Øystein Sørensen

• Walhovd, Kristine B; Amlien, Inge; Sørensen, Øystein; Wang, Yunpeng; Mowinckel, Athanasia Monika & Magnussen, Fredrik [Vis alle 8 forfattere av denne artikkelen] (2022). Brain aging differs with cognitive ability regardless of education. Scientific Reports. ISSN 2045-2322. 12(13886). doi: 10.1038/s41598-022-17727-6.
• Bråthen, Anne Cecilie Sjøli; Sørensen, Øystein; de Lange, Ann-Marie Glasø; Mowinckel, Athanasia Monika; Fjell, Anders Martin & Walhovd, Kristine B (2022). Cognitive and hippocampal changes weeks and years after memory training. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-11636-4.
• Vidal-Piñeiro, Didac; Sørensen, Øystein; Blennow, Kaj; Capogna, Elettra; Halaas, Nathalie Bodd & Idland, Ane-Victoria [Vis alle 12 forfattere av denne artikkelen] (2022). Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults. Neurobiology of Aging. ISSN 0197-4580. 116, s. 80–91. doi: 10.1016/j.neurobiolaging.2022.04.010.
• Ljøsne, Isabelle Sylvie Budin; Mowinckel, Athanasia Monika; Bodorkos Friedman, Barbara; Ebmeier, Klaus P; Drevon, Christian A & Carver, Rebecca Bruu [Vis alle 22 forfattere av denne artikkelen] (2022). Public perceptions of brain health: an international, online cross-sectional survey. BMJ Open. ISSN 2044-6055. 12(4). doi: 10.1136/bmjopen-2021-057999. Fulltekst i vitenarkiv
• Leonardsen, Esten Høyland; Peng, Han; Kaufmann, Tobias; Agartz, Ingrid; Andreassen, Ole & Celius, Elisabeth Gulowsen [Vis alle 19 forfattere av denne artikkelen] (2022). Deep neural networks learn general and clinically relevant representations of the ageing brain. NeuroImage. ISSN 1053-8119. 256. doi: 10.1016/j.neuroimage.2022.119210. Fulltekst i vitenarkiv
• Nyberg, Lars Erik; Magnussen, Fredrik; Lundquist, Anders; Baaré, William; Bartrés-Faz, David & Bertram, Lars [Vis alle 24 forfattere av denne artikkelen] (2021). Educational attainment does not influence brain aging. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 118(18), s. 1–3. doi: 10.1073/pnas.2101644118.
• Fjell, Anders Martin; Grydeland, Håkon; Wang, Yunpeng; Amlien, Inge; Bartrés-Faz, David & Brandmaier, Andreas M. [Vis alle 24 forfattere av denne artikkelen] (2021). The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change. eLIFE. ISSN 2050-084X. 10, s. 1–22. doi: 10.7554/eLife.66466.
• Walhovd, Kristine Beate; Fjell, Anders Martin; Wang, Yunpeng; Amlien, Inge; Mowinckel, Athanasia Monika & Lindenberger, Ulman [Vis alle 29 forfattere av denne artikkelen] (2021). Education and income show heterogeneous relationships to lifespan brain and cognitive differences across European and US cohorts. Cerebral Cortex. ISSN 1047-3211. 32(4), s. 839–854. doi: 10.1093/cercor/bhab248. Fulltekst i vitenarkiv
• Krogsrud, Stine Kleppe; Mowinckel, Athanasia Monika; Sederevicius, Donatas; Vidal-Piñeiro, Didac; Amlien, Inge Kasbohm & Wang, Yunpeng [Vis alle 9 forfattere av denne artikkelen] (2021). Relationships between apparent cortical thickness and working memory across the lifespan - Effects of genetics and socioeconomic status. Developmental Cognitive Neuroscience. ISSN 1878-9293. 51, s. 1–11. doi: 10.1016/j.dcn.2021.100997.
• Sederevicius, Donatas; Vidal-Piñeiro, Didac; Sørensen, Øystein; van Leemput, Koen; Iglesias, Juan Eugenio & Dalca, Adrian V. [Vis alle 11 forfattere av denne artikkelen] (2021). Reliability and sensitivity of two whole-brain segmentation approaches included in FreeSurfer – ASEG and SAMSEG. NeuroImage. ISSN 1053-8119. 237:118113, s. 1–14. doi: 10.1016/j.neuroimage.2021.118113.
• Roe, James Michael; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra & Gonzalez, Hector A. [Vis alle 18 forfattere av denne artikkelen] (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nature Communications. ISSN 2041-1723. 12:721, s. 1–11. doi: 10.1038/s41467-021-21057-y.
• Grydeland, Håkon; Sederevicius, Donatas; Wang, Yunpeng; Bartres-Faz, David; Bertram, Lars & Dobricic, Valerija [Vis alle 16 forfattere av denne artikkelen] (2021). Self-Reported Sleep Relates to Microstructural Hippocampal Decline in β-Amyloid Positive Adults Beyond Genetic Risk. Sleep. ISSN 0161-8105. 44(11). doi: 10.1093/sleep/zsab110. Fulltekst i vitenarkiv Vis sammendrag

