Didac Vidal Piñeiro

• Roe, James Michael; Vidal-Piñeiro, Didac; Sørensen, Øystein; Mowinckel, Athanasia Monika; Walhovd, Kristine B; Fjell, Anders Martin & Westerhausen, Rene (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s Disease. Nature Communications.  ISSN 2041-1723. . doi: https://doi.org/10.1101/2020.06.18.158980 Show summary

  Normal aging and Alzheimer’s Disease (AD) are accompanied by large-scale alterations in brain organization that undermine brain function. Although hemispheric asymmetry is a global organizing feature of cortex thought to promote brain efficiency, current descriptions of cortical thinning in aging and AD have largely overlooked cortical asymmetry. Consequently, the foundational question of whether and where the cerebral hemispheres change at different rates in aging and AD remains open. First, applying vertex-wise data-driven clustering in a longitudinal discovery sample (aged 20-89; 2577 observations; 1851 longitudinal) we identified cortical regions exhibiting similar age-trajectories of asymmetry across the adult lifespan. Next, we sought replication in 4 independent longitudinal aging cohorts. We show that higher-order regions of cortex that exhibit pronounced asymmetry at age ~20 also show asymmetry change in aging. Results revealed that both leftward and rightward asymmetry is progressively lost on a similar time-scale across adult life. Hence, faster thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This simple organizational principle showed high consistency across multiple aging cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Finally, we show that regions exhibiting gradual asymmetry-loss over healthy adult life exhibit faster asymmetry-change in AD. 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.06.18.158980; this version posted June 20, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Overall, our results suggest a system-wide breakdown in the adaptive asymmetric organization of cortex across adult life which is further accelerated in AD, and may implicate thickness asymmetry as a viable marker for declining hemispheric specialization in aging and AD.

• Danielsen, Vilde Marie; Vidal-Piñeiro, Didac; Mowinckel, Athanasia Monika; Sederevicius, Donatas; Fjell, Anders Martin; Walhovd, Kristine B & Westerhausen, Rene (2020). Lifespan trajectories of relative corpus callosum thickness: Regional differences and cognitive relevance. Cortex.  ISSN 0010-9452.  130, s 127- 141 . doi: https://doi.org/10.1016/j.cortex.2020.05.020 Show summary

  The cerebral hemispheres are specialized for different cognitive functions and receive divergent information from the sensory organs, so that the interaction between the hemispheres is a crucial aspect of perception and cognition. At the same time, the major fiber tract responsible for this interaction, the corpus callosum, shows a structural development across the lifespan which is over-proportional. That is, compared to changes in overall forebrain volume, the corpus callosum shows an accentuated growth during childhood, adolescence, and early adulthood, as well as pronounced decline in older age. However, this over-proportionality of growth and decline along with potential consequences for cognition, have been largely overlooked in empirical research. In the present study we systematically address the proportionality of callosal development in a large mixed cross-sectional and longitudinal sample (1867 datasets from 1014 unique participants), covering the human lifespan (age range 4–93 years), and examine the cognitive consequences of the observed changes. Relative corpus callosum thickness was measured at 60 segments along the midsagittal surface, and lifespan trajectories were clustered to identify callosal subsections of comparable lifespan development. While confirming the expected inverted u-shaped lifespan trajectories, we also found substantial regional variation. Compared with anterior clusters, the most posterior sections exhibited an accentuated growth during development which extends well into the third decade of life, and a protracted decline in older age which is delayed by about 10 years (starting mid to late 50s). We further showed that the observed longitudinal changes in relative thickness of the mid splenium significantly mediates age-related changes in tests assessing verbal knowledge and non-verbal visual-spatial abilities across the lifespan. In summary, we demonstrate that analyzing the proportionality of callosal growth and decline offers valuable insight into lifespan development of structural connectivity between the hemispheres, and suggests consequences for the cognitive development of perception and cognition.

