Exploring the links between specific depression symptoms and brain structure: A network study

Various patterns of structural brain abnormalities have been associated with depression, yet sensitive, specific and clinically predictive brain correlates have proven to be difficult to characterize.

Image may contain: Text, Font, Technology.


The currently best available empirical evidence on neuroanatomical differences between patients with major depression (MDD) and healthy controls are two meta‐analyses of approximately 10 000 individuals.These reports show widespread alterations in cortical regions and in hippocampal volume, but no associations between depression severity and brain structure. Inconsistencies in the neuroimaging literature may be explained by the fact that depression is highly heterogeneous, featuring over 50 symptoms,where symptom constellations may reflect different phenomena with distinct underlying biological causes.

Psychiatry and Clinical Neurosciences, 2020, 74 (3), 220-221, doi: 10.1111/pcn.12969. 

Published May 25, 2020 6:00 AM