  Background To test the hypothesis that worse self-reported sleep relates to memory decay and reduced hippocampal integrity as indexed by increased intra-hippocampal water diffusion, and that the relations are stronger in the presence of β-amyloid (Aβ) accumulation, a marker of Alzheimer’s disease (AD) pathology. Methods Two-hundred and forty-three cognitively healthy participants, aged 19-81 years, completed the Pittsburgh Sleep Quality Index, and 2 diffusion tensor imaging sessions, on average 3 years apart, allowing measures of decline in hippocampal microstructural integrity as indexed by increased mean diffusivity. We measured memory decay using delayed recall from the California Verbal Learning Test. 18F-Flutemetamol positron emission tomography, in 108 participants above 44 years of age, yielded 23 Aβ positive. Genotyping enabled controlling for APOE ε4 status, and polygenic scores for sleep efficiency and AD. Results Worse global sleep quality and sleep efficiency related to more rapid reduction in hippocampal microstructural integrity over time. Focusing on sleep efficiency, the relation was stronger in presence of Aβ accumulation. Sleep efficiency related to memory decay indirectly via hippocampal integrity decline. The results were not explained by genetic risk for sleep efficiency and AD. Conclusions Poor self-reported sleep efficiency related to decline in hippocampal integrity, especially in the presence of Aβ accumulation. Poor sleep and hippocampal microstructural decline may partly explain memory decline in older adults with Aβ pathology. The relationships were not explained by genetic risk. Poor self-reported sleep efficiency might constitute a risk factor for AD, although the causal mechanisms driving the of observed associations remain unknown.

