Lars Tjelta Westlye

Head of Research - Department of Psychology

Professor - Department of Psychology

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Email l.t.westlye@psykologi.uio.no

Phone +47-97163221

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Visiting address Psykologisk institutt Postboks 1094 Blindern 0317 Oslo

Postal address Psykologisk institutt Postboks 1094 Blindern 0317 Oslo

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Academic interests

I am a professor at the Department of Psychology, University of Oslo and Core Researcher and group leader at the Norwegian Center for Mental Disorders Research (NORMENT), Oslo University Hospital/University of Oslo.

Identifying mechanisms of disease is of vital importance to increase patient care and develop safe and effective treatment approaches. The heterogeneity and complexity of mental illnesses and other disorders of brain biology can only be fully appreciated by employing a cross-disciplinary and translational effort, preferably combined with a lifespan perspective.

Advanced neuroimaging techniques including MRI have revolutionized the understanding of the structural and functional makeup of the human brain. Structural and functional brain features are highly heritable, and our current research aims at characterizing the cognitive, brain and genetic mechanisms of severe neuropsychiatric disorders, in particular schizophrenia and bipolar spectrum disorders. In addition, in order to address questions pertaining to the clinical sensitivity and specificity of our results, we are aiming to compare and validate our findings across a range of brain disorders through a close collaboration with several clinical research groups. In addition, using brain network modeling approaches we are approaching the cognitive neuroscience of attention and memory functions, and questions related to the potential and mechanisms of neuroplasticity, both in clinical and non-clinical populations.

My research group utilizes various advanced MRI neuroimaging data and analysis approaches, with a particular emphasis on measures of structural (diffusion tensor imaging, DTI) and functional connectivity (functional magnetic resonance imaging, fMRI), and its integration using multimodal analysis approaches. In particular, by applying machine learning algorithms, we are investigating the clinical and cognitive sensitivity and specificity of various brain network-modeling approaches, including principles from graph theory.

In addition to the extended inter-disciplinary network of researchers at NORMENT and other clinical research groups at Oslo University Hospital, we are working closely with world-class international research groups, including the FMRIB Centre, Oxford University, and MMIL, UCSD.

Students interested in pursuing a cand psychol, MA or PhD within any of these areas of research are encouraged to contact me.

Higher education and employment history

Education

2011 PhD, University of Oslo
2007 Cand. Psychol. (professionally oriented degree in psychology), University of Oslo, accredited psychologist 2008

Employment history

2011 - 2012 Postdoctoral research fellow, Department of Psychology, University of Oslo
2011 Visiting Researcher, Multimodal Imaging Laboratory (MMIL), University of California San Diego, USA
2011 - Postdoctoral Research Fellow (research council of Norway), Center for the Study of Human Cognition, University of Oslo
2010 - 2011 Visiting Researcher, Oxford Centre for functional MRI of the Brain (FMRIB), University of Oxford, UK
2008 - 2011 PhD Research Fellow (The Research Council of Norway), Center for the Study of Human Cognition, Institute of Psychology, University of Oslo
2006 - 2007 Student Research Fellow (part time) (The Research Council of Norway), Department of Psychology, University of Oslo
2005 Student Research Fellow (full time) (The Research Council of Norway), Department of Psychology, University of Oslo

