Yunpeng Wang

• Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean & Wang, Yunpeng [Show all 20 contributors for this article] (2022). Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood. Molecular Psychiatry. ISSN 1359-4184.
• Walhovd, Kristine B; Amlien, Inge; Sørensen, Øystein; Wang, Yunpeng; Mowinckel, Athanasia Monika & Magnussen, Fredrik [Show all 8 contributors for this article] (2022). Brain aging differs with cognitive ability regardless of education. Scientific Reports. ISSN 2045-2322. 12(13886). doi: 10.1038/s41598-022-17727-6.
• Hu, Maolin; Zong, Xiaofen; Sweeney, John A.; Bishop, Jeffrey R; Liao, Yanhui & Giase, Gina [Show all 15 contributors for this article] (2022). Risperidone-induced changes in DNA methylation in peripheral blood from first-episode schizophrenia patients parallel changes in neuroimaging and cognitive phenotypes. Psychiatry Research. ISSN 0165-1781. doi: 10.1016/j.psychres.2022.114789. Show summary

  Background Second generation antipsychotics such as risperidone are first-line pharmacotherapy treatment choices for schizophrenia. However, our ability to reliably predict and monitor treatment reaction is impeded by the lack of relevant biomarkers. As a biomarker for the susceptibility of schizophrenia and clozapine treatment response, DNA methylation (DNAm) has been studied, but the impact of antipsychotics on DNAm has not been explored in drug-naïve patients. Objective The aim of the present study was to examine changes of DNAm after short-term antipsychotic therapy in first-episode drug-naïve schizophrenia (FES) to identify the beneficial and adverse effect of risperidone on DNAm and their relation to treatment outcome. Methods Thirty-eight never treated schizophrenia patients and 38 demographically matched individuals (healthy controls) were assessed at baseline and at 8-week follow-up with symptom ratings, and cognitive and functional imaging procedures, at which time a blood draw for DNAm studies was performed. During the 8-week period, patients received treatment with risperidone monotherapy. An independent data set was used as replication. Results We identified brain related pathways enriched in 4,888 FES-associated CpG sites relative to controls. Risperidone administration in patients altered DNAm in 5,979 CpG sites relative to baseline. Significant group differences in DNAm at follow-up were seen in FES patients at 6,760 CpG sites versus healthy controls. Through comparison of effect size, we found 87.54% out of the risperidone-associated changes in DNAm showed possible beneficial effect, while only 12.46% showed potential adverse effect. There were 580 DNAm sites in which changes shifted methylation levels to be indistinguishable from controls after risperidone treatment. The DNAm changes of some sites that normalized after treatment were correlated with treatment-related changes in symptom severity, spontaneous neurophysiological activity, and cognition. We replicated our results in an independent data set. Conclusion The normalizing effect of risperidone monotherapy on gene DNAm, and its correlation with clinically relevant phenotypes, indicates that risperidone therapy is associated with DNAm changes that are related to changes in brain physiology, cognition and symptom severity.

• Krantz, Mette Falkenberg; Ellersgaard, Ditte; Andersen, Klaus Kaae; Hemager, Nicoline; Christiani, Camilla & Spang, Katrine Søborg [Show all 23 contributors for this article] (2022). Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents with Schizophrenia or Bipolar Disorder: Clustering Data from the Danish High Risk and Resilience Study VIA 7. Schizophrenia Bulletin Open. ISSN 2632-7899. 3(1). doi: 10.1093/schizbullopen/sgac010. Show summary

  Objective Children with familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) are frequently affected in a range of domains known to be precursors of severe mental illness. No previous studies have gathered known precursors to examine whether they distribute evenly across familial high risk (FHR) children or if they cluster among a smaller group. Since such examination holds the potential to identify high and low risk of severe mental illness groups, we aimed to cluster FHR and control children affected to various degrees. Method In The Danish High Risk and Resilience Study VIA 7, a clinical cohort study, 514 7-year-old children with FHR-SZ or FHR-BP and matched controls were assessed in domains of motor function, neurocognition, emotional control, behavior, social cognition, self-perception, language, psychotic experiences, and psychopathology, and grouped using cluster analysis. Associations between clusters and parents' level of education, functioning, caregiver status, child's level of stimulation and support in the home, and polygenic risk scores were examined. Results A total of four groups including one of broadly affected children were identified. The broadly affected group was represented 4–5-fold (18.1%) amongst FHR-SZ children and 2–3-fold (10.2%) amongst FHR-BP children, compared to controls (4.1%) (P

• ALLESØE, ROSA LUNDBYE; Nudel, Ron; Thompson, Wesley K.; Wang, Yunpeng; Nordentoft, Merete & Børglum, Anders D [Show all 10 contributors for this article] (2022). Deep learning-based integration of genetics with registry data for stratification of schizophrenia and depression. Science Advances. ISSN 2375-2548. 8(26). doi: 10.1126/sciadv.abi7293. Show summary

