Alexandra Havdahl

Image of Alexandra Havdahl
Available hours By agreement
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Visiting address Forskningsveien 3A Harald Schjelderups hus 0373 Oslo
Postal address Postboks 1094 Blindern 0317 Oslo
Other affiliations Institutt for pedagogikk (Student)

Academic interests

I am an Associate Professor at the University of Oslo Department of Psychology and member of the PROMENTA research centre. I lead the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute of Lovisenberg Diaconal Hospital and the psychiatric genetics (PsychGen) group at the Norwegian Institute of Public Health in Oslo. At the MRC Integrative Epidemiology Unit at the University of Bristol I am an Honorary Research Fellow.

My research group has three primary aims:

  1. Elucidating when and how genetic risk for mental disorder manifests in signs and symptoms from birth to adulthood
  2. Distinguishing genetic and environmental pathways of within-family transmission of mental disorders
  3. Identifying causal environmental risk and protective factors for mental disorders

We utilize prospective and longitudinal pregnancy cohorts such as the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Avon Longitudinal Study of Parents and Children (ALSPAC). Our approaches include structural equation modelling, polygenic scoring, Mendelian randomization, negative control comparison, and diverse family designs.

I am involved in several international research collaborations, including the Psychiatric Genomics Consortium (PGC), the Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe (CAPICE), and the EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium.

Another line of research that I am strongly engaged in aims to improve early identification, assessment tools, and interventions for individuals with autism and other neurodevelopmental conditions. I am a member of the Lancet Commission on the Future of Care and Clinical Research in Autism and a lead trainer in the national network for clinician training in the use of autism diagnostic assessment tools.

Background

Education

  • 2016: PhD. Department of Psychology, University of Oslo

  • 2011: Cand. Psychol. (6-year clinical psychologist degree), University of Oslo, accredited psychologist 2011

Employment history

  • 2019 -current: Associate Professor (20%), Dept of Psychology, UO

  • 2018 -current: Research group leader (80%), head of the Psychiatric Genetic Epidemiology group, Nic Waals Institute, Lovisenberg Diaconal Hospital

  • 2018 -current: Researcher and co-PI of the psychiatric genetics (PsychGen) group (20%), Dept. of Mental Disorders, Norwegian Institute of Public Health (NIPH)

  • 2016-2018: Senior Research Associate (100%, permanent), MRC Integrative Epidemiology Unit, University of Bristol, UK

  • 2013-2016: PhD Fellow, Nic Waals Institute, Lovisenberg, Norway

  • 2013-2015: Visiting PhD Researcher (100%), Center for Autism and the Developing Brain, Weill Medical College, Cornell University, New York, USA

  • 2011-2012: Clinical Psychologist (100%) in the Autism Birth Cohort Study (ABC) nested in the Norwegian Mother, Father and Child Cohort, Nic Waals Institute, Lovisenberg

  • 2007-2011: Research Assistant (20%), ABC Study, Nic Waals Institute, Lovisenberg

Awards

  • 2020: Career grant from the South-Eastern Norway Regional Health Authority

  • 2019: Best paper of 2019 award from Lovisenberg Diaconal Hospital

  • 2018: Exchange fellowship for 1-year research stay at the University of Bristol. The South-Eastern Norway Regional Health Authority

  • 2016: Award for best clinical PhD dissertation from the International Society for Autism Research

  • 2012: Exchange fellowship for 1-year research stay at Cornell University. The South-Eastern Norway Regional Health Authority

  • 2012: PhD fellowship. The South-Eastern Norway Regional Health Authority

Organization of International Conferences

  • 2018: Established and organized the Norwegian and British population cohorts meeting 2018 (35 speakers) at the University of Bristol, UK

