Yunpeng Wang

• Fjell, Anders Martin; Sederevicius, Donatas; Sneve, Markus Handal; de Lange, Ann-Marie Glasø; Bråthen, Anne Cecilie Sjøli; Idland, Ane-Victoria; Watne, Leiv Otto; Wang, Yunpeng; Reinbold, Céline Sonja; Blennow, Kaj; Zetterberg, Henrik; Hong, S; Bertram, Lars & Walhovd, Kristine B (2020). Self-reported sleep problems are related to amyloid deposition in cortical regions with high HOMER1 gene expression. Cerebral Cortex.  ISSN 1047-3211.
• Bauer, Anna E.; Liu, Xiaoqin; Byrne, Enda M.; Sullivan, Patrick F.; Wray, Naomi R.; Agerbo, Esben; Nyegaard, Mette; Grove, Jakob; Musliner, Katherine L.; Ingstrup, Katja G.; Johannsen, Benedicte M.W.; Mægbæk, Merete Lund; Wang, Yunpeng; Nordentoft, Merete; Mors, Ole; Børglum, Anders D.; Werge, Thomas; Hougaard, David M.; Mortensen, Preben Bo; Munk-Olsen, Trine & Meltzer-Brody, Samantha (2019). Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders. Translational psychiatry.  ISSN 2158-3188.  9:288, s 1- 12 . doi: 10.1038/s41398-019-0629-9
• Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Bøen, Erlend; Elvsåshagen, Torbjørn; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne; Ødegaard, Ketil Joachim; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, MacIej; Pers, Tune H; Holmans, Peter A.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E & Pedersen, Carsten Bøcker (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience.  ISSN 1662-4548.  13 . doi: 10.3389/fnins.2019.00220 Full text in Research Archive. Show summary

  Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer’s Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect). Conclusion: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP.

• Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Mæland, Steffen; O`Connell, Kevin; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas & Dale, Anders (2019). Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nature Communications.  ISSN 2041-1723.  10(1) . doi: 10.1038/s41467-019-10310-0
• Gasse, Christiane; Wimberley, Theresa; Wang, Yunpeng; Mors, Ole; Børglum, Anders; Als, Thomas Damm; Werge, Thomas; Nordentoft, Merete; Hougaard, David M. & Horsdal, Henriette Thisted (2019). Schizophrenia polygenic risk scores, urbanicity and treatment-resistant schizophrenia. Schizophrenia Research.  ISSN 0920-9964.  212, s 79- 85 . doi: 10.1016/j.schres.2019.08.008
• Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas & Posthuma, Danielle (2019). Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nature Genetics.  ISSN 1061-4036.  51(3), s 404- 413 . doi: 10.1038/s41588-018-0311-9 Full text in Research Archive.
• Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob; Zhu, Zhaozhong; Tucker-Drob, Elliot M.; Nivard, Michel G.; Grotzinger, Andrew D.; Posthuma, Danielle; Yu, Dongmei; Stahl, Eli A.; Walters, Raymond K.; Anney, Richard J.L.; Duncan, Laramie E.; Ge, Tian; Belangero, Sintia I.; Cook, Edwin H.; Hoekstra, Pieter J.; Keski-Rahkonen, Anna; Kirov, George; Luykx, Jurjen J.; Rohde, Luis A.; Agerbo, Esben; Arranz, M.J.; Asherson, Philip; Bækvad-Hansen, Marie; Bellgrove, Mark A.; Belliveau Jr, Richard A.; Buitelaar, Jan; Bybjerg-Grauholm, Jonas; Casas, Miquel; Chambert, Kimberly; Cerrato, Felecia; Churchhouse, Claire; Cormand, Bru; Crosbie, Jennifer; Dalsgaard, Søren; Haavik, Jan; Hakonarson, Hakon; Hansen, Christine S.; Mors, Ole; Zayats, Tetyana; Bettella, Francesco; Hope, Sigrun; Hultman, Christina M.; Nærland, Terje; Bøen, Erlend; Elvsåshagen, Torbjørn; Ødegaard, Ketil Joachim; Malt, Ulrik Fredrik; Melle, Ingrid; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Espeseth, Thomas; Knudsen, Gun Peggy Strømstad; Le Hellard, Stephanie; Reichborn-Kjennerud, Ted; Jönsson, Erik Gunnar; Andreassen, Ole Andreas; Agartz, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne & Joa, Inge (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell.  ISSN 0092-8674.  179(7), s 1469- 1482 . doi: 10.1016/j.cell.2019.11.020
• Nievergelt, Caroline M.; Maihofer, Adam X.; Klengel, Torsten; Atkinson, Elizabeth G.; Chen, Chia-Yen; Choi, Karmel W.; Coleman, Jonathan R.I.; Dalvie, Shareefa; Duncan, Laramie E.; Gelernter, Joel; Levey, Daniel F.; Logue, Mark W.; Polimanti, Renato; Provost, Allison C.; Ratanatharathorn, Andrew; Stein, Murray B.; Torres, Katy; Aiello, Allison E.; Almli, Lynn M.; Amstadter, Ananda B.; Andersen, Søren B.; Andreassen, Ole Andreas; Arbisi, Paul A.; Ashley-Koch, Allison E.; Austin, S. Bryn; Avdibegovic, Esmina; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G.; Beckham, Jean C.; Bierut, Laura J; Bisson, Jonathan I; Boks, Marco P; Bolger, Elizabeth A; Børglum, Anders D.; Bradley, Bekh; Brashear, Megan; Breen, Gerome; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R.; Caldas-de-Almeida, José M.; Dale, Anders; Daly, Mark J.; Daskalakis, Nikolaos P.; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Disner, Seth G.; Domschke, Katharina; Dzubur-Kulenovic, Alma; Erbes, Christopher R.; Evans, Alexandra; Farrer, Lindsay A.; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gelaye, Bizu; Geuze, Elbert; Gillespie, Charles; Uka, Afërdita Goçi; Gordon, Scott D.; Guffanti, Guia; Hammamieh, Rasha; Harnal, Supriya; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian M.J.; Hougaard, David Michael; Jakovljevíc, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue-Jun; Junglen, Angela G.; Karstoft, Karen-Inge; Kaufman, Milissa L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kranzler, Henry R.; Kremen, William S.; Lawford, Bruce R.; Lebois, Lauren A.M.; Lewis, Catrin E.; Linnstaedt, Sarah D.; Lori, Adriana; Lugonja, Bozo; Luykx, Jurjen Justin; Lyons, Michael J.; Maples-Keller, Jessica; Marmar, Charles; Martin, Alicia R.; Martin, Nicholas G.; Maurer, Douglas; Mavissakalian, Matig R.; McFarlane, Alexander; McGlinchey, Regina E.; McLaughlin, Katie A.; McLean, Samuel A.; McLeay, Sarah; Mehta, Divya; Milberg, William P.; Miller, Mark W.; Morey, Rajendra A.; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B.; Neale, Benjamin M.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; O'Donnell, Meaghan; Orcutt, Holly K.; Panizzon, Matthew S.; Peters, Edward S.; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Rice, John P.; Ripke, Stephan; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy-Byrne, Peter; Ruggiero, Ken; Rung, Ariane; Rutten, Bart P.F.; Saccone, Nancy L.; Sanchez, Sixto E.; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V.; Seng, Julia S.; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Sponheim, Scott R.; Stein, Dan J.; Stevens, Jennifer S; Sumner, Jennifer A.; Teicher, Martin H.; Thompson, Wesley Kurt; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; van den Heuvel, Leigh Luella; van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Wolff, Jonathan D.; Yehuda, Rachel; Young, Ross McD.; Young, Keith A.; Zhao, Hongyu; Zoellner, Lori A.; Liberzon, Israel; Ressler, Kerry J.; Haas, Magali & Koenen, Karestan C. (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications.  ISSN 2041-1723.  10:4558, s 1- 16 . doi: 10.1038/s41467-019-12576-w