  Currently, psychiatric diagnoses are, in contrast to most other medical fields, based on subjective symptoms and observable signs and call for new and improved diagnostics to provide the most optimal care. On the basis of a deep learning approach, we performed unsupervised patient stratification of 19,636 patients with depression [major depressive disorder (MDD)] and/or schizophrenia (SCZ) and 22,467 population controls from the iPSYCH2012 case cohort. We integrated data of disorder severity, history of mental disorders and disease comorbidities, genetics, and medical birth data. From this, we stratified the individuals in six and seven unique clusters for MDD and SCZ, respectively. When censoring data until diagnosis, we could predict MDD clusters with areas under the curve (AUCs) of 0.54 to 0.80 and SCZ clusters with AUCs of 0.71 to 0.86. Overall cases and controls could be predicted with an AUC of 0.81, illustrating the utility of data-driven subgrouping in psychiatry.

• Jefsen, Oskar Hougaard; Nudel, Ron; Wang, Yunpeng; Bybjerg-Grauholm, Jonas; Hemager, Nicoline & Christiani, Camilla A J [Show all 17 contributors for this article] (2022). Genetic assortative mating for schizophrenia and bipolar disorder. European psychiatry. ISSN 0924-9338. doi: 10.1192/j.eurpsy.2022.2304.
• Hemager, Nicoline; Christiani, Camilla Jerlang; Thorup, Anne Amalie Elgaard; Spang, Katrine Søborg; Ellersgaard, Ditte & Burton, Birgitte Klee [Show all 14 contributors for this article] (2022). Neurocognitive heterogeneity in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study - VIA 7. Journal of Affective Disorders. ISSN 0165-0327. 302, p. 214–223. doi: 10.1016/j.jad.2022.01.096.
• Leonardsen, Esten Høyland; Peng, Han; Kaufmann, Tobias; Agartz, Ingrid; Andreassen, Ole & Celius, Elisabeth Gulowsen [Show all 19 contributors for this article] (2022). Deep neural networks learn general and clinically relevant representations of the ageing brain. NeuroImage. ISSN 1053-8119. 256. doi: 10.1016/j.neuroimage.2022.119210. Full text in Research Archive
• Amare, Azmeraw T.; Schubert, Klaus Oliver; Hou, Liping; Clark, Scott R.; Papiol, Sergi & Cearns, Micah [Show all 309 contributors for this article] (2021). Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry. ISSN 1359-4184. 26(6), p. 2457–2470. doi: 10.1038/s41380-020-0689-5.
• Blokland, Gabriella A. M.; Grove, Jakob; Chen, Chia-Yen; Cotsapas, Chris; Tobet, Stuart & Handa, Robert [Show all 50 contributors for this article] (2021). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry. ISSN 0006-3223. 91, p. 102–117. doi: 10.1016/j.biopsych.2021.02.972.
• Maihofer, Adam X.; Choi, Karmel W.; Coleman, Jonathan R.I.; Daskalakis, Nikolaos P.; Denckla, Christy A. & Ketema, Elizabeth [Show all 181 contributors for this article] (2021). Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biological Psychiatry. ISSN 0006-3223. p. 1–11. doi: 10.1016/j.biopsych.2021.09.020. Full text in Research Archive
• Li, Xue; Fan, Xiaoduo; Yuan, Xiuxia; Pang, Lijuan; Hu, Shaohua & Wang, Yunpeng [Show all 8 contributors for this article] (2021). The Role of Butyric Acid in Treatment Response in Drug-Naïve First Episode Schizophrenia. Frontiers in Psychiatry. ISSN 1664-0640. 12. doi: 10.3389/fpsyt.2021.724664.
• Uddin, Md Jamal; Ekstrøm, Claus Thorn; Hemager, Nicoline; Christiani, Camilla A J; Gregersen, Maja & Ellersgaard, Ditte Vestbjerg [Show all 23 contributors for this article] (2021). Is the Association Between Parents’ Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver’s Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study—VIA7, a Population-Based Cohort Study. Schizophrenia Bulletin Open. ISSN 2632-7899. 2(1). doi: 10.1093/schizbullopen/sgab024.
• Andlauer, Till F.M.; Guzman-Parra, José; Streit, Fabian; Strohmaier, Jana; González, Maria José & Flores, Susana Gil [Show all 50 contributors for this article] (2021). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry. ISSN 1359-4184. 26, p. 1286–1298. doi: 10.1038/s41380-019-0558-2. Full text in Research Archive
• Wang, Yunpeng; Grydeland, Håkon; Roe, James Michael; Pan, Mengyu; Magnussen, Fredrik & Amlien, Inge [Show all 17 contributors for this article] (2021). Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer’s disease in healthy samples across the lifespan. Brain, Behavior, and Immunity. ISSN 0889-1591. 100. doi: 10.1016/j.bbi.2021.12.008. Full text in Research Archive
• Vidal-Piñeiro, Didac; Wang, Yunpeng; Krogsrud, Stine Kleppe; Amlien, Inge; Baaré, William FC & Bartres-Faz, David [Show all 31 contributors for this article] (2021). Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change. eLIFE. ISSN 2050-084X. 10. doi: 10.7554/eLife.69995. Full text in Research Archive
• Fjell, Anders Martin; Grydeland, Håkon; Wang, Yunpeng; Amlien, Inge; Bartrés-Faz, David & Brandmaier, Andreas M. [Show all 24 contributors for this article] (2021). The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change. eLIFE. ISSN 2050-084X. 10, p. 1–22. doi: 10.7554/eLife.66466.
• Walhovd, Kristine Beate; Fjell, Anders Martin; Wang, Yunpeng; Amlien, Inge; Mowinckel, Athanasia Monika & Lindenberger, Ulman [Show all 29 contributors for this article] (2021). Education and income show heterogeneous relationships to lifespan brain and cognitive differences across European and US cohorts. Cerebral Cortex. ISSN 1047-3211. 32(4), p. 839–854. doi: 10.1093/cercor/bhab248. Full text in Research Archive
• Yuan, Xiuxia; Wang, Yunpeng; Li, Xue; Jiang, Jiajun; Kang, Yulin & Pang, Lijuan [Show all 13 contributors for this article] (2021). Gut microbial biomarkers for the treatment response in first-episode, drug-naïve schizophrenia: a 24-week follow-up study. Translational Psychiatry. ISSN 2158-3188. 11, p. 1–9. doi: 10.1038/s41398-021-01531-3. Full text in Research Archive Show summary

