov; Dag Alnæs & Lars Tjelta Westlye (2019). Towards an optimised processing pipeline for diffusion magnetic resonance imaging data: Effects of artefact corrections on diffusion metrics and their age associations in UK Biobank. Human Brain Mapping.  ISSN 1065-9471.  40, s 4146- 4162
  • Elena Kremneva; Ludmila Legostaeva; Sofya Morozova; Dmitry Sergeev; Dmitry Sinitsyn; Elizaveta Iazeva; Aleksandr Suslin; Natalia Suponeva; Marina Krotenkova; Michael Piradov & Ivan Maximov (2019). Feasibility of Non-Gaussian Diffusion Metrics in Chronic Disorders of Consciousness. Brain Sciences.  ISSN 2076-3425.  9, s 123
  • Nicolas Moutal; Ivan Maximov & Denis Grebenkov (2019). Probing surface-to-volume ratio of an anisotropic medium by diffusion NMR with general gradient encoding. IEEE Transactions on Medical Imaging.  ISSN 0278-0062.  38, s 2507- 2522
  • Daniel Quintana; Jaroslav Rokicki; Dennis van der Meer; Dag Alnæs; Tobias Kaufmann; Aldo Còrdova Palomera; Ingrid Dieset; Ole Andreas Andreassen & Lars Tjelta Westlye (2019). Oxytocin pathway gene networks in the human brain. Nature Communications.  ISSN 2041-1723.  10
  • Torgeir Moberget; Dag Alnæs; Tobias Kaufmann; Nhat Trung Doan; Aldo Còrdova Palomera; Linn Christin Bonaventure Norbom; Jaroslav Rokicki; Dennis van der Meer; Ole Andreas Andreassen & Lars Tjelta Westlye (2019). Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence. Biological Psychiatry.  ISSN 0006-3223.  86, s 65- 75
  • Tobias Kaufmann; Dennis van der Meer; Nhat Trung Doan; Emanuel Schwarz; Martina Jonette Lund; Ingrid Agartz; Dag Alnæs; Deanna M. Barch; Ramona Baur-Streubel; Alessandro Bertolino; Francesco Bettella; Mona K. Beyer; Erlend Bøen; Stefan Borgwardt; Christine Lycke Brandt; Jan Buitelaar; Elisabeth Gulowsen Celius; Simon Cervenka; Annette Conzelmann; Aldo Còrdova Palomera; Anders Dale; Dominique J.F. de Quervain; Pasquale di Carlo; Srdjan Djurovic; Erlend Solberg Dørum; Sarah Eisenacher; Torbjørn Elvsåshagen; Thomas Espeseth; Helena Fatouros-Bergman; Lena Flyckt; Barbara Franke; Oleksandr Frei; Beathe Haatveit; Asta Håberg; Hanne Flinstad Harbo; Catharina A Hartman; Dirk J Heslenfeld; Pieter J Hoekstra; Einar August Høgestøl; Terry L. Jernigan; Rune Jonassen; Erik Gunnar Jönsson; Peter Kirsch; Iwona Kłoszewska; Knut-Kristian Kolskår; Nils Inge Landrø; Stephanie Le Hellard; Klaus-Peter Lesch; Simon Lovestone; Arvid Lundervold; Astri Lundervold; Luigi Angelo Maglanoc; Ulrik Fredrik Malt; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Torgeir Moberget; Linn Christin Bonaventure Norbom; Jan Egil Nordvik; Lars Nyberg; Jaap Oosterlaan; Marco Papalino; Andreas Papassotiropoulos; Paul Pauli; Giulio Pergola; Karin Ester Torun Persson; Geneviève Richard; Jaroslav Rokicki; Anne-Marthe Sanders; Geir Selbæk; Alexey A. Shadrin; Olav Bjerkehagen Smeland; Hilkka Soininen; Piotr Sowa; Vidar Martin Steen; Magda Tsolaki; Kristine Moe Ulrichsen; Bruno Vellas; Lei Wang; Eric Westman; Georg C. Ziegler; Mathias Zink; Ole Andreas Andreassen & Lars Tjelta Westlye (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience.  ISSN 1097-6256.  22, s 1617- 1623
  • Steve Smith; Eugene Duff; Adrian Groves; Thomas E. Nichols; Saad Jbabdi; Lars Tjelta Westlye; Christian Krog Tamnes; Andreas Engvig; Kristine B Walhovd; Anders Martin Fjell; Heidi Johansen-Berg & Gwenaëlle Douaud (2019). Structural variability in the human brain reflects fine-grained functional architecture at the population level. Journal of Neuroscience.  ISSN 0270-6474.  39, s 6136- 6149
  • Luigi Angelo Maglanoc; Tobias Kaufmann; Rune Jonassen; Eva Hilland; Dani Beck; Nils Inge Landrø & Lars Tjelta Westlye (2019). Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis. Human Brain Mapping.  ISSN 1065-9471.