• Nudel, Ron; Wang, Yunpeng; Appadurai, Vivek; Schork, Andrew J.; Buil, Alfonso; Agerbo, Esben; Bybjerg-Grauholm, Jonas; Børglum, Anders D.; Daly, Mark J.; Mors, Ole; Hougaard, David M.; Mortensen, Preben B.; Werge, Thomas; Nordentoft, Merete; Thompson, Wesley K. & Benros, Michael E. (2019). A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population. Translational psychiatry.  ISSN 2158-3188.  9, s 1- 10 . doi: 10.1038/s41398-019-0622-3
• Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R.I.; Gaspar, Héléna A.; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M. Whitehead; Trzaskowski, Maciej; Byrne, Enda M.; Pers, Tune H.; Holmans, Peter A.; Richards, Alexander L.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E.; Pedersen, Carsten Bøcker; Bøen, Erlend; Boks, Marco P.; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Casas, Miquel; Cerrato, Felecia; Cervantes, Pablo; Chambert, Kimberly; Charney, Alxander W.; Chen, Danfeng; Churchhouse, Claire; Clarke, Toni-Kim; Coryell, William; Craig, David W.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders; de Jong, Simone; Degenhardt, Franziska; Del-Favero, Jurgen; Depaulo, J. Raymond; Djurovic, Srdjan; Dobbyn, Amanda L.; Dumont, Ashley; Elvsåshagen, Torbjørn; Escott-Price, Valentina; Fan, Chun Chieh; Fischer, Sascha B.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Fraser, Christine; Freimer, Nelson B.; Frisén, Louise; Gade, Katrin; Gage, Diane; Garnham, Julie; Giambartolomei, Claudia; Pedersen, Marianne Giørtz; Goldstein, Jaqueline; Gordon, Scott D.; Gordon-Smith, Katherine; Green, Elaine K.; Green, Melissa J.; Greenwood, Tifany A.; Grove, Jakob; Guan, Weihua; Guzman-Parra, José; Hamshere, Marian L.; Hautzinger, Martin; Heilbronner, Urs; Herms, Stefan; Hipolito, Maria; Hoffmann, Per; Holland, Dominic; Huckins, Laura; Jamain, Stéphane; Johnson, Jessica S.; Juréus, Anders; Kandaswamy, Radhika; Karlsson, Robert; Kennedy, James L.; Kittel-Schneider, Sarah; Knowles, James A.; Kogevinas, Manolis; Koller, Anna C.; Kupka, Ralph; Lavebratt, Catharina; Lawrence, Jacob; Lawson, William B.; Leber, Markus; Lee, Phil H.; Levy, Shawn E.; Li, Jun Z.; Liu, Chunyu; Lucae, Susanne; Maaser, Anna; MacIntyre, Donald J.; Mahon, Pamela B.; Maier, Wolfgang; Martinsson, Lina; McCarroll, Steve; McGuffin, Peter; McInnis, Melvin G.; McKay, James D.; Medeiros, Helena; Medland, Sarah E.; Meng, Fan; Milani, Lili; Montgomery, Grant W.; Morris, Derek W.; Mühleisen, Thomas W.; Mullins, Niamh; Nguyen, Hoang; Nievergelt, Caroline M.; Adolfsson, Annelie Nordin; Nwulia, Evaristus A.; O'Donovan, Claire; Loohuis, Loes M. Olde; Ori, Anil P.S.; Oruc, Lilijana; Ösby, Urban; Perlis, Roy H.; Perry, Amy; Pfennig, Andrea; Potash, James B.; Purcell, Shaun M.; Regeer, Eline J.; Reif, Andreas; Reinbold, Céline S.; Rice, John P.; Rivas, Fabio; Rivera, Margarita; Roussos, Panos; Ruderfer, Douglas M.; Ryu, Euijung; Sánchez-Mora, Cristina; Schatzberg, Alan F.; Scheftner, William A.; Schork, Nicholas J.; Shannon Weickert, Cynthia; Shehktman, Tatyana; Shilling, Paul D.; Sigurdsson, Engilbert; Slaney, Claire; Smeland, Olav Bjerkehagen; Sobell, Janet L.; Søholm Hansen, Christine; Spijker, Anne T.; St Clair, David; Steffens, Michael; Strauss, John S.; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabolcs; Thompson, Robert C.; Thorgeirsson, Thorgeir E; Treutlein, Jens; Vedder, Helmut; Wang, Weiqing; Watson, Stanley J.; Weickert, Thomas W.; Witt, Stephanie H.; Xi, Simon; Xu, Wei; Young, Allan H.; Zandi, Peter; Zhang, Peng; Zöllner, Sebastian; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Backlund, Lena; Baune, Bernhard T.; Bellivier, Frank; Berrettini, Wade H.; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boehnke, Michael; Børglum, Anders D.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Dannlowski, Udo; Esko, Tõnu; Etain, Bruno; Frye, Mark; Fullerton, Janice M.; Gershon, Elliot S.; Gill, Michael; Goes, Fernando; Grigoroiu-Serbanescu, Maria; Hauser, Joanna; Hougaard, David M.; Hultman, Christina M.; Jones, Ian; Jones, Lisa A.; Kahn, René S.; Kirov, George; Landén, Mikael; Leboyer, Marion; Lewis, Cathryn M.; Li, Qingqin S.; Lissowska, Jolanta; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McIntosh, Andrew M.; McMahon, Francis J.; Melle, Ingrid; Metspalu, Andres; Mitchell, Philip B.; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Myers, Richard M.; Neale, Benjamin M.; Nimgaonkar, Vishwajit; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C; Ødegaard, Ketil Joachim; Owen, Michael J.; Paciga, Sara A.; Pato, Carlos; Pato, Michele T.; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Ribasés, Marta; Rietschel, Marcella; Rouleau, Guy A.; Schalling, Martin; Schofield, Peter R.; Schulze, Thomas G.; Serretti, Alessandro; Smoller, Jordan W.; Stefansson, Hreinn; Stefansson, Kari; Stordal, Eystein; Sullivan, Patrick F.; Turecki, Gustavo; Vaaler, Arne; Vieta, Eduard; Vincent, John B.; Werge, Thomas; Nurnberger, John I.; Wray, Naomi R.; Di Florio, Arianna; Edenberg, Howard J.; Cichon, Sven; Ophoff, Roel A.; Scott, Laura J.; Andreassen, Ole Andreas; Kelsoe, John & Sklar, Pamela (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics.  ISSN 1061-4036.  51(5), s 793- 803 . doi: 10.1038/s41588-019-0397-8 Full text in Research Archive.
• Wang, Yunpeng; Karstoft, Karen-Inge; Nievergelt, Caroline M.; Maihofer, Adam X.; Stein, Murray B.; Ursano, Robert J.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Hougaard, David M.; Andreassen, Ole Andreas; Werge, Thomas; Thompson, Wesley Kurt & Andersen, Søren B. (2019). Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations. Journal of Affective Disorders.  ISSN 0165-0327.  252, s 350- 357 . doi: 10.1016/j.jad.2019.04.070
• Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Wang, Yunpeng; Bettella, Francesco; Moberget, Torgeir; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents. JAMA psychiatry.  ISSN 2168-6238.  75(3), s 287- 295 . doi: 10.1001/jamapsychiatry.2017.4277
• Bettella, Francesco; Brown, AA; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Witoelar, Aree; Buil Demur, AA; Thompson, WK; Zuber, Verena; Dale, AM; Djurovic, Srdjan & Andreassen, Ole Andreas (2018). Cross-tissue eQTL enrichment of associations in schizophrenia.. PLOS ONE.  ISSN 1932-6203.  13(9) . doi: 10.1371/journal.pone.0202812 Full text in Research Archive.
• Bonham, Luke W.; Karch, Celeste M.; Fan, Chun C.; Tan, Chin; Geier, Ethan G.; Wang, Yunpeng; Wen, Natalie; Broce, Iris J.; Li, Yi; Barkovich, Matthew J.; Ferrari, Raffaele; Hardy, John; Momeni, Parastoo; Höglinger, Günter U.; Müller, Ulrich; Hess, Christopher P.; Sugrue, Leo P.; Dillon, William P.; Schellenberg, Gerard D.; Miller, Bruce L.; Andreassen, Ole Andreas; Dale, Anders; Barkovich, A. James; Yokoyama, Jennifer S. & Desikan, Rahul S. (2018). CXCR4 involvement in neurodegenerative diseases. Translational psychiatry.  ISSN 2158-3188.  8:73, s 1- 10 . doi: 10.1038/s41398-017-0049-7 Full text in Research Archive.