Tags: Cognitive neuroscience, Neuroscience, Psychiatry, Neuropsychology

Chen, Jiayu; Li, Xiang; Calhoun, Vince D.; Turner, Jessica A.; van Erp, Theo G.M.; Wang, Lei; Andreassen, Ole Andreas; Agartz, Ingrid; Westlye, Lars Tjelta; Jönsson, Erik Gunnar; Ford, Judith M.; Mathalon, Daniel H.; Macciardi, Fabio; O'Leary, Daniel S.; Liu, Jingyu & Ji, Shihao (2021). Sparse deep neural networks on imaging genetics for schizophrenia case–control classification. Human Brain Mapping. ISSN 1065-9471. 42(8), s 2556- 2568 . doi: 10.1002/hbm.25387
Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin; Chu, Yunhan; Bahrami, Shahram; Shadrin, Alexey A.; Alnæs, Dag; Hindley, Guy Frederick Lanyon; Lin, Aihua; Karadag, Naz; Fan, Chun Chieh; Westlye, Lars Tjelta; Kaufmann, Tobias; Molden, Espen; Dale, Anders M.; Djurovic, Srdjan; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2021). Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness. JAMA psychiatry. ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2021.1435
Gurholt, Tiril Pedersen; Kaufmann, Tobias; Frei, Oleksandr; Alnæs, Dag; Haukvik, Unn Kristin H.; van der Meer, Dennis; Moberget, Torgeir; O'Connell, Kevin S.; Leinhard, Olof Dahlqvist; Linge, Jennifer; Simon, Rozalyn; Smeland, Olav Bjerkehagen; Sønderby, Ida Elken; Winterton, Adriano; Steen, Nils Eiel; Westlye, Lars Tjelta & Andreassen, Ole Andreas (2021). Population-based body–brain mapping links brain morphology with anthropometrics and body composition. Translational Psychiatry. ISSN 2158-3188. . doi: 10.1038/s41398-021-01414-7 Full text in Research Archive.
Hellstrøm, Torgeir; Andelic, Nada; de Lange, Ann-Marie Glasø; Helseth, Eirik; Eiklid, Kristin Louise & Westlye, Lars Tjelta (2021). Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging. Journal of Clinical Medicine. ISSN 2077-0383. . doi: 10.3390/jcm10030418 Full text in Research Archive.
Maximov, Ivan; van der Meer, Dennis; de Lange, Ann-Marie Glasø; Kaufmann, Tobias; Shadrin, Alexey A.; Frei, Oleksandr; Wolfers, Thomas & Westlye, Lars Tjelta (2021). Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: U.K. Biobank 18,608 example. Human Brain Mapping. ISSN 1065-9471. . doi: 10.1002/hbm.25424
Norbom, Linn Christin Bonaventure; Ferschmann, Lia; Parker, Nadine; Agartz, Ingrid; Andreassen, Ole Andreas; Paus, Tomas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2021). New insights into the dynamic development of the cerebral cortex in childhood and adolescence: Integrating macro- and microstructural MRI findings. Progress in Neurobiology. ISSN 0301-0082. s 1- 19 . doi: 10.1016/j.pneurobio.2021.102109
Roelfs, Daniel; Alnæs, Dag; Frei, Oleksandr; van der Meer, Dennis; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2021). Phenotypically independent profiles relevant to mental health are genetically correlated. Translational Psychiatry. ISSN 2158-3188. 11(1) . doi: 10.1038/s41398-021-01313-x Full text in Research Archive. Show summary
Genome-wide association studies (GWAS) and family-based studies have revealed partly overlapping genetic architectures between various psychiatric disorders. Given clinical overlap between disorders, our knowledge of the genetic architectures underlying specific symptom profiles and risk factors is limited. Here, we aimed to derive distinct profiles relevant to mental health in healthy individuals and to study how these genetically relate to each other and to common psychiatric disorders. Using independent component analysis, we decomposed self-report mental health questionnaires from 136,678 healthy individuals of the UK Biobank, excluding data from individuals with a diagnosed neurological or psychiatric disorder, into 13 distinct profiles relevant to mental health, capturing different symptoms as well as social and risk factors underlying reduced mental health. Utilizing genotypes from 117,611 of those individuals with White British ancestry, we performed GWAS for each mental health profile and assessed genetic correlations between these profiles, and between the profiles and common psychiatric disorders and cognitive traits. We found that mental health profiles were genetically correlated with a wide range of psychiatric disorders and cognitive traits, with strongest effects typically observed between a given mental health profile and a disorder for which the profile is common (e.g. depression symptoms and major depressive disorder, or psychosis and schizophrenia). Strikingly, although the profiles were phenotypically uncorrelated, many of them were genetically correlated with each other. This study provides evidence that statistically independent mental health profiles partly share genetic underpinnings and show genetic overlap with psychiatric disorders, suggesting that shared genetics across psychiatric disorders cannot be exclusively attributed to the known overlapping symptomatology between the disorders.
Ulrichsen, Kristine Moe; Kolskår, Knut-Kristian; Richard, Geneviève; Alnæs, Dag; Dørum, Erlend Solberg; Sanders, Anne-Marthe; Tornås, Sveinung; Sánchez, Jennifer Monereo; Engvig, Andreas; Ihle-Hansen, Hege; de Schotten, Michel Thiebaut; Nordvik, Jan Egil & Westlye, Lars Tjelta (2021). Structural brain disconnectivity mapping of post-stroke fatigue. NeuroImage: Clinical. ISSN 2213-1582. 30 . doi: 10.1016/j.nicl.2021.102635
Voldsbekk, Irene; Barth, Claudia; Maximov, Ivan I.; Kaufmann, Tobias; Beck, Dani; Richard, Genevive; Moberget, Torgeir; Westlye, Lars T. & de Lange, Ann-Marie G. (2021). A history of previous childbirths is linked to women's white matter brain age in midlife and older age. Human Brain Mapping. ISSN 1065-9471. s 1- 15 . doi: 10.1002/hbm.25553
Voldsbekk, Irene; Groote, Inge Rasmus; Zak, Nathalia; Roelfs, Daniël Thomas Heimen; Geier, Oliver; Due-Tønnessen, Paulina; Løkken, Lise Linn; Strømstad, Marie; Blakstvedt, Taran Y; Kuiper, Yvonne S; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Bjørnerud, Atle & Maximov, Ivan (2021). Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling. NeuroImage. ISSN 1053-8119. 226 . doi: 10.1016/j.neuroimage.2020.117540 Full text in Research Archive. Show summary
Sleep deprivation influences several critical functions, yet how it affects human brain white matter (WM) is not well understood. The aim of the present work was to investigate the effect of 32 hours of sleep deprivation on WM microstructure compared to changes observed in a normal sleep-wake cycle (SWC). To this end, we utilised diffusion weighted imaging (DWI) including the diffusion tensor model, diffusion kurtosis imaging and the spherical mean technique, a novel biophysical diffusion model. 46 healthy adults (23 sleep deprived vs 23 with normal SWC) underwent DWI across four time points (morning, evening, next day morning and next day afternoon, after a total of 32 hours). Linear mixed models revealed significant group × time interaction effects, indicating that sleep deprivation and normal SWC differentially affect WM microstructure. Voxel-wise comparisons showed that these effects spanned large, bilateral WM regions. These findings provide important insight into how sleep deprivation affects the human brain
Wolfers, Thomas; Rokicki, Jaroslav; Alnæs, Dag; Berthet, Pierre; Agartz, Ingrid; Kia, Seyed Mostafa; Kaufmann, Tobias; Zabihi, Mariam; Moberget, Torgeir; Melle, Ingrid; Beckmann, Christian F.; Andreassen, Ole Andreas; Marquand, Andre F. & Westlye, Lars Tjelta (2021). Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder. Human Brain Mapping. ISSN 1065-9471. 42(8), s 2546- 2555 . doi: 10.1002/hbm.25386
Alnæs, Dag; Kaufmann, Tobias; Marquand, Andre; Smith, Stephen M. & Westlye, Lars Tjelta (2020). Patterns of sociocognitive stratification and perinatal risk in the child brain. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(22) . doi: 10.1073/pnas.2001517117
Anatürk, Melis; Kaufmann, Tobias; Cole, James H.; Suri, Sana; Griffanti, Ludovica; Zsoldos, Enikő; Filippini, Nicola; Singh-Manoux, Archana; Kivimäki, Mika; Westlye, Lars Tjelta; Ebmeier, Klaus & de Lange, Ann-Marie Glasø (2020). Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging. Human Brain Mapping. ISSN 1065-9471. . doi: 10.1002/hbm.25316 Full text in Research Archive.
Beck, Dani; de Lange, Ann-Marie Glasø; Maximov, Ivan; Richard, Geneviève; Andreassen, Ole Andreas; Nordvik, Jan E. & Westlye, Lars Tjelta (2020). White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction. NeuroImage. ISSN 1053-8119. 224:117441, s 1- 14 . doi: 10.1016/j.neuroimage.2020.117441 Full text in Research Archive.
Benjamin, Silje Beatrice Rognås; Valstad, Mathias; Elvsåshagen, Torbjørn; Jönsson, Erik Gunnar; Moberget, Torgeir; Winterton, Adriano; Haram, Marit; Høegh, Margrethe Collier; Lagerberg, Trine Vik; Steen, Nils Eiel; Larsen, Lars; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Quintana, Daniel (2020). Heart rate variability is associated with disease severity in psychosis spectrum disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 00:110108, s 1- 8 . doi: 10.1016/j.pnpbp.2020.110108 Full text in Research Archive.
Chen, Junfang; Cao, Han; Kaufmann, Tobias; Westlye, Lars Tjelta; Tost, Heike; Meyer-Lindenberg, Andreas & Schwarz, Emanuel (2020). Identification of reproducible BCL11A alterations in schizophrenia through individual-level prediction of coexpression. Schizophrenia Bulletin. ISSN 0586-7614. 46(5), s 1165- 1171 . doi: 10.1093/schbul/sbaa047 Full text in Research Archive.
