ELiSE Early Life SocioEconomic status, mental health, and educational performance: an evaluation of sensitivity to the environment

Duration
01.01.2023–31.12.2028

The overall aim of the project is to increase our understanding of how and why socioeconomic status in early life is linked to mental health and school difficulties.

Contact

About the project

The ELiSE project provides an innovative framework that combines temporal, geographical, social, genetic, and individual level of understanding of the link between social inequality and mental health. By studying people with a similar genetic makeup, we can uncover how time periods, places of residence, schools, and families affect connections. This will give us the opportunity to simultaneously investigate hypotheses about direct and indirect pathways into poor mental health and school difficulties. ELiSE will provide completely new ways of studying how the risk of mental health problems and school difficulties is transferred from parents to children, why early mental health problems increase the risk of later school difficulties, how genes and environment interact to provide protective contexts and what characterizes places where children have the best psychological development. 

Objectives

The ELiSE project will address the impact of early life socioeconomic factors for mental health and educational success, while evaluating children’s individual sensitivity to contextual school and community environments, by studying:

  1. Transmission between generations: How the parents’ socioeconomic status and non-cognitive skills directly and indirectly affect child mental health and educational performance.
  2. Mental health as a process: Reveal whether children do well at school despite their low socioeconomic background if they are mentally healthy.
  3. Sensitivity to the environment: Evaluate models for how individual risk and resources for illbeing, wellbeing, and educational performance are differentially expressed across total school and community environments.
  4. Specific developmental contexts: Identify school and community characteristics that reduces individual risk and promotes individual resources.

Research methods

With a nested population-based cohort study comprising information from 100 000 genotyped families, combined with a with a wide array of survey data and data from national registries with information on kinship, place of residence, socio-economic status, mental health and educational background, we will investigate the interplay between neighborhood and family factors. This innovational investigation of the interaction between neighborhood and risk in families will help us understand inequality in mental health and school difficulties, and able us to study genes and the environment for social inequality and mental health. 

Participants

Publications

  • Carson, Alexis Christine; Zidan, Mahmoud; Olstad, Emilie Willoch; Gervin, Kristina; Galesloot, Tessel E. & Scholte, Iris [Show all 9 contributors for this article] (2026). Genetically Informed Research Designs in Perinatal Pharmacoepidemiology: A Methodological Overview. Drug Safety. ISSN 0114-5916. 49(7), p. 761–773. doi: 10.1007/s40264-026-01647-9. Full text in Research Archive
  • Ystrom, Eivind (2026). Editorial: When children also shape the family environment. JCPP Advances. 6(2). doi: 10.1002/jcv2.70136. Full text in Research Archive
  • Hoyos, Lucía de; Schlag, Fenja; Jahagirdar, Sanjeevan; Corfield, Elizabeth Claire; Allegrini, Andrea G. & Admiraal, Danielle [Show all 95 contributors for this article] (2026). Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach. Nature Human Behaviour. doi: 10.1038/s41562-026-02551-z. Full text in Research Archive