• Broce, Iris J.; Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Wang, Yunpeng; Hong Tan, Chin; Kouri, Naomi; Ross, Owen A.; Höglinger, Günter U.; Müller, Ulrich; Hardy, John; Momeni, Parastoo; Hess, Christopher P.; Dillon, William P.; Miller, Zachary A.; Bonham, Luke W.; Rabinovici, Gil D.; Rosen, Howard J.; Schellenberg, Gerard D.; Franke, Andre; Karlsen, Tom Hemming; Veldink, Jan H.; Ferrari, Raffaele; Yokoyama, Jennifer S.; Miller, Bruce L.; Andreassen, Ole Andreas; Dale, Anders; Desikan, Rahul S. & Sugrue, Leo P. (2018). Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.. PLoS Medicine.  ISSN 1549-1277.  15:e1002487(1), s 1- 20 . doi: 10.1371/journal.pmed.1002487 Full text in Research Archive.
• Chen, Chao; Meng, Qingtuan; Xia, Yan; Ding, Chaodong; Wang, Le; Dai, Rujia; Cheng, Lijun; Gunaratne, Preethi; Gibbs, Richard A.; Min, Shishi; Coarfa, Cristian; Reid, Jeffrey G.; Zhang, Chunling; Jiao, Chuan; Jiang, Yi; Giase, Gina; Thomas, Amber; Fitzgerald, Dominic; Brunetti, Tonya; Shieh, Annie; Xia, Cuihua; Wang, Yongjun; Wang, Yunpeng; Badner, Judith A.; Gershon, Elliot S.; White, Kevin P. & Liu, Chunyu (2018). The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders. Science Translational Medicine.  ISSN 1946-6234.  10:eaat8178(472), s 1- 11 . doi: 10.1126/scitranslmed.aat8178
• Còrdova Palomera, Aldo; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; van der Meer, Dennis; Alnæs, Dag; Rokicki, Jaroslav; Moberget, Torgeir; Sønderby, Ida Elken; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics.  ISSN 1018-4813.  26(7), s 1049- 1059 . doi: 10.1038/s41431-018-0134-2
• de Jong, Simone; Diniz, Mateus Jose Abdalla; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L.; Ota, Vanessa K.; Noto, Cristiano; Thompson, Wesley Kurt; Wang, Yunpeng; Djurovic, Srdjan; Melle, Ingrid; Morken, Gunnar; Andreassen, Ole Andreas; Mattingsdal, Morten; Curtis, Charles; Newhouse, Stephen J.; Patel, Hamel; Hall, Lynsey S.; O`Reilly, Paul F.; Belangero, Sintia I.; Bressan, Rodrigo A. & Breen, Gerome (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology.  ISSN 2399-3642.  1(163) . doi: 10.1038/s42003-018-0155-y Full text in Research Archive.
• Erlangsen, Annette; Appadurai, Vivek; Wang, Yunpeng; Turecki, Gustavo; Mors, Ole; Werge, Thomas; Mortensen, Preben B.; Starnawska, Anna; Børglum, Anders D.; Schork, Andrew J.; Nudel, Ron; Bækvad-Hansen, Marie; Bybjerg-Grauholm, Jonas; Hougaard, David M.; Thompson, Wesley Kurt; Nordentoft, Merete & Agerbo, Esben (2018). Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 12 . doi: 10.1038/s41380-018-0218-y
• Li, Wen; Fan, Chun Chieh; Mäki-Marttunen, Tuomo; Thompson, Wesley Kurt; Schork, Andrew J.; Bettella, Francesco; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole Andreas & Wang, Yunpeng (2018). A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  ISSN 1552-4841.  177(4), s 454- 467 . doi: 10.1002/ajmg.b.32634
• Maier, Robert M.; Zhu, Zhihong; Lee, Sang Hong; Trzaskowski, Maciej; Ruderfer, Douglas M.; Stahl, Eli A.; Ripke, Stephan; Wray, Naomi R.; Yang, Jian; Visscher, Peter M.; Robinson, Matthew R.; Wang, Yunpeng; Elvsåshagen, Torbjørn; Djurovic, Srdjan; Agartz, Ingrid; Mattingsdal, Morten & Melle, Ingrid (2018). Improving genetic prediction by leveraging genetic correlations among human diseases and traits. Nature Communications.  ISSN 2041-1723.  9:989, s 1- 17 . doi: 10.1038/s41467-017-02769-6
• Psychiatric Genomics Consorti, Bipolar Sczhizophrenia; Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alxander W.; Ori, Anil P.S.; Domenici, Enrico; Di Florio, A; Papiol, S; Kalman, Janos; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Joa, Inge; Malt, Ulrik Fredrik; Mattingsdal, Morten; Melle, Ingrid; Morken, Gunnar; Nordentoft, Merete; Nordin, Annelie; Ødegaard, Ketil Joachim; Smeland, Olav Bjerkehagen; Stordal, Eystein; Vaaler, Arne; Wang, Yunpeng; Zheng, Xuebin; Zimprich, Fritz; Zöllner, Sebastian; Corvin, Aiden; Fanous, Ayman H.; Rietschel, Marcella; Gershon, Elliot S.; Schulze, Thomas G.; Cuellar-Barboza, Alfredo B.; Forstner, Andreas J.; Holmans, Peter A.; Nurnberger, John I.; Andreassen, Ole Andreas; Hong Lee, S; O'Donovan, Michael C.; Sullivan, Patrick F.; Ophoff, Roel A.; Wray, Naomi R.; Sklar, Pamela & Kendler, Kenneth S. (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.. Cell.  ISSN 0092-8674.  173(7), s 1705- 1715 . doi: 10.1016/j.cell.2018.05.046
• Seibert, Tyler M.; Fan, Chun Chieh; Wang, Yunpeng; Zuber, Verena; Karunamuni, Roshan; Parsons, J. Kellogg; Eeles, Rosalind A.; Easton, Douglas F.; Kote-Jarai, Zsofia; Al Olama, Ali Amin; Garcia, Sara Benlloch; Muir, Kenneth; Grönberg, Henrik; Wiklund, Fredrik; Aly, Markus; Schleutker, Johanna; Sipeky, Csilla; Tammela, Teuvo L.J.; Nordestgaard, Børge G.; Nielsen, Sune F.; Weischer, Maren; Bisbjerg, Rasmus; Røder, M. Andreas; Iversen, Peter; Key, Tim J.; Travis, Ruth C.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Pharoah, Paul; Pashayan, Nora; Khaw, Kay-Tee; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam S.; Cybulski, Cezary; Wokolorczyk, Dominika; Kluzniak, Wojciech; Cannon-Albright, Lisa; Brenner, Hermann; Cuk, Katarina; Saum, Kai-Uwe; Park, Jong Y.; Sellers, Thomas A.; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Batra, Jyotsna; Clements, Judith A.; Spurdle, Amanda; Teixeira, Manuel R.; Paulo, Paula; Maia, Sofia; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Karow, David S.; Mills, Ian Geoffrey; Andreassen, Ole Andreas & Dale, Anders (2018). Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. BMJ. British Medical Journal.  ISSN 1756-1833.  360:j5757, s 1- 7 . doi: 10.1136/bmj.j5757 Full text in Research Archive.
• Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Davies, Gail; Desikan, Rahul S.; Deary, Ian J.; Melle, Ingrid; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2018). Enrichment of genetic markers of recent human evolution in educational and cognitive traits. Scientific Reports.  ISSN 2045-2322.  8:12585, s 1- 9 . doi: 10.1038/s41598-018-30387-9 Full text in Research Archive.
• Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra; Espeseth, Thomas; Vaskinn, Anja; Wang, Yunpeng; Westlye, Lars Tjelta; Jacquemont, Sébastien; Djurovic, Srdjan; Stefánsson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry.  ISSN 1359-4184.  s 1- 16 . doi: 10.1038/s41380-019-0358-8 Full text in Research Archive.
• Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fred; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod & Andreassen, Ole Andreas (2018). Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports.  ISSN 2045-2322.  8 . doi: 10.1038/s41598-018-36429-6 Full text in Research Archive.
• Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, MacIej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, Tracy M.; Andlauer, Till M.F.; Bacanu, Silviu-Alin; Bækvad-Hansen, Marie; Beekman, Aartjan F.T.; Bigdeli, Tim B.; Binder, Elisabeth B.; Blackwood, Douglas R.H.; Bryois, Julien; Buttenschøn, Henriette Nørmølle; Bybjerg-Grauholm, Jonas; Cai, Na; Castelao, Enrique; Christensen, Jane Hvarregaard; Clarke, Toni-Kim; Coleman, Jonathan I.R.; Colodro-Conde, Lucía; Couvy-Duchesne, Baptiste; Craddock, Nick; Crawford, Gregory E.; Crowley, Cheynna A.; Dashti, Hassan S.; Davies, Gail; Deary, Ian J.; Degenhardt, Franziska; Derks, Eske M.; DIrek, Nese; Dolan, Conor V.; Dunn, Erin C.; Eley, Thalia C.; Eriksson, Nicholas; Escott-Price, Valentina; Kiadeh, Farnush Hassan Farhadi; Finucane, Hilary K.; Forstner, Andreas J.; Frank, Josef; Gaspar, Héléna A.; Gill, Michael; Giusti-Rodríguez, Paola; Goes, Fernando S.; Gordon, Scott D.; Grove, Jakob; Hall, Lynsey S.; Hannon, Eilis; Hansen, Christine Søholm; Hansen, Thomas F.; Herms, Stefan; Hickie, Ian B.; Hoffmann, Per; Homuth, Georg; Horn, Carsten; Hottenga, Jouke-Jan; Hougaard, David M.; Hu, Ming; Hyde, Craig L.; Ising, Marcus; Jansen, Rick; Jin, Fulai; Jorgenson, Eric; Knowles, James A.; Kohane, Isaac S.; Kraft, Julia; Kretzschmar, Warren W.; Krogh, Jesper; Kutalik, Zoltán; Lane, Jacqueline M.; Li, Yihan; Li, Yun; Lind, Penelope A.; Liu, Xiaoxiao; Lu, Leina; MacIntyre, Donald J.; MacKinnon, Dean F.; Maier, Robert M.; Maier, Wolfgang; Marchini, Jonathan; Mbarek, Hamdi; McGrath, Patrick; McGuffin, Peter; Medland, Sarah E.; Mehta, DIvya; Middeldorp, Christel M.; Mihailov, Evelin; Milaneschi, Yuri; Milani, Lili; Mill, Jonathan; Mondimore, Francis M.; Montgomery, Grant W.; Mostafavi, Sara; Mullins, Niamh; Nauck, Matthias; Ng, Bernard; Nivard, Michel G.; Nyholt, Dale R.; O'Reilly, Paul F.; Oskarsson, Hogni; Owen, Michael J.; Painter, Jodie N.; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; Peterson, Roseann E.; Pettersson, Erik; Peyrot, Wouter J.; Pistis, Giorgio; Posthuma, Danielle; Purcell, Shaun M.; Quiroz, Jorge A.; Qvist, Per; Rice, John P.; Riley, Brien P.; Rivera, Margarita; Saeed Mirza, Saira; Saxena, Richa; Schoevers, Robert; Schulte, Eva C.; Shen, Ling; Shi, Jianxin; Shyn, Stanley I.; Sigurdsson, Engilbert; Sinnamon, Grant B.C.; Smit, Johannes H.; Smith, Daniel J.; Stefansson, Hreinn; Steinberg, Stacy; Stockmeier, Craig A.; Streit, Fabian; Strohmaier, Jana; Tansey, Katherine E.; Teismann, Henning; Teumer, Alexander; Thompson, Wesley Kurt; Thomson, Pippa A; Thorgeirsson, Thorgeir E; Tian, Chao; Traylor, Matthew; Treutlein, Jens; Trubetskoy, Vassily; Uitterlinden, André G.; Umbricht, Daniel; van der Auwera, Sandra; van Hemert, Albert M.; Viktorin, Alexander; Visscher, Peter M.; Wang, Yunpeng; Webb, Bradley T.; Weinsheimer, Shantel Marie; Wellmann, Jürgen; Willemsen, Gonneke; Witt, Stephanie H.; Wu, Yang; Xi, Hualin S.; Yang, Jian; Zhang, Futao; Arolt, Volker; Baune, Bernhard T.; Berger, Klaus; Boomsma, Dorret I.; Cichon, Sven; Dannlowski, Udo; de Geus, Eco J.C.N.; Depaulo, J. Raymond; Domenici, Enrico; Domschke, Katharina; Esko, Tõnu; Grabe, Hans J.; Hamilton, Steven P.; Hayward, Caroline; Heath, Andrew C.; Hinds, David A.; Kendler, Kenneth S.; Kloiber, Stefan; Lewis, Glyn; Li, Qingqin S.; Lucae, Susanne; Madden, Pamela F.A.; Magnusson, Patrik K.; Martin, Nicholas G.; McIntosh, Andrew M.; Metspalu, Andres; Mors, Ole; Mortensen, Preben Bo; Muller-Myhsok, Bertram; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C.; Paciga, Sara A.; Pedersen, Nancy L.; Penninx, Brenda W.J.H.; Perlis, Roy H.; Porteous, David J.; Potash, James B.; Preisig, Martin; Rietschel, Marcella; Schaefer, Catherine; Schulze, Thomas G.; Smoller, Jordan W.; Stefansson, Kari; Tiemeier, Henning; Uher, Rudolf; Völzke, Henry; Weissman, Myrna M.; Werge, Thomas; Winslow, Ashley R.; Lewis, Cathryn M.; Levinson, Douglas F.; Breen, Gerome; Børglum, Anders D. & Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics.  ISSN 1061-4036.  50(5), s 668- 681 . doi: 10.1038/s41588-018-0090-3
• Zhang, Qian; Liang, Zhe; Cui, Xuean; Ji, Changmian; Li, Yun; Zhang, Pingxian; Liu, Jingrong; Riaz, Adeel; Yao, Pu; Liu, Min; Wang, Yunpeng; Lu, Tiegang; Yu, Hao; Yang, Donglei; Zheng, Hongkun & Gu, Xiaofeng (2018). N6-methyladenine DNA methylation in Japonica and Indica rice genomes and its association with gene expression, plant development, and stress responses. Molecular Plant.  ISSN 1674-2052.  11(12), s 1492- 1508 . doi: 10.1016/j.molp.2018.11.005
• Zuber, Verena; Jönsson, Erik Gunnar; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley Kurt; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Dieset, Ingrid; Fanous, Ayman H.; Desikan, Rahul S; Küry, Sébastien; Bézieau, Stéphane; Dale, Anders; Mills, Ian Geoffrey & Andreassen, Ole Andreas (2018). Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports.  ISSN 2045-2322.  674(8), s 1- 8 . doi: 10.1038/s41598-017-16481-4 Full text in Research Archive.