  Preclinical studies have shown that the gut microbiota can play a role in schizophrenia (SCH) pathogenesis via the gut-brain axis. However, its role in the antipsychotic treatment response is unclear. Here, we present a 24-week follow-up study to identify gut microbial biomarkers for SCH diagnosis and treatment response, using a sample of 107 first-episode, drug-naïve SCH patients, and 107 healthy controls (HCs). We collected biological samples at baseline (all participants) and follow-up time points after risperidone treatment (SCH patients). Treatment response was assessed using the Positive and Negative Symptoms Scale total (PANSS-T) score. False discovery rate was used to correct for multiple testing. We found that SCH patients showed lower α-diversity (the Shannon and Simpson’s indices) compared to HCs at baseline (p = 1.21 × 10−9, 1.23 × 10−8, respectively). We also found a significant difference in β-diversity between SCH patients and HCs (p = 0.001). At baseline, using microbes that showed different abundance between patients and controls as predictors, a prediction model can distinguish patients from HCs with an area under the curve (AUC) of 0.867. In SCH patients, after 24 weeks of risperidone treatment, we observed an increase of α-diversity toward the basal level of HCs. At the genus level, we observed decreased abundance of Lachnoclostridium (p = 0.019) and increased abundance Romboutsia (p = 0.067). Moreover, the treatment response in SCH patients was significantly associated with the basal levels of Lachnoclostridium and Romboutsia (p = 0.005 and 0.006, respectively). Our results suggest that SCH patients may present characteristic microbiota, and certain microbiota biomarkers may predict treatment response in this patient population.

• Sun, Jiangming; Wang, Yunpeng; Folkersen, Lasse; Borne, Yan; Amlien, Inge & Buil, Alfonso [Show all 13 contributors for this article] (2021). Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction. Nature Communications. ISSN 2041-1723. doi: 10.1038/s41467-021-25014-7. Full text in Research Archive
• Krogsrud, Stine Kleppe; Mowinckel, Athanasia Monika; Sederevicius, Donatas; Vidal-Piñeiro, Didac; Amlien, Inge Kasbohm & Wang, Yunpeng [Show all 9 contributors for this article] (2021). Relationships between apparent cortical thickness and working memory across the lifespan - Effects of genetics and socioeconomic status. Developmental Cognitive Neuroscience. ISSN 1878-9293. 51, p. 1–11. doi: 10.1016/j.dcn.2021.100997.
• Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin & Chu, Yunhan [Show all 20 contributors for this article] (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. 78(9), p. 1020–1030. doi: 10.1001/jamapsychiatry.2021.1435. Full text in Research Archive
• Grydeland, Håkon; Sederevicius, Donatas; Wang, Yunpeng; Bartres-Faz, David; Bertram, Lars & Dobricic, Valerija [Show all 16 contributors for this article] (2021). Self-Reported Sleep Relates to Microstructural Hippocampal Decline in β-Amyloid Positive Adults Beyond Genetic Risk. Sleep. ISSN 0161-8105. 44(11). doi: 10.1093/sleep/zsab110. Full text in Research Archive Show summary

