Yunpeng Wang

• Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Bøen, Erlend; Elvsåshagen, Torbjørn; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne; Ødegaard, Ketil Joachim; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, MacIej; Pers, Tune H; Holmans, Peter A.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E & Pedersen, Carsten Bøcker (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience.  ISSN 1662-4548.  13 . doi: 10.3389/fnins.2019.00220 Full text in Research Archive. Show summary

  Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer’s Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect). Conclusion: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP.

• Fjell, Anders Martin; Sederevicius, Donatas; Sneve, Markus Handal; de Lange, Ann-Marie Glasø; Bråthen, Anne Cecilie Sjøli; Idland, Ane-Victoria; Watne, Leiv Otto; Wang, Yunpeng; Reinbold, Céline Sonja; Blennow, Kaj; Zetterberg, Henrik; Hong, S; Bertram, Lars & Walhovd, Kristine B (2019). Self-reported sleep problems are related to amyloid deposition in cortical regions with high HOMER1 gene expression. Cerebral Cortex.  ISSN 1047-3211.
• Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Mæland, Steffen; O`Connell, Kevin; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas & Dale, Anders (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications.  ISSN 2041-1723.  10(1) . doi: 10.1038/s41467-019-10310-0
• Gasse, Christiane; Wimberley, Theresa; Wang, Yunpeng; Mors, Ole; Børglum, Anders; Als, Thomas Damm; Werge, Thomas; Nordentoft, Merete; Hougaard, David M. & Horsdal, Henriette Thisted (2019). Schizophrenia polygenic risk scores, urbanicity and treatment-resistant schizophrenia. Schizophrenia Research.  ISSN 0920-9964.  212, s 79- 85 . doi: 10.1016/j.schres.2019.08.008
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• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob; Zhu, Zhaozhong; Tucker-Drob, Elliot M.; Nivard, Michel G.; Grotzinger, Andrew D.; Posthuma, Danielle; Yu, Dongmei; Stahl, Eli A.; Walters, Raymond K.; Anney, Richard J.L.; Duncan, Laramie E.; Ge, Tian; Belangero, Sintia I.; Cook, Edwin H.; Hoekstra, Pieter J.; Keski-Rahkonen, Anna; Kirov, George; Luykx, Jurjen J.; Rohde, Luis A.; Agerbo, Esben; Arranz, M.J.; Asherson, Philip; Bækvad-Hansen, Marie; Bellgrove, Mark A.; Belliveau Jr, Richard A.; Buitelaar, Jan; Bybjerg-Grauholm, Jonas; Casas, Miquel; Chambert, Kimberly; Cerrato, Felecia; Churchhouse, Claire; Cormand, Bru; Crosbie, Jennifer; Dalsgaard, Søren; Haavik, Jan; Hakonarson, Hakon; Hansen, Christine S.; Mors, Ole; Zayats, Tetyana; Bettella, Francesco; Hope, Sigrun; Hultman, Christina M.; Nærland, Terje; Bøen, Erlend; Elvsåshagen, Torbjørn; Ødegaard, Ketil Joachim; Malt, Ulrik Fredrik; Melle, Ingrid; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Espeseth, Thomas; Knudsen, Gun Peggy Strømstad; Le Hellard, Stephanie; Reichborn-Kjennerud, Ted; Jönsson, Erik Gunnar; Andreassen, Ole Andreas; Agartz, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne & Joa, Inge (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell.  ISSN 0092-8674.  179(7), s 1469- 1482 . doi: 10.1016/j.cell.2019.11.020
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• Erlangsen, Annette; Appadurai, Vivek; Wang, Yunpeng; Turecki, Gustavo; Mors, Ole; Werge, Thomas; Mortensen, Preben B.; Starnawska, Anna; Børglum, Anders D.; Schork, Andrew J.; Nudel, Ron; Bækvad-Hansen, Marie; Bybjerg-Grauholm, Jonas; Hougaard, David M.; Thompson, Wesley Kurt; Nordentoft, Merete & Agerbo, Esben (2018). Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 12 . doi: 10.1038/s41380-018-0218-y