• Chen, Chi-Hua; Wang, Yunpeng; Lo, Min-Tzu; Schork, Andrew; Fan, Chun-Chieh; Holland, Dominic; Kauppi, Karolina; Smeland, Olav Bjerkehagen; Djurovic, Srdjan; Sanyal, Nilotpal; Hibar, Derrek; Thompson, Paul M.; Thompson, Wesley Kurt; Andreassen, Ole Andreas & Dale, Anders (2017). Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure. Scientific Reports.  ISSN 2045-2322.  7:15736, s 1- 9 . doi: 10.1038/s41598-017-15705-x
• Desikan, Rahul S.; Fan, Chun Chieh; Wang, Yunpeng; Schork, Andrew J; Cabral, Howard J; Cupples, L. Adrienne; Thompson, Wesley Kurt; Besser, Lilah; Kukull, Walter A.; Holland, Dominic; Chen, Chi-Hua; Brewer, James B.; Karow, David S.; Kauppi, Karolina; Witoelar, Aree; Karch, Celeste M.; Bonham, Luke W.; Yokoyama, Jennifer S.; Rosen, Howard J.; Miller, Bruce L.; Dillon, William P.; Wilson, David M.; Hess, Christopher P.; Pericak-Vance, Margaret; Haines, Jonathan L.; Farrer, Lindsay A.; Mayeux, Richard; Hardy, John; Goate, Alison M.; Hyman, Bradley T.; Schellenberg, Gerard D.; McEvoy, Linda K.; Andreassen, Ole Andreas & Dale, Anders (2017). Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Nature Methods.  ISSN 1548-7091.  14(3:e1002258), s 1- 17 . doi: 10.1371/journal.pmed.1002258
• Devor, Anna; Andreassen, Ole Andreas; Wang, Yunpeng; Mäki-Marttunen, Tuomo; Smeland, Olav Bjerkehagen; Fan, Chun Chieh; Schork, Andrew J.; Holland, Dominic; Thompson, Wesley Kurt; Witoelar, Aree; Chen, Chi-Hua; Desikan, Rahul S.; McEvoy, Linda K.; Djurovic, Srdjan; Greengard, Paul; Svenningsson, Per; Einevoll, Gaute & Dale, Anders (2017). Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia. Molecular Psychiatry.  ISSN 1359-4184.  22(6), s 792- 801 . doi: 10.1038/mp.2017.33 Full text in Research Archive.
• Ferrari, Raffaele; Wang, Yunpeng; Vandrovcova, Jana; Guelfi, Sebastian; Witoelar, Aree; Karch, Celeste M.; Schork, Andrew J.; Fan, Chun C.; Brewer, James B.; Momeni, Parastoo; Schellenberg, Gerard D.; Dillon, William P.; Sugrue, Leo P.; Hess, Christopher P.; Yokoyama, Jennifer S.; Bonham, Luke W.; Rabinovici, Gil D.; Miller, Bruce L.; Andreassen, Ole Andreas; Dale, Anders; Hardy, John & Desikan, Rahul S. (2017). Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery and Psychiatry.  ISSN 0022-3050.  88(2), s 152- 164 . doi: 10.1136/jnnp-2016-314411
• Joshi, Peter K.; Pirastu, Nicola; Kentistou, Katherine A.; Fischer, Krista; Hofer, Edith; Schraut, Katharina E.; Clark, David W.; Nutile, Teresa; Barnes, Catriona L.K.; Timmers, Paul R.H.J.; Shen, Xia; Gandin, Ilaria; McDaid, Aaron F.; Hansen, Thomas Folkmann; Gordon, Scott D.; Giulianini, Franco; Boutin, Thibaud S.; Abdellaoui, Abdel; Zhao, Wei; Medina-Gomez, Carolina; Bartz, Traci M.; Trompet, Stella; Lange, Leslie A.; Raffield, Laura; Van Der Spek, Ashley; Galesloot, Tessel E.; Proitsi, Petroula; Yanek, Lisa R.; Bielak, Lawrence F.; Payton, Antony; Murgia, Federico; Concas, Maria Pina; Biino, Ginevra; Tajuddin, Salman M.; Seppäla, Ilkka; Amin, Najaf; Boerwinkle, Eric; Børglum, Anders D.; Campbell, Archie; Demerath, Ellen W.; Demuth, Ilja; Faul, Jessica D.; Ford, Ian; Gialluisi, Alessandro; Gögele, Martin; Graff, Mariaelisa; Hingorani, Aroon; Hottenga, Jouke-Jan; Hougaard, David M.; Hurme, Mikko A.; Ikram, M. Arfan; Jylhä, Marja; Kuh, Diana; Ligthart, Lannie; Lill, Christina M.; Lindenberger, Ulman; Lumley, Thomas; Mägi, Reedik; Marques-Vidal, Pedro; Medland, Sarah E.; Milani, Lili; Nagy, Reka; Ollier, William E.R.; Peyser, Patricia A.; Pramstaller, Peter P.; Ridker, Paul M.; Rivadeneira, Fernando; Ruggiero, Daniela; Saba, Yasaman; Schmidt, Reinhold; Schmidt, Helena; Slagboom, P. Eline; Smith, Blair H.; Smith, Jennifer A.; Sotoodehnia, Nona; Steinhagen-Thiessen, Elisabeth; Van Rooij, Frank J.A.; Verbeek, André L.; Vermeulen, Sita H.; Vollenweider, Peter; Wang, Yunpeng; Werge, Thomas; Whitfield, John B.; Zonderman, Alan B.; Lehtimäki, Terho; Evans, Michele K.; Pirastu, Mario; Fuchsberger, Christian; Bertram, Lars; Pendleton, Neil; Kardia, Sharon L.R.; Ciullo, Marina; Becker, Diane M.; Wong, Andrew; Psaty, Bruce M.; Van Duijn, Cornelia M.; Wilson, James G.; Jukema, J. Wouter; Kiemeney, Lambertus; Uitterlinden, André G.; Franceschini, Nora; North, Kari E.; Weir, David R.; Metspalu, Andres; Boomsma, Dorret I.; Hayward, Caroline; Chasman, Daniel; Martin, Nicholas G.; Sattar, Naveed; Campbell, Harry; Esko, Tõnu; Kutalik, Zoltán & Wilson, James F. (2017). Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications.  ISSN 2041-1723.  8:910(1), s 1- 13 . doi: 10.1038/s41467-017-00934-5
• Le Hellard, Stephanie; Wang, Yunpeng; Witoelar, Aree; Zuber, Verena; Bettella, Francesco; Hugdahl, Kenneth; Espeseth, Thomas; Steen, Vidar Martin; Melle, Ingrid; Desikan, Rahul S.; Schork, Andrew J.; Thompson, Wesley Kurt; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Identification of gene loci that overlap between schizophrenia and educational attainment. Schizophrenia Bulletin.  ISSN 0586-7614.  43(3), s 654- 664 . doi: 10.1093/schbul/sbw085
• Lo, Min-Tzu; Wang, Yunpeng; Kauppi, Karolina; Sanyal, Nilotpal; Fan, Chun-Chieh; Smeland, Olav Bjerkehagen; Schork, Andrew; Holland, Dominic; Hinds, David A; Tung, Joyce Y; Andreassen, Ole Andreas; Dale, Anders M & Chen, Chi-Hua (2017). Modeling prior information of common genetic variants improves gene discovery for neuroticism. Human Molecular Genetics.  ISSN 0964-6906.  26(22), s 4530- 4539 . doi: 10.1093/hmg/ddx340
• Rietschel, Liz; Streit, Fabian; Zhu, Gu; McAloney, Kerrie; Frank, Josef; Couvy-Duchesne, Baptiste; Witt, Stephanie H.; Binz, Tina M.; Thompson, Wesley Kurt; Wang, Yunpeng; McGrath, John; Hickie, Ian B.; Hansell, Narelle K.; Wright, Margaret J.; Gillespie, Nathan A.; Forstner, Andreas J.; Schulze, Thomas G.; Wüst, Stefan; Nöthen, Markus M.; Baumgartner, Markus R.; Walker, Brian R.; Crawford, Andrew A.; Colodro-Conde, Lucía; Medland, Sarah E.; Martin, Nicholas G. & Rietschel, Marcella (2017). Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific Reports.  ISSN 2045-2322.  7:15351, s 1- 15 . doi: 10.1038/s41598-017-11852-3
• Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Zayats, Tetyana; Schork, Andrew J; Frei, Oleksandr; Bettella, Francesco; Witoelar, Aree; Li, Wen; Eriksen, Jon Alm; Krull, Florian; Djurovic, Srdjan; Faraone, Stephen V.; Reichborn-Kjennerud, Ted; Thompson, Wesley K; Johansson, Stefan; Haavik, Jan; Dale, Anders; Wang, Yunpeng & Andreassen, Ole Andreas (2017). Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment. Journal of the American Academy of Child and Adolescent Psychiatry.  ISSN 0890-8567.  57(2), s 86- 95 . doi: 10.1016/j.jaac.2017.11.013 Full text in Research Archive.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Kauppi, Karolina; Hill, W. David; Li, Wen; Wang, Yunpeng; Krull, Florian; Bettella, Francesco; Eriksen, Jon Alm; Witoelar, Aree; Davies, Gail; Fan, Chun Chieh; Thompson, Wesley Kurt; Lam, Max; Lencz, Todd; Chen, Chi-Hua; Ueland, Torill; Jönsson, Erik Gunnar; Djurovic, Srdjan; Deary, Ian J.; Dale, Anders & Andreassen, Ole Andreas (2017). Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA psychiatry.  ISSN 2168-6238.  74(10), s 1065- 1075 . doi: 10.1001/jamapsychiatry.2017.1986 Full text in Research Archive.
