Causes, consequences, and life-course trajectories of personality pathology - a longitudinal extended children-of-twins study

Duration
01.12.2021–30.09.2027

Contact

About the project

Personality pathology can manifest in very different ways, as extreme distrust and paranoia, emotional volatility, reckless disregard for the wellbeing of others, crippling perfectionism or social inhibition.

Since personality pathology can have a detrimental impact on virtually all social interactions, the risk of distress and negative outcomes also extends to people in close relationships with those afflicted, in particular their spouses and children.

With this study we aim to better understand how personality pathology changes through life, and what long-term psychosocial outcomes they lead to. We also want to shed light on the underlying causes of pathological personality, how they influence other members within families.

Objectives

  1. To investigate the developmental trajectories of personality pathology from early to middle adulthood, determine the degrees of stable and time varying etiological factors, and their longitudinal relationship with clinical disorders.
  2. Evaluate life-course functional, psychosocial and health outcomes of personality pathology, as evidenced by information from Norwegian national registries.
  3. Determine the processes by which personality pathology and clinical disorders in parents increase the risk of ill mental health and negative psychosocial outcomes in offspring, and visa versa.

Methods

In addition to using data from previous waves of the study, we will also conduct a major new round of data collection. This time we will not only invite twins from the original 1969-79 cohort, but also their partners, non-twin siblings, and children over 16 years. In addition, we will make use of the rich data in Norwegian national registries to assess life-course outcomes.

Since people with pathological personality traits, such as avoidant or antisocial traits, often decline to participate in research studies, an important part of this study will be to investigate personality disorders using registry data from the complete 1967-79 cohort of Norwegian citizens, as well as their close relatives. This gives us a unique opportunity not only to tackle non-response in our data collections, but also to critically evaluate the assumptions underlying twin studies.

