Catherine Harmer

Professor II
Bilde av Catherine Harmer
English version of this page
Telefon +44 (0)1865 223961
Brukernavn
Postadresse Department of Psychiatry Warneford Hospital Oxford OX3 7JX

Faglige interesser

My research focuses on the cognitive mechanisms of treatments for depression and anxiety disorders. 

To explore these questions we use a variety of techniques such as fMRI, MEG, TMS, psychopharmacological challenge techniques and neuropsychological assessments in healthy volunteers and patients with depression. 

This work has led to the novel idea that antidepressants may work by rapidly resolving negative affective bias in depression which leads to gradual improvements in mood, social dysfunction and other key symptoms of depression over time. 

This concept has stimulated new research approaches for the treatment of depression with implications for stratification of treatment, early prediction of therapeutic response and identification of novel therapeutic targets.

Bakgrunn

  • Professor of cognitive neuroscience at University of Oxford

  • Adjunct Professor at the Department of Psychology, UiO

Emneord: Kognitiv psykologi og nevropsykologi, Nevrovitenskap, Avdeling for kognitiv og klinisk nevrovitenskap

Publikasjoner

Reinecke A, Waldenmaier L, Cooper MJ, Harmer CJ. Changes in automatic threat processing precede and predict clinical changes with exposure-based cognitive-behavior therapy for panic disorder. Biol Psychiatry. 2013, 73(11):1064-70

Browning M, Holmes EA, Charles M, Cowen PJ, Harmer CJ. Using attentional bias modification as a cognitive vaccine against depression. Biol Psychiatry. 2012 Oct 1;72(7):572-9

Di Simplicio M, Norbury R, Harmer CJ. Short-term antidepressant administration reduces negative self-referential processing in the medial prefrontal cortex in subjects at risk for depression. Mol Psychiatry. 2012, 17: 503-510

Browning M, Holmes EA, Murphy SE, Goodwin GM, Harmer CJ. Lateral prefrontal cortex mediates the cognitive modification of attentional bias. Biol Psychiatry.  2010, 67:919-25.

McCabe C, Mishor Z, Cowen PJ, Harmer CJ. Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment. Biol Psychiatry. 2010, 67:439-45.

Harmer CJ, O'Sullivan U, Favaron E, Massey-Chase R, Ayres R, Reinecke A, Goodwin GM, Cowen PJ. Effect of acute antidepressant administration on negative affective bias in depressed patients. Am J Psychiatry. 2009, 166:1178-84.

Harmer CJ, Goodwin GM, Cowen PJ. Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action. Br J Psychiatry. 2009, 195: 102-8

Harmer CJ, Mackay CE, Reid CB, Cowen PJ, Goodwin GM. Antidepressant drug treatment modifies the neural processing of nonconscious threat cues. Biol Psychiatry. 2006, 59:816-20.

Hayward G, Goodwin GM, Cowen PJ, Harmer CJ. Low-dose tryptophan depletion in  recovered depressed patients induces changes in cognitive processing without depressive symptoms. Biol Psychiatry. 2005,57:517-24.

Harmer CJ, Shelley NC, Cowen PJ, Goodwin GM. Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. Am J Psychiatry. 2004,161:1256-63.