  Background To test the hypothesis that worse self-reported sleep relates to memory decay and reduced hippocampal integrity as indexed by increased intra-hippocampal water diffusion, and that the relations are stronger in the presence of β-amyloid (Aβ) accumulation, a marker of Alzheimer’s disease (AD) pathology. Methods Two-hundred and forty-three cognitively healthy participants, aged 19-81 years, completed the Pittsburgh Sleep Quality Index, and 2 diffusion tensor imaging sessions, on average 3 years apart, allowing measures of decline in hippocampal microstructural integrity as indexed by increased mean diffusivity. We measured memory decay using delayed recall from the California Verbal Learning Test. 18F-Flutemetamol positron emission tomography, in 108 participants above 44 years of age, yielded 23 Aβ positive. Genotyping enabled controlling for APOE ε4 status, and polygenic scores for sleep efficiency and AD. Results Worse global sleep quality and sleep efficiency related to more rapid reduction in hippocampal microstructural integrity over time. Focusing on sleep efficiency, the relation was stronger in presence of Aβ accumulation. Sleep efficiency related to memory decay indirectly via hippocampal integrity decline. The results were not explained by genetic risk for sleep efficiency and AD. Conclusions Poor self-reported sleep efficiency related to decline in hippocampal integrity, especially in the presence of Aβ accumulation. Poor sleep and hippocampal microstructural decline may partly explain memory decline in older adults with Aβ pathology. The relationships were not explained by genetic risk. Poor self-reported sleep efficiency might constitute a risk factor for AD, although the causal mechanisms driving the of observed associations remain unknown.

