James Michael Roe

• Leonardsen, Esten Høyland; Persson, Karin Ester Torun; Grødem, Edvard Olaf Sætersdal; Dinsdale, Nicola; SCHELLHORN, TILL & Roe, James Michael [Show all 16 contributors for this article] (2024). Constructing personalized characterizations of structural brain aberrations in patients with dementia using explainable artificial intelligence. npj Digital Medicine. 7(1). doi: 10.1038/s41746-024-01123-7.
• Iakunchykova, Olena; Pan, Mengyu; Amlien, Inge; Roe, James Michael; Walhovd, Kristine B & Fjell, Anders Martin [Show all 9 contributors for this article] (2024). Genetic evidence for the causal effects of C–reactive protein on self-reported habitual sleep duration. Brain, Behavior, and Immunity - Health (BBI - Health). ISSN 2666-3546. 37. doi: 10.1016/j.bbih.2024.100754.
• Roe, James Michael; Vidal-Piñeiro, Didac; Amlien, Inge; Pan, Mengyu; Sneve, Markus Handal & de Schotten, Michel Thiebaut [Show all 14 contributors for this article] (2023). Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex. eLIFE. ISSN 2050-084X. 12, p. 1–32. doi: 10.7554/eLife.84685.
• Leonardsen, Esten Høyland; Vidal-Piñeiro, Didac; Roe, James Michael; Frei, Oleksandr; Shadrin, Alexey & Iakunchykova, Olena [Show all 14 contributors for this article] (2023). Genetic architecture of brain age and its casual relations with brain and mental disorders. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-023-02087-y. Full text in Research Archive
• Pan, Mengyu; Roe, James Michael; Nudel, Ron; Schork, Andrew J.; Iakunchykova, Olena & Fjell, Anders Martin [Show all 11 contributors for this article] (2023). Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study. Translational Psychiatry. ISSN 2158-3188. 13(1). doi: 10.1038/s41398-023-02478-3.
• Nyberg, Lars Erik; Andersson, Micael; Lundquist, Anders; Baaré, William F C; Bartrés-Faz, David & Bertram, Lars [Show all 29 contributors for this article] (2022). Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates. Cerebral Cortex. ISSN 1047-3211. 33(9), p. 5075–5081. doi: 10.1093/cercor/bhac400. Full text in Research Archive
• Leonardsen, Esten Høyland; Peng, Han; Kaufmann, Tobias; Agartz, Ingrid; Andreassen, Ole & Celius, Elisabeth Gulowsen [Show all 19 contributors for this article] (2022). Deep neural networks learn general and clinically relevant representations of the ageing brain. NeuroImage. ISSN 1053-8119. 256. doi: 10.1016/j.neuroimage.2022.119210. Full text in Research Archive Show summary

  The discrepancy between chronological age and the apparent age of the brain based on neuroimaging data — the brain age delta — has emerged as a reliable marker of brain health. With an increasing wealth of data, approaches to tackle heterogeneity in data acquisition are vital. To this end, we compiled raw structural magnetic resonance images into one of the largest and most diverse datasets assembled (n=53542), and trained convolutional neural networks (CNNs) to predict age. We achieved state-of-the-art performance on unseen data from unknown scanners (n=2553), and showed that higher brain age delta is associated with diabetes, alcohol intake and smoking. Using transfer learning, the intermediate representations learned by our model complemented and partly outperformed brain age delta in predicting common brain disorders. Our work shows we can achieve generalizable and biologically plausible brain age predictions using CNNs trained on heterogeneous datasets, and transfer them to clinical use cases.