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• Holland, Dominic; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Chen, Chi-Hua; Lo, Min-Tzu; Witoelar, Aree; Werge, Thomas; O'Donovan, Michael; Andreassen, Ole Andreas & Dale, Anders (2016). Estimating effect sizes and expected replication probabilities from GWAS summary statistics. Frontiers in Genetics.  ISSN 1664-8021.  7(15) . doi: 10.3389/fgene.2016.00015
• Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y.; Franz, Carol E.; Fan, Chun Chieh; Wang, Yunpeng; Smeland, Olav Bjerkehagen; Schork, Andrew J.; Holland, Dominic; Kauppi, Karolina; Nilotpal, Sanyal; Escott-Price, Valentina; Smith, Daniel J.; O'Donovan, Michael; Stefansson, Hreinn; Bjornsdottir, Gyda; Thorgeirsson, Thorgeir E; Stefansson, Kari; McEvoy, Linda K.; Dale, Anders; Andreassen, Ole Andreas & Chen, Chi-Hua (2016). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics.  ISSN 1061-4036.  49(1), s 152- 156 . doi: 10.1038/ng.3736
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2016). Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: a modeling study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.  ISSN 2451-9022.  1(1), s 49- 59 . doi: 10.1016/j.bpsc.2015.09.002 Show summary

  BACKGROUND: Recent genome-wide association studies have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical pyramidal cells and identified possible common alterations in behavior across SCZ-related genes. METHODS: We applied a biophysically detailed multicompartmental model to study the excitability of a layer V pyramidal cell. We reviewed the literature on functional genomics for variants of genes associated with SCZ and used changes in neuron model parameters to represent the effects of these variants. RESULTS: We present and apply a framework for examining the effects of subtle single nucleotide polymorphisms in ion channel and calcium transporter-encoding genes on neuron excitability. Our analysis indicates that most of the considered SCZ-related genetic variants affect the spiking behavior and intracellular calcium dynamics resulting from summation of inputs across the dendritic tree. CONCLUSIONS: Our results suggest that alteration in the ability of a single neuron to integrate the inputs and scale its excitability may constitute a fundamental mechanistic contributor to mental disease, alongside the previously proposed deficits in synaptic communication and network behavior. Keywords: Biophysical modeling, Functional genomics, Genome-wide association studies, Layer V pyramidal cell, Neuron excitability, Schizophrenia

• Schork, AJ; Wang, Yunpeng; Thompson, Kurt Wesley; Dale, AM & Andreassen, Ole Andreas (2016). New statistical approaches exploit the polygenic architecture of schizophrenia-implications for the underlying neurobiology. Current Opinion in Neurobiology.  ISSN 0959-4388.  36, s 89- 98 . doi: 10.1016/j.conb.2015.10.008
• Wang, Yunpeng; Bos, Steffan Daniel; Harbo, Hanne Flinstad; Thompson, Wesley K.; Schork, Andrew J.; Bettella, Francesco; Witoelar, Aree; Lie, Benedicte Alexandra; Li, Wen; McEvoy, Linda K.; Djurovic, Srdjan; Desikan, Rahul S.; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.. Multiple Sclerosis.  ISSN 1352-4585.  22(14), s 1783- 1793 . doi: 10.1177/1352458516635873
• Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Holland, Dominic; Chen, Chi-Hua; Bettella, Francesco; Desikan, Rahul S.; Li, Wen; Witoelar, Aree; Zuber, Verena; Devor, Anna; Nöthen, Markus M; Rietschel, Marcella; Chen, Qiang; Werge, Thomas; Cichon, Sven; Weinberger, Daniel R.; Djurovic, Srdjan; O'Donovan, Michael; Visscher, Peter M; Andreassen, Ole Andreas & Dale, Anders (2016). Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. PLoS Genetics.  ISSN 1553-7390. . doi: 10.1371/journal.pgen.1005803 Full text in Research Archive.