• Shen, Xueyi; Howard, David M.; Adams, Mark J.; Hill, W. David; Clarke, Toni-Kim & McIntosh, Andrew M. [Show all 202 contributors for this article] (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications. ISSN 2041-1723. 11(1). doi: 10.1038/s41467-020-16022-0.
• Coleman, Jonathan R. I.; Peyrot, Wouter J.; Purves, Kirstin L.; Davis, Katrina A. S.; Rayner, Christopher & Choi, Shing Wan [Show all 215 contributors for this article] (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry. ISSN 1359-4184. 25(7), p. 1430–1446. doi: 10.1038/s41380-019-0546-6.
• Tao, Qi; Miao, Yun; Li, Huihui; Yuan, Xiuxia; Huang, Xufeng & Wang, Yunpeng [Show all 10 contributors for this article] (2020). Insulin Resistance and Oxidative Stress: In Relation to Cognitive Function and Psychopathology in Drug-Naïve, First-Episode Drug-Free Schizophrenia. Frontiers in Psychiatry. ISSN 1664-0640. doi: 10.3389/fpsyt.2020.537280. Full text in Research Archive
• Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang & Li, Shuo [Show all 51 contributors for this article] (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-18367-y. Full text in Research Archive
• Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita & Hibar, DP [Show all 50 contributors for this article] (2020). The genetic architecture of the human cerebral cortex. Science. ISSN 0036-8075. 367(6484). doi: 10.1126/science.aay6690. Full text in Research Archive
• Coleman, Jonathan R.I.; Gaspar, Helena A; Bryois, Julien; Byrne, Enda M; Forstner, Andreas J & Holmans, Peter A [Show all 51 contributors for this article] (2020). The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2019.10.015.
• Walhovd, Kristine B; Fjell, Anders Martin; Sørensen, Øystein; Mowinckel, Athanasia Monika; Reinbold, Céline Sonja & Idland, Ane-Victoria [Show all 12 contributors for this article] (2020). Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan. Neurology: Genetics. ISSN 2376-7839. 6(5). doi: 10.1212/NXG.0000000000000506. Full text in Research Archive
• Wang, Yunpeng; Nudel, Ron; Benros, Michael Eriksen; Skogstrand, Kristin; Fishilevich, Simon & Lancet, Doron [Show all 14 contributors for this article] (2020). Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth. PLoS Genetics. ISSN 1553-7390. doi: 10.1371/journal.pgen.1009163. Full text in Research Archive
• Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng & Alnæs, Dag [Show all 40 contributors for this article] (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry. ISSN 1359-4184. p. 1–8. doi: 10.1038/s41380-020-0664-1. Full text in Research Archive
• Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen & Frei, Oleksandr [Show all 22 contributors for this article] (2020). Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci. Biological Psychiatry. ISSN 0006-3223. 89(3), p. 227–235. doi: 10.1016/j.biopsych.2020.01.026. Full text in Research Archive
• Fjell, Anders Martin; Sederevicius, Donatas; Sneve, Markus Handal; de Lange, Ann-Marie Glasø; Bråthen, Anne Cecilie Sjøli & Idland, Ane-Victoria [Show all 16 contributors for this article] (2020). Self-reported sleep problems are related to amyloid deposition in cortical regions with high HOMER1 gene expression. Cerebral Cortex. ISSN 1047-3211. 30(4), p. 2144–2156. doi: 10.1093/cercor/bhz228. Full text in Research Archive
• Choi, Karmel W.; Chen, Chia-Yen; Stein, Murray B.; Klimentidis, Yann C.; Wang, Min-Jung & Koenen, Karestan C. [Show all 203 contributors for this article] (2019). Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization study. JAMA psychiatry. ISSN 2168-6238. 76(4), p. 399–408. doi: 10.1001/jamapsychiatry.2018.4175.
• Bauer, Anna E.; Liu, Xiaoqin; Byrne, Enda M.; Sullivan, Patrick F.; Wray, Naomi R. & Agerbo, Esben [Show all 21 contributors for this article] (2019). Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders. Translational Psychiatry. ISSN 2158-3188. 9:288, p. 1–12. doi: 10.1038/s41398-019-0629-9.
• Nudel, Ron; Wang, Yunpeng; Appadurai, Vivek; Schork, Andrew J.; Buil, Alfonso & Agerbo, Esben [Show all 16 contributors for this article] (2019). A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population. Translational Psychiatry. ISSN 2158-3188. 9, p. 1–10. doi: 10.1038/s41398-019-0622-3.
• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob & Zhu, Zhaozhong [Show all 66 contributors for this article] (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. ISSN 0092-8674. 179(7), p. 1469–1482. doi: 10.1016/j.cell.2019.11.020. Full text in Research Archive
• Nievergelt, Caroline M.; Maihofer, Adam X.; Klengel, Torsten; Atkinson, Elizabeth G.; Chen, Chia-Yen & Choi, Karmel W. [Show all 179 contributors for this article] (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications. ISSN 2041-1723. 10:4558, p. 1–16. doi: 10.1038/s41467-019-12576-w. Full text in Research Archive
• Gasse, Christiane; Wimberley, Theresa; Wang, Yunpeng; Mors, Ole; Børglum, Anders & Als, Thomas Damm [Show all 10 contributors for this article] (2019). Schizophrenia polygenic risk scores, urbanicity and treatment-resistant schizophrenia. Schizophrenia Research. ISSN 0920-9964. 212, p. 79–85. doi: 10.1016/j.schres.2019.08.008.
• Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan & Trubetskoy, Vassily [Show all 277 contributors for this article] (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. ISSN 1061-4036. 51(5), p. 793–803. doi: 10.1038/s41588-019-0397-8. Full text in Research Archive
• Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh & Mæland, Steffen [Show all 12 contributors for this article] (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-10310-0. Full text in Research Archive
• Wang, Yunpeng; Karstoft, Karen-Inge; Nievergelt, Caroline M.; Maihofer, Adam X.; Stein, Murray B. & Ursano, Robert J. [Show all 13 contributors for this article] (2019). Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations. Journal of Affective Disorders. ISSN 0165-0327. 252, p. 350–357. doi: 10.1016/j.jad.2019.04.070.
• Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree & Frei, Oleksandr [Show all 52 contributors for this article] (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience. ISSN 1662-4548. 13. doi: 10.3389/fnins.2019.00220. Full text in Research Archive
• Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M. & Steinberg, Stacy [Show all 53 contributors for this article] (2019). Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nature Genetics. ISSN 1061-4036. 51(3), p. 404–413. doi: 10.1038/s41588-018-0311-9. Full text in Research Archive
• de Jong, Simone; Diniz, Mateus Jose Abdalla; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L. & Ota, Vanessa K. [Show all 22 contributors for this article] (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology. ISSN 2399-3642. 1(163). doi: 10.1038/s42003-018-0155-y. Full text in Research Archive
• Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas & White, Linda Rosemary [Show all 33 contributors for this article] (2018). Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-36429-6. Full text in Research Archive
• Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, MacIej; Byrne, Enda M. & Abdellaoui, Abdel [Show all 216 contributors for this article] (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics. ISSN 1061-4036. 50(5), p. 668–681. doi: 10.1038/s41588-018-0090-3.
• Psychiatric Genomics Consorti, Bipolar Sczhizophrenia; Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James & Stahl, Eli A. [Show all 52 contributors for this article] (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. Cell. ISSN 0092-8674. 173(7), p. 1705–1715. doi: 10.1016/j.cell.2018.05.046.
• Bettella, Francesco; Brown, AA; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Witoelar, Aree & Buil Demur, AA [Show all 11 contributors for this article] (2018). Cross-tissue eQTL enrichment of associations in schizophrenia. PLOS ONE. ISSN 1932-6203. 13(9). doi: 10.1371/journal.pone.0202812. Full text in Research Archive
• Erlangsen, Annette; Appadurai, Vivek; Wang, Yunpeng; Turecki, Gustavo; Mors, Ole & Werge, Thomas [Show all 17 contributors for this article] (2018). Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. Molecular Psychiatry. ISSN 1359-4184. p. 1–12. doi: 10.1038/s41380-018-0218-y.