  • Dag Alnæs; Tobias Kaufmann; Dennis van der Meer; Aldo Còrdova Palomera; Jaroslav Rokicki; Torgeir Moberget; Francesco Bettella; Ingrid Agartz; Deanna M. Barch; Alessandro Bertolino; Christine Lycke Brandt; Simon Cervenka; Srdjan Djurovic; Nhat Trung Doan; Sarah Eisenacher; Helena Fatouros-Bergman; Lena Flyckt; Annabella di Giorgio; Beathe Haatveit; Erik Gunnar Jönsson; Peter Kirsch; Martina Jonette Lund; Andreas Meyer-Lindenberg; Giulio Pergola; Emanuel Schwarz; Olav Bjerkehagen Smeland; Tiziana Quarto; Mathias Zink; Ole Andreas Andreassen & Lars Tjelta Westlye (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry.  ISSN 2168-6238.  76, s 739- 748
  • Geneviève Richard; Knut-Kristian Kolskår; Kristine Moe Ulrichsen; Tobias Kaufmann; Dag Alnæs; Anne-Marthe Sanders; Erlend Solberg Dørum; Jennifer Monereo Sanchez; Anders Petersen; Hege Ihle-Hansen; Jan Egil Nordvik & Lars Tjelta Westlye (2019). Brain age prediction in stroke patients: Highly reliable but limited sensitivity to cognitive performance and response to cognitive training. NeuroImage: Clinical.  ISSN 2213-1582.  25, s 1- 11
  • Derrek Hibar; Lars Tjelta Westlye; Nhat Trung Doan; Neda Jahanshad; J. W. Cheung; Christopher R K Ching; Amelia Versace; A Bilderbeck; Anne Uhlmann; B Mwangi; B Krämer; B Overs; Cecilie Bhandari Hartberg; Christoph Abé; Danai Dima; Dominik Grotegerd; Emma Sprooten; Erlend Bøen; Enrique Jimenez; Fleur M. Howells; G Delvecchio; H Temmingh; J Starke; JRC Almeida; JM Goikolea; J Houenou; Lauren M. Beard; L Rauer; Lucija Abramovic; M. Bonnin; MF Ponteduro; M Keil; MM Rive; N Yao; N Yalin; P Najt; PG Rosa; Ronny Redlich; S Trost; Saskia Hagenaars; SC Fears; S Alonso-Lana; TGM Van Erp; Thomas Nickson; TM Chaim-Avancini; TB Meier; Torbjørn Elvsåshagen; Unn Kristin H. Haukvik; Who-Seung Lee; AH Schene; AJ Lloyd; AH Young; Allison C Nugent; AM Dale; Andrea Pfennig; AM McIntosh; Beny Lafer; BT Baune; CJ Ekman; CA Zarate; CE Bearden; C Henry; Christian Simhandl; C McDonald; C Bourne; DJ Stein; DH Wolf; DM Cannon; DC Glahn; DJ Veltman; E Pomarol-Clotet; E Vieta; EJ Canales-Rodriguez; FG Nery; FLS Duran; GF Busatto; G Roberts; GD Pearlson; GM Goodwin; H Kugel; HC Whalley; HG Ruhe; JC Soares; JM Fullerton; JK Rybakowski; Jonathan Savitz; KT Chaim; Mar Fatjo-Vilas; MG Soeiro-de-Souza; MP Boks; MV Zanetti; MCG Otaduy; MS