• Yokoyama, Jennifer S.; Wang, Yunpeng; Schork, Andrew J.; Thompson, Wesley K.; Karch, Celeste M.; Cruchaga, Carlos; McEvoy, Linda K.; Witoelar, Aree; Chen, Chi-Hua; Holland, Dominic; Brewer, James B.; Franke, Andre; Dillon, William P.; Wilson, David M.; Mukherjee, Pratik; Hess, Christopher P.; Miller, Zachary; Bonham, Luke W.; Shen, Jeffrey; Rabinovici, Gil D.; Rosen, Howard J.; Miller, Bruce L.; Hyman, Bradley T.; Schellenberg, Gerard D.; Karlsen, Tom Hemming; Andreassen, Ole Andreas; Dale, Anders & Desikan, Rahul S. (2016). Association between genetic traits for immune-mediated diseases and Alzheimer disease. JAMA Neurology.  ISSN 2168-6149.  73(6), s 691- 697 . doi: 10.1001/jamaneurol.2016.0150
• Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, Eva; Albrecht, Mario; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte Alexandra; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom Hemming & Dale, Anders (2015). Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLOS ONE.  ISSN 1932-6203.  10:e 0123057(4) . doi: 10.1371/journal.pone.0123057 Full text in Research Archive.
• Andreassen, Ole Andreas; Harbo, Hanne Flinstad; Wang, Yunpeng; Thompson, WK; Schork, AJ; Mattingsdal, Morten; Zuber, Verena; Bettella, Franscesco; Ripke, S; Kelsoe, JR; Kendler, KS; O'Donovan, MC; Sklar, P; McEvoy, LK; Desikan, RS; Lie, Benedicte Alexandra; Djurovic, Srdjan & Dale, Anders M. (2015). Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular Psychiatry.  ISSN 1359-4184.  20(2), s 207- 214 . doi: 10.1038/mp.2013.195 Full text in Research Archive.
• Chen, Chi-Hua; Peng, Qian; Schork, Andrew J.; Lo, Min-Tzu; Fan, Chun-Chieh; Wang, Yunpeng; Desikan, Rahul S.; Bettella, Franscesco; Hagler, Donald J.; Westlye, Lars Tjelta; Kremen, William S.; Jernigan, Terry L.; Le Hellard, Stephanie; Steen, Vidar Martin; Espeseth, Thomas; Huentelman, Matt; Håberg, Asta; Agartz, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas; Schork, Nicholas & Dale, Anders (2015). Large-scale genomics unveil polygenic architecture of human cortical surface area. Nature Communications.  ISSN 2041-1723.  6:7549 . doi: 10.1038/ncomms8549 Full text in Research Archive.
• Desikan, Rahul S.; Schork, Andrew J.; Wang, Yunpeng; Thompson, Wesley K.; Dehghan, Abbas; Ridker, Paul M.; Chasman, Daniel I.; McEvoy, Linda K.; Holland, Dominic; Chen, Chi-Hua; Karow, David S.; Brewer, James B.; Hess, Christopher P.; Williams, Julie; Sims, Rebecca; O'Donovan, Michael C.; Choi, Seung Hoan; Bis, Joshua C.; Ikram, M. Arfan; Gudnason, Vilmundur; DeStefano, Anita L.; Van Der Lee, Sven J.; Psaty, Bruce M.; Van Duijn, Cornelia M.; Launer, Lenore; Seshadri, Sudha; Pericak-Vance, Margaret A.; Mayeux, Richard; Haines, Jonathan L.; Farrer, Lindsay A.; Hardy, John; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; White, Linda; Sando, Sigrid Botne; Rongve, Arvid; Witoelar, Aree; Djurovic, Srdjan; Hyman, Bradley T.; Snædal, Jon; Steinberg, Stacy; Stefansson, Hreinn; Stefánsson, Kári; Schellenberg, Gerard D.; Andreassen, Ole Andreas & Dale, Anders (2015). Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease. Circulation.  ISSN 0009-7322.  131(23), s 2061- 2069 . doi: 10.1161/CIRCULATIONAHA.115.015489 Full text in Research Archive.