View all works in NVA

  • Ystrom, Eivind; Timpe, Clara Marie Fides & Jole, Oda van (2027). Sosial ulikhet i Norge og barns psykiske utvikling - en megakobling. Full text in Research Archive
  • Smajlagic, Dinka; Sunde, Hans Fredrik; Valenza-Troubat, Noemie; Kelly, Kristen; Lyu, Xuanyu & Sapin, Emmanuel [Show all 12 contributors for this article] (2026). Estimating assortative mating using haplotype-specific polygenic scores across physiological, psychological, and social traits in the Norwegian MoBa Cohort. doi: https:/s3.amazonaws.com/ClubExpressClubFiles/971921/documents/BGA_2026_Final_Program_1883376854.pdf?AWSAccessKeyId=AKIA6MYUE6DNCQ7GISON&Expires=1790839847&response-content-disposition=inline%3B%20filename%3DBGA_2026_Final_Program.pdf&Signature=nfauyWIWzAanx8Du1HeYli1Hi0Q%3D. Full text in Research Archive
  • Madhavan, Vaishnavi K; Demange, Perline Aline Delle; Ayorech, Ziada; Hottenga, Jouke Jan; Bartels, Meike & Ystrom, Eivind [Show all 8 contributors for this article] (2026). Bipolar Disorder and Education: Deciphering a Complex Relationship using Genetic and Sibling Differences. doi: https:/s3.amazonaws.com/ClubExpressClubFiles/971921/documents/BGA_2026_Final_Program_1883376854.pdf?AWSAccessKeyId=AKIA6MYUE6DNCQ7GISON&Expires=1790839847&response-content-disposition=inline%3B%20filename%3DBGA_2026_Final_Program.pdf&Signature=nfauyWIWzAanx8Du1HeYli1Hi0Q%3D. Full text in Research Archive
  • Demange, Perline Aline Delle; Akingbuwa, Wonuola; Cheesman, Rosa Catherine Gillespie & Ystrom, Eivind (2026). A Genomic Test of Goodness-of-Fit: Using Personality Polygenic Indices to Model Parent–Child Fit during Development. Full text in Research Archive
  • Demange, Perline Aline Delle; Cheesman, Rosa Catherine Gillespie; Akingbuwa, Wonuola & Ystrom, Eivind (2026). A Genomic Test of Goodness-of-Fit: Using Personality Polygenic Indices to Model Parent–Child Fit. Full text in Research Archive
  • Tabori, Mia; Enander, Hilda; Ystrom, Eivind & Demange, Perline Aline Delle (2026). To What Extent Does Early Temperament Predict Symptoms of Anxiety and Depression in Adolescence? A Sibling Design. Full text in Research Archive
  • Ofstad, Sverre Berg; Peng, Qiyuan; Ebeltoft, Joakim; Bjørndal, Ludvig Daae; Rayner, Christopher & Ayorech, Ziada [Show all 10 contributors for this article] (2026). PGI-by-Environment interactions: practical guidelines for robust research. Full text in Research Archive
  • Ystrom, Eivind & Torvik, Fartein Ask (2026). How to study GxE in schools. Full text in Research Archive
  • Ystrom, Eivind; Demange, Perline Aline Delle; Cheesman, Rosa Catherine Gillespie; McAdams, Thomas Andrew; Eilertsen, Espen Moen & Timpe, Clara Marie Fides [Show all 8 contributors for this article] (2026). Child Personality Polygenic Indices and Parental Distress: Evidence of Active Gene-Environment Correlations and Interactions from Parent–Offspring Trios. doi: https:/osf.io/fwaqp/overview. Full text in Research Archive
  • Ystrom, Eivind (2026). Disentangling Direct and Indirect Genetic Effects on Complex Traits: Insights from Two Large-Scale Family Studies. doi: https:/bga.org/docs.ashx?id=1781704. Full text in Research Archive
  • Ystrom, Eivind; Ayorech, Ziada; Bjørndal, Ludvig Daae; Timpe, Clara Marie Fides; Cheesman, Rosa Catherine Gillespie & Eilertsen, Espen Moen [Show all 8 contributors for this article] (2026). Child Personality Polygenic Indices and Parental Distress: Evidence of Active Gene- Environment Correlations and Interactions from Parent–Offspring Trios. doi: https:/bga.org/docs.ashx?id=1781704. Full text in Research Archive
  • Ystrom, Eivind (2026). Da Mette og Helle ble gravide, ble de en snakkis blant helsepersonell. [Journal]. Aftenposten. Full text in Research Archive
  • Ystrom, Eivind (2026). Are You Mostly Noise? Eivind Ystrøm on the Genetics of Personality. doi: https:/www.podbean.com/ew/pb-x24tj-1a9abb6. Full text in Research Archive
  • Ystrom, Eivind & Ivanova, Anna (2026). Do reproductive factors shape depression stability? Early menarche, endometriosis and PMS in longitudinal registry data. doi: https:/2026.ehps.net/wp-content/uploads/2026/08/ehps26_final_program_27_08-1.pdf. Full text in Research Archive
  • Ystrom, Eivind (2026). No Link Between Acetaminophen in Pregnancy and Autism, a Study Finds. [Journal]. The New York Times. doi: https:/www.nytimes.com/2026/01/16/health/tylenol-autism-acetaminophen-study.html. Full text in Research Archive
  • Ystrom, Eivind & Madsen, Ole Jacob (2026). Fritt hjemme, strengt på skolen. [Internet]. forskning.no. Full text in Research Archive
  • Ystrom, Eivind (2026). Ny studie tilbakeviser Trumps Paracet-teori. [Internet]. tv2. Full text in Research Archive

View all works in NVA

Funding

Funded by The Research Council of Norway

Project number: 336078

Published Jan. 27, 2025 1:05 PM - Last modified Sep. 11, 2025 12:03 PM