Ching, Christopher R. K.; Hibar, Derrek P.; Gurholt, Tiril Pedersen; Nunes, Abraham; Thomopoulos, Sophia I.; Abé, Chritsoph; Agartz, Ingrid; Brouwer, Rachel M.; Cannon, Dara M.; de Zwarte, Sonja M. C.; Eyler, Lisa T.; Favre, Pauline; Hajek, Tomas; Haukvik, Unn Kristin H.; Houenou, Josselin; Zeng, Ling-Li; Almeida, Jorge; Alnæs, Dag; Alonso-Lana, Silvia; Altimus, Cara; Bauer, Michael; Baune, Bernhard T.; Bearden, Carrie E.; Bellani, Marcella; Benedetti, Francesco; Berk, Michael; Bilderbeck, Amy C.; Blumberg, Hilary P.; Bøen, Erlend; Bollettini, Irene; del Mar Bonnin, Caterina; Brambilla, Paolo; Díaz-Zuluaga, Ana M.; Dima, Danai; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Fears, Scott C.; Jansen, Andreas; Kircher, Tilo T.J.; Knochel, Christian; Krämer, Bernd; Tamnes, Christian Krog; Thomaidis, Georgios V.; Upegui, Cristian Vargas; Veltman, Dick J; Wessa, Michele; Westlye, Lars Tjelta; Whalley, Heather C.; Wolf, Daniel H.; Thompson, Paul M & Andreassen, Ole Andreas (2020). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping. ISSN 1065-9471. . doi: https://doi.org/10.1002/hbm.25098 Full text in Research Archive.
Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Alnæs, Dag; Doan, Nhat Trung; Agartz, Ingrid; Bertolino, Alessandro; Buitelaar, Jan; Coynel, David; Djurovic, Srdjan; Dørum, Erlend Solberg; Espeseth, Thomas; Fazio, Leonardo; Franke, Barbara; Frei, Oleksandr; Håberg, Asta; Le Hellard, Stephanie; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Lund, Martina Jonette; Moberget, Torgeir; Nordvik, Jan; Nyberg, Lars; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique; Rampino, Antonio; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Starrfelt, Jostein; Sønderby, Ida Elken; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry. ISSN 1359-4184. s 1- 8 . doi: 10.1038/s41380-020-0664-1 Full text in Research Archive.
de Lange, Ann-Marie Glasø; Anatürk, Melis; Suri, Sana; Kaufmann, Tobias; Cole, James H.; Griffanti, Ludovica; Zsoldos, Enikő; Jensen, Daria E.A.; Filippini, Nicola; Singh-Manoux, Archana; Kivimäki, Mika; Westlye, Lars Tjelta & Ebmeier, Klaus (2020). Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study. NeuroImage. ISSN 1053-8119. 222 . doi: https://doi.org/10.1016/j.neuroimage.2020.117292
de Lange, Ann-Marie Glasø; Barth, Claudia; Kaufmann, Tobias; Anatürk, Melis; Suri, Sana; Ebmeier, Klaus & Westlye, Lars Tjelta (2020). The maternal brain: region-specific patterns of brain aging are traceable decades after childbirth. Human Brain Mapping. ISSN 1065-9471. . doi: https://doi.org/10.1002/hbm.25152 Full text in Research Archive.
de Lange, Ann-Marie Glasø; Barth, Claudia; Kaufmann, Tobias; Maximov, Ivan; van der Meer, Dennis; Agartz, Ingrid & Westlye, Lars Tjelta (2020). Women's brain aging: effects of sex-hormone exposure, pregnancies, and genetic risk for Alzheimer's disease. Human Brain Mapping. ISSN 1065-9471. s 1- 10 . doi: 10.1002/hbm.25180 Full text in Research Archive.
Dørum, Erlend Solberg; Kaufmann, Tobias; Alnæs, Dag; Richard, Geneviève; Kolskår, Knut-Kristian; Engvig, Andreas; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Ihle-Hansen, Hege; Nordvik, Jan Egil & Westlye, Lars Tjelta (2020). Functional brain network modeling in sub-acute stroke patients and healthy controls during rest and continuous attentive tracking. Heliyon. ISSN 2405-8440. 6:e04854(9), s 1- 11 . doi: 10.1016/j.heliyon.2020.e04854 Full text in Research Archive.
Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K.; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A.; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J.; Høgestøl, Einar August; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; O`Connell, Kevin; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; de Quervain, Dominique; Reif, Andreas; Rokicki, Jaroslav; Van Rooij, Daan; Shadrin, Alexey A.; Schmidt, André; Schwarz, Emanuel; Selbæk, Geir; Sowa, Piotr; Soininen, Hilkka; Steen, Vidar Martin; Vellas, Bruno; Tsolaki, Magda; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications. ISSN 2041-1723. 11 . doi: 10.1038/s41467-020-17376-1 Full text in Research Archive. Show summary
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita; Hibar, DP; Lind, Penelope A.; Pizzagalli, Fabrizio; Ching, Christopher R.K.; McMahon, Mary Agnes B.; Shatokhina, Natalia; Zsembik, Leo C.P.; Thomopoulos, Sophia I.; Zhu, Alyssa H.; Strike, Lachlan T.; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Wolfers, Thomas; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Melle, Ingrid; Andreassen, Ole Andreas; Espeseth, Thomas; Jönsson, Erik Gunnar; Steen, Vidar Martin; Håberg, Asta; Trollor, Julian N.; Van Der Wee, Nic J.A.; Volzke, Henry; Walter, Henrik; Weber, Bernd; Weinberger, Daniel R.; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M. & Medland, Sarah E. (2020). The genetic architecture of the human cerebral cortex. Science. ISSN 0036-8075. 367(6484) . doi: 10.1126/science.aay6690 Full text in Research Archive. Show summary
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.
Hauger, Lisa Evju; Westlye, Lars Tjelta & Bjørnebekk, Astrid (2020). Anabolic androgenic steroid dependence is associated with executive dysfunction. Drug and Alcohol Dependence. ISSN 0376-8716. 208:107874, s 1- 8 . doi: 10.1016/j.drugalcdep.2020.107874 Full text in Research Archive.
Haukvik, Unn Kristin H.; Gurholt, Tiril Pedersen; Nerland, Stener; Elvsåshagen, Torbjørn; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T.; Benedetti, Francesco; Berk, Michael; Bettella, Francesco; Bøen, Erlend; Bonnín, Caterina M.; Brambilla, Paolo; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Dandash, Orwa; Dannlowski, Udo; Delvecchio, Giuseppe; Díaz-Zuluaga, Ana M.; van Erp, Theo G.M.; Fatjó-Vilas, Mar; Foley, Sonya F.; Förster, Katharina; Fullerton, Janice M.; Goikolea, Jose M.; Grotegerd, Dominik; Gruber, Oliver; Haarman, Bartholomeus C. M.; Haatveit, Beathe; Hajek, Tomas; Hallahan, Brian; Harris, Mathew; Hawkins, Emma L.; Howells, Fleur M.; Hülsmann, Carina; Jahanshad, Neda; Jørgensen, Kjetil Nordbø; Kircher, Tilo; Krämer, Bernd; Krug, Axel; Kuplicki, Rayus; Lagerberg, Trine Vik; Lancaster, Thomas M.; Lenroot, Rhoshel K.; Lonning, Vera Louise Hiorth; López-Jaramillo, Carlos; Malt, Ulrik Fredrik; McDonald, Colm; McIntosh, Andrew M.; McPhilemy, Genevieve; van der Meer, Dennis; Melle, Ingrid; Melloni, Elisa M. T.; Mitchell, Philip B.; Nabulsi, Leila; Nenadic, Igor; Oertel, Viola; Oldani, Lucio; Opel, Nils; Otaduy, Maria C. G.; Overs, Bronwyn; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Radua, Joaquim; Rauer, Lisa; Redlich, Ronny; Repple, Jonathan; Rive, Maria M.; Roberts, Gloria; Ruhe, Henricus G.; Salminen, Lauren E.; Salvador, Raymond; Sarró, Salvador; Savitz, Jonathan; Schene, Aart H.; Sim, Kang; Soeiro-de-Souza, Marcio G.; Stäblein, Michael; Stein, Dan J.; Stein, Frederike; Tamnes, Christian Krog; Temmingh, Henk S.; Thomopoulos, Sophia I.; Veltman, Dick J.; Vieta, Eduard; Waltemate, Lena; Westlye, Lars Tjelta; Whalley, Heather C.; Sämann, Philipp G.; Thompson, Paul M.; Ching, Christopher; Andreassen, Ole Andreas & Agartz, Ingrid (2020). In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group. Human Brain Mapping. ISSN 1065-9471. s 1- 14 . doi: 10.1002/hbm.25249 Full text in Research Archive.
Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Panizzon, Matthew S.; Andreassen, Ole Andreas; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Van Duijn, Cornelia M.; Grabe, Hans J.; Longstreth, William T.; Fornage, Myriam; Paus, Tomas; Debette, Stephanie; Ikram, M. Arfan; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Melle, Ingrid; Nordvik, Jan Egil; Steen, Vidar Martin; Espeseth, Thomas; Håberg, Asta; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M. & Medland, Sarah E. (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications. ISSN 2041-1723. 11 . doi: 10.1038/s41467-020-18367-y Full text in Research Archive.
Juvodden, Hilde Therese; Viken, Marte Kathrine; Nordstrand, Sebjørg Elizabeth Hesla; Viste, Rannveig; Westlye, Lars Tjelta; Thorsby, Per Medbøe; Lie, Benedicte Alexandra & Knudsen, Stine (2020). HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and first-degree relatives. Sleep. ISSN 0161-8105. 43(3), s 1- 11 . doi: 10.1093/sleep/zsz239 Full text in Research Archive.
Kia, Seyed Mostafa; Huijsdens, Hester; Dinga, Richard; Wolfers, Thomas; Mennes, Maarten; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Beckmann, Christian F. & Marquand, Andre (2020). Hierarchical bayesian regression for multi-site normative modeling of neuroimaging data. Lecture Notes in Computer Science (LNCS). ISSN 0302-9743. 12267, s 699- 709 . doi: 10.1007/978-3-030-59728-3_68
Koenig, Julian; Abler, Birgit; Agartz, Ingrid; Åkerstedt, Torbjørn; Andreassen, Ole Andreas; Anthony, Mia; Bär, Karl-Jürgen; Bertsch, Katja; Brown, Rebecca C.; Brunner, Romuald; Carnevali, Luca; Critchley, Hugo D.; Cullen, Kathryn R.; De Geus, Eco J C; de la Cruz, Feliberto; Dziobek, Isabel; Ferger, Marc D.; Fischer, Håkan; Flor, Herta; Gaebler, Michael; Gianaros, Peter J; Giummarra, Melita J.; Greening, Steven G.; Guendelman, Simon; Heathers, James A. J.; Herpertz, Sabine C.; Hu, Mandy X.; Jentschke, Sebastian; Kaess, Michael; Kaufmann, Tobias; Klimes-Dougan, Bonnie; Koelsch, Stefan; Krauch, Marlene; Kumral, Deniz; Lamers, Femke; Lee, Tae-Ho; Lekander, Mats; Lin, Feng; Lotze, Martin; Makovac, Elena; Mancini, Matteo; Mancke, Falk; Månsson, Kristoffer N. T.; Manuck, Stephen B.; Mather, Mara; Meeten, Frances; Min, Jungwon; Mueller, Bryon A.; Muench, Vera; Nees, Frauke; Nga, Lin; Nilsonne, Gustav; Ordonez Acuna, Daniela; Osnes, Berge; Ottaviani, Cristina; Penninx, Brenda; Ponzio, Allison; Poudel, Govinda R.; Reinelt, Janis; Ren, Ping; Sakaki, Michiko; Schumann, Andy; Sørensen, Lin; Specht, Karsten; Straub, Joana; Tamm, Sandra; Thai, Michelle; Thayer, Julian F.; Ubani, Benjamin; van der Mee, Denise J.; van Velzen, Laura S.; Ventura-Bort, Carlos; Villringer, Arno; Watson, David R.; Wei, Luqing; Wendt, Julia; Schreiner, Melinda Westlund; Westlye, Lars Tjelta; Weymar, Mathias; Winkelmann, Tobias; Wu, Guo-Rong; Yoo, Hyun Joo & Quintana, Daniel (2020). Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis. Psychophysiology. ISSN 0048-5772. . doi: 10.1111/psyp.13688 Full text in Research Archive. Show summary
Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega‐analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.
Kolskår, Knut-Kristian; Richard, Geneviève; Alnæs, Dag; Dørum, Erlend Solberg; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Monereo Sanchez, Jennifer; Ihle-Hansen, Hege; Nordvik, Jan Egil & Westlye, Lars Tjelta (2020). Reliability, sensitivity, and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors. Human Brain Mapping. ISSN 1065-9471. . doi: 10.1002/hbm.25284 Full text in Research Archive.
Leu, Costin; Richardson, Tom G.; Kaufmann, Tobias; van der Meer, Dennis; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Busch, Robyn M.; Smith, George Davey & Lal, Dennis (2020). Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population. PLOS ONE. ISSN 1932-6203. 15(4) . doi: 10.1371/journal.pone.0232292 Full text in Research Archive.
Liew, Sook-Lei; Zavaliangos-Petropulu, Artemis; Jahanshad, Neda; Lang, Catherine E.; Hayward, Kathryn S.; Lohse, Keith R.; Juliano, Julia M.; Assogna, Francesca; Baugh, Lee A.; Bhattacharya, Anup K.; Bigjahan, Bavrina; Borich, Michael R.; Boyd, Lara A.; Brodtmann, Amy; Buetefisch, Cathrin M.; Byblow, Winston D.; Cassidy, Jessica M.; Conforto, Adriana B.; Craddock, R. Cameron; Dimyan, Michael A.; Dula, Adrienne N.; Ermer, Elsa; Etherton, Mark R.; Fercho, Kelene A.; Gregory, Chris M.; Hadidchi, Shahram; Holguin, Jess A.; Hwang, Darryl H.; Jung, Simon; Kautz, Steven A.; Khlif, Mohamed Salah; Khoshab, Nima; Kim, Bokkyu; Kim, Hosung; Kuceyeski, Amy; Lotze, Martin; MacIntosh, Bradley J.; Margetis, John L.; Mohamed, Feroze B.; Piras, Fabrizio; Ramos-Murguialday, Ander; Richard, Geneviève; Roberts, Pamela; Robertson, Andrew D.; Rondina, Jane M.; Rost, Natalia S.; Sanossian, Nerses; Schweighofer, Nicolas; Seo, Na Jin; Shiroishi, Mark S.; Soekadar, Surjo R.; Spalletta, Gianfranco; Stinear, Cathy M.; Suri, Anisha; Tang, Wai Kwong W.; Thielman, Gregory T.; Vecchio, Daniela; Villringer, Arno; Ward, Nick S.; Werden, Emilio; Westlye, Lars Tjelta; Winstein, Carolee; Wittenberg, George F.; Wong, Kristin A.; Yu, Chunshui; Cramer, Steven C. & Thompson, Paul M. (2020). The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain - behavior relationships after stroke. Human Brain Mapping. ISSN 1065-9471. s 1- 20 . doi: 10.1002/hbm.25015 Full text in Research Archive.
Lund, Martina Jonette; Alnæs, Dag; Schwab, Simon; van der Meer, Dennis; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Kaufmann, Tobias (2020). Differences in directed functional brain connectivity related to age, sex and mental health. Human Brain Mapping. ISSN 1065-9471. 41(15), s 4173- 4186 . doi: 10.1002/hbm.25116 Full text in Research Archive.
Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2020). Maturation of cortical microstructure and cognitive development in childhood and adolescence: A T1w/T2w ratio MRI study. Human Brain Mapping. ISSN 1065-9471. 41(16), s 4676- 4690 . doi: 10.1002/hbm.25149 Full text in Research Archive.
Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Doan, Nhat Trung; Moberget, Torgeir; Kaufmann, Tobias; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2020). Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents. Translational Psychiatry. ISSN 2158-3188. 10(251) . doi: 10.1038/s41398-020-00931-1 Full text in Research Archive.
Olsen, Alexander; Babikian, Talin; Bigler, Erin D.; Caeyenberghs, Karen; Conde, Virginia; Dams-O’Connor, Kristen; Dobryakova, Ekaterina; Genova, Helen; Grafman, Jordan; Håberg, Asta; Heggland, Ingrid; Hellstrøm, Torgeir; Hodges, Cooper B.; Irimia, Andrei; Jha, Ruchira M.; Johnson, Paula K.; Koliatsos, Vassilis E.; Levin, Harvey; Li, Lucia M.; Lindsey, Hannah M.; Livny, Abigail; Løvstad, Marianne; Medaglia, John; Menon, David; Mondello, Stefania; Monti, Martin M.; Newcombe, Virginia F.J.; Petroni, Agustin; Ponsford, Jennie; Sharp, David; Spitz, Gershon; Westlye, Lars Tjelta; Thompson, Paul M.; Dennis, Emily L.; Tate, David; Wilde, Elisabeth A. & Hillary, Frank G. (2020). Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group. Brain Imaging and Behavior. ISSN 1931-7557. s 1- 29 . doi: 10.1007/s11682-020-00313-7 Full text in Research Archive.
Richard, Geneviève; Petersen, Anders; Ulrichsen, Kristine Moe; Kolskår, Knut-Kristian; Alnæs, Dag; Sanders, Anne-Marthe; Dørum, Erlend Solberg; Ihle-Hansen, Hege; Nordvik, Jan Egil & Westlye, Lars Tjelta (2020). TVA-based modeling of short-term memory capacity, speed of processing and perceptual threshold in chronic stroke patients undergoing cognitive training: Case-control differences, reliability, and associations with cognitive performance. PeerJ. ISSN 2167-8359. 8:e9948, s 1- 21 . doi: 10.7717/peerj.9948 Full text in Research Archive.
Rokicki, Jaroslav; Wolfers, Thomas; Nordhøy, Wibeke; Tesli, Natalia; Quintana, Daniel; Alnæs, Dag; Richard, Geneviève; de Lange, Ann-Marie Glasø; Lund, Martina Jonette; Norbom, Linn Christin Bonaventure; Agartz, Ingrid; Melle, Ingrid; Nærland, Terje; Selbæk, Geir; Persson, Karin Ester Torun; Nordvik, Jan Egil; Schwarz, Emanuel; Andreassen, Ole Andreas; Kaufmann, Tobias & Westlye, Lars Tjelta (2020). Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders. Human Brain Mapping. ISSN 1065-9471. s 1- 13 . doi: 10.1002/hbm.25323 Full text in Research Archive.
Schwarz, Emanuel; Alnæs, Dag; Andreassen, Ole Andreas; Cao, Han; Chen, Junfang; Degenhardt, Franziska; Doncevic, Daria; Dwyer, Dominic; Eils, Roland; Erdmann, Jeanette; Herrmann, Carl; Hofmann-Apitius, Martin; Kaufmann, Tobias; Koutsouleris, Nikolaos; Kodamullil, Alpha T.; Khuntia, A.; Mucha, Sören; Nöthen, Markus M.; Paul, Riya; Pedersen, Mads Lund; Quintero, Andres; Schunkert, Heribert; Sharma, Ashwini; Tost, Heike; Westlye, Lars Tjelta; Zhang, Youcheng & Meyer-Lindenberg, Andreas (2020). Identifying multimodal signatures underlying the somatic comorbidity of psychosis: the COMMITMENT roadmap. Molecular Psychiatry. ISSN 1359-4184. . doi: 10.1038/s41380-020-00915-z Full text in Research Archive.
Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Doan, Nhat Trung; Alnæs, Dag; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Maximov, Ivan; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Beck, Dani; Barch, Deanna M.; Beresniewicz, Justyna; Cervenka, Simon; Fatouros-Bergman, Helena; Craven, Alexander R.; Flyckt, Lena; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Hugdahl, Kenneth; Johnsen, Erik; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Kroken, Rune Andreas; Lagerberg, Trine Vik; Løberg, Else-Marie; Nordvik, Jan Egil; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2020). Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 5(12), s 1095- 1103 . doi: 10.1016/j.bpsc.2020.06.014 Full text in Research Archive.
Ulrichsen, Kristine Moe; Alnæs, Dag; Kolskår, Knut-Kristian; Richard, Geneviève; Sanders, Anne-Marthe; Dørum, Erlend Solberg; Ihle-Hansen, Hege; Pedersen, Mads Lund; Tornås, Sveinung; Nordvik, Jan Egil & Westlye, Lars Tjelta (2020). Dissecting the cognitive phenotype of post-stroke fatigue using computerized assessment and computational modeling of sustained attention. European Journal of Neuroscience. ISSN 0953-816X. 52(7), s 3828- 3845 . doi: 10.1111/ejn.14861 Full text in Research Archive.
Valstad, Mathias; Moberget, Torgeir; Roelfs, Daniël Thomas Heimen; Slapø, Nora Berz; Timpe, Clara Marie Fides; Beck, Dani; Richard, Geneviève; Sæther, Linn Sofie; Haatveit, Beathe Christin; Skaug, Knut-André; Nordvik, Jan Egil; Hatlestad-Hall, Christoffer; Einevoll, Gaute; Mäki-Marttunen, Tuomo; Westlye, Lars Tjelta; Jönsson, Erik Gunnar; Andreassen, Ole Andreas & Elvsåshagen, Torbjørn (2020). Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals. NeuroImage. ISSN 1053-8119. . doi: 10.1016/j.neuroimage.2020.117302 Full text in Research Archive.
van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Chen, Chi-Hua; Thompson, Wesley K.; O'Connell, Kevin S.; Monereo Sanchez, Jennifer; Linden, David E.J.; Westlye, Lars Tjelta; Dale, Anders M & Andreassen, Ole Andreas (2020). Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area. Cerebral Cortex. ISSN 1047-3211. 30(10), s 5597- 5603 . doi: 10.1093/cercor/bhaa146 Full text in Research Archive.
van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey A.; Devor, Anna; Smeland, Olav Bjerkehagen; Thompson, Wesley Kurt; Fan, Chun Chieh; Holland, Dominic; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Dale, Anders (2020). Understanding the genetic determinants of the brain with MOSTest. Nature Communications. ISSN 2041-1723. 11:3512, s 1- 9 . doi: 10.1038/s41467-020-17368-1
Wierenga, Lara M.; Doucet, Gaëlle E.; Dima, Danai; Agartz, Ingrid; Aghajani, Moji; Akudjedu, Theophilus N.; Albajes-Eizagirre, Anton; Alnæs, Dag; Alpert, Kathryn I.; Andreassen, Ole Andreas; Anticevic, Alan; Gurholt, Tiril Pedersen; De Haan, Lieuwe; Haatveit, Beathe Christin; Jönsson, Erik Gunnar; Joska, John; Kalnin, Andrew J.; Klein, Marieke; Koenders, Laura; Kolskår, Knut-Kristian; van der Meer, Dennis; Menchon, José M.; Naaijen, Jilly; Nyberg, Lars; Oosterlaan, Jaap; Paloyelis, Yannis; Pauli, Paul; Pergola, Giulio; Pomarol-Clotet, Edith; Portella, Maria J.; Radua, Joaquim; Reif, Andreas; Richard, Geneviéve´; Weber, Bernd; Wen, Wei; West, John D.; Westlye, Lars Tjelta; Whalley, Heather C.; Williams, Steven Charles Rees; Wittfeld, Katharina; Wolf, Daniel H.; Wright, Margaret J.; Yoncheva, Yuliya N.; Zanetti, Marcus V.; Ziegler, Georg C.; de Zubicaray, Greig I.; Thompson, Paul M.; Crone, Eveline A.; Frangou, Sophia & Tamnes, Christian Krog (2020). Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping. ISSN 1065-9471. . doi: 10.1002/hbm.25204 Full text in Research Archive.
