Lia Ferschmann

• Ferschmann, Lia; Vijayakumar, Nandita; Grydeland, Håkon; Øverbye, Knut; Sederevicius, Donatas; Due-Tønnessen, Paulina; Fjell, Anders Martin; Walhovd, Kristine B; Pfeifer, Jennifer H. & Tamnes, Christian Krog (2019). Prosocial behavior relates to the rate and timing of cortical thinning from adolescence to young adulthood. Developmental Cognitive Neuroscience.  ISSN 1878-9293.  40:100734, s 1- 8 . doi: 10.1016/j.dcn.2019.100734 Full text in Research Archive.
• Fjell, Anders Martin; Chen, Chi-Hua Chen; Sederevicius, Donatas; Sneve, Markus Handal; Grydeland, Håkon; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Ferschmann, Lia; Ness, Hedda; Folvik, Line; Beck, Dani; Mowinckel, Athanasia Monika; Tamnes, Christian Krog; Westerhausen, René; Håberg, Asta; Dale, Anders M & Walhovd, Kristine B (2019). Continuity and discontinuity in human cortical development and change from embryonic stages to old age. Cerebral Cortex.  ISSN 1047-3211.  29(9), s 3879- 3890 . doi: 10.1093/cercor/bhy266 Full text in Research Archive.
• Ferschmann, Lia; Fjell, Anders Martin; Vollrath, Margarete E.; Grydeland, Håkon; Walhovd, Kristine B & Tamnes, Christian Krog (2018). Personality Traits Are Associated With Cortical Development Across Adolescence: A Longitudinal Structural MRI Study. Child Development.  ISSN 0009-3920.  89(3), s 811- 822 . doi: 10.1111/cdev.13016 Full text in Research Archive.
• Tamnes, Christian Krog; Øverbye, Knut; Ferschmann, Lia; Fjell, Anders Martin; Walhovd, Kristine B; Blakemore, Sarah-Jayne & Dumontheil, Iroise (2018). Social perspective taking is associated with self-reported prosocial behavior and regional cortical thickness across adolescence. Developmental Psychology.  ISSN 0012-1649.  54(9), s 1745- 1757 . doi: 10.1037/dev0000541 Full text in Research Archive.
• Krogsrud, Stine Kleppe; Fjell, Anders Martin; Tamnes, Christian Krog; Grydeland, Håkon; Ferschmann, Lia; Due-Tønnessen, Paulina; Bjørnerud, Atle; Sampaio-Baptista, Cassandra; Andersson, Jesper; Johansen-Berg, Heidi & Walhovd, Kristine B (2016). Changes in white matter microstructure in the developing brain - A longitudinal diffusion tensor imaging study of children from 4 to 11years of age. NeuroImage.  ISSN 1053-8119.  124, s 473- 486 . doi: 10.1016/j.neuroimage.2015.09.017
• Walhovd, Kristine B; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Bartsch, Hauke; Bjørnerud, Atle; Due-Tønnessen, Paulina; Grydeland, Håkon; Hagler, D.; Håberg, Asta; Kremen, William S.; Ferschmann, Lia; Nyberg, Lars; Panizzon, Matthew S; Rohani, Darius; Skranes, Jon Sverre; Storsve, Andreas Berg; Sølsnes, Anne Elisabeth; Tamnes, Christian Krog; Thompson, Wesley K.; Reuter, Chase; Dale, Anders & Fjell, Anders Martin (2016). Neurodevelopmental origins of lifespan changes in brain and cognition. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  113(33), s 9357- 9362 . doi: 10.1073/pnas.1524259113 Full text in Research Archive.
• Fjell, Anders Martin; Grydeland, Håkon; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Rohani, Darius Adam; Ferschmann, Lia; Storsve, Andreas Berg; Tamnes, Christian Krog; Sala Llonch, Roser; Due-Tønnessen, Paulina; Bjørnerud, Atle; Sølsnes, Anne Elisabeth; Håberg, Asta; Skranes, Jon Sverre; Bartsch, Hauke; Chen, Chi-Hua; Thompson, Wesley K.; Panizzon, Matthew S.; Kremen, William S.; Dale, Anders M. & Walhovd, Kristine B (2015). Development and aging of cortical thickness correspond to genetic organization patterns. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  112(50), s 15462- 15467 . doi: 10.1073/pnas.1508831112 Full text in Research Archive. Show summary