• Sørensen, Øystein; Brandmaier, Andreas M.; Macià, Dídac; Ebmeier, Klaus; Ghisletta, Paolo & Kievit, Rogier A. [Vis alle 10 forfattere av denne artikkelen] (2021). Meta-analysis of generalized additive models in neuroimaging studies. NeuroImage. ISSN 1053-8119. doi: 10.1016/j.neuroimage.2020.117416.
• Sørensen, Øystein; Walhovd, Kristine B & Fjell, Anders Martin (2021). A recipe for accurate estimation of lifespan brain trajectories, distinguishing longitudinal and cohort effects. NeuroImage. ISSN 1053-8119. 226. doi: 10.1016/j.neuroimage.2020.117596. Fulltekst i vitenarkiv
• Walhovd, Kristine B; Bråthen, Anne Cecilie Sjøli; Panizzon, Matthew S.; Mowinckel, Athanasia Monika; Sørensen, Øystein & de Lange, Ann-Marie Glasø [Vis alle 11 forfattere av denne artikkelen] (2020). Within-session verbal learning slope is predictive of lifespan delayed recall, hippocampal volume, and memory training benefit, and is heritable. Scientific Reports. ISSN 2045-2322. 10, s. 1–13. doi: 10.1038/s41598-020-78225-1. Fulltekst i vitenarkiv
• Gorbach, Tetiana; Pudas, Sara; Bartrés-Faz, David; Brandmaier, Andreas M.; Düzel, Sandra & Henson, Rik [Vis alle 17 forfattere av denne artikkelen] (2020). Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented APOE ε4 carriers. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. ISSN 2352-8729. 12(1). doi: 10.1002/dad2.12110. Fulltekst i vitenarkiv
• Fjell, Anders Martin; Sørensen, Øystein; Amlien, Inge Kasbohm; Bartrés-Faz, David; Brandmaier, Andreas M. & Buchmann, Nikolaus [Vis alle 32 forfattere av denne artikkelen] (2020). Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium. Cerebral Cortex. ISSN 1047-3211. s. 1–17. doi: 10.1093/cercor/bhaa332.
• Vidal-Piñeiro, Didac; Sneve, Markus Handal; Amlien, Inge Kasbohm; Grydeland, Håkon; Mowinckel, Athanasia Monika & Roe, James Michael [Vis alle 10 forfattere av denne artikkelen] (2020). The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan. Cerebral Cortex. ISSN 1047-3211. doi: 10.1093/cercor/bhaa348. Fulltekst i vitenarkiv
• Vidal-Piñeiro, Didac; Parker, Nadine; Shin, Jean; French, Leon; Grydeland, Håkon & Jackowski, Andrea [Vis alle 14 forfattere av denne artikkelen] (2020). Cellular correlates of cortical thinning throughout the lifespan. Scientific Reports. ISSN 2045-2322. 10(1), s. 1–14. doi: 10.1038/s41598-020-78471-3. Fulltekst i vitenarkiv
• Sørensen, Øystein; Crispino, Marta; Liu, Qinghua & Vitelli, Valeria (2020). BayesMallows: An R Package for the Bayesian Mallows Model. The R Journal. ISSN 2073-4859. 12(1), s. 324–342. doi: 10.32614/RJ-2020-026. Fulltekst i vitenarkiv
• Sørensen, Øystein & Westerhausen, René (2020). From observed laterality to latent hemispheric differences: Revisiting the inference problem. Laterality: Asymmetries of Body, Brain and Cognition. ISSN 1357-650X. s. 1–24. doi: 10.1080/1357650X.2020.1769124. Fulltekst i vitenarkiv
• Idland, Ane-Victoria; Sala Llonch, Roser; Watne, Leiv; Brækhus, Anne; Hansson, Oskar & Blennow, Kaj [Vis alle 11 forfattere av denne artikkelen] (2020). Biomarker Profiling Beyond Amyloid and Tau: Cerebrospinal Fluid Markers, Hippocampal Atrophy, and Memory Change in Cognitively Unimpaired Older Adults. Neurobiology of Aging. ISSN 0197-4580. 93, s. 1–15. doi: 10.1016/j.neurobiolaging.2020.04.002. Fulltekst i vitenarkiv
• Fjell, Anders Martin; Sørensen, Øystein; Amlien, Inge Kasbohm; Bartrés-Faz, David; Bros, Didac Macia & Buchmann, Nikolaus [Vis alle 28 forfattere av denne artikkelen] (2019). Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium. Sleep. ISSN 0161-8105. doi: 10.1093/sleep/zsz280. Fulltekst i vitenarkiv
• Fjell, Anders Martin; Sneve, Markus Handal; Sederevicius, Donatas; Sørensen, Øystein; Krogsrud, Stine Kleppe & Mowinckel, Athanasia Monika [Vis alle 7 forfattere av denne artikkelen] (2019). Volumetric and microstructural regional changes of the hippocampus underlying development of recall performance after extended retention intervals. Developmental Cognitive Neuroscience. ISSN 1878-9293. 40:100723, s. 1–12. doi: 10.1016/j.dcn.2019.100723. Fulltekst i vitenarkiv
• Sørensen, Øystein (2019). hdme: High-Dimensional Regression with Measurement Error. Journal of Open Source Software (JOSS). ISSN 2475-9066. doi: 10.21105/joss.01404. Fulltekst i vitenarkiv
• Sørensen, Øystein; Hellton, Kristoffer Herland; Frigessi Di Rattalma, Arnoldo & Thoresen, Magne (2018). Covariate Selection in High-Dimensional Generalized Linear Models With Measurement Error. Journal of Computational And Graphical Statistics (JCGS). ISSN 1061-8600. 27(4), s. 739–749. doi: 10.1080/10618600.2018.1425626. Fulltekst i vitenarkiv Vis sammendrag

  In many problems involving generalized linear models, the covariates are subject to measurement error. When the number of covariates p exceeds the sample size n, regularized methods like the lasso or Dantzig selector are required. Several recent papers have studied methods which correct for measurement error in the lasso or Dantzig selector for linear models in the p > n setting. We study a correction for generalized linear models, based on Rosenbaum and Tsybakov’s matrix uncertainty selector. By not requiring an estimate of the measurement error covariance matrix, this generalized matrix uncertainty selector has a great practical advantage in problems involving high-dimensional data. We further derive an alternative method based on the lasso, and develop efficient algorithms for both methods. In our simulation studies of logistic and Poisson regression with measurement error, the proposed methods outperform the standard lasso and Dantzig selector with respect to covariate selection, by reducing the number of false positives considerably. We also consider classification of patients on the basis of gene expression data with noisy measurements. Supplementary materials for this article are available online.

