OPIOIDREWARD: Brain mechanisms in reward and decision-making

How do the activation of different neurochemical systems influence reward and decision making in the brain?

About the Project

We are investigating how activation of various neurochemical systems play into the brain's way of processing decisions and rewards. To address this question we will, among other things, use medication that blocks or activates central neurochemical systems in the brain.


To shed light on how the activation of different neurochemical systems influences reward and decision-making in the brain

Participation in the project is voluntary and involves 4 visits to our lab at the Department of Psychology, University of Oslo (for approximately 3 hours duration per session).

Some key information about the study

  • On each visit you perform various tasks orally and on a computer.
  • You will also receive a low dose of a drug intravenously, which means that we will put two venous catheters (a plastic tube that is inserted into a vein) into your arm. The drug can be morphine, oxycodone, haloperidol, saline or a combination of these. There are known drugs used medically in Norway. The drugs may have side effects, but as the treatment in this study is short-lived and the doses are low, any side effects are expected to be short-lived and of mild intensity.
  • We will measure heart rate and breathing, collect blood to measure levels of signaling substances and relevant gene information.
  • Participants can withdraw consent at any time and without giving any reason. (Participation is voluntary!)

Do you want more information? Feel free to contact us by e-mail

Link to registration: https://nettskjema.no/a/213234

Link to participant information sheet (Norwegian).
Link to participant information sheet (English).


Project full title: OPIOIDREWARD: Brain mechanisms in reward and decision-making.

Bildet kan inneholde: font, logo.This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 802885).

Published June 27, 2019 12:50 PM - Last modified Dec. 16, 2021 12:22 PM


Principal investigator

Professor Siri Leknes

Project type

Starting Grant 2018

ERC funding

EUR 1,500,000.00

Project duration

60 months

Start date

1 July 2019