• Desikan, RS; Schork, AJ; Wang, Yunpeng; Witoelar, Aree; Sharma, M; McEvoy, LK; Holland, D; Brewer, JB; Chen, CH; Thompson, WK; Harold, D; Williams, J; Owen, MJ; O'Donovan, MC; Pericak-Vance, MA; Mayeux, R; Haines, JL; Farrer, LA; Schellenberg, GD; Heutink, P; Singleton, AB; Brice, A; Wood, NW; Hardy, J; Martinez, M; Choi, SH; Destefano, A; Ikram, MA; Bis, JC; Smith, A; Fitzpatrick, AL; Launer, L; Van Duijn, C; Seshadri, S; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; Djurovic, Srdjan; Hyman, BT; Snaedal, J; Stefansson, H; Stefansson, K; Gasser, T; Andreassen, Ole Andreas & Dale, AM (2015). Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Molecular Psychiatry.  ISSN 1359-4184.  20(12), s 1588- 1595 . doi: 10.1038/mp.2015.6
• Fan, Chun Chieh; Bartsch, Hauke; Schork, Andrew J.; Chen, Chi-Hua; Wang, Yunpeng; Lo, Min-Tzu; Brown, Timothy T.; Kuperman, Joshua M.; Hagler, Donald J.; Schork, Nicholas J.; Jernigan, Terry L. & Dale, Anders (2015). Modeling the 3D geometry of the cortical surface with genetic ancestry. Current Biology.  ISSN 0960-9822.  25(15), s 1988- 1992 . doi: 10.1016/j.cub.2015.06.006
• Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, Andrew J.; Thompson, Kurt Wesley; Mattingsdal, Morten; Steen, Vidar Martin; Zuber, Verena; Wang, Yunpeng; Dale, Anders; Andreassen, Ole Andreas & Djurovic, Srdjan (2015). MicroRNAs enrichment in GWAS of complex human phenotypes. BMC Genomics.  ISSN 1471-2164.  16:304 . doi: 10.1186/s12864-015-1513-5 Full text in Research Archive.
• LeBlanc, Marissa; Zuber, Verena; Kulle, Bettina; Witoelar, Aree; Zeng, Limin; Bettella, Francesco; Wang, Yunpeng; McEvoy, LK; Thompson, Kurt Wesley; Schork, AJ; Reppe, Sjur; Barrett-Connor, Elizabeth; Lighart, Symen; Dehghan, A; Gautvik, Kaare M; Nelson, CP; Schunkert, Heribert; Samani, Nilesh J; Ridker, PM; Chasman, Daniel I; Aukrust, Pål; Djurovic, Srdjan; Frigessi, Arnoldo; Desikan, RS; Dale, Anders & Andreassen, Ole Andreas (2015). Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes with Several Cardiovascular Risk Factors.. Circulation Research.  ISSN 0009-7330.  1, s 83- 94 . doi: 10.1161/CIRCRESAHA.115.306629
• Reppe, Sjur; Wang, Yunpeng; Thompson, Wesley K.; McEvoy, Linda K.; Schork, Andrew J.; Zuber, Verena; LeBlanc, Marissa; Bettella, Franscesco; Mills, Ian Geoffrey; Desikan, Rahul S.; Djurovic, Srdjan; Gautvik, Kaare M; Dale, Anders & Andreassen, Ole Andreas (2015). Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci. PLOS ONE.  ISSN 1932-6203.  10:e0144531(12) . doi: 10.1371/journal.pone.0144531 Full text in Research Archive.