Participants

Publications

  • Valstad, Mathias; Eilertsen, Espen Moen; Ayorech, Ziada; Cheesman, Rosa Catherine Gillespie; Demange, Perline Aline Delle & Eftedal, Nikolai Haahjem [Show all 8 contributors for this article] (2026). Indirect genetic effects of siblings. Journal of Child Psychology and Psychiatry. ISSN 0021-9630. doi: 10.1111/jcpp.70130. Full text in Research Archive
  • Valstad, Mathias; Eftedal, Nikolai Haahjem; Yang, Tianfang; Kvarstein, Elfrida Hartveit; Reichborn-Kjennerud, Ted & Ystrom, Eivind [Show all 7 contributors for this article] (2026). The epidemiology of personality disorders in Norway: a nationwide patient registry study. Social Psychiatry and Psychiatric Epidemiology. ISSN 0933-7954. doi: 10.1007/s00127-026-03083-7. Full text in Research Archive
  • Prydz, Monica Beer; Bjørndal, Ludvig Daae; Czajkowski, Nikolai Olavi; Røysamb, Espen & Nes, Ragnhild Bang (2025). Direct and indirect effects of a digital Five Ways to Wellbeing intervention: A network intervention analysis. Behaviour Research and Therapy. ISSN 0005-7967. 191. doi: 10.1016/j.brat.2025.104781. Full text in Research Archive
  • Arneberg, Vilde Sofie; Sundsvold, Vilde; Bjørndal, Ludvig Daae & Ystrøm, Eivind (2024). Borderline Personality Disorder Symptoms and Stressful Life Events: An Evaluation of Gene-Environment Interplay. Biological Psychiatry: Global Open Science. 4(6). doi: 10.1016/j.bpsgos.2024.100390. Full text in Research Archive
  • Bjørndal, Ludvig Daae; Nes, Ragnhild Bang; Czajkowski, Nikolai Olavi & Røysamb, Espen (2023). The structure of well-being: a single underlying factor with genetic and environmental influences. Quality of Life Research. ISSN 0962-9343. 32, p. 2805–2816. doi: 10.1007/s11136-023-03437-7. Full text in Research Archive
  • Tesli, Martin Steen; Nesvåg, Ragnar; Haukvik, Unn Kristin Hansen; Gustavson, Kristin; Tesli, Natalia & Friestad, Christine [Show all 12 contributors for this article] (2023). Common genetic and environmental risk for personality disorders and psychotic-like experiences in young adult twins. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 148(6), p. 561–569. doi: 10.1111/acps.13596. Full text in Research Archive
  • Eftedal, Nikolai Haahjem; Kleppestø, Thomas Haarklau; Czajkowski, Nikolai Olavi; Sheehy-Skeffington, Jennifer; Røysamb, Espen & Vassend, Olav Mandt [Show all 8 contributors for this article] (2022). Justice sensitivity is undergirded by separate heritable motivations to be morally principled and opportunistic. Scientific Reports. 12. doi: 10.1038/s41598-022-09253-2. Full text in Research Archive
  • Skaug, Eirunn; Czajkowski, Nikolai Olavi; Waaktaar, Trine & Torgersen, Svenn (2022). The role of sense of coherence and loneliness in borderline personality disorder traits: a longitudinal twin study. Borderline Personality Disorder and Emotion Dysregulation. 9. doi: 10.1186/s40479-022-00190-0. Full text in Research Archive
  • Skaug, Eirunn; Czajkowski, Nikolai Olavi; Waaktaar, Trine & Torgersen, Svenn (2022). Childhood Trauma and Borderline Personality Disorder Traits: A Discordant Twin Study. Journal of Psychopathology and Clinical Science. ISSN 2769-7541. 131(4), p. 365–374. doi: 10.1037/abn0000755. Full text in Research Archive
  • Skaug, Eirunn; Czajkowski, Nikolai Olavi; Waaktaar, Trine & Torgersen, Svenn (2022). The relationship between life events and sense of coherence in adolescence. A longitudinal twin study. Journal of Research in Personality. ISSN 0092-6566. 99. doi: 10.1016/j.jrp.2022.104259. Full text in Research Archive
  • Vassend, Olav Mandt; Czajkowski, Nikolai Olavi; Røysamb, Espen & Nielsen, Christopher Sivert (2022). The role of neuroticism and pain in dental anxiety: A twin study. Community Dentistry and Oral Epidemiology. ISSN 0301-5661. doi: 10.1111/cdoe.12763. Full text in Research Archive