• Zhang, Qian; Liang, Zhe; Cui, Xuean; Ji, Changmian; Li, Yun & Zhang, Pingxian [Show all 16 contributors for this article] (2018). N6-methyladenine DNA methylation in Japonica and Indica rice genomes and its association with gene expression, plant development, and stress responses. Molecular Plant. ISSN 1674-2052. 11(12), p. 1492–1508. doi: 10.1016/j.molp.2018.11.005.
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• Bonham, Luke W.; Karch, Celeste M.; Fan, Chun C.; Tan, Chin; Geier, Ethan G. & Wang, Yunpeng [Show all 25 contributors for this article] (2018). CXCR4 involvement in neurodegenerative diseases. Translational Psychiatry. ISSN 2158-3188. 8:73, p. 1–10. doi: 10.1038/s41398-017-0049-7. Full text in Research Archive
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• Broce, Iris J.; Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Wang, Yunpeng & Hong Tan, Chin [Show all 29 contributors for this article] (2018). Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Medicine. ISSN 1549-1277. 15:e1002487(1), p. 1–20. doi: 10.1371/journal.pmed.1002487. Full text in Research Archive
• Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley Kurt & Schork, Andrew J. [Show all 18 contributors for this article] (2018). Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports. ISSN 2045-2322. 674(8), p. 1–8. doi: 10.1038/s41598-017-16481-4. Full text in Research Archive
• Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Wang, Yunpeng & Bettella, Francesco [Show all 9 contributors for this article] (2018). Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents. JAMA psychiatry. ISSN 2168-6238. 75(3), p. 287–295. doi: 10.1001/jamapsychiatry.2017.4277.
• Seibert, Tyler M.; Fan, Chun Chieh; Wang, Yunpeng; Zuber, Verena; Karunamuni, Roshan & Parsons, J. Kellogg [Show all 62 contributors for this article] (2018). Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. The BMJ. ISSN 1756-1833. 360:j5757, p. 1–7. doi: 10.1136/bmj.j5757. Full text in Research Archive
• Zablocki, Rong W.; Levine, Richard A.; Schork, Andrew J.; Xu, Shujing; Wang, Yunpeng & Fan, Chun C. [Show all 7 contributors for this article] (2017). Semiparametric covariate-modulated local false discovery rate for genome-wide association studies. Annals of Applied Statistics. ISSN 1932-6157. 11(4), p. 2252–2269. doi: 10.1214/17-AOAS1077.
• Rietschel, Liz; Streit, Fabian; Zhu, Gu; McAloney, Kerrie; Frank, Josef & Couvy-Duchesne, Baptiste [Show all 26 contributors for this article] (2017). Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific Reports. ISSN 2045-2322. 7:15351, p. 1–15. doi: 10.1038/s41598-017-11852-3.
• Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr & Bettella, Francesco [Show all 19 contributors for this article] (2017). Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment. Journal of the American Academy of Child and Adolescent Psychiatry. ISSN 0890-8567. 57(2), p. 86–95. doi: 10.1016/j.jaac.2017.11.013. Full text in Research Archive
• Joshi, Peter K.; Pirastu, Nicola; Kentistou, Katherine A.; Fischer, Krista; Hofer, Edith & Schraut, Katharina E. [Show all 113 contributors for this article] (2017). Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications. ISSN 2041-1723. 8:910(1), p. 1–13. doi: 10.1038/s41467-017-00934-5.
• Winsvold, Bendik K S; Bettella, Francesco; Witoelar, Aree; Anttila, Verneri; Gormley, Padhraig & Kurth, Tobias [Show all 18 contributors for this article] (2017). Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLOS ONE. ISSN 1932-6203. p. 1–15. doi: 10.1371/journal.pone.0185663. Full text in Research Archive
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• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek P & Franke, Barbara [Show all 13 contributors for this article] (2017). Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms. Schizophrenia Bulletin. ISSN 0586-7614. 44(4), p. 854–864. doi: 10.1093/schbul/sbx148.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Kauppi, Karolina; Hill, W. David; Li, Wen & Wang, Yunpeng [Show all 22 contributors for this article] (2017). Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA psychiatry. ISSN 2168-6238. 74(10), p. 1065–1075. doi: 10.1001/jamapsychiatry.2017.1986. Full text in Research Archive
• Desikan, Rahul S.; Fan, Chun Chieh; Wang, Yunpeng; Schork, Andrew J; Cabral, Howard J & Cupples, L. Adrienne [Show all 34 contributors for this article] (2017). Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Nature Methods. ISSN 1548-7091. 14(3:e1002258), p. 1–17. doi: 10.1371/journal.pmed.1002258.
• Witoelar, Aree; Jansen, Iris E.; Wang, Yunpeng; Desikan, Rahul S.; Gibbs, J. Raphael & Thompson, Wesley Kurt [Show all 26 contributors for this article] (2017). Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurology. ISSN 2168-6149. 74(7), p. 780–792. doi: 10.1001/jamaneurol.2017.0469.
• Ferrari, Raffaele; Wang, Yunpeng; Vandrovcova, Jana; Guelfi, Sebastian; Witoelar, Aree & Karch, Celeste M. [Show all 22 contributors for this article] (2017). Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. 88(2), p. 152–164. doi: 10.1136/jnnp-2016-314411.
• Yokoyama, Jennifer S.; Karch, Celeste M.; Fan, Chun C.; Bonham, Luke W.; Kouri, Naomi & Ross, Owen A. [Show all 31 contributors for this article] (2017). Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathologica. ISSN 0001-6322. 133(5), p. 825–837. doi: 10.1007/s00401-017-1693-y.
• Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen & Fan, Chun Chieh [Show all 18 contributors for this article] (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry. ISSN 1359-4184. 22(6), p. 792–801. doi: 10.1038/mp.2017.33. Full text in Research Archive
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Lo, Min-Tzu; Li, Wen; Frei, Oleksandr & Witoelar, Aree [Show all 13 contributors for this article] (2017). Identification of genetic loci shared between schizophrenia and the Big Five personality traits. Scientific Reports. ISSN 2045-2322. 7:2222(1), p. 1–9. doi: 10.1038/s41598-017-02346-3. Full text in Research Archive
• Srinivasan, Saurabh; Bettella, Francesco; Hassani, Sahar; Wang, Yunpeng; Witoelar, Aree & Schork, Andrew J. [Show all 13 contributors for this article] (2017). Probing the association between early evolutionary markers and schizophrenia. PLOS ONE. ISSN 1932-6203. 12:e0169227(1), p. 1–15. doi: 10.1371/journal.pone.0169227.
• Le Hellard, Stephanie; Wang, Yunpeng; Witoelar, Aree; Zuber, Verena; Bettella, Francesco & Hugdahl, Kenneth [Show all 15 contributors for this article] (2017). Identification of gene loci that overlap between schizophrenia and educational attainment. Schizophrenia Bulletin. ISSN 0586-7614. 43(3), p. 654–664. doi: 10.1093/schbul/sbw085.
• Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y.; Franz, Carol E.; Fan, Chun Chieh & Wang, Yunpeng [Show all 22 contributors for this article] (2016). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics. ISSN 1061-4036. 49(1), p. 152–156. doi: 10.1038/ng.3736.
• Yokoyama, Jennifer S.; Wang, Yunpeng; Schork, Andrew J.; Thompson, Wesley K.; Karch, Celeste M. & Cruchaga, Carlos [Show all 28 contributors for this article] (2016). Association between genetic traits for immune-mediated diseases and Alzheimer disease. JAMA Neurology. ISSN 2168-6149. 73(6), p. 691–697. doi: 10.1001/jamaneurol.2016.0150.
• Wang, Yunpeng; Bos, Steffan Daniel; Harbo, Hanne Flinstad; Thompson, Wesley K.; Schork, Andrew J. & Bettella, Francesco [Show all 14 contributors for this article] (2016). Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors. Multiple Sclerosis. ISSN 1352-4585. 22(14), p. 1783–1793. doi: 10.1177/1352458516635873.
• Holland, Dominic; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Chen, Chi-Hua & Lo, Min-Tzu [Show all 11 contributors for this article] (2016). Estimating effect sizes and expected replication probabilities from GWAS summary statistics. Frontiers in Genetics. ISSN 1664-8021. 7(15). doi: 10.3389/fgene.2016.00015.
• Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Holland, Dominic; Chen, Chi-Hua & Bettella, Francesco [Show all 22 contributors for this article] (2016). Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. PLoS Genetics. ISSN 1553-7390. doi: 10.1371/journal.pgen.1005803. Full text in Research Archive
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco & Djurovic, Srdjan [Show all 10 contributors for this article] (2016). Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: a modeling study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 1(1), p. 49–59. doi: 10.1016/j.bpsc.2015.09.002. Show summary