Winterton, Adriano; Rødevand, Linn; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Associations of loneliness and social isolation with cardiovascular and metabolic health: A systematic review and meta-analysis protocol. Systematic Reviews. ISSN 2046-4053. 9(1) . doi: 10.1186/s13643-020-01369-8 Full text in Research Archive.
Winterton, Adriano; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole Andreas & Quintana, Daniel (2020). Improving the precision of intranasal oxytocin research. Nature Human Behaviour. ISSN 2397-3374. s 1- 10 . doi: 10.1038/s41562-020-00996-4
Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia; Djurovic, Srdjan; Melle, Ingrid; van der Meer, Dennis; Martin-Ruiz, Carmen; Steen, Nils Eiel; Agartz, Ingrid & Andreassen, Ole Andreas (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational Psychiatry. ISSN 2158-3188. 9 . doi: 10.1038/s41398-019-0432-7 Full text in Research Archive.
Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav; Moberget, Torgeir; Bettella, Francesco; Agartz, Ingrid; Barch, Deanna M.; Bertolino, Alessandro; Brandt, Christine Lycke; Cervenka, Simon; Djurovic, Srdjan; Doan, Nhat Trung; Eisenacher, Sarah; Fatouros-Bergman, Helena; Flyckt, Lena; di Giorgio, Annabella; Haatveit, Beathe; Jönsson, Erik Gunnar; Kirsch, Peter; Lund, Martina Jonette; Meyer-Lindenberg, Andreas; Pergola, Giulio; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Quarto, Tiziana; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry. ISSN 2168-6238. 76(7), s 739- 748 . doi: 10.1001/jamapsychiatry.2019.0257
Bjørnebekk, Astrid; Westlye, Lars Tjelta; Walhovd, Kristine B; Jørstad, Marie Lindvik; Sundset, Øyvind & Fjell, Anders Martin (2019). Cognitive Performance and Structural Brain Correlates in Long-Term Anabolic-Androgenic Steroid Exposed and Nonexposed Weightlifters. Neuropsychology. ISSN 0894-4105. 33(4), s 547- 559 . doi: 10.1037/neu0000537
de Lange, Ann-Marie Glasø; Kaufmann, Tobias; van der Meer, Dennis; Maglanoc, Luigi Angelo; Alnæs, Dag; Moberget, Torgeir; Douaud, Gwenaëlle; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Population-based neuroimaging reveals traces of childbirth in the maternal brain. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 116(44), s 22341- 22346 . doi: 10.1073/pnas.1910666116
Grydeland, Håkon; Vértes, Petra; Váša, František; Romero-Garcia, Rafael; Whitaker, Kirstie; Aaron F., Alexander-Bloch; Bjørnerud, Atle; Patel, Ameera X.; Sederevicius, Donatas; Tamnes, Christian Krog; Westlye, Lars Tjelta; White, Simon; Walhovd, Kristine B; Fjell, Anders Martin & Bullmore, Edward T. (2019). Waves of Maturation and Senescence in Microstructural MRI Markers of Human Cortical Myelination over the Lifespan. Cerebral Cortex. ISSN 1047-3211. 29(3), s 1369- 1381 . doi: 10.1093/cercor/bhy330 Full text in Research Archive.
Hauger, Lisa Evju; Westlye, Lars Tjelta; Fjell, Anders Martin; Walhovd, Kristine B & Bjørnebekk, Astrid (2019). Structural brain characteristics of anabolic-androgenic steroid dependence in men. Addiction. ISSN 0965-2140. s 1- 11 . doi: 10.1111/add.14629
Høgestøl, Einar August; Kaufmann, Tobias; Nygaard, Gro Owren; Beyer, Mona K.; Sowa, Piotr; Nordvik, Jan Egil; Kolskår, Knut-Kristian; Richard, Geneviève; Andreassen, Ole Andreas; Harbo, Hanne Flinstad & Westlye, Lars Tjelta (2019). Cross-sectional and longitudinal MRI brain scans reveal accelerated brain aging in multiple sclerosis. Frontiers in Neurology. ISSN 1664-2295. 10:450, s 1- 9 . doi: 10.3389/fneur.2019.00450 Full text in Research Archive.
Høgestøl, Einar August; Nygaard, Gro Owren; Alnæs, Dag; Beyer, Mona K.; Westlye, Lars Tjelta & Harbo, Hanne Flinstad (2019). Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis. PLOS ONE. ISSN 1932-6203. 14(4) . doi: 10.1371/journal.pone.0210375 Full text in Research Archive.
Izzo, Jessica; Andreassen, Ole Andreas; Westlye, Lars Tjelta & van der Meer, Dennis (2019). The association between hippocampal subfield volumes in mild cognitive impairment and conversion to Alzheimer’s disease. Brain Research. ISSN 0006-8993. s 1- 7 . doi: 10.1016/j.brainres.2019.146591
Jiang, Wenhao; Andreassen, Ole Andreas; Agartz, Ingrid; Lagerberg, Trine Vik; Westlye, Lars Tjelta; Calhoun, Vince D. & Turner, Jessica A. (2019). Distinct structural brain circuits indicate mood and apathy profiles in bipolar disorder.. NeuroImage: Clinical. ISSN 2213-1582. s 1- 9 . doi: 10.1016/j.nicl.2019.101989 Full text in Research Archive.
Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Dietrichs, Espen; Thorsby, Per Medbøe; Westlye, Lars Tjelta & Knudsen, Stine (2019). Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing. Sleep. ISSN 0161-8105. 42:zsz082(7), s 1- 12 . doi: 10.1093/sleep/zsz082 Full text in Research Archive.
Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22(10), s 1617- 1623 . doi: 10.1038/s41593-019-0471-7 Full text in Research Archive.
Maglanoc, Luigi Angelo; Kaufmann, Tobias; Jonassen, Rune; Hilland, Eva; Beck, Dani; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis. Human Brain Mapping. ISSN 1065-9471. . doi: 10.1002/hbm.24802 Full text in Research Archive.
Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas; Jonassen, Rune; Hilland, Eva; Andreassen, Ole Andreas; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Brain connectome mapping of complex human traits and their polygenic architecture using machine learning. Biological Psychiatry. ISSN 0006-3223. s 1- 10 . doi: 10.1016/j.biopsych.2019.10.011 Full text in Research Archive. Show summary
Background Mental disorders and individual characteristics such as intelligence and personality are complex traits sharing a largely unknown neuronal basis. Their genetic architectures are highly polygenic and overlapping, which is supported by heterogeneous phenotypic expression and substantial clinical overlap. Brain network analysis provides a non-invasive means of dissecting biological heterogeneity yet its sensitivity, specificity and validity in assessing individual characteristics relevant for brain function and mental health and their genetic underpinnings in clinical applications remains a challenge. Methods In a machine learning approach, we predicted individual scores for educational attainment, fluid intelligence and dimensional measures of depression, anxiety and neuroticism using fMRI-based static and dynamic temporal synchronization between large-scale brain network nodes in 10,343 healthy individuals from the UK Biobank. In addition to age and sex to serve as our reference point, we also predicted individual polygenic scores for related phenotypes, and 13 different neuroticism traits and schizophrenia. Results Beyond high accuracy for age and sex, supporting the biological sensitivity of the connectome-based features, permutation tests revealed above chance-level prediction accuracy for trait-level educational attainment and fluid intelligence. Educational attainment and fluid intelligence were mainly negatively associated with static brain connectivity in frontal and default mode networks, whereas age showed positive correlations with a more widespread pattern. In contrast, prediction accuracy was at chance level for depression, anxiety, neuroticism and polygenic scores across traits. Conclusion These novel findings provide a benchmark for future studies linking the genetic architecture of individual and mental health traits with fMRI-based brain connectomics.
Maglanoc, Luigi Angelo; Kaufmann, Tobias; van der Meer, Dennis; Marquand, André F.; Wolfers, Thomas; Jonassen, Rune; Hilland, Eva; Andreassen, Ole Andreas; Landrø, Nils Inge & Westlye, Lars Tjelta (2019). Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics. Nature Neuroscience. ISSN 1097-6256. . doi: 10.1101/609586
Mäki-Marttunen, Tuomo; Kaufmann, Tobias; Elvsåshagen, Torbjørn; Devor, Anna; Djurovic, Srdjan; Westlye, Lars Tjelta; Linne, Marja-Leena; Rietschel, Marcella; Schubert, Dirk; Borgwardt, Stefan; Efrim-Budisteanu, Magdalena; Bettella, Francesco; Halnes, Geir; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Edwards, Andrew G.; Metzner, Christoph; Fyhn, Marianne; Dale, Anders M.; Einevoll, Gaute & Andreassen, Ole Andreas (2019). Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.. Frontiers in Psychiatry. ISSN 1664-0640. 10 . doi: 10.3389/fpsyt.2019.00534 Full text in Research Archive.
Maximov, Ivan; Alnæs, Dag & Westlye, Lars Tjelta (2019). Towards an optimised processing pipeline for diffusion magnetic resonance imaging data: Effects of artefact corrections on diffusion metrics and their age associations in UK Biobank. Human Brain Mapping. ISSN 1065-9471. 40, s 4146- 4162 . doi: https://doi.org/10.1002/hbm.24691 Full text in Research Archive.
Moberget, Torgeir; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence. Biological Psychiatry. ISSN 0006-3223. 86(1), s 65- 75 . doi: 10.1016/j.biopsych.2019.01.019 Full text in Research Archive.
Ousdal, Olga Therese; Kaufmann, Tobias; Kolskår, Knut-Kristian; Vik, Alexandra; Wehling, Eike; Lundervold, Astri; Lundervold, Arvid & Westlye, Lars Tjelta (2019). Longitudinal stability of the brain functional connectome is associated with episodic memory performance in aging. Human Brain Mapping. ISSN 1065-9471. 41, s 697- 709 . doi: 10.1002/hbm.24833 Full text in Research Archive.