Tags: Developmental psychology, genetics, Psychopathology

Publications

  • Torvik, Fartein Ask; Eilertsen, Espen Moen; Hannigan, Laurie J.; Cheesman, Rosa; Howe, Laurence J. & Magnus, Per Minor [Show all 11 contributors for this article] (2022). Modeling assortative mating and genetic similarities between partners, siblings, and in-laws. Nature Communications. ISSN 2041-1723. 13(1), p. 1–10. doi: 10.1038/s41467-022-28774-y. Full text in Research Archive
  • Dack, Kyle; Fell, Matthew; Taylor, Caroline M.; Havdahl, Alexandra & Lewis, Sarah J. (2022). Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review. International Journal of Environmental Research and Public Health. 19(4), p. 1–25. doi: 10.3390/ijerph19041976. Full text in Research Archive
  • Watson, H; et, al.; Andreassen, Ole; Ask, Helga; et, al. & Havdahl, Alexandra [Show all 7 contributors for this article] (2021). Common Genetic Variation And Age at Onset Of Anorexia Nervosa. biological psychiatry: global open science. ISSN 2667-1743.
  • Ask, Helga; Eilertsen, Espen Moen; Gjerde, Line Cecilie; Hannigan, Laurie John; Gustavson, Kristin & Havdahl, Alexandra [Show all 12 contributors for this article] (2021). Intergenerational transmission of parental neuroticism to emotional problems in 8-year-old children: Genetic and environmental influences. JCPP Advances. ISSN 2692-9384. 1(4). doi: 10.1002/jcv2.12054. Full text in Research Archive
  • Haan, Elis; Sallis, Hannah M.; Zuccolo, Luisa; Labrecque, Jeremy; Ystrøm, Eivind & Reichborn-Kjennerud, Ted [Show all 9 contributors for this article] (2021). Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses. Addiction. ISSN 0965-2140. doi: 10.1111/add.15746. Full text in Research Archive
  • Lord, Catherine; Charman, Tony; Havdahl, Alexandra; Carbone, Paul; Anagnostou, Evdokia & Boyd, Brian [Show all 32 contributors for this article] (2021). The Lancet Commission on the future of care and clinical research in autism. The Lancet. ISSN 0140-6736. 399, p. 271–334. doi: 10.1016/S0140-6736%2821%2901541-5. Full text in Research Archive
  • Ip, Hill F.; van der Laan, Camiel M.; Krapohl, Eva M. L.; Brikell, Isabell; Sánchez-Mora, Cristina & Nolte, Ilja M. [Show all 50 contributors for this article] (2021). Genetic association study of childhood aggression across raters, instruments, and age. Translational Psychiatry. ISSN 2158-3188. 11, p. 1–9. doi: 10.1038/s41398-021-01480-x. Full text in Research Archive
  • Askeland, Ragna Bugge; Hannigan, Laurie J.; Ask, Helga; Ayorech, Ziada; Tesli, Martin Steen & Corfield, Elizabeth [Show all 12 contributors for this article] (2021). Early manifestations of genetic risk for neurodevelopmental disorders. Journal of Child Psychology and Psychiatry. ISSN 0021-9630. p. 1–10. doi: 10.1111/jcpp.13528. Full text in Research Archive
  • Haan, E; Sallis, H; Ystrøm, Eivind; Njølstad, Pål Rasmus; Andreassen, Ole & Reichborn-Kjennerud, Ted [Show all 9 contributors for this article] (2021). Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring. Alcoholism: Clinical and Experimental Research. ISSN 0145-6008. 45(10), p. 2090–2102. doi: 10.1111/acer.14692. Full text in Research Archive
  • Friel, Catherine; Leyland, Alastair H.; Anderson, Jana J.; Havdahl, Alexandra; Borge, Tiril Cecilie & Shimonovich, Michal [Show all 7 contributors for this article] (2021). Prenatal vitamins and the risk of offspring autism spectrum disorder: Systematic review and meta-analysis. Nutrients. ISSN 2072-6643. 13. doi: 10.3390/nu13082558. Full text in Research Archive
  • Peyre, Hugo; Schoeler, Tabea; Liu, Chaoyu; Williams, Camille Michèle; Hoertel, Nicolas & Havdahl, Alexandra [Show all 7 contributors for this article] (2021). Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry. ISSN 0021-9630. 62(11), p. 1285–1296. doi: 10.1111/jcpp.13479.
  • Dack, Kyle; Fell, Matthew; Taylor, Caroline M.; Havdahl, Alexandra Karoline Saasen & Lewis, Sarah J. (2021). Mercury and prenatal growth: A systematic review. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. 18:7140(13), p. 1–19. doi: 10.3390/ijerph18137140.