  BACKGROUND: Recent genome-wide association studies have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical pyramidal cells and identified possible common alterations in behavior across SCZ-related genes. METHODS: We applied a biophysically detailed multicompartmental model to study the excitability of a layer V pyramidal cell. We reviewed the literature on functional genomics for variants of genes associated with SCZ and used changes in neuron model parameters to represent the effects of these variants. RESULTS: We present and apply a framework for examining the effects of subtle single nucleotide polymorphisms in ion channel and calcium transporter-encoding genes on neuron excitability. Our analysis indicates that most of the considered SCZ-related genetic variants affect the spiking behavior and intracellular calcium dynamics resulting from summation of inputs across the dendritic tree. CONCLUSIONS: Our results suggest that alteration in the ability of a single neuron to integrate the inputs and scale its excitability may constitute a fundamental mechanistic contributor to mental disease, alongside the previously proposed deficits in synaptic communication and network behavior. Keywords: Biophysical modeling, Functional genomics, Genome-wide association studies, Layer V pyramidal cell, Neuron excitability, Schizophrenia

• Schork, AJ; Wang, Yunpeng; Thompson, Kurt Wesley; Dale, AM & Andreassen, Ole Andreas (2016). New statistical approaches exploit the polygenic architecture of schizophrenia-implications for the underlying neurobiology. Current Opinion in Neurobiology. ISSN 0959-4388. 36, p. 89–98. doi: 10.1016/j.conb.2015.10.008.