Quintana, Daniel; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Kaufmann, Tobias; Còrdova Palomera, Aldo; Dieset, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Oxytocin pathway gene networks in the human brain. Nature Communications. ISSN 2041-1723. 10(1) . doi: 10.1038/s41467-019-08503-8 Full text in Research Archive.
Richard, Geneviève; Kolskår, Knut-Kristian; Ulrichsen, Kristine Moe; Kaufmann, Tobias; Alnæs, Dag; Sanders, Anne-Marthe; Dørum, Erlend Solberg; Monereo Sanchez, Jennifer; Petersen, Anders; Ihle-Hansen, Hege; Nordvik, Jan Egil & Westlye, Lars Tjelta (2019). Brain age prediction in stroke patients: Highly reliable but limited sensitivity to cognitive performance and response to cognitive training. NeuroImage: Clinical. ISSN 2213-1582. 25, s 1- 11 . doi: 10.1016/j.nicl.2019.102159 Full text in Research Archive.
Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J.; Stein, Jason L.; Scholz, Markus; Sargurupremraj, Muralidharan; Jahanshad, Neda; Roshchupkin, Gennady V.; Smith, Albert V.; Bis, Joshua C.; Jian, Xueqiu; Luciano, Michelle; Hofer, Edith; Teumer, Alexander; van der Lee, Sven J.; Yang, Jingyun; Yanek, Lisa R.; Lee, Tom V.; Li, Shuo; Hu, Yanhui; Koh, Jia Yu; Eicher, John D.; Desrivières, Sylvane; Arias-Vasquez, Alejandro; Chauhan, Ganesh; Athanasiu, Lavinia; Rentería, Miguel E.; Kim, Sungeun; Hoehn, David; Armstrong, Nicola J.; Chen, Qiang; Holmes, Avram J.; den Braber, Anouk; Kloszewska, Iwona; Andersson, Micael; Espeseth, Thomas; Grimm, Oliver; Abramovic, Lucija; Alhusaini, Saud; Milaneschi, Yuri; Papmeyer, Martina; Axelsson, Tomas; Ehrlich, Stefan; Roiz-Santiáñez, Roberto; Kraemer, Bernd; Håberg, Asta; Jones, Hannah J; Pike, G. Bruce; Stein, Dan J.; Stevens, Allison; Bralten, Janita; Vernooij, Meike W.; Harris, Tamara B.; Filippi, Irina; Witte, A Veronica; Guadalupe, Tulio; Wittfeld, Katharina; Mosley, Thomas H.; Becker, James T.; Hagenaars, Saskia P.; Saba, Yasaman; Cuellar-Partida, Gabriel; Amin, Najaf; Hilal, Saima; Nho, Kwangsik; Mirza-Schreiber, Nazanin; Arfanakis, Konstantinos; Becker, Diane M.; Ames, David; Goldman, Aaron L.; Lee, Phil H.; Boomsma, Dorret I.; Lovestone, Simon; Giddaluru, Sudheer; Le Hellard, Stephanie; Mattheisen, Manuel; Bohlken, Marc M.; Kasperaviciute, Dalia; Schmaal, Lianne; Lawrie, Stephen M.; Agartz, Ingrid; Walton, Esther; Tordesillas-Gutierrez, Diana; Davies, Gareth E.; Shin, Jean; Ipser, Jonathan C.; Vinke, Louis N.; Hoogman, Martine; Jia, Tianye; Burkhardt, Ralph; Klein, Marieke; Crivello, Fabrice; Janowitz, Deborah; Carmichael, Owen; Haukvik, Unn Kristin H.; Aribisala, Benjamin S.; Schmidt, Helena; Strike, Lachlan T.; Cheng, Ching-Yu; Risacher, Shannon L.; Putz, Benno; Fleischman, Debra A.; Assareh, Amelia A.; Mattay, Venkata S.; Buckner, Randy L.; Mecocci, Patrizia; Dale, Anders; Cichon, Sven; Boks, Marco P.; Matarin, Mar; Penninx, Brenda W.J.H.; Calhoun, Vince D.; Chakravarty, M. Mallar; Marquand, André F.; Macare, Christine; Kharabian Masouleh, Shahrzad; Oosterlaan, Jaap; Amouyel, Philippe; Hegenscheid, Katrin; Rotter, Jerome I.; Schork, Andrew J.; Liewald, David C.M.; de Zubicaray, Greig I.; Wong, Tien Yin; Shen, Li; Sämann, Philipp G.; Brodaty, Henry; Roffman, Joshua L.; de Geus, Eco J.C.; Tsolaki, Magda; Erk, Susanne; van Eijk, Kristel R.; Cavalleri, Gianpiero L.; Van Der Wee, Nic J.A.; McIntosh, Andrew M.; Gollub, Randy L.; Bulayeva, Kazima B.; Bernard, Manon; Richards, Jennifer S.; Himali, Jayandra J.; Loeffler, Markus; Rommelse, Nanda; Hoffmann, Wolfgang; Westlye, Lars Tjelta; Valdés Hernández, Maria C.; Hansell, Narelle K.; van Erp, Theo G.M.; Wolf, Christiane; Kwok, John B.J.; Vellas, Bruno; Heinz, Andreas; Olde Loohuis, Loes M.; Delanty, Norman; Ho, Beng-Choon; Ching, Christopher R.K.; Shumskaya, Elena; Singh, Baljeet; Hofman, Albert; Homuth, Georg; Psaty, Bruce M.; Bastin, Mark E.; Montgomery, Grant W.; Foroud, Tatiana M.; Reppermund, Simone; Hottenga, Jouke-Jan; Simmons, Andrew; Meyer-Lindenberg, Andreas; Cahn, Wiepke; Whelan, Christopher D; van Donkelaar, Marjolein M.J.; Yang, Qiong; Hosten, Norbert; Green, Robert C.; Thalamuthu, Anbupalam; Mohnke, Sebastian; Hulshoff Pol, Hilleke E.; Lin, Honghuang; Jack, Clifford R.; Schofield, Peter R.; Mühleisen, Thomas W.; Maillard, Pauline; Potkin, Steven G.; Wen, Wei; Fletcher, Evan; Toga, Arthur W.; Gruber, Oliver; Huentelman, Matthew; Davey Smith, George; Launer, Lenore J.; Nyberg, Lars; Jönsson, Erik Gunnar; Crespo-Facorro, Benedicto; Koen, Nastassja; Greve, Douglas N.; Uitterlinden, André G.; Weinberger, Daniel R.; Steen, Vidar Martin; Fedko, Iryna O.; Groenewold, Nynke A.; Niessen, Wiro J.; Toro, Roberto; Tzourio, Christophe; Longstreth, William T.; Ikram, M. Kamran; Smoller, Jordan W.; van Tol, Marie-Jose; Sussmann, Jessika E.; Paus, Tomáš; Lemaître, Hervé; Schroeter, Matthias L.; Mazoyer, Bernard; Andreassen, Ole Andreas; Holsboer, Florian; Depondt, Chantal; Veltman, Dick J.; Turner, Jessica A.; Pausova, Zdenka; Schumann, Gunter; van Rooij, Daan; Djurovic, Srdjan; Deary, Ian J.; McMahon, Katie L; Müller-Myhsok, Bertram; Brouwer, Rachel M.; Soininen, Hilkka; Pandolfo, Massimo; Wassink, Thomas H.; Cheung, Joshua W.; Wolfers, Thomas; Martinot, Jean-Luc; Zwiers, Marcel P.; Nauck, Matthias; Melle, Ingrid; Martin, Nicholas G.; Kanai, Ryota; Westman, Eric; Kahn, René S.; Sisodiya, Sanjay M.; White, Tonya; Saremi, Arvin; van Bokhoven, Hans; Brunner, Han G.; Völzke, Henry; Wright, Margaret J.; van `t Ent, Dennis; Nöthen, Markus M.; Ophoff, Roel A.; Buitelaar, Jan K.; Fernandéz, Guillén; Sachdev, Perminder S.; Rietschel, Marcella; van Haren, Neeltje E.M.; Fisher, Simon E.; Beiser, Alexa S.; Francks, Clyde; Saykin, Andrew J.; Mather, Karen A.; Romanczuk-Seiferth, Nina; Hartman, Catharina A.; DeStefano, Anita L; Heslenfeld, Dirk J.; Weiner, Michael W.; Walter, Henrik; Hoekstra, Pieter J.; Nyquist, Paul A.; Franke, Barbara; Bennett, David A.; Grabe, Hans J.; Johnson, Andrew D.; Chen, Christopher; van Duijn, Cornelia M.; Lopez, Oscar L.; Fornage, Myriam; Wardlaw, Joanna M.; Schmidt, Reinhold; DeCarli, Charles; De Jager, Philip L.; Villringer, Arno; Debette, Stéphanie; Gudnason, Vilmundur; Medland, Sarah E.; Shulman, Joshua M.; Thompson, Paul M.; Seshadri, Sudha; Ikram, M. Arfan; Doan, Nhat Trung & van der Meer, Dennis (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics. ISSN 1061-4036. 51, s 1624- 1636 . doi: 10.1038/s41588-019-0511-y Full text in Research Archive. Show summary
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
Schwarz, Emanuel; Doan, Nhat Trung; Pergola, Giulio; Westlye, Lars Tjelta; Kaufmann, Tobias; Wolfers, Thomas; Brecheisen, Ralph; Quarto, Tiziana; Ing, Alex J.; di Carlo, Pasquale; Gurholt, Tiril Pedersen; Harms, Robbert L.; Noirhomme, Quentin; Moberget, Torgeir; Agartz, Ingrid; Andreassen, Ole Andreas; Bellani, Marcella; Bertolino, Alessandro; Blasi, Giuseppe; Brambilla, Paolo; Buitelaar, Jan K.; Cervenka, Simon; Flyckt, Lena; Frangou, Sophia; Franke, Barbara; Hall, Jeremy; Heslenfeld, Dirk J.; Kirsch, Peter; McIntosh, Andrew M.; Nöthen, Markus M.; Papassotiropoulos, Andreas; de Quervain, Dominique J.F.; Rietschel, Marcella; Schumann, Gunter; Tost, Heike; Witt, Stephanie H.; Zink, Mathias & Meyer-Lindenberg, Andreas (2019). Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder. Translational Psychiatry. ISSN 2158-3188. 9(12) . doi: 10.1038/s41398-018-0225-4 Full text in Research Archive.
Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta & Bellivier, Frank (2019). Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. ISSN 2194-7511. 7(1), s 1- 10 . doi: 10.1186/s40345-019-0156-x Full text in Research Archive.
Smith, Steve; Duff, Eugene; Groves, Adrian; Nichols, Thomas E.; Jbabdi, Saad; Westlye, Lars Tjelta; Tamnes, Christian Krog; Engvig, Andreas; Walhovd, Kristine B; Fjell, Anders Martin; Johansen-Berg, Heidi & Douaud, Gwenaëlle (2019). Structural variability in the human brain reflects fine-grained functional architecture at the population level. Journal of Neuroscience. ISSN 0270-6474. 39(31), s 6136- 6149 . doi: 10.1523/JNEUROSCI.2912-18.2019 Full text in Research Archive.
Tesli, Natalia; Westlye, Lars Tjelta; Storvestre, Guttorm Breivik; Gurholt, Tiril Pedersen; Agartz, Ingrid; Melle, Ingrid; Andreassen, Ole Andreas & Haukvik, Unn Kristin H. (2019). White matter microstructure in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. . doi: 10.1007/s00406-019-00988-0
van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel; Ames, David; Amunts, Katrin; Andersson, Micael; Armstrong, Nicola J.; Bernard, Manon; Blackburn, Nicholas B.; Blangero, John; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Bülow, Robin; Cahn, Wiepke; Calhoun, Vince D.; Caspers, Svenja; Cavalleri, Gianpiero L.; Ching, Christopher R.K.; Cichon, Sven; Ciufolini, Simone; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Dalvie, Shareefa; Dazzan, Paola; de Geus, Eco J.C.; de Zubicaray, Greig I.; de Zwarte, Sonja M.C.; Delanty, Norman; den Braber, Anouk; Desrivieres, Sylvane; di Forti, Marta; Doherty, Joanne L.; Donohoe, Gary; Ehrlich, Stefan; Eising, Else; Espeseth, Thomas; Fisher, Simon E.; Fladby, Tormod; Frei, Oleksandr; Frouin, Vincent; Fukunaga, Masaki; Gareau, Thomas; Glahn, David C.; Grabe, Hans J.; Groenewold, Nynke A.; Gustafsson, Omar; Haavik, Jan; Håberg, Asta; Hashimoto, Ryota; Hehir-Kwa, Jayne Y.; Hibar, Derrek; Hillegers, Manon H.J.; Hoffmann, Per; Holleran, Laurena; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Ikeda, Masashi; Jacquemont, Sébastien; Jahanshad, Neda; Jockwitz, Christiane; Johansson, Stefan; Jönsson, Erik Gunnar; Kikuchi, Masataka; Knowles, Emma E.M.; Kwok, John B.; Le Hellard, Stephanie; Linden, David E.J.; Liu, Jingyu; Lundervold, Arvid; Lundervold, Astri; Martin, Nicholas G.; Mather, Karen A.; Mathias, Samuel R.; McMahon, Katie L.; McRae, Allan F.; Medland, Sarah E.; Moberget, Torgeir; Moreau, Clara; Morris, Derek W.; Mühleisen, Thomas W.; Murray, Robin M.; Nordvik, Jan Egil; Nyberg, Lars; Olde Loohuis, Loes M.; Ophoff, Roel A.; Owen, Michael J.; Paus, Tomáš; Pausova, Zdenka; Peralta, Juan M.; Pike, Bruce; Prieto, Carlos; Quinlan, Erin Burke; Reinbold, Céline Sonja; Reis Marques, Tiago; Rucker, James J.H.; Sachdev, Perminder S.; Sando, Sigrid Botne; Schofield, Peter R.; Schork, Andrew J.; Schumann, Gunter; Shin, Jean; Shumskaya, Elena; Silva, Ana I.; Sisodiya, Sanjay M.; Steen, Vidar Martin; Stein, Dan J.; Strike, Lachlan T.; Tamnes, Christian Krog; Teumer, Alexander; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; Uhlmann, Anne; Ülfarsson, Magnús Ö; van 't Ent, Dennis; van den Bree, Marianne B.M.; Vassos, Evangelos; Wen, Wei; Wittfeld, Katharina; Wright, Margaret J.; Zayats, Tetyana; Dale, Anders; Djurovic, Srdjan; Agartz, Ingrid; Westlye, Lars Tjelta; Stefansson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry. ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2019.3779 Show summary
IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders
Zak, Nathalia; Bøen, Erlend; Boye, Birgitte; Andreassen, Ole Andreas; Doan, Nhat Trung; Malt, Ulrik Fredrik; Westlye, Lars Tjelta & Elvsåshagen, Torbjørn (2019). Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II. Bipolar Disorders. ISSN 1398-5647. 21, s 525- 538 . doi: 10.1111/bdi.12771 Full text in Research Archive.
Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Wang, Yunpeng; Bettella, Francesco; Moberget, Torgeir; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents. JAMA psychiatry. ISSN 2168-6238. 75(3), s 287- 295 . doi: 10.1001/jamapsychiatry.2017.4277
Chen, Jiayu; Calhoun, Vince D.; Lin, Dongdong; Perrone-Bizzozero, Nora I.; Bustillo, Juan R.; Pearlson, Godfrey D.; Potkin, Steven G.; Van Erp, Theo G.M.; Macciardi, Fabio; Ehrlich, Stefan; Ho, Beng-Choon; Sponheim, Scott R.; Wang, Lei; Stephen, Julia M.; Mayer, Julia M.; Hanlon, Faith M.; Jung, Rex E.; Clementz, Brett A.; Keshavan, Matcheri S.; Gershon, Elliot S.; Sweeney, John A.; Tamminga, Carol A.; Andreassen, Ole Andreas; Agartz, Ingrid; Westlye, Lars Tjelta; Sui, Jing; Du, Yuhui; Turner, Jessica A. & Liu, Jingyuan (2018). Shared genetic risk of schizophrenia and gray matter reduction in 6p22.1. Schizophrenia Bulletin. ISSN 0586-7614. 45(1), s 222- 232 . doi: 10.1093/schbul/sby010
Còrdova Palomera, Aldo; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; van der Meer, Dennis; Alnæs, Dag; Rokicki, Jaroslav; Moberget, Torgeir; Sønderby, Ida Elken; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics. ISSN 1018-4813. 26(7), s 1049- 1059 . doi: 10.1038/s41431-018-0134-2
Elvsåshagen, Torbjørn; Mutsaerts, Henri J.M.M; Zak, Nathalia; Norbom, Linn Christin Bonaventure; Quiraishi, Sophia; Pedersen, Per Øystein Heiberg; Malt, Ulrik Fredrik; Westlye, Lars Tjelta; van Someren, Eus; Bjørnerud, Atle & Groote, Inge Rasmus (2018). Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation. NeuroImage. ISSN 1053-8119. 186, s 497- 509 . doi: 10.1016/j.neuroimage.2018.11.032 Show summary
Elucidating the neurobiological effects of sleep and wake is an important goal of the neurosciences. Whether and how human cerebral blood flow (CBF) changes during the sleep-wake cycle remain to be clarified. Based on the synaptic homeostasis hypothesis of sleep and wake, we hypothesized that a day of wake and a night of sleep deprivation would be associated with gray matter resting CBF (rCBF) increases and that sleep would be associated with rCBF decreases. Thirty-eight healthy adult males (age 22.1 ± 2.5 years) underwent arterial spin labeling perfusion magnetic resonance imaging at three time points: in the morning after a regular night's sleep, the evening of the same day, and the next morning, either after total sleep deprivation (n = 19) or a night of sleep (n = 19). All analyses were adjusted for hematocrit and head motion. rCBF increased from morning to evening and decreased after a night of sleep. These effects were most prominent in bilateral hippocampus, amygdala, thalamus, and in the occipital and sensorimotor cortices. Group × time interaction analyses for evening versus next morning revealed significant interaction in bilateral lateral and medial occipital cortices and in bilateral insula, driven by rCBF increases in the sleep deprived individuals and decreases in the sleepers, respectively. Furthermore, group × time interaction analyses for first morning versus next morning showed significant effects in medial and lateral occipital cortices, in anterior cingulate gyrus, and in the insula, in both hemispheres. These effects were mainly driven by CBF increases from TP1 to TP3 in the sleep deprived individuals. There were no associations between the rCBF changes and sleep characteristics, vigilant attention, or subjective sleepiness that remained significant after adjustments for multiple analyses. Altogether, these results encourage future studies to clarify mechanisms underlying sleep-related rCBF changes.
Hibar, Derrek; Westlye, Lars Tjelta; Doan, Nhat Trung; Jahanshad, Neda; Cheung, J. W.; Ching, Christopher R K; Versace, Amelia; Bilderbeck, A; Uhlmann, Anne; Mwangi, B; Krämer, B; Overs, B; Hartberg, Cecilie Bhandari; Abé, Christoph; Dima, Danai; Grotegerd, Dominik; Sprooten, Emma; Bøen, Erlend; Jimenez, Enrique; Howells, Fleur M.; Delvecchio, G; Temmingh, H; Starke, J; Almeida, JRC; Goikolea, JM; Houenou, J; Beard, Lauren M.; Rauer, L; Abramovic, Lucija; Bonnin, M.; Ponteduro, MF; Keil, M; Rive, MM; Yao, N; Yalin, N; Najt, P; Rosa, PG; Redlich, Ronny; Trost, S; Hagenaars, Saskia; Fears, SC; Alonso-Lana, S; Van Erp, TGM; Nickson, Thomas; Chaim-Avancini, TM; Meier, TB; Elvsåshagen, Torbjørn; Haukvik, Unn Kristin H.; Lee, Who-Seung; Schene, AH; Lloyd, AJ; Young, AH; Nugent, Allison C; Dale, AM; Pfennig, Andrea; McIntosh, AM; Lafer, Beny; Baune, BT; Ekman, CJ; Zarate, CA; Bearden, CE; Henry, C; Simhandl, Christian; McDonald, C; Bourne, C; Stein, DJ; Wolf, DH; Cannon, DM; Glahn, DC; Veltman, DJ; Pomarol-Clotet, E; Vieta, E; Canales-Rodriguez, EJ; Nery, FG; Duran, FLS; Busatto, GF; Roberts, G; Pearlson, GD; Goodwin, GM; Kugel, H; Whalley, HC; Ruhe, HG; Soares, JC; Fullerton, JM; Rybakowski, JK; Savitz, Jonathan; Chaim, KT; Fatjo-Vilas, Mar; Soeiro-de-Souza, MG; Boks, MP; Zanetti, MV; Otaduy, MCG; Schaufelberger, MS; Alda, Martin; Ingvar, Martin; Phillips, ML; Kempton, MJ; Bauer, M; Landén, M; Lawrence, NS; Van Haren, NEM; Horn, NR; Freimer, NB; Gruber, Oliver; Schofield, PR; Mitchell, PB; Kahn, RS; Lenroot, R; Machado-Vieira, R; Ophoff, RA; Sarró, S; Frangou, Sophia; Satterthwaite, TD; Hajek, Tomas; Dannlowski, Udo; Malt, Ulrik Fredrik; Arolt, Volker; Gattaz, WF; Drevets, WC; Caseras, Xavier; Agartz, Ingrid; Thompson, PM & Andreassen, Ole Andreas (2018). Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, s 932- 942 . doi: 10.1038/mp.2017.73 Full text in Research Archive.
Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Agartz, Ingrid; Andreassen, Ole Andreas; Dietrichs, Espen; Thorsby, Per Medbøe; Westlye, Lars Tjelta & Knudsen, Stine (2018). Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives. Sleep. ISSN 0161-8105. 41(10) . doi: 10.1093/sleep/zsy145 Full text in Research Archive.
Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Bettella, Francesco; Djurovic, Srdjan; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia. JAMA psychiatry. ISSN 2168-6238. . doi: 10.1001/jamapsychiatry.2018.0844
Kelly, S; Jahanshad, Neda; Zalesky, A; P, Kochunov; Agartz, Ingrid; Alloza, C; Andreassen, Ole Andreas; Arango, C; Banaj, Nerisa; Bouix, S; Bousman, CA; Brouwer, RM; Bruggemann, J; Bustillo, Juan R; Cahn, Wiepke; Calhoun, Vince; Cannon, Dara M; Carr, Vaughan J.; Catts, Stanley V.; Chen, J; Chen, JX; Chen, X; Chiapponi, C; Cho, KK; Ciullo, Valentina; Corvin, A; Crespo-Facorro, Benedicto; Cropley, V; De Rossi, Pietro; Diaz-Caneja, CM; Dickie, EW; Ehrlich, S; Fan, FM; Faskowitz, Joshua; Fatouros-Bergman, Helena; Flyckt, Lena; Ford, JM; Fouche, JP; Fukunaga, Masaki; Gill, M; Glahn, DC; Gollub, Randy L; Goudzwaard, ED; Guo, H; Gur, RE; Gur, RC; Gurholt, Tiril Pedersen; Hashimoto, Ryota; Hatton, SN; Henskens, FA; Hibar, DP; Hickie, IB; Hong, LE; Horacek, Jan; Howells, FM; Hulshoff Pol, Hilleke E; Hyde, CL; Isaev, D; Jablensky, Assen; Jansen, PR; Janssen, J; Jönsson, Erik Gunnar; Jung, LA; Kahn, RS; Kikinis, Z; Liu, K; Klauser, Paul; Knöchel, C; Kubicki, M; Lagopoulos, Jim; Langen, C; Lawrie, Stephen M; Lenroot, R; Lim, KO; Lopez-Jaramillo, Carlos; Lyall, A; Magnotta, V; Mandl, RCW; Mathalon, DH; McCarley, RW; McCarthy-Jones, Simon; McDonald, C; McEwen, S; McIntosh, A; Melicher, T; Mesholam-Gately, RI; Michie, PT; Mowry, Bryan J.; Mueller, BA; Newell, DT; O'donnell, P; Oertel-Knöchel, V; Oestreich, L; Paciga, SA; Pantelis, Christos; Pasternak, O; Pearlson, Godfrey D; Pellicano, GR; Pereira, A; Pineda Zapata, J; Piras, Fabrizio; Potkin, SG; Preda, Adrian; Rasser, PE; Roalf, DR; Roiz, R; Roos, A; Rotenberg, D; Satterthwaite, TD; Savadjiev, P; Schall, Ulrich; Scott, RJ; Seal, ML; Seidman, LJ; Shannon Weickert, C; Whelan, CD; Shenton, ME; Kwon, JS; Spalletta, Gianfranco; Spaniel, F; Sprooten, Emma; Stäblein, M; Stein, DJ; Sundram, S; Tan, Y; Tan, S; Tang, S; Temmingh, HS; Westlye, Lars Tjelta; Tønnesen, Siren; Tordesillas-Gutierrez, Diana; Doan, Nhat Trung; Vaidya, Jatin G.; Van Haren, NEM; Vargas, CD; Vecchio, D; Velakoulis, D; Voineskos, Aristotle N.; Voyvodic, JQ; Wang, Z; Wan, P; Wei, D; Weickert, TW; Whalley, Heather Clare; White, T; Whitford, TJ; Wojcik, JD; XIANG, HUA; Xie, Z; Yamamori, Hidenaga; Yang, F; Yao, N; Zhang, G.; Zhao, J; Van Erp, Theo G M; Turner, J; Thompson, PM & Donohoe, Gary (2018). Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, s 1261- 1269 . doi: 10.1038/mp.2017.170 Full text in Research Archive.