  • Magnus, Maria Christine; Havdahl, Alexandra; Morken, Nils-Halvdan; Wensaas, Knut-Arne; Wilcox, Allen J. & Håberg, Siri Eldevik (2021). Risk of miscarriage in women with psychiatric disorders. British Journal of Psychiatry. ISSN 0007-1250. 219(3), p. 501–506. doi: 10.1192/bjp.2020.259. Full text in Research Archive
  • Havdahl, Alexandra; Niarchou, Maria; Starnawska, A; Uddin, M; van der Merwe, Celia & Warrier, Varun (2021). Genetic contributions to autism spectrum disorder. Psychological Medicine. ISSN 0033-2917. 51(13), p. 2260–2273. doi: 10.1017/S0033291721000192. Full text in Research Archive
  • Eilertsen, Espen Moen; Jami, Eshim Shahid; McAdams, Tom A.; Hannigan, Laurie J.; Havdahl, Alexandra & Magnus, Per [Show all 8 contributors for this article] (2021). Direct and Indirect Effects of Maternal, Paternal, and Offspring Genotypes: Trio-GCTA. Behavior Genetics. ISSN 0001-8244. 51, p. 154–161. doi: 10.1007/s10519-020-10036-6. Full text in Research Archive
  • Hannigan, Laurie John; Askeland, Ragna Bugge; Ask, Helga; Tesli, Martin; Corfield, Elizabeth & Ayorech, Ziada [Show all 15 contributors for this article] (2021). Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population. Schizophrenia Bulletin. ISSN 0586-7614. 47(4), p. 1179–1189. doi: 10.1093/schbul/sbaa193. Full text in Research Archive
  • Sallis, Hannah M.; Croft, Jazz; Havdahl, Alexandra; Jones, Hannah J.; Dunn, Erin C. & Smith, George Davey [Show all 8 contributors for this article] (2020). Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood. Psychological Medicine. ISSN 0033-2917. doi: 10.1017/S0033291720000537.
  • Havdahl, Alexandra; Farmer, Cristan; Schjølberg, Synnve; Øyen, Anne-Siri; Suren, Pål & Reichborn-Kjennerud, Ted [Show all 15 contributors for this article] (2020). Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population‐based study. Journal of Child Psychology and Psychiatry. ISSN 0021-9630. p. 1–9. doi: 10.1111/jcpp.13369. Full text in Research Archive
  • Kiselev, Yury; Handal, Marte; Hjellvik, Vidar; Reichborn-Kjennerud, Ted; Stoltenberg, Camilla & Suren, Pål [Show all 8 contributors for this article] (2020). Nationwide study of neuropsychiatric comorbidity and medicines use in children with autism spectrum disorder in Norway. Frontiers in Psychiatry. ISSN 1664-0640. 11, p. 1–8. doi: 10.3389/fpsyt.2020.596032.
  • Cheesman, Rosa; Eilertsen, Espen Moen; Ahmadzadeh, Yasmin I.; Gjerde, Line C.; Hannigan, Laurie John & Havdahl, Alexandra [Show all 13 contributors for this article] (2020). How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa). BMC Medicine. ISSN 1741-7015. 18. doi: 10.1186/s12916-020-01760-1. Full text in Research Archive
  • Akingbuwa, Wonuola A.; Hammerschlag, Anke R.; Jami, Eshim S.; Allegrini, Andrea G.; Karhunen, Ville & Sallis, Hannah [Show all 35 contributors for this article] (2020). Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-analysis. JAMA psychiatry. ISSN 2168-6238. 77(7), p. 715–728. doi: 10.1001/jamapsychiatry.2020.0527. Full text in Research Archive
  • Brumpton, Ben Michael; Sanderson, Eleanor; Heilbron, Karl; Hartwig, FP; Harrison, S & Vie, Gunnhild Åberge [Show all 35 contributors for this article] (2020). Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-17117-4. Full text in Research Archive
  • Torvik, Fartein Ask; Eilertsen, Espen Moen; McAdams, Tom A.; Gustavson, Kristin; Zachrisson, Henrik Daae & Brandlistuen, Ragnhild Eek [Show all 11 contributors for this article] (2020). Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study. Journal of Child Psychology and Psychiatry. ISSN 0021-9630. 61(9), p. 1009–1018. doi: 10.1111/jcpp.13197. Full text in Research Archive
  • Davies, Neil M.; Howe, Laurence; Brumpton, Ben Michael; Havdahl, Alexandra; Evans, David M. & Smith, George Davey (2019). Within family Mendelian randomization studies. Human Molecular Genetics. ISSN 0964-6906. 28(2), p. R170–R179. doi: 10.1093/hmg/ddz204. Full text in Research Archive
  • Suren, Pål; Havdahl, Alexandra; Øyen, Anne-Siri; Schjølberg, Synnve; Reichborn-Kjennerud, Ted & Magnus, Per [Show all 8 contributors for this article] (2019). Diagnosing autism spectrum disorder among children in Norway . Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(14), p. 1372–1379. doi: 10.4045/tidsskr.18.0960. Full text in Research Archive