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek P; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms. Schizophrenia Bulletin.  ISSN 0586-7614.  44(4), s 854- 864 . doi: 10.1093/schbul/sbx148
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Lo, Min-Tzu; Li, Wen; Frei, Oleksandr; Witoelar, Aree; Tesli, Martin Steen; Hinds, David A.; Tung, Joyce Y.; Djurovic, Srdjan; Chen, Chi-Hua; Dale, Anders & Andreassen, Ole Andreas (2017). Identification of genetic loci shared between schizophrenia and the Big Five personality traits. Scientific Reports.  ISSN 2045-2322.  7:2222(1), s 1- 9 . doi: 10.1038/s41598-017-02346-3 Full text in Research Archive.
• Srinivasan, Saurabh; Bettella, Francesco; Hassani, Sahar; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Collier, David A.; Desikan, Rahul S.; Melle, Ingrid; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Probing the association between early evolutionary markers and schizophrenia. PLOS ONE.  ISSN 1932-6203.  12:e0169227(1), s 1- 15 . doi: 10.1371/journal.pone.0169227
• Winsvold, Bendik K S; Bettella, Francesco; Witoelar, Aree; Anttila, Verneri; Gormley, Padhraig; Kurth, Tobias; Terwindt, Gisela M; Freilinger, Tobias; Frei, Oleksandr; Shadrin, Alexey A.; Wang, Yunpeng; Dale, Anders; Van Den Maagdenberg, Arn M.J.M.; Chasman, Daniel I; Nyholt, Dale R; Palotie, Aarno; Andreassen, Ole Andreas & Zwart, John-Anker (2017). Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLOS ONE.  ISSN 1932-6203.  s 1- 15 . doi: 10.1371/journal.pone.0185663 Full text in Research Archive.
• Witoelar, Aree; Jansen, Iris E.; Wang, Yunpeng; Desikan, Rahul S.; Gibbs, J. Raphael; Thompson, Wesley Kurt; Hernandez, Dena G.; Djurovic, Srdjan; Schork, Andrew J.; Bettella, Francesco; Ellinghaus, David; Franke, Andre; Lie, Benedicte Alexandra; McEvoy, Linda K.; Karlsen, Tom Hemming; Lesage, Suzanne; Morris, Huw R.; Brice, Alexis; Wood, Nicholas W.; Heutink, Peter; Hardy, John; Singleton, Andrew B.; Dale, Anders; Gasser, Thomas; Andreassen, Ole Andreas & Sharma, Manu (2017). Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurology.  ISSN 2168-6149.  74(7), s 780- 792 . doi: 10.1001/jamaneurol.2017.0469
• Yokoyama, Jennifer S.; Karch, Celeste M.; Fan, Chun C.; Bonham, Luke W.; Kouri, Naomi; Ross, Owen A.; Rademakers, Rosa; Kim, Jungsu; Wang, Yunpeng; Höglinger, Günter U.; Müller, Ulrich; Ferrari, Raffaele; Hardy, John; Momeni, Parastoo; Sugrue, Leo P.; Hess, Christopher P.; Barkovich, A. James; Boxer, Adam L.; Seeley, William W.; Rabinovici, Gil D.; Rosen, Howard J.; Miller, Bruce L.; Schmansky, Nicholas J.; Fischl, Bruce; Hyman, Bradley T.; Dickson, Dennis W.; Schellenberg, Gerard D.; Andreassen, Ole Andreas; Dale, Anders; Desikan, Rahul S. & Desikan, Rahul S (2017). Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathologica.  ISSN 0001-6322.  133(5), s 825- 837 . doi: 10.1007/s00401-017-1693-y
• Holland, Dominic; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Chen, Chi-Hua; Lo, Min-Tzu; Witoelar, Aree; Werge, Thomas; O'Donovan, Michael; Andreassen, Ole Andreas & Dale, Anders (2016). Estimating effect sizes and expected replication probabilities from GWAS summary statistics. Frontiers in Genetics.  ISSN 1664-8021.  7(15) . doi: 10.3389/fgene.2016.00015
• Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y.; Franz, Carol E.; Fan, Chun Chieh; Wang, Yunpeng; Smeland, Olav Bjerkehagen; Schork, Andrew J.; Holland, Dominic; Kauppi, Karolina; Nilotpal, Sanyal; Escott-Price, Valentina; Smith, Daniel J.; O'Donovan, Michael; Stefansson, Hreinn; Bjornsdottir, Gyda; Thorgeirsson, Thorgeir E; Stefansson, Kari; McEvoy, Linda K.; Dale, Anders; Andreassen, Ole Andreas & Chen, Chi-Hua (2016). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics.  ISSN 1061-4036.  49(1), s 152- 156 . doi: 10.1038/ng.3736
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2016). Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: a modeling study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.  ISSN 2451-9022.  1(1), s 49- 59 . doi: 10.1016/j.bpsc.2015.09.002 Show summary

  BACKGROUND: Recent genome-wide association studies have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical pyramidal cells and identified possible common alterations in behavior across SCZ-related genes. METHODS: We applied a biophysically detailed multicompartmental model to study the excitability of a layer V pyramidal cell. We reviewed the literature on functional genomics for variants of genes associated with SCZ and used changes in neuron model parameters to represent the effects of these variants. RESULTS: We present and apply a framework for examining the effects of subtle single nucleotide polymorphisms in ion channel and calcium transporter-encoding genes on neuron excitability. Our analysis indicates that most of the considered SCZ-related genetic variants affect the spiking behavior and intracellular calcium dynamics resulting from summation of inputs across the dendritic tree. CONCLUSIONS: Our results suggest that alteration in the ability of a single neuron to integrate the inputs and scale its excitability may constitute a fundamental mechanistic contributor to mental disease, alongside the previously proposed deficits in synaptic communication and network behavior. Keywords: Biophysical modeling, Functional genomics, Genome-wide association studies, Layer V pyramidal cell, Neuron excitability, Schizophrenia

• Schork, AJ; Wang, Yunpeng; Thompson, Kurt Wesley; Dale, AM & Andreassen, Ole Andreas (2016). New statistical approaches exploit the polygenic architecture of schizophrenia-implications for the underlying neurobiology. Current Opinion in Neurobiology.  ISSN 0959-4388.  36, s 89- 98 . doi: 10.1016/j.conb.2015.10.008
• Wang, Yunpeng; Bos, Steffan Daniel; Harbo, Hanne Flinstad; Thompson, Wesley K.; Schork, Andrew J.; Bettella, Francesco; Witoelar, Aree; Lie, Benedicte Alexandra; Li, Wen; McEvoy, Linda K.; Djurovic, Srdjan; Desikan, Rahul S.; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.. Multiple Sclerosis.  ISSN 1352-4585.  22(14), s 1783- 1793 . doi: 10.1177/1352458516635873
• Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Holland, Dominic; Chen, Chi-Hua; Bettella, Francesco; Desikan, Rahul S.; Li, Wen; Witoelar, Aree; Zuber, Verena; Devor, Anna; Nöthen, Markus M; Rietschel, Marcella; Chen, Qiang; Werge, Thomas; Cichon, Sven; Weinberger, Daniel R.; Djurovic, Srdjan; O'Donovan, Michael; Visscher, Peter M; Andreassen, Ole Andreas & Dale, Anders (2016). Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS. PLoS Genetics.  ISSN 1553-7390. . doi: 10.1371/journal.pgen.1005803 Full text in Research Archive.