• Fjell, Anders Martin; Sørensen, Øystein; Amlien, Inge Kasbohm; Bartrés-Faz, David; Brandmaier, Andreas M.; Buchmann, Nikolaus; Demuth, Ilja; Drevon, Christian A; Düzel, Sandra; Ebmeier, Klaus; Ghisletta, Paolo; Idland, Ane-Victoria; Kietzmann, Tim C; Kievit, Rogier A.; Kühn, Simone; Lindenberger, Ulman; Magnussen, Fredrik; Macià Bros, Didac; Mowinckel, Athanasia Monika; Nyberg, Lars Erik; Sexton, Claire E; Sole-Padulles, Cristina; Pudas, Sara; Roe, James Michael; Sederevicius, Donatas; Suri, Sana; Vidal-Piñeiro, Didac; Wagner, Gerd; Watne, Leiv Otto; Westerhausen, Rene; Zsoldos, Eniko & Walhovd, Kristine B (2020). Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium. Cerebral Cortex.  ISSN 1047-3211.  s 1- 17 . doi: 10.1093/cercor/bhaa332 Show summary

  We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. “PSQI # 1 Subjective sleep quality” and “PSQI #5 Sleep disturbances” were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with “PSQI #5 Sleep disturbances” emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.

• Mowinckel, Athanasia Monika & Vidal-Piñeiro, Didac (2020). Visualization of Brain Statistics With R Packages ggseg and ggseg3d. Advances in Methods and Practices in Psychological Science (AMPPS).  ISSN 2515-2459. . doi: https://doi.org/10.1177/2515245920928009
• Vidal-Piñeiro, Didac; Parker, Nadine; Shin, Jean; French, Leon; Grydeland, Håkon; Jackowski, Andrea; Mowinckel, Athanasia Monika; Patel, Yash; Pausova, Zdenka; Salum, Giovanni; Sørensen, Øystein; Walhovd, Kristine B; Paus, Tomáš & Fjell, Anders Martin (2020). Cellular correlates of cortical thinning throughout the lifespan. Scientific Reports.  ISSN 2045-2322.  10(1), s 1- 14 . doi: 10.1038/s41598-020-78471-3 Full text in Research Archive.
• Vidal-Piñeiro, Didac; Sneve, Markus Handal; Amlien, Inge Kasbohm; Grydeland, Håkon; Mowinckel, Athanasia Monika; Roe, James Michael; Sørensen, Øystein; Nyberg, Lars; Walhovd, Kristine B & Fjell, Anders Martin (2020). The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan. Cerebral Cortex.  ISSN 1047-3211. . doi: 10.1093/cercor/bhaa348 Full text in Research Archive.
• Amlien, Inge Kasbohm; Sneve, Markus Handal; Vidal-Piñeiro, Didac; Walhovd, Kristine B & Fjell, Anders Martin (2019). Elaboration Benefits Source Memory Encoding Through Centrality Change. Scientific Reports.  ISSN 2045-2322.  9(1), s 1- 13 . doi: 10.1038/s41598-019-39999-1 Full text in Research Archive.
• Halaas, Nathalie Bodd; Henjum, Kristi; Blennow, Kaj; Dakhil, Shams; Idland, Ane-Victoria; Nilsson, Lars; Sederevicius, Donatas; Vidal-Piñeiro, Didac; Walhovd, Kristine B; Wyller, Torgeir Bruun; Zetterberg, Henrik; Watne, Leiv & Fjell, Anders Martin (2019). CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral Cortex.  ISSN 1047-3211.  00, s 1- 12 . doi: 10.1093/cercor/bhz240 Full text in Research Archive.
• Parker, Nadine; Vidal-Piñeiro, Didac; French, Leon; Shin, Jean; Adams, Hieab H.; Brodaty, Henry; Cox, Simon R; Deary, Ian; Fjell, Anders Martin; Frenzel, Stefan; Grabe, Hans; Hosten, Norbert; Ikram, Mohammad A.; jiang, jiyang; Knol, Maria J.; Mazoyer, Bernard; Mishra, Aniket; Sachdev, Perminder; salum, giovanni; Satizabal, Claudia L; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Schumann, Gunter; Volzke, Henry; Walhovd, Kristine B; Wen, Wei; Wittfeld, Katharina; Yang, Qiong; debette, stephanie; Pausova, Zdenka & Paus, Tomáš (2019). Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan. Cerebral Cortex.  ISSN 1047-3211.  30(2), s 575- 586 . doi: 10.1093/cercor/bhz108 Full text in Research Archive.