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  • Yang, Tianfang; Anderson, Jacob; Corley, Robin; Hopfer, Christian; McGue, Matt & Rhee, Soo [Show all 10 contributors for this article] (2026). Linking Pathological Personality Trait to Parenting, Romantic Relationship, and Workplace Behaviors: Using Co-Twin Control to Understand Variances in Pathways. Full text in Research Archive
  • Yang, Tianfang; Anderson, Jacob E.; Corley, Robin P.; Hopfer, Christian J.; McGue, Matt K. & Rhee, Soo [Show all 11 contributors for this article] (2026). Etiologic Links Between Personality Pathology and Workplace Behavior. Full text in Research Archive
  • Yang, Tianfang; Anderson, Jacob E.; Corley, Robin P.; Hopfer, Christian J.; McGue, Matt K. & Rhee, Soo [Show all 11 contributors for this article] (2026). Linking pathological personality trait to workplace behaviors: using co-twin control to understand pathways. Full text in Research Archive
  • Yang, Tianfang; Nikolic, Milena; Grønnerød, Cato & Czajkowski, Nikolai Olavi (2026). A Person-Centered Examination on the Overlap Between Maladaptive and Normal Personality Profiles: Evidence from Norwegian Community Sample. Full text in Research Archive
  • Ystrom, Eivind (2026). Da Mette og Helle ble gravide, ble de en snakkis blant helsepersonell. [Journal]. Aftenposten. Full text in Research Archive
  • Ystrom, Eivind (2026). Are You Mostly Noise? Eivind Ystrøm on the Genetics of Personality. doi: https:/www.podbean.com/ew/pb-x24tj-1a9abb6. Full text in Research Archive
  • Ofstad, Sverre Berg; Demange, Perline Aline Delle; Ayorech, Ziada; Valstad, Mathias & Ystrom, Eivind (2026). Temporal Trends in the Severity and Impairment of Childhood and Adolescent ADHD: A Population-Wide Genetic Study in Norway. Full text in Research Archive
  • Ofstad, Sverre Berg; Demange, Perline Aline Delle; Ayorech, Ziada; Valstad, Mathias & Ystrom, Eivind (2026). Temporal Trends in the Severity and Impairment of Childhood and Adolescent ADHD: A Population-Wide Genetic Study in Norway. Full text in Research Archive
  • Yang, Tianfang; Eftedal, Nikolai Haahjem; Valstad, Mathias; Reichborn-Kjennerud, Ted; Ystrom, Eivind & Czajkowski, Nikolai Olavi (2025). The lifespan impact of personality disorder on marital outcome: a Norwegian population study. Full text in Research Archive
  • Czajkowski, Nikolai Olavi; Gustavson, Kristin & Ystrom, Eivind (2025). When Dracula Takes the PID-5: What Can We Learn from Psychometric Exploration of Data Simulated Using Large Language Models. Full text in Research Archive
  • Czajkowski, Nikolai Olavi; Solbakken, Ole Andre; Stenberg, Jan-Henry; Suoma, Saarni E. & Rosenström, Tom Henrik (2025). Evaluating Internet-Based CBT for Depression in Patients with Prior Borderline Personality Disorder: Evidence from Finnish Registry Data. Full text in Research Archive
  • Valstad, Mathias; Eftedal, Nikolai Haahjem; Yang, Tianfang; Reichborn-Kjennerud, Ted; Ystrom, Eivind & Czajkowski, Nikolai Olavi (2025). Epidemiology of personality disorders in Norway, 2010 to 2022. Full text in Research Archive
  • Czajkowski, Nikolai Olavi; Eilertsen, Espen Moen; Valstad, Mathias; Eftedal, Nikolai Haahjem & Ystrøm, Eivind (2025). A Bayesian Framework for Zygosity Classification and Heritability Estimation Using Nationwide Registry Data. Full text in Research Archive
  • Yang, Tianfang; Ystrøm, Eivind; Valstad, Mathias; Eftedal, Nikolai Haahjem; Reichborn-Kjennerud, Ted & Czajkowski, Nikolai Olavi (2025). Marital Consequence of Personality Disorder: Evidence from Norwegian Registry. Full text in Research Archive
  • Yang, Tianfang; Ystrøm, Eivind; Valstad, Mathias; Eftedal, Nikolai Haahjem; Reichborn-Kjennerud, Ted & Krueger, Robert F [Show all 7 contributors for this article] (2024). The Intergenerational Impact of Borderline and Avoidant Personality Disorders on Child Academic Achievement: A Registry Study in Norway. Full text in Research Archive
  • Czajkowski, Nikolai Olavi; Eftedal, Nikolai Haahjem; Yang, Tianfang; Valstad, Mathias; Reichborn-Kjennerud, Ted & Ystrøm, Eivind (2024). The Role of Parental Personality Disorders in High School Dropout: Insights from a Nationwide Cohort Study. Full text in Research Archive
  • Valstad, Mathias; Eilertsen, Espen Moen; Timpe, Clara Marie Fides; Yang, Tianfang; Eftedal, Nikolai Haahjem & Reichborn-Kjennerud, Ted [Show all 8 contributors for this article] (2024). Genetic and environmental effects on diagnosed Borderline Personality Disorder (BPD) without clinic bias. Full text in Research Archive
  • Ystrøm, Eivind (2024). Gene-Environment Interplay and Borderline Personality Disorder Symptoms Amid Stressful Life Events. Full text in Research Archive

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Funding

Funded by The Research Council of Norway

Project number: 326350

Published Jan. 22, 2025 8:43 AM - Last modified Sep. 11, 2025 12:03 PM