• Yokoyama, Jennifer S.; Wang, Yunpeng; Schork, Andrew J.; Thompson, Wesley K.; Karch, Celeste M.; Cruchaga, Carlos; McEvoy, Linda K.; Witoelar, Aree; Chen, Chi-Hua; Holland, Dominic; Brewer, James B.; Franke, Andre; Dillon, William P.; Wilson, David M.; Mukherjee, Pratik; Hess, Christopher P.; Miller, Zachary; Bonham, Luke W.; Shen, Jeffrey; Rabinovici, Gil D.; Rosen, Howard J.; Miller, Bruce L.; Hyman, Bradley T.; Schellenberg, Gerard D.; Karlsen, Tom Hemming; Andreassen, Ole Andreas; Dale, Anders & Desikan, Rahul S. (2016). Association between genetic traits for immune-mediated diseases and Alzheimer disease. JAMA Neurology.  ISSN 2168-6149.  73(6), s 691- 697 . doi: 10.1001/jamaneurol.2016.0150
• Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, Eva; Albrecht, Mario; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte Alexandra; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom Hemming & Dale, Anders (2015). Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLOS ONE.  ISSN 1932-6203.  10:e 0123057(4) . doi: 10.1371/journal.pone.0123057 Full text in Research Archive.
• Andreassen, Ole Andreas; Harbo, Hanne Flinstad; Wang, Yunpeng; Thompson, WK; Schork, AJ; Mattingsdal, Morten; Zuber, Verena; Bettella, Franscesco; Ripke, S; Kelsoe, JR; Kendler, KS; O'Donovan, MC; Sklar, P; McEvoy, LK; Desikan, RS; Lie, Benedicte Alexandra; Djurovic, Srdjan & Dale, Anders M. (2015). Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular Psychiatry.  ISSN 1359-4184.  20(2), s 207- 214 . doi: 10.1038/mp.2013.195 Full text in Research Archive.
• Chen, Chi-Hua; Peng, Qian; Schork, Andrew J.; Lo, Min-Tzu; Fan, Chun-Chieh; Wang, Yunpeng; Desikan, Rahul S.; Bettella, Franscesco; Hagler, Donald J.; Westlye, Lars Tjelta; Kremen, William S.; Jernigan, Terry L.; Le Hellard, Stephanie; Steen, Vidar Martin; Espeseth, Thomas; Huentelman, Matt; Håberg, Asta; Agartz, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas; Schork, Nicholas & Dale, Anders (2015). Large-scale genomics unveil polygenic architecture of human cortical surface area. Nature Communications.  ISSN 2041-1723.  6:7549 . doi: 10.1038/ncomms8549 Full text in Research Archive.
• Desikan, Rahul S.; Schork, Andrew J.; Wang, Yunpeng; Thompson, Wesley K.; Dehghan, Abbas; Ridker, Paul M.; Chasman, Daniel I.; McEvoy, Linda K.; Holland, Dominic; Chen, Chi-Hua; Karow, David S.; Brewer, James B.; Hess, Christopher P.; Williams, Julie; Sims, Rebecca; O'Donovan, Michael C.; Choi, Seung Hoan; Bis, Joshua C.; Ikram, M. Arfan; Gudnason, Vilmundur; DeStefano, Anita L.; Van Der Lee, Sven J.; Psaty, Bruce M.; Van Duijn, Cornelia M.; Launer, Lenore; Seshadri, Sudha; Pericak-Vance, Margaret A.; Mayeux, Richard; Haines, Jonathan L.; Farrer, Lindsay A.; Hardy, John; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; White, Linda; Sando, Sigrid Botne; Rongve, Arvid; Witoelar, Aree; Djurovic, Srdjan; Hyman, Bradley T.; Snædal, Jon; Steinberg, Stacy; Stefansson, Hreinn; Stefánsson, Kári; Schellenberg, Gerard D.; Andreassen, Ole Andreas & Dale, Anders (2015). Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease. Circulation.  ISSN 0009-7322.  131(23), s 2061- 2069 . doi: 10.1161/CIRCULATIONAHA.115.015489 Full text in Research Archive.
• Desikan, RS; Schork, AJ; Wang, Yunpeng; Witoelar, Aree; Sharma, M; McEvoy, LK; Holland, D; Brewer, JB; Chen, CH; Thompson, WK; Harold, D; Williams, J; Owen, MJ; O'Donovan, MC; Pericak-Vance, MA; Mayeux, R; Haines, JL; Farrer, LA; Schellenberg, GD; Heutink, P; Singleton, AB; Brice, A; Wood, NW; Hardy, J; Martinez, M; Choi, SH; Destefano, A; Ikram, MA; Bis, JC; Smith, A; Fitzpatrick, AL; Launer, L; Van Duijn, C; Seshadri, S; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; Djurovic, Srdjan; Hyman, BT; Snaedal, J; Stefansson, H; Stefansson, K; Gasser, T; Andreassen, Ole Andreas & Dale, AM (2015). Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Molecular Psychiatry.  ISSN 1359-4184.  20(12), s 1588- 1595 . doi: 10.1038/mp.2015.6
• Fan, Chun Chieh; Bartsch, Hauke; Schork, Andrew J.; Chen, Chi-Hua; Wang, Yunpeng; Lo, Min-Tzu; Brown, Timothy T.; Kuperman, Joshua M.; Hagler, Donald J.; Schork, Nicholas J.; Jernigan, Terry L. & Dale, Anders (2015). Modeling the 3D geometry of the cortical surface with genetic ancestry. Current Biology.  ISSN 0960-9822.  25(15), s 1988- 1992 . doi: 10.1016/j.cub.2015.06.006
• Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, Andrew J.; Thompson, Kurt Wesley; Mattingsdal, Morten; Steen, Vidar Martin; Zuber, Verena; Wang, Yunpeng; Dale, Anders; Andreassen, Ole Andreas & Djurovic, Srdjan (2015). MicroRNAs enrichment in GWAS of complex human phenotypes. BMC Genomics.  ISSN 1471-2164.  16:304 . doi: 10.1186/s12864-015-1513-5 Full text in Research Archive.
• LeBlanc, Marissa; Zuber, Verena; Kulle, Bettina; Witoelar, Aree; Zeng, Limin; Bettella, Francesco; Wang, Yunpeng; McEvoy, LK; Thompson, Kurt Wesley; Schork, AJ; Reppe, Sjur; Barrett-Connor, Elizabeth; Lighart, Symen; Dehghan, A; Gautvik, Kaare M; Nelson, CP; Schunkert, Heribert; Samani, Nilesh J; Ridker, PM; Chasman, Daniel I; Aukrust, Pål; Djurovic, Srdjan; Frigessi, Arnoldo; Desikan, RS; Dale, Anders & Andreassen, Ole Andreas (2015). Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes with Several Cardiovascular Risk Factors.. Circulation Research.  ISSN 0009-7330.  1, s 83- 94 . doi: 10.1161/CIRCRESAHA.115.306629
• Reppe, Sjur; Wang, Yunpeng; Thompson, Wesley K.; McEvoy, Linda K.; Schork, Andrew J.; Zuber, Verena; LeBlanc, Marissa; Bettella, Franscesco; Mills, Ian Geoffrey; Desikan, Rahul S.; Djurovic, Srdjan; Gautvik, Kaare M; Dale, Anders & Andreassen, Ole Andreas (2015). Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci. PLOS ONE.  ISSN 1932-6203.  10:e0144531(12) . doi: 10.1371/journal.pone.0144531 Full text in Research Archive.
• Srinivasan, Saurabh; Bettella, Francesco; Mattingsdal, Morten; Wang, Yunpeng; Witoelar, Aree; Schork, AJ; Thompson, WK; Zuber, Verena; Winsvold, Bendik K S; Zwart, John-Anker; Collier, David A.; Desikan, RS; Melle, Ingrid; Werge, Thomas; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2015). Genetic Markers of Human Evolution Are Enriched in Schizophrenia. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2015.10.009
• Thompson, WK; Wang, Yunpeng; Schork, AJ; Witoelar, Aree; Zuber, Verena; Xu, S; Werge, T; Holland, D; Andreassen, Ole Andreas & Dale, AM (2015). An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies. PLoS Genetics.  ISSN 1553-7390.  11(12) . doi: 10.1371/journal.pgen.1005717
• Andreassen, Ole Andreas; McEvoy, Linda K.; Thompson, Wesley K.; Wang, Yunpeng; Reppe, Sjur; Schork, Andrew J.; Zuber, Verena; Barrett-Connor, Elizabeth; Gautvik, Kaare M; Aukrust, Pål; Karlsen, Tom Hemming; Djurovic, Srdjan; Desikan, Rahul S. & Dale, Anders (2014). Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes. Hypertension.  ISSN 0194-911X.  63(4), s 819- 826 . doi: 10.1161/HYPERTENSIONAHA.113.02077 Full text in Research Archive.