Kolskår, Knut-Kristian; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Sanders, Anne-Marthe; Ulrichsen, Kristine Moe; Moberget, Torgeir; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2018). Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence. eNeuro. ISSN 2373-2822. 5(4), s 1- 13 . doi: 10.1523/ENEURO.0092-18.2018 Full text in Research Archive.
Kong, Xiang-Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Agartz, Ingrid; Andreassen, Ole Andreas; Bøen, Erlend; Còrdova Palomera, Aldo; Dale, Anders; Doan, Nhat Trung; Elvsåshagen, Torbjørn; Faraone, Stephen V.; Gurholt, Tiril Pedersen; Haavik, Jan; Høvik, Marie Farstad; Hugdahl, Kenneth; Jönsson, Erik Gunnar; Lundervold, Astri; Malt, Ulrik Fredrik; Nerland, Stener; Nordvik, Jan Egil; Plessen, Kerstin J.; Smelror, Runar; van den Heuvel, Odile A; van der Meer, Dennis; Lønning, Kjersti; Westlye, Lars Tjelta; Glahn, David C.; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E.; Thompson, Paul M. & Francks, Clyde (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(22), s E5154- E5163 . doi: 10.1073/pnas.1718418115
Kuhn, Taylor; Kaufmann, Tobias; Doan, Nhat Trung; Westlye, Lars Tjelta; Jones, Jacob L.; Nunez, Rodolfo A; Bookheimer, Susan Y; Singer, Elyse J; Hinkin, Charles H & Thames, April D (2018). An augmented aging process in brain white matter in HIV. Human Brain Mapping. ISSN 1065-9471. 39(6), s 2532- 2540 . doi: 10.1002/hbm.24019
Liew, Sook-Lei; Anglin, Julia M.; Banks, Nick W.; Sondag, Matt; Ito, Kaori L.; Kim, Hosung; Chan, Jennifer; Ito, Joyce; Jung, Connie; Khoshab, Nima; Lefebvre, Stephanie; Nakamura, William; Saldaña, David; Schmiesing, Allie; Tran, Cathy; Vo, Danny; Ard, Tyler; Heydari, Panthea; Kim, Bokkyu; Aziz-Zadeh, Lisa; Cramer, Steven C.; Liu, Jingchun; Soekadar, Surjo; Nordvik, Jan Egil; Westlye, Lars Tjelta; Wang, Junping; Winstein, Carolee; Yu, Chunshui; Ai, Lei; Koo, Bonhwang; Craddock, R. Cameron; Milham, Michael Peter; Lakich, Matthew; Pienta, Amy & Stroud, Alison (2018). A large, open source dataset of stroke anatomical brain images and manual lesion segmentations. Scientific Data. ISSN 2052-4463. 5 . doi: 10.1038/sdata.2018.11 Full text in Research Archive.
Maglanoc, Luigi Angelo; Landrø, Nils Inge; Jonassen, Rune; Kaufmann, Tobias; Còrdova Palomera, Aldo; Hilland, Eva & Westlye, Lars Tjelta (2018). Data-driven clustering reveals a link between symptoms and functional brain connectivity in depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 4(1), s 16- 26 . doi: 10.1016/j.bpsc.2018.05.005 Full text in Research Archive.
Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Moberget, Torgeir; Rokicki, Jaroslav; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Tamnes, Christian Krog (2018). Probing brain developmental patterns of myelination and associations with psychopathology in youths using gray/white matter contrast. Biological Psychiatry. ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.09.027 Full text in Research Archive.
Nunes, Abraham; Schnack, Hugo G.; Ching, Christopher R.K.; Agartz, Ingrid; Akudjedu, Theophilus N.; Alda, Martin; Alnæs, Dag; Alonso-Lana, Silvia; Bauer, Jochen; Baune, Bernhard T; Bøen, Erlend; Bonnin, Caterina del Mar; Busatto, Geraldo F.; Canales-Rodriguez, Erick J.; Cannon, Dara M.; Caseras, Xavier; Chaim-Avancini, Tiffany M.; Dannlowski, Udo; Díaz-Zuluaga, Ana M.; Dietsche, Bruno; Doan, Nhat Trung; Duchesnay, Edouard; Elvsåshagen, Torbjørn; Emden, Daniel; Eyler, Lisa T.; Fatjó-Vilas, Mar; Favre, Pauline; Foley, Sonya F.; Fullerton, Janice M.; Glahn, David C.; Goikolea, Jose M.; Grotegerd, Dominik; Hahn, Tim; Henry, Chantal; Hibar, Derrek; Houenou, Josselin; Howells, Fleur M.; Jahanshad, Neda; Kaufmann, Tobias; Kenney, Joanne; Kircher, Tilo T.J.; Krug, Axel; Lagerberg, Trine Vik; Lenroot, Rhoshel K.; López-Jaramillo, Carlos; Machado-Vieira, Rodrigo; Malt, Ulrik Fredrik; McDonald, Colm; Mitchell, Philip B.; Mwangi, Benson; Nabulsi, Leila; Opel, Nils; Overs, Bronwyn J.; Pineda-Zapata, Julian A.; Pomarol-Clotet, Edith; Redlich, Ronny; Roberts, Gloria; Rosa, Pedro G.; Salvador, Raymond; Satterthwaite, Theodore D.; Soares, Jair C.; Stein, Dan J.; Temmingh, Henk S.; Trappenberg, Thomas; Uhlmann, Anne; van Haren, Neeltje E.M.; Vieta, Eduard; Westlye, Lars Tjelta; Wolf, Daniel H.; Yüksel, Dilara; Zanetti, Marcus V.; Andreassen, Ole Andreas; Thompson, Paul M. & Hájek, Tomás (2018). Using structural MRI to identify bipolar disorders ? 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Molecular Psychiatry. ISSN 1359-4184. . doi: 10.1038/s41380-018-0228-9 Full text in Research Archive.
Quintana, Daniel; Westlye, Lars Tjelta; Alnæs, Dag; Kaufmann, Tobias; Mahmoud, Ramy A.; Smerud, Knut Terje; Djupesland, Per G. & Andreassen, Ole Andreas (2018). Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study. Neuropsychopharmacology. ISSN 0893-133X. 44, s 306- 313 . doi: 10.1038/s41386-018-0241-3
Quintana, Daniel; Westlye, Lars Tjelta; Smerud, Knut Terje; Mahmoud, Ramy A.; Andreassen, Ole Andreas & Djupesland, Per G. (2018). Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men. Hormones and Behavior. ISSN 0018-506X. 102, s 85- 92 . doi: 10.1016/j.yhbeh.2018.05.004
Richard, Geneviève; Kolskår, Knut-Kristian; Sanders, Anne-Marthe; Kaufmann, Tobias; Petersen, Anders; Doan, Nhat Trung; Monereo Sanchez, Jennifer; Alnæs, Dag; Ulrichsen, Kristine Moe; Dørum, Erlend Solberg; Andreassen, Ole Andreas; Nordvik, Jan Egil & Westlye, Lars Tjelta (2018). Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry. PeerJ. ISSN 2167-8359. . doi: 10.7717/peerj.5908 Full text in Research Archive. Show summary
Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and interpretations. Multivariate age prediction reduces the dimensionality to one biologically informative summary measure with potential for assessing deviations from normal lifespan trajectories. A number of studies documented remarkably accurate age prediction, but the differential age trajectories and the cognitive sensitivity of distinct brain tissue classes have yet to be adequately characterized. Exploring differential brain age models driven by tissue- specific classifiers provides a hitherto unexplored opportunity to disentangle indepen- dent sources of heterogeneity in brain biology. We trained machine-learning models to estimate brain age using various combinations of FreeSurfer based morphometry and diffusion tensor imaging based indices of white matter microstructure in 612 healthy controls aged 18–87 years. To compare the tissue-specific brain ages and their cognitive sensitivity, we applied each of the 11 models in an independent and cognitively well- characterized sample ( n = 265, 20–88 years). Correlations between true and estimated age and mean absolute error (MAE) in our test sample were highest for the most comprehensive brain morphometry ( r = 0 . 83, CI:0.78–0.86, MAE = 6.76 years) and white matter microstructure ( r = 0 . 79, CI:0.74–0.83, MAE = 7.28 years) models, confirming sensitivity and generalizability. The deviance from the chronological age were sensitive to performance on several cognitive tests for various models, including spatial Stroop and symbol coding, indicating poorer performance in individuals with an over-estimated age. Tissue-specific brain age models provide sensitive measures of brain integrity, with implications for the study of a range of brain disorders.
Sowa, Piotr; Harbo, Hanne Flinstad; White, Nathan S.; Celius, Elisabeth Gulowsen; Bartsch, Hauke; Berg-Hansen, Pål; Moen, Stine Marit; Bjørnerud, Atle; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Dale, Anders & Beyer, Mona K. (2018). Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. s 1- 12 . doi: 10.1177/1352458518765671 Full text in Research Archive.
Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra; Espeseth, Thomas; Vaskinn, Anja; Wang, Yunpeng; Westlye, Lars Tjelta; Jacquemont, Sébastien; Djurovic, Srdjan; Stefánsson, Hreinn; Stefánsson, Kári; Thompson, Paul M. & Andreassen, Ole Andreas (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry. ISSN 1359-4184. s 1- 16 . doi: 10.1038/s41380-019-0358-8 Full text in Research Archive.
Tønnesen, Siren; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; van der Meer, Dennis; Rokicki, Jaroslav; Moberget, Torgeir; Gurholt, Tiril Pedersen; Haukvik, Unn Kristin H.; Ueland, Torill; Lagerberg, Trine Vik; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging. Scientific Reports. ISSN 2045-2322. 8 . doi: 10.1038/s41598-018-32355-9 Full text in Research Archive.

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Maximov, Ivan; Alnæs, Dag & Westlye, Lars Tjelta (2019). Influence of diffusion pipeline on data analysis: UK Biobank example for age-diffusion dependences.
Maximov, Ivan & Westlye, Lars Tjelta (2019). Variability of NODDI metrics between AMICO and original NODDI in UK Biobank data.
Ousdal, Olga Therese; Lundervold, Astri; Westlye, Lars Tjelta & Lundervold, Arvid (2018). Longitudinal stability of the brain functional connectome is associated with episodic memory performance.

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Published Sep. 21, 2010 10:03 AM - Last modified June 30, 2020 1:19 PM

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Lars Tjelta Westlye

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Lars Tjelta Westlye

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