Schaufelberger; Martin Alda; Martin Ingvar; ML Phillips; MJ Kempton; M Bauer; M Landén; NS Lawrence; NEM Van Haren; NR Horn; NB Freimer; Oliver Gruber; PR Schofield; PB Mitchell; RS Kahn; R Lenroot; R Machado-Vieira; RA Ophoff; S Sarró; Sophia Frangou; TD Satterthwaite; Tomas Hajek; Udo Dannlowski; Ulrik Fredrik Malt; Volker Arolt; WF Gattaz; WC Drevets; Xavier Caseras; Ingrid Agartz; PM Thompson & Ole Andreas Andreassen (2018). Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Molecular Psychiatry.  ISSN 1359-4184.  23, s 932- 942
  • S Kelly; Neda Jahanshad; A Zalesky; Kochunov P; Ingrid Agartz; C Alloza; Ole Andreas Andreassen; C Arango; Nerisa Banaj; S Bouix; CA Bousman; RM Brouwer; J Bruggemann; Juan R Bustillo; Wiepke Cahn; Vince Calhoun; Dara M Cannon; Vaughan J. Carr; Stanley V. Catts; J Chen; JX Chen; X Chen; C Chiapponi; KK Cho; Valentina Ciullo; A Corvin; Benedicto Crespo-Facorro; V Cropley; Pietro De Rossi; CM Diaz-Caneja; EW Dickie; S Ehrlich; FM Fan; Joshua Faskowitz; Helena Fatouros-Bergman; Lena Flyckt; JM Ford; JP Fouche; Masaki Fukunaga; M Gill; DC Glahn; Randy L Gollub; ED Goudzwaard; H Guo; RE Gur; RC Gur; Tiril Pedersen Gurholt; Ryota Hashimoto; SN Hatton; FA Henskens; DP Hibar; IB Hickie; LE Hong; Jan Horacek; FM Howells; Hilleke E Hulshoff Pol; CL Hyde; D Isaev; Assen Jablensky; PR Jansen; J Janssen; Erik Gunnar Jönsson; LA Jung; RS Kahn; Z Kikinis; K Liu; Paul Klauser; C Knöchel; M Kubicki; Jim Lagopoulos; C Langen; Stephen M Lawrie; R Lenroot; KO Lim; Carlos Lopez-Jaramillo; A Lyall; V Magnotta; RCW Mandl; DH Mathalon; RW McCarley; Simon McCarthy-Jones; C McDonald; S McEwen; A McIntosh; T Melicher; RI Mesholam-Gately; PT Michie; Bryan J. Mowry; BA Mueller; DT Newell; P O'donnell; V Oertel-Knöchel; L Oestreich; SA Paciga; Christos Pantelis; O Pasternak; Godfrey D Pearlson; GR Pellicano; A Pereira; J Pineda Zapata; Fabrizio Piras; SG Potkin; Adrian Preda; PE Rasser; DR Roalf; R Roiz; A Roos; D Rotenberg; TD Satterthwaite; P Savadjiev; Ulrich Schall; RJ Scott; ML Seal; LJ Seidman; C Shannon Weickert; CD Whelan; ME Shenton; JS Kwon; Gianfranco Spalletta; F Spaniel; Emma Sprooten; M Stäblein; DJ Stein; S Sundram; Y Tan; S Tan; S Tang; HS Temmingh; Lars Tjelta Westlye; Siren Tønnesen; Diana Tordesillas-Gutierrez; Nhat Trung Doan; Jatin G. Vaidya; NEM Van Haren; CD Vargas; D Vecchio; D Velakoulis; Aristotle N. Voineskos; JQ Voyvodic; Z Wang; P Wan; D Wei; TW Weickert; Heather Clare Whalley; T White; TJ Whitford; JD Wojcik; HUA XIANG; Z Xie; Hidenaga Yamamori; F Yang; N Yao; G. Zhang; J Zhao; Theo G M Van Erp; J Turner; PM Thompson & Gary Donohoe (2018). Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry.  ISSN 1359-4184.  23, s 1261- 1269
  • Dag Alnæs; Tobias Kaufmann; Nhat Trung Doan; Aldo Còrdova Palomera; Yunpeng Wang; Francesco Bettella; Torgeir Moberget; Ole Andreas Andreassen & Lars Tjelta Westlye (2018). Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents. JAMA psychiatry.  ISSN 2168-6238.  75, s 287- 295
  • Luigi Angelo Maglanoc; Nils Inge Landrø; Rune Jonassen; Tobias Kaufmann; Aldo Còrdova Palomera; Eva Hilland & Lars Tjelta Westlye (2018). Data-driven clustering reveals a link between symptoms and functional brain connectivity in depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.  ISSN 2451-9022.  4, s 16- 26
  • Sook-Lei Liew; Julia M. Anglin; Nick W. Banks; Matt Sondag; Kaori L. Ito; Hosung Kim; Jennifer Chan; Joyce Ito; Connie Jung; Nima Khoshab; Stephanie Lefebvre; William Nakamura; David Saldaña; Allie Schmiesing; Cathy Tran; Danny Vo; Tyler Ard; Panthea Heydari; Bokkyu Kim; Lisa Aziz-Zadeh; Steven C. Cramer; Jingchun Liu; Surjo Soekadar; Jan Egil Nordvik; Lars Tjelta Westlye; Junping Wang; Carolee Winstein; Chunshui Yu; Lei Ai; Bonhwang Koo; R. Cameron Craddock; Michael Peter Milham; Matthew Lakich; Amy Pienta & Alison Stroud (2018). A large, open source dataset of stroke anatomical brain images and manual lesion segmentations. Scientific Data.  ISSN 2052-4463.  5
  • Aldo Còrdova Palomera; Tobias Kaufmann; Francesco Bettella; Yunpeng Wang; Nhat Trung Doan; Dennis van der Meer; Dag Alnæs; Jaroslav Rokicki; Torgeir Moberget; Ida Elken Sønderby; Ole Andreas Andreassen & Lars Tjelta Westlye (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics.  ISSN 1018-4813.  26, s 1049- 1059
  • Theo G.M. Van Erp; Esther Walton; Derrek Hibar; Lianne Schmaal; Wenhao Jiang; David C. Glahn; Godfrey D. Pearlson; Nailin Yao; Masaki Fukunaga; Ryota Hashimoto; Naohiro Okada; Hidenaga Yamamori; Juan R. Bustillo; Vincent P. Clark; Ingrid Agartz; Bryon A. Mueller; Wiepke Cahn; Sonja M.C. de Zwarte; Hilleke E. Hulshoff Pol; René S. Kahn; Roel A. Ophoff; Neeltje