Ruth Elizabeth Hypher

• Brandt, Anne Elisabeth; Rø, Torstein Baade; Finnanger, Torun Gangaune; Hypher, Ruth Elizabeth; Lien, Espen August & Lund, Bendik [Vis alle 10 forfattere av denne artikkelen] (2023). Intelligence and executive function are associated with age at insult, time post-insult, and disability following chronic pediatric acquired brain injury. Frontiers in Neurology. ISSN 1664-2295. 14. doi: 10.3389/fneur.2023.1192623.
• Sargénius, Hanna Lovise; Andersson, Stein; Haugen, Ingvild; Hypher, Ruth Elizabeth; Brandt, Anne Elisabeth & Finnanger, Torun Gangaune [Vis alle 9 forfattere av denne artikkelen] (2023). Cognitive rehabilitation in paediatric acquired brain injury—A 2-year follow-up of a randomised controlled trial. Frontiers in Neurology. ISSN 1664-2295. 14. doi: 10.3389/fneur.2023.1173480. Fulltekst i vitenarkiv Vis sammendrag

  Background: Goal management training (GMT), a metacognitive rehabilitation method that has been demonstrated to improve executive function (EF) in adults with acquired brain injury (ABI), could potentially be effective for children in the chronic phase of ABI. In a previously published randomised controlled trial (RCT), the efficacy of a paediatric adaptation of GMT (pGMT) compared to a psychoeducative control intervention (paediatric Brain Health Workshop, pBHW) was investigated. Comparable improvements in EF in both groups were found at 6-month follow-up. However, a specific effect of pGMT could not be conclusively proven. The present study reports 2-year follow-up data (T4; T1: baseline, T2: post-intervention, T3: 6-month follow-up, and T4: 2-year follow-up) from this original RCT. Methods: A total of 38 children and adolescents and also their parents completed questionnaires tapping into daily life EF. Explorative analyses were conducted comparing the 2-year follow-up data (T4) with the baseline (T1) and 6-month follow-up data (T3) for T4-participants in the two intervention groups (pGMT; n = 21, pBHW; n = 17), and we also assessed T4-participants vs. non-responders (n = 38) in the RCT. Primary outcome measures were the Behavioural Regulation Index (BRI) and the Metacognition Index (MI) derived from the Behaviour Rating Inventory of Executive Function (BRIEF) parent report. Results: No difference between intervention groups was found (BRI, F = 2.25, p = 0.143, MI, F = 1.6, p = 0.213), and no time*group interaction (BRI, F = 0.07, p = 0.976, MI, F = 0.137, p = 0.937) could be seen at the 2-year follow-up. Nevertheless, both pGMT and the pBHW groups improved daily EF as measured by parental reports over time from the baseline to T4 (p = 0.034). T4 participants and non-responders shared similar baseline characteristics. Conclusion: Our results extend the findings from the 6-month follow-up previously published. Both pGMT and pBHW groups sustained their improvements in daily life EFs from the baseline, but additional effectiveness of pGMT relative to pBHW was not found.

• Hypher, Ruth Elizabeth; Brandt, Anne Elisabeth; Skovlund, Eva; Skarbø, Anne-Britt; Barder, Helene & Andersson, Stein [Vis alle 10 forfattere av denne artikkelen] (2022). Metacognitive Strategy Training Versus Psychoeducation for Improving Fatigue in Children and Adolescents With Acquired Brain Injuries: A Randomized Controlled Trial. Neuropsychology. ISSN 0894-4105. 36(7), s. 579–596. doi: 10.1037/neu0000845.
• Torske, Tonje; Nærland, Terje; Quintana, Daniel; Hypher, Ruth Elizabeth; Kaale, Anett & Høyland, Anne Lise [Vis alle 10 forfattere av denne artikkelen] (2022). Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. ISSN 0162-3257. doi: 10.1007/s10803-022-05629-5. Fulltekst i vitenarkiv Vis sammendrag

  Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and adolescents (25 girls) aged 5-19 years with an intelligence quotient above 70 and an autism spectrum disorder (ASD) diagnosis. They were rated with the behavior rating inventory of executive function (BRIEF) and the autism diagnostic interview revised (ADI-R). We found a positive association between EF and the ADI-R domains of reciprocal social interaction (p < 0.001) and communication (p = 0.001) in girls, while these relationships were small and non-significant in boys. Our results provide a greater understanding of the sex-specific characteristics of children and adolescents with ASD. Keywords: Autism diagnostic interview revised (ADI-R); Autism spectrum disorder; Behavior rating inventory of executive function (BRIEF); Executive function; Sex differences. © 2022. The Author(s).