• Roe, James Michael; Vidal-Piñeiro, Didac; Sneve, Markus Handal; Kompus, Kristiina; Greve, Douglas N.; Walhovd, Kristine B; Fjell, Anders Martin & Westerhausen, René (2019). Age-Related Differences in Functional AsymmetryDuring Memory Retrieval Revisited: No Evidence forContralateral Overactivation or Compensation. Cerebral Cortex.  ISSN 1047-3211.  0(0), s 1- 19 . doi: 10.1093/cercor/bhz153 Full text in Research Archive.
• Vidal-Piñeiro, Didac; Sneve, Markus Handal; Nyberg, Lars; Mowinckel, Athanasia Monika; Sederevicius, Donatas; Walhovd, Kristine B & Fjell, Anders Martin (2019). Maintained Frontal Activity Underlies High Memory Function Over 8 Years in Aging. Cerebral Cortex.  ISSN 1047-3211.  29(7), s 3111- 3123 . doi: 10.1093/cercor/bhy177 Full text in Research Archive.
• Abellaneda-Perez, Kilian; Vaque-Alcazar, Lidia; Vidal-Piñeiro, Didac; Jannati, A; Solana, Elisabeth; Bargallo, Nuria; Santarnecchi, E; Pascual-Leone, Alvaro & Bartres-Faz, David (2018). Age-related differences in default-mode network connectivity in response to intermittent theta-burst stimulation and its relationships with maintained cognition and brain integrity in healthy aging. NeuroImage.  ISSN 1053-8119.  188, s 794- 806 . doi: 10.1016/j.neuroimage.2018.11.036 Full text in Research Archive.
• Amlien, Inge Kasbohm; Sneve, Markus Handal; Vidal-Piñeiro, Didac; Walhovd, Kristine B & Fjell, Anders Martin (2018). The lifespan trajectory of the encoding-retrieval flip: A multimodal examination of medial parietal cortex contributions to episodic memory. Journal of Neuroscience.  ISSN 0270-6474.  38(40), s 8666- 8679 . doi: 10.1523/JNEUROSCI.1702-17.2018 Full text in Research Archive.
• Langnes, Espen; Vidal-Piñeiro, Didac; Sneve, Markus Handal; Amlien, Inge Kasbohm; Walhovd, Kristine B & Fjell, Anders Martin (2018). Development and decline of the hippocampal long-axis specialization and differentiation during encoding and retrieval of episodic memories. Cerebral Cortex.  ISSN 1047-3211.  s 1- 17 . doi: 10.1093/cercor/bhy209 Full text in Research Archive.
• Lidia, Vaque-Alcazar; Sala Llonch, Roser; Valls-Pedret, Cinta; Vidal-Piñeiro, Didac; Fernandez-Cabello, Sara; Bargallo, Nuria; Ros, Emilio & Bartres-Faz, David (2017). Differential age-related gray and white matter impact mediates educational influence on elders' cognition.. Brain Imaging and Behavior.  ISSN 1931-7557.  11(2), s 318- 332 . doi: 10.1007/s11682-016-9584-8
• Vidal-Piñeiro, Didac; Sneve, Markus Handal; Storsve, Andreas Berg; Roe, James Michael; Walhovd, Kristine B & Fjell, Anders Martin (2017). Neural correlates of durable memories across the adult lifespan: brain activity at encoding and retrieval. Neurobiology of Aging.  ISSN 0197-4580.  60, s 20- 33 . doi: 10.1016/j.neurobiolaging.2017.08.017 Full text in Research Archive.
• Bartres-Faz, D & Piñeiro, Didac Vidal (2016). Noninvasive Brain Stimulation for the Study of Memory Enhancement in Aging. European Psychologist.  ISSN 1016-9040.  21(1), s 41- 54 . doi: 10.1027/1016-9040/a000241
• Fernandez-Cabello, Sara; Valls-Pedret, Cinta; Schurz, Matthias; Piñeiro, Didac Vidal; Sala Llonch, Roser; Bargallo, Nuria; Ros, Emilio & Bartres-Faz, David (2016). White matter hyperintensities and cognitive reserve during a working memory task: a functional magnetic resonance imaging study in cognitively normal older adults. Neurobiology of Aging.  ISSN 0197-4580.  48, s 23- 33 . doi: 10.1016/j.neurobiolaging.2016.08.008