E.M. van Haren; Ole Andreas Andreassen; Anders Dale; Nhat Trung Doan; Tiril Pedersen Gurholt; Cecilie Bhandari Hartberg; Unn Kristin H. Haukvik; Kjetil Nordbø Jørgensen; Trine Vik Lagerberg; Ingrid Melle; Lars Tjelta Westlye; Oliver Gruber; Bernd Kraemer; Anja Richter; David Zilles; Vince D. Calhoun; Benedicto Crespo-Facorro; Roberto Roiz-Santiañez; Diana Tordesillas-Gutiérrez; Carmel Loughland; Vaughan J. Carr; Stanley Catts; Vanessa L. Cropley; Janice M. Fullerton; Melissa J. Green; Frans A. Henskens; Assen Jablensky; Rhoshel K. Lenroot; Bryan J. Mowry; Patricia T. Michie; Christos Pantelis; Yann Quide; Ulrich Schall; Rodney J. Scott; Murray J. Cairns; Marc Seal; Paul A. Tooney; Paul E. Rasser; Gavin Cooper; Cynthia Shannon Weickert; Thomas W. Weickert; Derek W. Morris; Elliot Hong; Peter Kochunov; Lauren M. Beard; Raquel E. Gur; Ruben C. Gur; Theodore D Satterthwaite; Daniel H. Wolf; Aysenil Belger; Gregory G. Brown; Judith M. Ford; Fabio Macciardi; Daniel H. Mathalon; Daniel S. O'Leary; Steven G. Potkin; Adrian Preda; James Voyvodic; Kelvin O. Lim; Sarah McEwen; Fude Yang; Yunlong Tan; Shuping Tan; Zhiren Wang; Fengmei Fan; Jingxu Chen; Hong Xiang; Shiyou Tang; Hua Guo; Ping Wan; Dong Wei; Henry J. Bockholt; Stefan Ehrlich; Rick P.F. Wolthusen; Margaret D. King; Jody M. Shoemaker; Scott R. Sponheim; Lieuwe De Haan; Laura Koenders; Marise W. Machielsen; Therese van Amelsvoort; Dick J. Veltman; Francesca Assogna; Nerisa Banaj; Pietro de Rossi; Mariangela Iorio; Fabrizio Piras; Gianfranco Spalletta; Peter J. McKenna; Edith Pomarol-Clotet; Raymond Salvador; Aiden Corvin; Gary Donohoe; Sinead Kelly; Christopher D. Whelan; Erin W. Dickie; David Rotenberg; Aristotle N. Voineskos; Simone Ciufolini; Joaquim Radua; Paola Dazzan; Robin Murray; Tiago Reis Marques; Andrew Simmons; Stefan Borgwardt; Laura Egloff; Fabienne Harrisberger; Anita Riecher-Rössler; Renata Smieskova; Kathryn I. Alpert; Lei Wang; Erik Gunnar Jönsson; Sanne Koops; Iris Else Clara Sommer; Alessandro Bertolino; Aurora Bonvino; Annabella Di Giorgio; Emma Neilson; Andrew R. Mayer; Julia M. Stephen; Jun Soo Kwon; Je-Yeon Yun; Dara M. Cannon; Colm McDonald; Irina Lebedeva; Alexander S. Tomyshev; Tolibjohn Akhadov; Vasily Kaleda; Helena Fatouros-Bergman & Lena Flyckt (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry.  ISSN 0006-3223.