• Srinivasan, Saurabh; Bettella, Francesco; Mattingsdal, Morten; Wang, Yunpeng; Witoelar, Aree; Schork, AJ; Thompson, WK; Zuber, Verena; Winsvold, Bendik K S; Zwart, John-Anker; Collier, David A.; Desikan, RS; Melle, Ingrid; Werge, Thomas; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2015). Genetic Markers of Human Evolution Are Enriched in Schizophrenia. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2015.10.009
• Thompson, WK; Wang, Yunpeng; Schork, AJ; Witoelar, Aree; Zuber, Verena; Xu, S; Werge, T; Holland, D; Andreassen, Ole Andreas & Dale, AM (2015). An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies. PLoS Genetics.  ISSN 1553-7390.  11(12) . doi: 10.1371/journal.pgen.1005717
• Andreassen, Ole Andreas; McEvoy, Linda K.; Thompson, Wesley K.; Wang, Yunpeng; Reppe, Sjur; Schork, Andrew J.; Zuber, Verena; Barrett-Connor, Elizabeth; Gautvik, Kaare M; Aukrust, Pål; Karlsen, Tom Hemming; Djurovic, Srdjan; Desikan, Rahul S. & Dale, Anders (2014). Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes. Hypertension.  ISSN 0194-911X.  63(4), s 819- 826 . doi: 10.1161/HYPERTENSIONAHA.113.02077 Full text in Research Archive.
• Gjuvsland, Arne Bjørke; Wang, Yunpeng; Plahte, Erik & Omholt, Stig W (2013). Monotonicity is a key feature of genotype-phenotype maps. Frontiers in Genetics.  ISSN 1664-8021.  4 . doi: 10.3389/fgene.2013.00216 Full text in Research Archive.
• Wang, Yunpeng; Vik, Jon Olav; Omholt, Stig W & Gjuvsland, Arne Bjørke (2013). Effect of regulatory architecture on broad versus narrow sense heritability. PLoS Computational Biology.  ISSN 1553-734X.  9(5) . doi: 10.1371/journal.pcbi.1003053 Full text in Research Archive.
• Wang, Yunpeng; Gjuvsland, Arne Bjørke; Vik, Jon Olav; Smith, Nicolas P; Hunter, Peter J & Omholt, Stig W (2012). Parameters in Dynamic Models of Complex Traits are Containers of Missing Heritability. PLoS Computational Biology.  ISSN 1553-734X.  8(4) . doi: 10.1371/journal.pcbi.1002459

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• Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y; Franz, C; Fan, Chun Chieh; Wang, Yunpeng; Smeland, Olav Bjerkehagen; Schork, A.; Holland, D.; Kauppi, Karolina; Sanyal, Nilotpal; Escott-Price, Valentina; Smith, DJ; O'Donovan, Michael C; Stefansson, H; Bjornsdottir, Gyda; Thorgeirsson, TE; Stefansson, K; McEvoy, LK; Dale, AM; Andreassen, Ole Andreas & Chen, CH (2017). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.. Nature Genetics.  ISSN 1061-4036.  49(1), s 152- 156 . doi: 10.1038/ng.3736
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Dale, Anders & Andreassen, Ole Andreas (2017). Combined Analysis of Large Genetic Samples. New Statistical Approaches Improve Gene Discovery.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Alexey, Shadrin; Li, Wen; Florian, Krull; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). Increased discovery of risk loci for bipolar disorder by leveraging prior probabilities of true associations using the covariate modulated mixture model (CM3).
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Shadrin, Alexey A.; Li, Wen; Krull, Florian; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). C-Reactive Protein Levels and Schizophrenia Share Genetic Influences.
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Conditional false discovery rate analysis of genome-wide association studies uncovers genetic loci shared between schizophrenia and volumes of hippocampus, putamen and intracranial volume.
• Córdova-Palomera, Aldo; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; Alnæs, Dag; Moberget, Torgeir; Kaufmann, Tobias; Sønderby, Ida Elken; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2016). POTENTIAL BRAIN MORPHOLOGY INSTABILITY FEATURES MEDIATING THE ASSOCIATION BETWEEN GENOME-WIDE HOMOZYGOSITY AND ALTERED NEUROCOGNITION.