• Gjuvsland, Arne Bjørke; Wang, Yunpeng; Plahte, Erik & Omholt, Stig W (2013). Monotonicity is a key feature of genotype-phenotype maps. Frontiers in Genetics.  ISSN 1664-8021.  4 . doi: 10.3389/fgene.2013.00216 Full text in Research Archive.
• Wang, Yunpeng; Vik, Jon Olav; Omholt, Stig W & Gjuvsland, Arne Bjørke (2013). Effect of regulatory architecture on broad versus narrow sense heritability. PLoS Computational Biology.  ISSN 1553-734X.  9(5) . doi: 10.1371/journal.pcbi.1003053 Full text in Research Archive.
• Wang, Yunpeng; Gjuvsland, Arne Bjørke; Vik, Jon Olav; Smith, Nicolas P; Hunter, Peter J & Omholt, Stig W (2012). Parameters in Dynamic Models of Complex Traits are Containers of Missing Heritability. PLoS Computational Biology.  ISSN 1553-734X.  8(4) . doi: 10.1371/journal.pcbi.1002459

View all works in Cristin

• Lo, Min-Tzu; Hinds, David A; Tung, Joyce Y; Franz, C; Fan, Chun Chieh; Wang, Yunpeng; Smeland, Olav Bjerkehagen; Schork, A.; Holland, D.; Kauppi, Karolina; Sanyal, Nilotpal; Escott-Price, Valentina; Smith, DJ; O'Donovan, Michael C; Stefansson, H; Bjornsdottir, Gyda; Thorgeirsson, TE; Stefansson, K; McEvoy, LK; Dale, AM; Andreassen, Ole Andreas & Chen, CH (2017). Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.. Nature Genetics.  ISSN 1061-4036.  49(1), s 152- 156 . doi: 10.1038/ng.3736
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Dale, Anders & Andreassen, Ole Andreas (2017). Combined Analysis of Large Genetic Samples. New Statistical Approaches Improve Gene Discovery.
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Alexey, Shadrin; Li, Wen; Florian, Krull; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). Increased discovery of risk loci for bipolar disorder by leveraging prior probabilities of true associations using the covariate modulated mixture model (CM3).
• Smeland, Olav Bjerkehagen; Frei, Oleksandr; Wang, Yunpeng; Fan, Chun Chieh; Shadrin, Alexey A.; Li, Wen; Krull, Florian; Bettella, Francesco; Witoelar, Aree; Thompson, Wesley Kurt; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2017). C-Reactive Protein Levels and Schizophrenia Share Genetic Influences.
• Smeland, Olav Bjerkehagen; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hibar, Derrek; Franke, Barbara; Bettella, Francesco; Witoelar, Aree; Djurovic, Srdjan; Chen, Chi-Hua; Thompson, P.M.; Dale, Anders & Andreassen, Ole Andreas (2017). Conditional false discovery rate analysis of genome-wide association studies uncovers genetic loci shared between schizophrenia and volumes of hippocampus, putamen and intracranial volume.
• Córdova-Palomera, Aldo; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; Alnæs, Dag; Moberget, Torgeir; Kaufmann, Tobias; Sønderby, Ida Elken; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2016). POTENTIAL BRAIN MORPHOLOGY INSTABILITY FEATURES MEDIATING THE ASSOCIATION BETWEEN GENOME-WIDE HOMOZYGOSITY AND ALTERED NEUROCOGNITION.
• Smeland, Olav Bjerkehagen; Kauppi, Karolina; Wang, Yunpeng; Frei, Oleksandr; Li, Wen; Hill, David W; Davies, Gail; Eriksen, Jon Alm; Witoelar, Aree; Bettella, Francesco; Fan, Chun Chieh; Thompson, Wesley Kurt; Chen, Chi-Hua; Djurovic, Srdjan; Deary, Ian J.; Dale, Anders & Andreassen, Ole Andreas (2016). Schizophrenia and general cognitive function share genetic influences.
• Smeland, Olav Bjerkehagen; Witoelar, Aree; Lo, Min-Tzu; Tesli, Martin Steen; Wang, Yunpeng; Hinds, David A.; Tung, Joyce Y.; Djurovic, Srdjan; Chen, Chi-Hua; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between schizophrenia and the Big Five personality traits.
• Smeland, Olav Bjerkehagen; Witoelar, Aree; Wang, Yunpeng; Chen, Chi-Hua; Djurovic, Srdjan; Dale, Anders & Andreassen, Ole Andreas (2016). Genetic overlap between schizophrenia and brain structural volumes indicates shared molecular genetic mechanisms with potential relevance for antipsychotics.
• Zuber, Verena; Marconett, Crystal; Shi, Jianxin; Hua, Xing; Wheeler, William; Yang, Chenchen; Song, Lei; Dale, Anders M.; Laplana, Marina; Risch, Angela; Witoelar, Aree; Thompson, Wesley K; Schork, Andrew J.; Bettella, Francesco; Wang, Yunpeng; Djurovic, Srdjan; Zhou, Beiyun; Borok, Zea; van der Heijden, Henricus FM; de Graaf, Jacqueline; Swinkels, Dorine; Aben, Katja K.; McKay, James; Hung, Rayjean J.; Bikeböller, Heike; Stevens, Victoria L.; Albanes, Demetrius; Caporaso, Neil E.; Han, Younghun; Wei, Youngyue; Panadero, Maria A; Mayordomo, Jose Ignacio; Christiani, David C.; Kiemeney, Lambertus; Andreassen, Ole Andreas; Houlston, Richard; Amos, Christopher I.; Chatterjee, Nilanjan; Laird-Offringa, Ite A.; Mills, Ian Geoffrey & Landi, Maria Teresa (2016). Pleiotropic analysis of lung cancer and blood triglycerides. Journal of the National Cancer Institute.  ISSN 0027-8874.  108:djv167(12), s 1- 4 . doi: 10.1093/jnci/djw167
• Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, Eva; Albrecht, Mario; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte A.; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom Hemming & Dale, Anders (2015). Correction: Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLOS ONE.  ISSN 1932-6203.  10(5) . doi: 10.1371/journal.pone.0128048
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked genes on single-neuron excitability.
• Mäki-Marttunen, Tuomo; Halnes, Geir; Devor, Anna; Witoelar, Aree; Bettella, Francesco; Djurovic, Srdjan; Wang, Yunpeng; Einevoll, Gaute; Andreassen, Ole Andreas & Dale, Anders M. (2015). Towards biophysical psychiatry: A modeling approach for studying effects of schizophrenia-linked gens on single-neuron excitability.
• Gjuvsland, Arne Bjørke; Wang, Yunpeng; Plahte, Erik & Omholt, Stig W (2014). Highly monotone genotype-phenotype maps emerging from gene regulatory networks.
• Wang, Yunpeng; Omholt, Stig W; Gjuvsland, Arne Bjørke & Vik, Jon Olav (2013). LINKING THE HERITABILITY CONCEPT TO SYSTEMS DYNAMICS. Philosophiae Doctor (PhD) Thesis. 18.
• Gjuvsland, Arne Bjørke; Wang, Yunpeng; Plahte, Erik & Omholt, Stig William (2012). Monotonicity is a key measure of genotype-phenotype maps.
• Vik, Jon Olav; Gjuvsland, Arne Bjørke; Wang, Yunpeng; Omholt, Stig W; Smith, Nicolas P & Hunter, Peter J (2012). A toolbox for causally cohesive genotype-phenotype modeling.
• Wang, Yunpeng; Vik, Jon Olav; Omholt, Stig W & Gjuvsland, Arne Bjørke (2012). Disclosing the relationship between heritability and regulatory architecture.
• Wang, Yunpeng & Omholt, Stig W. (2010). Genetics meets multiscale and multiphysics modelling: the epistemic value of causally cohesive genotype-phenotype models.

View all works in Cristin