  • Kahori Kita; Jaroslav Rokicki; Shinichi Furuya; Takashi Sakamoto & Takashi Hanakawa (2018). Resting‐state basal ganglia network codes a motor musical skill and its disruption from dystonia. Movement Disorders.  ISSN 0885-3185.  s 1- 9
  • Jiayu Chen; Vince D. Calhoun; Dongdong Lin; Nora I. Perrone-Bizzozero; Juan R. Bustillo; Godfrey D. Pearlson; Steven G. Potkin; Theo G.M. Van Erp; Fabio Macciardi; Stefan Ehrlich; Beng-Choon Ho; Scott R. Sponheim; Lei Wang; Julia M. Stephen; Julia M. Mayer; Faith M. Hanlon; Rex E. Jung; Brett A. Clementz; Matcheri S. Keshavan; Elliot S. Gershon; John A. Sweeney; Carol A. Tamminga; Ole Andreas Andreassen; Ingrid Agartz; Lars Tjelta Westlye; Jing Sui; Yuhui Du; Jessica A. Turner & Jingyuan Liu (2018). Shared genetic risk of schizophrenia and gray matter reduction in 6p22.1. Schizophrenia Bulletin.  ISSN 0586-7614.  45, s 222- 232
  • Siren Tønnesen; Tobias Kaufmann; Nhat Trung Doan; Dag Alnæs; Aldo Còrdova Palomera; Dennis van der Meer; Jaroslav Rokicki; Torgeir Moberget; Tiril Pedersen Gurholt; Unn Kristin H. Haukvik; Torill Ueland; Trine Vik Lagerberg; Ingrid Agartz; Ole Andreas Andreassen & Lars Tjelta Westlye (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging. Scientific Reports.  ISSN 2045-2322.  8
  • Knut-Kristian Kolskår; Dag Alnæs; Tobias Kaufmann; Geneviéve´ Richard; Anne-Marthe Sanders; Kristine Moe Ulrichsen; Torgeir Moberget; Ole Andreas Andreassen; Jan Egil Nordvik & Lars Tjelta Westlye (2018). Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence. eNeuro.  ISSN 2373-2822.  5, s 1- 13
  • Dennis van der Meer; Jaroslav Rokicki; Tobias Kaufmann; Aldo Còrdova Palomera; Torgeir Moberget; Dag Alnæs; Francesco Bettella; Oleksandr Frei; Nhat Trung Doan; Ida Elken Sønderby; Olav Bjerkehagen Smeland; Ingrid Agartz; Alessandro Bertolino; Janita Bralten; Christine Lycke Brandt; Jan K. Buitelaar; Srdjan Djurovic; Marjolein van Donkelaar; Erlend Solberg Dørum; Thomas Espeseth; Stephen V. Faraone; Guillén Fernandéz; Simon E. Fisher; Barbara Franke; Beathe Christin Haatveit; Catharina A. Hartman; Pieter J. Hoekstra; Asta Håberg; Erik Gunnar Jönsson; Knut-Kristian Kolskår; Stephanie Le Hellard; Martina Jonette Lund; Astri Lundervold; Arvid Lundervold; Ingrid Melle; Jennifer Monereo Sanchez; Linn Christin Bonaventure Norbom; Jan Egil Nordvik; Lars Nyberg; Jaap Oosterlaan; Marco Papalino; Andreas Papassotiropoulos; Giulio Pergola; Dominique J.F. de Quervain; Geneviéve´ Richard; Anne-Marthe Sanders; Pierluigi Selvaggi; Elena Shumskaya; Vidar Martin Steen; Siren Tønnesen; Kristine Moe Ulrichsen; Marcel P. Zwiers; Ole Andreas Andreassen & Lars Tjelta Westlye (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 13
  • Ida Elken Sønderby; Omar Gustafsson; Nhat Trung Doan; Derrek Hibar; Sandra Martin-Brevet; Thomas Espeseth; Anja Vaskinn; Yunpeng Wang; Lars Tjelta Westlye; Sébastien Jacquemont; Srdjan Djurovic; Hreinn Stefánsson; Kári Stefánsson; Paul M. Thompson & Ole Andreas Andreassen (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 16
  • Linn Christin Bonaventure Norbom; Nhat Trung Doan; Dag Alnæs; Tobias Kaufmann; Torgeir Moberget; Jaroslav Rokicki; Ole Andreas Andreassen; Lars Tjelta Westlye & Christian Krog Tamnes (2018). Probing brain developmental patterns of myelination and associations with psychopathology in youths using gray/white matter contrast. Biological Psychiatry.  ISSN 0006-3223.
  • Tobias Kaufmann; Dag Alnæs; Christine Lycke Brandt; Francesco Bettella; Srdjan Djurovic; Ole Andreas Andreassen & Lars Tjelta Westlye (2018). Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia. JAMA psychiatry.  ISSN 2168-6238.