• Smeland, Olav Bjerkehagen; Kauppi, Karolina; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hill, David W; Davies, Gail; Eriksen, Jon Alm; Witoelar, Aree; Bettella, Francesco; Fan, Chun Chieh; Thompson, Wesley Kurt; Chen, Chi-Hua; Djurovic, Srdjan; Deary, Ian J.; Dale, Anders & Andreassen, Ole Andreas (2016). Schizophrenia and general cognitive function share genetic influences.
• Smeland, Olav Bjerkehagen; Witoelar, Aree; Lo, Min-Tzu; Tesli, Martin Steen; Wang, Yunpeng; Hinds, David A.; Tung, Joyce Y.; Djurovic, Srdjan; Chen, Chi-Hua; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between schizophrenia and the Big Five personality traits.
• Smeland, Olav Bjerkehagen; Witoelar, Aree; Wang, Yunpeng; Chen, Chi-Hua; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between schizophrenia and brain structural volumes indicates shared molecular genetic mechanisms with potential relevance for antipsychotics.
• Zuber, Verena; Marconett, Crystal; Shi, Jianxin; Hua, Xing; Wheeler, William; Yang, Chenchen; Song, Lei; Dale, Anders M.; Laplana, Marina; Risch, Angela; Witoelar, Aree; Thompson, Wesley K; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Zhou, Beiyun; Borok, Zea; van der Heijden, Henricus FM; de Graaf, Jacqueline; Swinkels, Dorine; Aben, Katja K.; McKay, James; Hung, Rayjean J.; Bikeböller, Heike; Stevens, Victoria L.; Albanes, Demetrius; Caporaso, Neil E.; Han, Younghun; Wei, Youngyue; Panadero, Maria A; Mayordomo, Jose Ignacio; Christiani, David C.; Kiemeney, Lambertus; Andreassen, Ole Andreas; Houlston, Richard; Amos, Christopher I.; Chatterjee, Nilanjan; Laird-Offringa, Ite A.; Mills, Ian Geoffrey & Landi, Maria Teresa (2016). Pleiotropic analysis of lung cancer and blood triglycerides. Journal of the National Cancer Institute.  ISSN 0027-8874.  108:djv167(12), s 1- 4 . doi: 10.1093/jnci/djw167
• Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, Eva; Albrecht, Mario; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte A.; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom Hemming & Dale, Anders (2015). Correction: Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLOS ONE.  ISSN 1932-6203.  10(5) . doi: 10.1371/journal.pone.0128048
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked genes on single-neuron excitability.
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked gens on single-neuron excitability.
• Gjuvsland, Arne Bjørke; Wang, Yunpeng; Plahte, Erik & Omholt, Stig W (2014). Highly monotone genotype-phenotype maps emerging from gene regulatory networks.
• Wang, Yunpeng; Omholt, Stig W; Gjuvsland, Arne Bjørke & Vik, Jon Olav (2013). LINKING THE HERITABILITY CONCEPT TO SYSTEMS DYNAMICS. Philosophiae Doctor (PhD) Thesis. 18.
• Gjuvsland, Arne Bjørke; Wang, Yunpeng; Plahte, Erik & Omholt, Stig William (2012). Monotonicity is a key measure of genotype-phenotype maps.
• Vik, Jon Olav; Gjuvsland, Arne Bjørke; Wang, Yunpeng; Omholt, Stig W; Smith, Nicolas P & Hunter, Peter J (2012). A toolbox for causally cohesive genotype-phenotype modeling.
• Wang, Yunpeng; Vik, Jon Olav; Omholt, Stig W & Gjuvsland, Arne Bjørke (2012). Disclosing the relationship between heritability and regulatory architecture.
• Wang, Yunpeng & Omholt, Stig W. (2010). Genetics meets multiscale and multiphysics modelling: the epistemic value of causally cohesive genotype-phenotype models.

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