• Sha, Zhiqiang; Pepe, Antonietta; Schijven, Dick; Carrion-Castillo, Amaia; Roe, James Michael & Westerhausen, Rene [Show all 10 contributors for this article] (2021). Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 118(47), p. 1–9. doi: 10.1073/pnas.2113095118. Full text in Research Archive
• Wang, Yunpeng; Grydeland, Håkon; Roe, James Michael; Pan, Mengyu; Magnussen, Fredrik & Amlien, Inge [Show all 17 contributors for this article] (2021). Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer’s disease in healthy samples across the lifespan. Brain, Behavior, and Immunity. ISSN 0889-1591. 100. doi: 10.1016/j.bbi.2021.12.008. Full text in Research Archive
• Vidal-Piñeiro, Didac; Wang, Yunpeng; Krogsrud, Stine Kleppe; Amlien, Inge; Baaré, William FC & Bartres-Faz, David [Show all 31 contributors for this article] (2021). Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change. eLIFE. ISSN 2050-084X. 10. doi: 10.7554/eLife.69995. Full text in Research Archive
• Roe, James Michael; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra & Gonzalez, Hector A. [Show all 18 contributors for this article] (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nature Communications. ISSN 2041-1723. 12:721, p. 1–11. doi: 10.1038/s41467-021-21057-y. Full text in Research Archive
• Fjell, Anders Martin; Sørensen, Øystein; Amlien, Inge Kasbohm; Bartrés-Faz, David; Brandmaier, Andreas M. & Buchmann, Nikolaus [Show all 32 contributors for this article] (2020). Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium. Cerebral Cortex. ISSN 1047-3211. p. 1–17. doi: 10.1093/cercor/bhaa332. Full text in Research Archive Show summary

  We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. “PSQI # 1 Subjective sleep quality” and “PSQI #5 Sleep disturbances” were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with “PSQI #5 Sleep disturbances” emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.

• Vidal-Piñeiro, Didac; Sneve, Markus Handal; Amlien, Inge Kasbohm; Grydeland, Håkon; Mowinckel, Athanasia Monika & Roe, James Michael [Show all 10 contributors for this article] (2020). The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan. Cerebral Cortex. ISSN 1047-3211. doi: 10.1093/cercor/bhaa348. Full text in Research Archive
• Roe, James Michael; Vidal-Piñeiro, Didac; Sneve, Markus Handal; Kompus, Kristiina; Greve, Douglas N. & Walhovd, Kristine B [Show all 8 contributors for this article] (2019). Age-Related Differences in Functional AsymmetryDuring Memory Retrieval Revisited: No Evidence forContralateral Overactivation or Compensation. Cerebral Cortex. ISSN 1047-3211. 0(0), p. 1–19. doi: 10.1093/cercor/bhz153. Full text in Research Archive
• Vidal-Piñeiro, Didac; Sneve, Markus Handal; Storsve, Andreas Berg; Roe, James Michael; Walhovd, Kristine B & Fjell, Anders Martin (2017). Neural correlates of durable memories across the adult lifespan: brain activity at encoding and retrieval. Neurobiology of Aging. ISSN 0197-4580. 60, p. 20–33. doi: 10.1016/j.neurobiolaging.2017.08.017. Full text in Research Archive
• Roe, James; Nesheim, Mathias; Mathiesen, Nina Chung; Moberget, Torgeir; Alnæs, Dag & Sneve, Markus Handal (2016). The effects of tDCS upon sustained visual attention are dependent on cognitive load. Neuropsychologia. ISSN 0028-3932. 80, p. 1–8. doi: 10.1016/j.neuropsychologia.2015.11.005.

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• Roe, James Michael & Leonardsen, Esten Høyland (2023). Brain age as a marker of overall brain health: Phenotypic associations, genetic foundations and causal relationships.
• Roe, James Michael (2023). Individual-specific change in Alzheimer’s disease vulnerable brain regions across healthy adult life is associated with genetic risk for AD.
• Roe, James Michael (2022). Colloquial: Interdisciplinary research on mental health.
• Roe, James Michael (2022). Individual-specific change in AD-vulnerable brain regions across healthy adult life is associated with genetic risk for AD.
• Roe, James Michael (2022). Tracing the developmental origins of population-level asymmetry of the cerebral cortex.
• Roe, James Michael (2022). Tracing the developmental origins of population-level asymmetry of the cerebral cortex.
• Roe, James Michael; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra & Gonzalez, Hector A. [Show all 78 contributors for this article] (2022). Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease (Nature Communications, (2021), 12, 1, (721), 10.1038/s41467-021-21057-y). Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-28514-2.
• Roe, James Michael (2021). Tracking functional and structural brain asymmetry in aging.
• Roe, James Michael (2021). Ung forskar har gjort banebrytande funn om aldring og Alzheimer. [Internet]. uniforum.
• Roe, James Michael (2021). Alzheimer: Vil du vite om du kan bli ramma? [Internet]. NRK.
• Roe, James Michael (2021). Left and right-brain age differently – linked to Alzheimer’s Disease.

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