  • Geneviève Richard; Knut-Kristian Kolskår; Anne-Marthe Sanders; Tobias Kaufmann; Anders Petersen; Nhat Trung Doan; Jennifer Monereo Sanchez; Dag Alnæs; Kristine Moe Ulrichsen; Erlend Solberg Dørum; Ole Andreas Andreassen; Jan Egil Nordvik & Lars Tjelta Westlye (2018). Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry. PeerJ.  ISSN 2167-8359.
  • Aldo Còrdova Palomera; Tobias Kaufmann; Karin Persson; Dag Alnæs; Nhat Trung Doan; Torgeir Moberget; Martina Jonette Lund; Maria Lage Barca; Andreas Engvig; Anne Brækhus; Knut Engedal; Ole Andreas Andreassen; Geir Selbæk & Lars Tjelta Westlye (2017). Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum. Scientific Reports.  ISSN 2045-2322.  7, s 1- 14
  • Tobias Kaufmann; Dag Alnæs; Christine Lycke Brandt; Nhat Trung Doan; Karolina Kauppi; Francesco Bettella; Trine Vik Lagerberg; Akiah Ottesen Berg; Srdjan Djurovic; Ingrid Agartz; Ingrid Melle; Torill Ueland; Ole Andreas Andreassen & Lars Tjelta Westlye (2017). Task modulations and clinical manifestations in the brain functional connectome in 1615 fMRI datasets. NeuroImage.  ISSN 1053-8119.  147, s 243- 252
  • Lars Tjelta Westlye; Tobias Kaufmann; Dag Alnæs; Ingunn Riise Hullstein & Astrid Bjørnebekk (2017). Brain connectivity aberrations in anabolic-androgenic steroid users. NeuroImage: Clinical.  ISSN 2213-1582.  13, s 62- 69
  • Nhat Trung Doan; Andreas Engvig; Karin Persson; Dag Alnæs; Tobias Kaufmann; Jaroslav Rokicki; Aldo Còrdova Palomera; Torgeir Moberget; Anne Brækhus; Maria Lage Barca; Knut Engedal; Ole Andreas Andreassen; Geir Selbæk & Lars Tjelta Westlye (2017). Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum. Scientific Reports.  ISSN 2045-2322.  7:45131
  • Torgeir Hellstrøm; Tobias Kaufmann; Nada Andelic; Helene L. Søberg; Solrun Sigurdardottir; Eirik Helseth; Ole Andreas Andreassen & Lars Tjelta Westlye (2017). Predicting outcome 12 months after mild traumatic brain injury in patients admitted to a neurosurgery service. Frontiers in Neurology.  ISSN 1664-2295.  8:125, s 1- 12
  • Tobias Kaufmann; Dag Alnæs; Nhat Trung Doan; Christine Lycke Brandt; Ole Andreas Andreassen & Lars Tjelta Westlye (2017). Delayed stabilization and individualization in connectome development are related to psychiatric disorders. Nature Neuroscience.  ISSN 1097-6256.  20, s 513- 515
  • Nhat Trung Doan; Andreas Engvig; Krystal Zaske; Karin Persson; Martina Jonette Lund; Tobias Kaufmann; Aldo Còrdova Palomera; Dag Alnæs; Torgeir Moberget; Anne Brækhus; Maria Lage Barca; Jan Egil Nordvik; Knut Engedal; Ingrid Agartz; Geir Selbæk; Ole Andreas Andreassen & Lars Tjelta Westlye (2017). Distinguishing early and late brain aging from the Alzheimer's disease spectrum: Consistent morphological patterns across independent samples. NeuroImage.  ISSN 1053-8119.  158, s 282- 295
  • Torgeir Hellstrøm; Lars Tjelta Westlye; Tobias Kaufmann; Nhat Trung Doan; Helene L. Søberg; Solrun Sigurdardottir; Wibeke Nordhøy; Eirik Helseth; Ole Andreas Andreassen & Nada Andelic (2017). White matter microstructure is associated with functional, cognitive and emotional symptoms 12 months after mild traumatic brain injury. Scientific Reports.  ISSN 2045-2322.  7