• Penadés, Rafael; Pujol, Nuria; Catalán, Rosa; Masana, Guillem; Garcia-Rizo, Clemente; Bargallo, Nuria; Gonzales-Rodriguez, Alexandre; Piñeiro, Didac Vidal; Bernardo, Miquel & Junqué, Carme (2016). Cortical thickness in regions of frontal and temporal lobes is associated with responsiveness to cognitive remediation therapy in schizophrenia. Schizophrenia Research.  ISSN 0920-9964.  171(1-3), s 110- 116 . doi: 10.1016/j.schres.2016.01.006
• Piñeiro, Didac Vidal; Walhovd, Kristine B; Storsve, Andreas Berg; Grydeland, Håkon; Rohani, Darius Adam & Fjell, Anders Martin (2016). Accelerated longitudinal gray/white matter contrast decline in aging in lightly myelinated cortical regions. Human Brain Mapping.  ISSN 1065-9471.  37(10), s 3669- 3684 . doi: 10.1002/hbm.23267 Full text in Research Archive.
• Vaque-Alcazar, Lidia; Sala Llonch, Roser; Valls-Pedret, Cinta; Vidal-Piñeiro, Didac; Fernandez-Cabello, Sara; Bargallo, Nuria; Ros, Emilio & Bartres-Faz, David (2016). Differential age-related gray and white matter impact mediates educational influence on elders’ cognition. Brain Imaging and Behavior.  ISSN 1931-7557.  s 1- 15 . doi: 10.1007/s11682-016-9584-8
• Alcolea, Daniel; Vilaplana, Eduard; Pegueroles, Jordi; Montal, Victor; Sanchez-Juan, Pascual; Gonzales-Suarez, Andrea; Pozueta, Ana; Rodriguez-Rodriguez, Eloy; Bartres-Faz, D; Piñeiro, Didac Vidal; Gonzalez-Ortiz, Sofia; Medrano, Santiago; Carmona-Iragui, Maria; Sanchez-Saudinos, MaBelen; Sala, Isabel; Anton-Aguirre, Sofia; Sampedro, Frederic; Morenas-Rodriguez, Estrella; Clarimon, Jordi; Blesa, Rafael; Lleó, Alberto & Fortea, Juan (2015). Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease. Neurobiology of Aging.  ISSN 0197-4580.  36(6), s 2018- 2023 . doi: 10.1016/j.neurobiolaging.2015.03.001
• Piñeiro, Didac Vidal; Martin-Trias, Pablo; Falcon, Carles; Bargallo, Nuria; Clemente, Imma; Valls-Sole, J; Junqué, Carme; Pascual-Leone, Alvaro & Bartres-Faz, D (2015). Neurochemical modulation in posteromedial default-mode network cortex induced by transcranial magnetic stimulation. Brain Stimulation.  ISSN 1935-861X.  8(5), s 937- 944 . doi: 10.1016/j.brs.2015.04.005
• Piñeiro, Didac Vidal; Martin-Trias, Pablo; Arenaza-Urquijo, Eider; Sala Llonch, Roser; Clemente, Imma; Mena-Sanchez, Isaias; Bargallo, Nuria; Falcon, Carles; Pascual-Leone, Alvaro & Bartres-Faz, D (2014). Task-dependent Activity and Connectivity Predict Episodic Memory Network-based Responses to Brain Stimulation in Healthy Aging. Brain Stimulation.  ISSN 1935-861X.  7(2), s 287- 296 . doi: 10.1016/j.brs.2013.12.016
• Piñeiro, Didac Vidal; Valls-Pedret, Cinta; Fernandez-Cabello, Sara; Arenaza-Urquijo, Eider; Sala Llonch, Roser; Solana-Diaz, Elisabeth; Bargallo, Nuria; Junqué, Carme; Ros, Emilio & Bartres-Faz, D (2014). Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes. Frontiers in Aging Neuroscience.  ISSN 1663-4365. . doi: 10.3389/fnagi.2014.00256
• Sala-Llonch, Roser; Junqué, Carme; Arenaza-Urquijo, Eider; Vidal-Piñeiro, Didac; Valls-Pedret, Cinta; Palacios, Eva M; Domenech, Sara; Salva, Antoni; Bargallo, Nuria & Bartres-Faz, David (2014). Changes in whole-brain functional networks and memory performance in aging. Neurobiology of Aging.  ISSN 0197-4580.  35(10), s 2193- 2202 . doi: 10.1016/j.neurobiolaging.2014.04.007

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