• Vitelli, Valeria; Sørensen, Øystein; Crispino, Marta; Frigessi Di Rattalma, Arnoldo & Arjas, Elja (2018). Probabilistic preference learning with the Mallows rank model. Journal of machine learning research. ISSN 1532-4435. 18, s. 1–49. Fulltekst i vitenarkiv
• Asprusten, Tarjei Tørre; Fagermoen, Frode Even; Sulheim, Dag; Skovlund, Eva; Sørensen, Øystein & Mollnes, Tom Eirik [Vis alle 7 forfattere av denne artikkelen] (2015). Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome. Acta Paediatrica. ISSN 0803-5253. 104(5), s. 498–503. doi: 10.1111/apa.12950.
• Wyller, Vegard Bruun; Sørensen, Øystein; Sulheim, Dag; Fagermoen, Frode Even; Ueland, Thor & Mollnes, Tom Eirik (2015). Plasma cytokine expression in adolescent chronic fatigue syndrome. Brain, Behavior, and Immunity. ISSN 0889-1591. 46, s. 80–86. doi: 10.1016/j.bbi.2014.12.025. Vis sammendrag

  Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescents. The pathophysiology is poorly understood, but low-grade systemic inflammation has been suggested as an important component. This study compared circulating levels of individual cytokines and parameters of cytokine networks in a large set of adolescent CFS patients and healthy controls, and explored associations between cytokines and symptoms in the CFS group. CFS patients (12–18 years old) were recruited nation-wide to a single referral center as part of the NorCAPITAL project (ClinicalTrials ID: NCT01040429). A broad case definition of CFS was applied, requiring three months of unexplained, disabling chronic/relapsing fatigue of new onset, whereas no accompanying symptoms were necessary. Thus, the case definition was broader than the Fukuda-criteria of CFS. Healthy controls having comparable distribution of gender and age were recruited from local schools. Twenty-seven plasma cytokines, including interleukins, chemokines and growth factors were assayed using multiplex technology. The results were subjected to network analyses using the ARACNE algorithm. Symptoms were charted by a questionnaire, and patients were subgrouped according to the Fukuda-criteria. A total of 120 CFS patients and 68 healthy controls were included. CFS patients had higher scores for fatigue (p < 0.001) and inflammatory symptoms (p < 0.001) than healthy controls. All cytokine levels and cytokine network parameters were similar, and none of the differences were statistically different across the two groups, also when adjusting for adherence to the Fukuda criteria of CFS. Within the CFS group, there were no associations between aggregate cytokine network parameters and symptom scores. Adolescent CFS patients are burdened by symptoms that might suggest low-grade systemic inflammation, but plasma levels of individual cytokines as well as cytokine network measures were not different from healthy controls, and there were no associations between symptoms and cytokine expression in the CFS group. Low-grade systemic inflammation does not appear to be a central part of adolescent CFS pathophysiology.

• Sørensen, Øystein; Frigessi, Arnoldo & Thoresen, Magne (2015). Measurement error in Lasso: Impact and likelihood bias correction. Statistica sinica. ISSN 1017-0405. 25(2), s. 809–829. doi: 10.5705/ss.2013.180. Fulltekst i vitenarkiv

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• Roe, James Michael; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra & Gonzalez, Hector A. [Vis alle 78 forfattere av denne artikkelen] (2022). Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease (Nature Communications, (2021), 12, 1, (721), 10.1038/s41467-021-21057-y). Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-28514-2.
• Sørensen, Øystein (2021). Longitudinal modeling of age-dependent latent traits.
• Sørensen, Øystein (2021). A gentle introduction to Bayesian statistics.
• Netto, Waldir Leoncio; Ghannoum, Salim; Fantini, Damiano & Sørensen, Øystein (2021). cellmigRation: Track Cells, Analyze Cell Trajectories and Compute Migration Statistics.
• Sørensen, Øystein (2021). Get Your Results Faster With {future}.
• Sørensen, Øystein (2021). Longitudinal modeling of age-dependent latent traits with generalized additive latent and mixed models.
• Sørensen, Øystein (2021). Generalized additive latent and mixed models.
• Sørensen, Øystein (2020). Meta analysis of non-parametric models with {metagam}.
• Vitelli, Valeria; Sørensen, Øystein; Frigessi, Arnoldo & Arjas, Elja (2018). Probabilistic preference learning with the Mallows rank model. Journal of Machine Learning Research.

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