  • Nhat Trung Doan; Tobias Kaufmann; Francesco Bettella; Kjetil Nordbø Jørgensen; Christine Lycke Brandt; Torgeir Moberget; Dag Alnæs; Gwenaëlle Douaud; Eugene Duff; Srdjan Djurovic; Ingrid Melle; Torill Ueland; Ingrid Agartz; Ole Andreas Andreassen & Lars Tjelta Westlye (2017). Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders. NeuroImage: Clinical.  ISSN 2213-1582.  15, s 719- 731
  • Torbjørn Elvsåshagen; Nathalia Zak; Linn Christin Bonaventure Norbom; Per Øystein Heiberg Pedersen; Sophia H. Quraishi; Atle Bjørnerud; Dag Alnæs; Nhat Trung Doan; Ulrik Fredrik Malt; Inge Rasmus Groote & Lars Tjelta Westlye (2017). Evidence for cortical structural plasticity in humans after a day of waking and sleep deprivation. NeuroImage.  ISSN 1053-8119.  156, s 214- 223
  • Hiroki Togo; Jaroslav Rokicki; Kenji Yoshinaga; Tatushiro Hisatsune; Hiroshi Matsuda; Nobuhiko Haga & Takashi Hanakawa (2017). Effects of Field-Map Distortion Correction on Resting State Functional Connectivity MRI. Frontiers in Neuroscience.  ISSN 1662-4548.  11
  • Erlend Solberg Dørum; Dag Alnæs; Tobias Kaufmann; Geneviéve´ Richard; Martina Jonette Lund; Siren Tønnesen; Markus Handal Sneve; Nina Christine Mathiesen; Øyvind Rustan; Øivind Gjertsen; Sigurd Vatn; Brynjar Fure; Ole Andreas Andreassen; Jan Egil Nordvik & Lars Tjelta Westlye (2016). Age-related differences in brain network activation and co-activation during multiple object tracking. Brain and Behavior.  ISSN 2162-3279.  6

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  • Nicolas Moutal; Ivan Maximov & Denis Grebenkov (2019). An accurate surface-to-volume ratio estimation by general diffusion gradient waveform.
  • Nicolas Moutal; Ivan Maximov & Denis Grebenkov (2019). Optimized diffusion gradient waveforms for estimating surface-to-volume ratio of an anisotropic medium.
  • Oliver Geier; Helle Viekilde Pfeiffer; Bac Nguyen; Åsmund Hagen Kersten; Sissel Jenifer Moltu & Ivan Maximov (2019). Survey of maturation state in premature neonates using diffusion weighted and multi-echo T2 imaging.
  • Ivan Maximov & Lars Tjelta Westlye (2019). Variability of NODDI metrics between AMICO and original NODDI in UK Biobank data.
  • Ivan Maximov; Dag Alnæs & Lars Tjelta Westlye (2019). Influence of diffusion pipeline on data analysis: UK Biobank example for age-diffusion dependences.
  • Daichi Sone; Masako Watanabe; Miho Ota; Etsuko Imabayashi; Jaroslav Rokicki; Norihide Maikusa; Atsuhiko Sugiyama; Tomoko Maekawa; Mikako Enokizono; Yukio Kimura; Hiroshi Matsuda & Noriko Sato (2018). Subtle abnormality in neurite dispersion in idiopathic generalized epilepsy detected by an advanced diffusion imaging technique. Epilepsy and Seizure.  ISSN 1882-5567.  10, s 33- 43

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Published Aug. 17, 2016 12:47 PM - Last modified Feb. 9, 2021 12:10 PM