  There is a growing realization that early life influences have lasting impact on brain function and structure. Recent research has demon- strated that genetic relationships in adults can be used to parcellate the cortex into regions of maximal shared genetic influence, and a major hypothesis is that genetically progr ammed neurodevel opmental events cause a lasting impact on the organization of the cerebral cortex observable decades later. Here we tested how developmental and lifespan changes in cortical thickness fit the underlying genetic organi- zational principles of co rtical thickness in a longitudinal sample of 974 participants between 4.1 and 88.5 y of age with a total of 1,633 scans, including 773 scans from children below 12 y. Genetic clustering of cortical thickness was based on an independent dataset of 406 adult twins. Developmental and adult age- related changes in cortical thick- ness followed closely the genetic organization of the cerebral cortex, with change rates varying as a functi on of genetic similarity between regions. Cortical regions with overlapping genetic architecture showed correlated development al and adult age change trajectories and vice versa for regions with low genetic overlap. Thus, effects of genes on regional variations in cortical thickness in middle age can be traced to regional differences in neurodevelopmental change rates and extrap- olated to further adult aging-related cortical thinning. This finding suggests that genetic factors contribute to cortical changes through life and calls for a lifespan perspective i n research aimed at identifying the genetic and environmental determinants of cortical development and aging.

• Drozd, Filip; Mork, Lia; Nielsen, Bettina; Raeder, Sabine & Bjørkli, Cato Alexander (2014). Better Days - A randomized controlled trial of an internet-based positive psychology intervention. Journal of Positive Psychology.  ISSN 1743-9760.  9(5), s 377- 388 . doi: 10.1080/17439760.2014.910822 Show summary

  The internet seems promising for delivering interventions to enhance well-being in a normal population. The aim of this study was to test the effects of an internet-based positive psychology intervention targeting gratitude, pleasant activities, strengths, mastery, acts of kindness, optimism, flow, attributions, and mindfulness. One-hundred and twelve participants were randomized to the intervention and 94 to the control group, and data were collected at baseline, one, two, and six months after intervention onset. The balance of positive to negative affect increased over time among participants in the intervention group (unstandardized beta coefficient [B] = 0.07, p < 0.01), as compared to the controls (B = 0.02, p = 010). The intervention worked equally well regardless of participants’ gender, age, or education. However, optimism did not mediate the effect of the intervention on affect balance. In conclusion, the intervention had a small, but significant effect on affect balance among healthy adults.

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• Nielsen, Bettina; Mork, Lia; Kraft, Pål & Drozd, Filip (2012). Evaluation of an internet-based intervention for mild-to-moderate depression and promotion of psychological well-being: A randomized controlled trial. Show summary

  Background: High prevalence of minor depression and low well-being constitutes both individual and societal burden. The Internet provides a promising platform for treatment delivery. Objective and Method: A randomized controlled trial was conducted to determine the efficacy of an internet-based self-help intervention Bedre Hverdag (BH) for mild-to-moderate depression and promotion of well-being. Long-term effects (i.e.6 months) of BH were assessed in comparison to a waiting-list control group. Results: Of the 206 eligible participants, 112 were randomized to the experimental group and 94 to the waiting-list control group. Data from 34 participants in the experimental group and 47 from the control group were subjected to statistical analyses. Individuals assigned to BH reported significant increases in positive affect (PA) at 1 month follow-up, as measured by Positive Affect Schedual (PANAS); z = - 2.49, p = .011, r = .42 , which were significantly different from levels of PA at the same time period in the control group, U = 589, z = -2.01 , p = .044 , r = .2. Increases in PA were no longer significant at 2 and 6 month follow-ups. No statistically significant reductions in negative affect (NA) as measured by the Negative Affect Schedual (PANAS) and depressive symptoms as measured by the Center for Epidemiologic Studies Depression scale (CES-D) were observed in the experimental group as compared to the control group. Treatment x Educational attainment interaction explained 5.3% of variance in depressive symptoms, and 10.7% of variance in NA at 1 month follow-up, above and beyond the main effects. Individuals with lowest level of educational attainment reported largest reductions in both CES-D scores and NA. Conclusion: BH produced significant increases in PA at 1 month post-treatment. No significant reductions were observed in either depressive symptoms or NA. Educational attainment moderated the intervention's effects on depressive symptoms and NA.

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