• Romundstad, Bendik; Solem, Stian; Brandt, Anne Elisabeth; Hypher, Ruth Elizabeth; Risnes, Kari & Rø, Torstein Baade [Vis alle 8 forfattere av denne artikkelen] (2022). Validity of the Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) in children and adolescents with pediatric acquired brain injury. Neuropsychological Rehabilitation. ISSN 0960-2011. 33(4), s. 551–573. doi: 10.1080/09602011.2022.2034649. Fulltekst i vitenarkiv Vis sammendrag

  The Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) was developed to address the need for a standardized ecologically valid test of executive function (EF) in the pediatric population. Our study aimed to investigate the discriminant, concurrent, and ecological validity of BADS-C in a sample with pediatric acquired brain injury (pABI). Seventy-four participants with pABI aged 10–17 years were included to a pre-registered randomized controlled trial, and baseline assessment was used for the current study. Controls consisted of 60 participants aged 10–17 years. Participants with pABI were assessed with neuropsychological tests and questionnaires of EF, and measurements of general intellectual ability (IQ). Results showed that all BADS-C subtests discriminated between participants with pABI and controls, except for the Playing Cards Test. Concurrent and ecological validity was demonstrated through associations between BADS-C total score, Key Search Test, and Zoo Map Test 1, and neuropsychological tests and teacher questionnaire ratings of EF. Key Search Test and Zoo Map Test 1 predicted teacher ratings of EF, beyond IQ and other neuropsychological test of EF. These findings provide support for BADS-C as a valid clinical assessment tool that can detect everyday executive dysfunction in the pABI population, and guide rehabilitation and treatment decisions.

• Finnanger, Torun Gangaune; Andersson, Stein; Chevignard, Mathilde; Johansen, Gøril Okkenhaug; Brandt, Anne Elisabeth & Hypher, Ruth Elizabeth [Vis alle 9 forfattere av denne artikkelen] (2022). Assessment of Executive Function in Everyday Life—Psychometric Properties of the Norwegian Adaptation of the Children’s Cooking Task. Frontiers in Human Neuroscience. ISSN 1662-5161. 15. doi: 10.3389/fnhum.2021.761755. Fulltekst i vitenarkiv
• Stubberud, Jan Egil; Hypher, Ruth Elizabeth; Brandt, Anne Elisabeth; Finnanger, Torun Gangaune; Skovlund, Eva & Andersson, Stein [Vis alle 8 forfattere av denne artikkelen] (2022). Predictors of Functional School Outcome in Children With Pediatric Acquired Brain Injury. Frontiers in Neurology. ISSN 1664-2295. 13. doi: 10.3389/fneur.2022.872469. Fulltekst i vitenarkiv
• Brandt, Anne Elisabeth; Finnanger, Torun Gangaune; Hypher, Ruth E.; Rø, Torstein Baade; Skovlund, Eva & Andersson, Stein [Vis alle 8 forfattere av denne artikkelen] (2021). Rehabilitation of executive function in chronic paediatric brain injury: a randomized controlled trial. BMC Medicine. ISSN 1741-7015. 19(1), s. 1–15. doi: 10.1186/s12916-021-02129-8. Fulltekst i vitenarkiv
• Hypher, Ruth Elizabeth; Andersson, Stein; Finnanger, Torun Gangaune; Brandt, Anne Elisabeth; Hoorelbeke, Kristof & Lie, Hanne Cathrine [Vis alle 11 forfattere av denne artikkelen] (2021). Fatigue Following Pediatric Acquired Brain Injury: Interplay With Associated Factors in a Clinical Trial Population Compared to Healthy Controls. Neuropsychology. ISSN 0894-4105. 35(6), s. 609–621. doi: 10.1037/neu0000753. Vis sammendrag

  Objective: The aims of the present study were to compare fatigue levels in children with pediatric acquired brain injury (pABI) with healthy controls (HCs), and examine the interplay of fatigue with associated factors. Method: We used baseline data from a preregistered randomized controlled trial. Seventy-six children aged 10–17 (median 13 years) with pABI in the chronic phase (88% with confirmatory cerebral imaging findings) and executive function (EF) complaints were included, most with moderate disability according to The Glasgow Outcome Scale Extended (GOSE-E) categorization. HCs consisted of 60 children aged 10–17 (median 13 years). All 127 participants completed measures of fatigue and intelligence. pABI participants were also assessed for behavioral problems, health-related quality of life (HRQoL), and EF. Nonparametric statistics were employed, in addition to a network analysis to model the unique associations between parent-reported fatigue and related factors. Results: Parents reported significantly more fatigue in the pABI-group (75% of scores in clinical range; < 70) compared to HCs (11.7% of scores in clinical range). No strong associations were found between fatigue and injury characteristics, but findings indicated more fatigue in the older than younger age-group for pABI participants. Network modeling revealed a central role for HRQoL, behavioral, and EF symptoms in relation to fatigue. Conclusions: Fatigue is reported to be highly prevalent in the chronic phase of pABI. When addressing fatigue, our findings demonstrate the advantage of including multidimensional measures of fatigue and examining associated psychological and cognitive constructs, such as HRQoL, behavioral problems, and EF. Impact Statement Question: What is the prevalence and severity of fatigue in children and adolescents with pediatric brain injuries, and is it related to other factors? Findings: For the majority of children in chronic phase of pABI, parents reported fatigue in the clinical range. Fatigue is associated with health-related quality of life, behavioral problems, and executive function. Importance: Fatigue is a complex symptom that negatively impacts functioning across a range of areas, and needs to be addressed in all phases of brain injury rehabilitation. Next Steps: Longitudinal studies are needed to confirm the directionality of the relationships between factors associated with fatigue.

• Hypher, Ruth Elizabeth; Brandt, Anne Elisabeth; Risnes, Kari Ravndal; Rø, Torstein Baade; Skovlund, Eva & Andersson, Stein [Vis alle 8 forfattere av denne artikkelen] (2019). Paediatric goal management training in patients with acquired brain injury: study protocol for a randomised controlled trial. BMJ Open. ISSN 2044-6055. 9:e029273(8), s. 1–12. doi: 10.1136/bmjopen-2019-029273. Fulltekst i vitenarkiv

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