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• Coleman, Jonathan R. I.; Peyrot, Wouter J.; Purves, Kirstin L.; Davis, Katrina A. S.; Rayner, Christopher & Choi, Shing Wan [Show all 223 contributors for this article] (2021). Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank (Molecular Psychiatry, (2020), 25, 7, (1430-1446), 10.1038/s41380-019-0546-6). Molecular Psychiatry. ISSN 1359-4184. 26(9). doi: 10.1038/s41380-020-0779-4.
• Wang, Yunpeng (2021). How does your immune system impact your brain health?
• Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y; Franz, C; Fan, Chun Chieh & Wang, Yunpeng [Show all 22 contributors for this article] (2017). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics. ISSN 1061-4036. 49(1), p. 152–156. doi: 10.1038/ng.3736.
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek & Franke, Barbara [Show all 13 contributors for this article] (2017). Conditional false discovery rate analysis of genome-wide association studies uncovers genetic loci shared between schizophrenia and volumes of hippocampus, putamen and intracranial volume.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Shadrin, Alexey A. & Li, Wen [Show all 13 contributors for this article] (2017). C-Reactive Protein Levels and Schizophrenia Share Genetic Influences.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Alexey, Shadrin & Li, Wen [Show all 13 contributors for this article] (2017). Increased discovery of risk loci for bipolar disorder by leveraging prior probabilities of true associations using the covariate modulated mixture model (CM3).
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Dale, Anders & Andreassen, Ole Andreas (2017). Combined Analysis of Large Genetic Samples. New Statistical Approaches Improve Gene Discovery.
• Córdova-Palomera, Aldo; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; Alnæs, Dag & Moberget, Torgeir [Show all 11 contributors for this article] (2016). POTENTIAL BRAIN MORPHOLOGY INSTABILITY FEATURES MEDIATING THE ASSOCIATION BETWEEN GENOME-WIDE HOMOZYGOSITY AND ALTERED NEUROCOGNITION.
• Zuber, Verena; Marconett, Crystal; Shi, Jianxin; Hua, Xing; Wheeler, William & Yang, Chenchen [Show all 41 contributors for this article] (2016). Pleiotropic analysis of lung cancer and blood triglycerides. Journal of the National Cancer Institute. ISSN 0027-8874. 108:djv167(12), p. 1–4. doi: 10.1093/jnci/djw167.
• Smeland, Olav Bjerkehagen; Kauppi, Karolina; Wang, Yunpeng; Frei, Oleksandr; Li, Wen & Hill, David W [Show all 17 contributors for this article] (2016). Schizophrenia and general cognitive function share genetic influences.
• Smeland, Olav Bjerkehagen; Witoelar, Aree; Wang, Yunpeng; Chen, Chi-Hua; Djurovic, Srdjan & Dale, Anders [Show all 7 contributors for this article] (2016). Genetic overlap between schizophrenia and brain structural volumes indicates shared molecular genetic mechanisms with potential relevance for antipsychotics .
• Smeland, Olav Bjerkehagen; Witoelar, Aree; Lo, Min-Tzu; Tesli, Martin Steen; Wang, Yunpeng & Hinds, David A. [Show all 11 contributors for this article] (2016). Genetic overlap between schizophrenia and the Big Five personality traits.
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco & Djurovic, Srdjan [Show all 10 contributors for this article] (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked gens on single-neuron excitability.

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