  • Leppert, Beate; Havdahl, Alexandra; Riglin, Lucy; Jones, Hannah J.; Zheng, Jie & Davey Smith, George [Show all 10 contributors for this article] (2019). Association of maternal neurodevelopmental risk alleles with early-life exposures. JAMA psychiatry. ISSN 2168-6238. 76(8), p. 834–842. doi: 10.1001/jamapsychiatry.2019.0774. Full text in Research Archive
  • Suren, Pål; Havdahl, Alexandra; Bresnahan, Michaeline; Hirtz, Deborah; Hornig, Mady & Lord, Catherine [Show all 13 contributors for this article] (2019). Sensitivity and specificity of early screening for autism. BJPsych Open. ISSN 2056-4724. 5(3). doi: 10.1192/bjo.2019.34. Full text in Research Archive
  • Havdahl, Alexandra; Ruth, Mitchell; Lavinia, Paternoster & Davey Smith, George (2019). Investigating causality in the association between vitamin D status and self-reported tiredness. Scientific Reports. ISSN 2045-2322. 9. doi: 10.1038/s41598-019-39359-z. Full text in Research Archive
  • Caramaschi, Doretta; Taylor, Amy; Richmond, Rebecca C.; Havdahl, Alexandra; Golding, Jean & Relton, Caroline [Show all 9 contributors for this article] (2018). Maternal smoking during pregnancy and autism: using causal inference methods in a birth cohort study. Translational Psychiatry. ISSN 2158-3188. 8(262). doi: 10.1038/s41398-018-0313-5.
  • Ask, Helga; Gustavson, Kristin; Ystrøm, Eivind; Havdahl, Karoline Alexandra; Tesli, Martin Steen & Askeland, Ragna Bugge [Show all 7 contributors for this article] (2018). Association of Gestational Age at Birth With Symptoms of Attention-Deficit/Hyperactivity Disorder in Children. JAMA pediatrics. ISSN 2168-6203. 172(8), p. 749–756. doi: 10.1001/jamapediatrics.2018.1315. Full text in Research Archive
  • Øien, Roald A; Schjølberg, Synnve; Volkmar, Fred R.; Shic, Frederick; Cicchetti, Domenic V. & Nordahl-Hansen, Anders Johan [Show all 14 contributors for this article] (2018). Clinical Features of Children With Autism Who Passed 18-Month Screening. Pediatrics. ISSN 0031-4005. 141(6). doi: 10.1542/peds.2017-3596. Full text in Research Archive
  • Havdahl, Karoline Alexandra; Bishop, Somer L.; Surén, Pål; Øyen, Anne-Siri; Lord, Catherine & Pickles, Andrew [Show all 17 contributors for this article] (2017). The influence of parental concern on the utility of autism diagnostic instruments. Autism Research. ISSN 1939-3792. 10(10), p. 1672–1686. doi: 10.1002/aur.1817.
  • Bishop, Somer L.; Farmer, Cristan; Hus Bal, Vanessa; Robinson, Elise; Willsey, AJ & Werling, DM [Show all 9 contributors for this article] (2017). Identification of Developmental and Behavioral Markers Associated With Genetic Abnormalities in Autism Spectrum Disorder. American Journal of Psychiatry. ISSN 0002-953X. 174(6), p. 576–585. doi: 10.1176/appi.ajp.2017.16101115.
  • Bishop, Somer L.; Huerta, Marisela; Gotham, K.; Havdahl, Karoline Alexandra; Pickles, Andrew & Duncan, A. [Show all 9 contributors for this article] (2017). The autism symptom interview, school-age: A brief telephone interview to identify autism spectrum disorders in 5-to-12-year-old children. Autism Research. ISSN 1939-3792. 10(1), p. 78–88. doi: 10.1002/aur.1645.
  • Havdahl, Karoline Alexandra; Hus Bal, Vanessa; Huerta, Marisela; Pickles, Andrew; Øyen, Anne-Siri & Stoltenberg, Camilla [Show all 8 contributors for this article] (2016). Multidimensional influences on autism symptom measures: Implications for use in etiological research. Journal of the American Academy of Child and Adolescent Psychiatry. ISSN 0890-8567. 55(12), p. 1054–1063. doi: 10.1016/j.jaac.2016.09.490.
  • Bishop, Somer L.; Havdahl, Alexandra; Huerta, Marisela & Lord, Catherine (2016). Subdimensions of social-communication impairment in autism spectrum disorder. Journal of Child Psychology and Psychiatry. ISSN 0021-9630. 57(8), p. 909–916. doi: 10.1111/jcpp.12510.
  • Havdahl, Alexandra; Tetzchner, Stephen von; Huerta, Marisela; Lord, Catherine & Bishop, Somer L. (2016). Utility of the Child Behavior Checklist as a Screener for Autism Spectrum Disorder. Autism Research. ISSN 1939-3792. 9(1), p. 33–42. doi: 10.1002/aur.1515.

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Published Dec. 9, 2020 11:35 AM - Last modified Dec. 9, 2020 4:09 PM

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