Cecilia Magdalena Eriksson

• Siafarikas, Nikias Ioannis; Kirsebom, Bjørn-Eivind; Srivastava, Deepak P; Eriksson, Cecilia Magdalena; Auning, Eirik & Hessen, Erik [Vis alle 10 forfattere av denne artikkelen] (2021). Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression. Scientific Reports. ISSN 2045-2322. 11. doi: 10.1038/s41598-021-99794-9. Fulltekst i vitenarkiv Vis sammendrag

  To explore markers for synaptic function and Alzheimer disease (AD) pathology in late life depression (LLD), predementia AD and normal controls (NC). A cross-sectional study to compare cerebrospinal fluid (CSF) levels of neurogranin (Ng), Beta-site amyloid-precursor-protein cleaving enzyme1 (BACE1), Ng/BACE1 ratio and Amyloid-β 42/40 ratio, phosphorylated-tau and total-tau in LLD with (LLD AD) or without (LLD NoAD) AD pathology, predementia AD and normal controls (NC). We included 145 participants (NC = 41; predementia AD = 66 and LLD = 38). LLD comprised LLD AD (n = 16), LLD NoAD (n = 19), LLD with non-AD typical changes (n = 3, excluded). LLD AD (pADJ < 0.05) and predementia AD (pADJ < 0.0001) showed significantly higher Ng than NC. BACE1 and Ng/BACE1 ratio were altered similarly. Compared to LLD NoAD, LLD AD showed significantly higher Ng (pADJ < 0.001), BACE1 (pADJ < 0.05) and Ng/BACE1 ratio (pADJ < 0.01). All groups had significantly lower Aβ 42/40 ratio than NC (predementia AD and LLD AD, p < 0.0001; LLD NoAD, p < 0.05). Both LLD groups performed similarly on tests of memory and executive function, but significantly poorer than NC. Synaptic function in LLD depended on AD pathology. LLD showed an association to Amyloid dysmetabolism. The LLD groups performed poorer cognitively than NC. LLD AD may be conceptualized as “predementia AD with depression”.

• Espenes, Ragna; Kirsebom, Bjørn-Eivind; Eriksson, Cecilia Magdalena; Waterloo, Knut K; Hessen, Erik & Johnsen, Stein Harald [Vis alle 8 forfattere av denne artikkelen] (2020). Amyloid plaques and symptoms of depression links to medical help-seeking due to subjective cognitive decline. Journal of Alzheimer's Disease. ISSN 1387-2877. 75(3), s. 879–890. doi: 10.3233/JAD-190712. Fulltekst i vitenarkiv
• Hessen, Erik; Kirsebom, Bjørn-Eivind; Eriksson, Cecilia Magdalena; Eliassen, Carl Fredrik Andestad; Nakling, Arne & Bråthen, Geir [Vis alle 9 forfattere av denne artikkelen] (2019). In Brief Neuropsychological Assessment, Amnestic Mild Cognitive Impairment (MCI) Is associated with Cerebrospinal Fluid Biomarkers for Cognitive Decline in Contrast to the Prevailing NIA-AA MCI Criterion. Journal of Alzheimer's Disease. ISSN 1387-2877. 67(2), s. 715–723. doi: 10.3233/JAD-180964. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Siafarikas, Nikias Ioannis; Kirsebom, Bjørn-Eivind; Srivastava, Deepak P.; Eriksson, Cecilia Magdalena; Auning, Eirik & Hessen, Erik [Vis alle 10 forfattere av denne artikkelen] (2022). Author Correction: Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression (Scientific Reports, (2021), 11, 1, (20375), 10.1038/s41598-021-99794-9). Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-22274-1.
• Espenes, Ragna; Kirsebom, Bjørn-Eivind; Eriksson, Cecilia Magdalena; Waterloo, Knut; Johnsen, Stein Harald & Hessen, Erik [Vis alle 7 forfattere av denne artikkelen] (2019). Medical help-seeking in Subjective Cognitive Decline associated with lower CSF Aβ1-42 and reduced memory performance.

Se alle arbeider i Cristin