  • Bø, Ragnhild; Kraft, Brage; Joormann, Jutta; Jonassen, Rune; Harmer, Catherine & Landrø, Nils Inge (2023). Cognitive predictors of stress-induced mood malleability in depression. Anxiety, Stress, & Coping. ISSN 1061-5806. 37(2), s. 278–292. doi: 10.1080/10615806.2023.2255531. Fulltekst i vitenarkiv
  • Kraft, Brage; Bø, Ragnhild; Hoorelbeke, Kristof; Koster, Ernst; Jonassen, Rune & Harmer, Catherine [Vis alle 7 forfattere av denne artikkelen] (2023). Examining attentional functioning in depression using a personalized network approach: A proof-of-principle study. Psychiatry Research Communications. ISSN 2772-5987. 3(3). doi: 10.1016/j.psycom.2023.100137. Fulltekst i vitenarkiv
  • Bø, Ragnhild; Kraft, Brage; Jonassen, Rune; Pedersen, Mads Lund; Harmer, Catherine & Landrø, Nils Inge (2023). The long-term effects of ABM on symptom severity in patients with recurrent depression: A randomized sham-controlled trial. Journal of Affective Disorders. ISSN 0165-0327. 340, s. 886–892. doi: 10.1016/j.jad.2023.08.024. Fulltekst i vitenarkiv
  • Bø, Ragnhild; Kraft, Brage; Pedersen, Mads Lund; Joormann, Jutta; Jonassen, Rune & Osnes, Kåre [Vis alle 8 forfattere av denne artikkelen] (2023). The effect of attention bias modification on depressive symptoms in a comorbid sample: a randomized controlled trial. Psychological Medicine. ISSN 0033-2917. 53(13), s. 6389–6396. doi: 10.1017/S0033291722003956. Fulltekst i vitenarkiv
  • Jonassen, Rune; Hilland, Eva; Harmer, Catherine J.; Abebe, Dawit Shawel; Bergem, Anne Kristine & Skarstein, Siv (2021). Over-the-counter analgesics use is associated with pain and psychological distress among adolescents: a mixed effects approach in cross-sectional survey data from Norway. BMC Public Health. ISSN 1471-2458. 21(1), s. 1–12. doi: 10.1186/s12889-021-12054-3.
  • Bø, Ragnhild; Kraft, Brage; Jonassen, Rune; Harmer, Catherine; Hilland, Eva & Stiles, Tore C [Vis alle 10 forfattere av denne artikkelen] (2021). Symptom severity moderates the outcome of attention bias modification for depression: An exploratory study. Journal of Psychiatric Research. ISSN 0022-3956. 138, s. 528–534. doi: 10.1016/j.jpsychires.2021.04.027. Fulltekst i vitenarkiv
  • Jonassen, Rune; Hilland, Eva; Harmer, Catherine; Abebe, Dawit Shawel; Bergem, Anne Kristine & Skarstein, Siv (2021). Use of Over-The-Counter Analgesics for Pain and Psychological Distress Among Adolescents: A Mixed Effects Approach in Cross-Sectional Survey Data From Norway. BMC Public Health. ISSN 1471-2458. doi: 10.21203/rs.3.rs-78057/v1.
  • Hilland, Eva; Landrø, Nils Inge; Harmer, Catherine; Browning, Michael ; Maglanoc, Luigi Angelo & Jonassen, Rune (2019). Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial. Journal of Psychiatry & Neuroscience. ISSN 1180-4882. 45(1), s. 23–33. doi: 10.1503/jpn.180118.
  • Østergaard, Tom; Lundgren, Tobias; Rosendahl, Ingvar; Zettle, Robert; Jonassen, Rune & Harmer, Catherine [Vis alle 9 forfattere av denne artikkelen] (2019). Acceptance and Commitment Therapy Preceded by Attention Bias Modification on Residual Symptoms in Depression: A 12-Month Follow-Up. Frontiers in Psychology. ISSN 1664-1078. 10, s. 1–13. doi: 10.3389/fpsyg.2019.01995. Fulltekst i vitenarkiv
  • Hilland, Eva; Landrø, Nils Inge; Harmer, Catherine; Browning, Michael; Maglanoc, Luigi Angelo & Jonassen, Rune (2019). Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial. Journal of Psychiatry & Neuroscience. ISSN 1180-4882. doi: 10.1503/jpn.180118. Fulltekst i vitenarkiv
  • Jonassen, Rune; Harmer, Catherine; Hilland, Eva; Maglanoc, Luigi Angelo; Kraft, Brage & Browning, Michael [Vis alle 10 forfattere av denne artikkelen] (2019). Effects of Attentional Bias Modification on residual symptoms in depression: A randomized controlled trial. BMC Psychiatry. ISSN 1471-244X. 19(141). doi: 10.1186/s12888-019-2105-8. Fulltekst i vitenarkiv
  • Kraft, Brage; Jonassen, Rune; Heeren, Alexandre; Harmer, Catherine; Stiles, Tore C & Landrø, Nils Inge (2019). Attention Bias Modification in Remitted Depression Is Associated With Increased Interest and Leads to Reduced Adverse Impact of Anxiety Symptoms and Negative Cognition. Clinical Psychological Science. ISSN 2167-7026. 7(3), s. 530–544. doi: 10.1177/2167702618822480.
  • Hilland, Eva; Landrø, Nils Inge; Harmer, Catherine; Maglanoc, Luigi Angelo & Jonassen, Rune (2018). Within-network connectivity in the salience network after attention bias modification training in residual depression: Report from a preregistered clinical trial. Frontiers in Human Neuroscience. ISSN 1662-5161. 12. doi: 10.3389/fnhum.2018.00508. Fulltekst i vitenarkiv
  • Østergaard, Tom; Lundgren, Tobias; Zettle, Robert; Jonassen, Rune; Harmer, Catherine & Stiles, Tore C [Vis alle 8 forfattere av denne artikkelen] (2018). Acceptance and Commitment Therapy preceded by an experimental Attention Bias Modification procedure in recurrent depression: Study protocol for a randomized controlled trial. Trials. ISSN 1745-6215. 19(203), s. 1–12. doi: 10.1186/s13063-018-2515-9. Fulltekst i vitenarkiv
  • Aker, Martin; Bø, Ragnhild; Harmer, Catherine; Stiles, Tore C & Landrø, Nils Inge (2015). Inhibition and response to error in remitted major depression. Psychiatry Research. ISSN 0165-1781. 235, s. 116–122. doi: 10.1016/j.psychres.2015.11.038.
  • Jonassen, Rune; Chelnokova, Olga V; Harmer, Catherine; Leknes, Siri & Landrø, Nils Inge (2015). A single dose of antidepressant alters eye-gaze patterns across face stimuli in healthy women. Psychopharmacology. ISSN 0033-3158. 232(5), s. 953–958. doi: 10.1007/s00213-014-3729-5.
  • Aker, Martin; Harmer, Catherine & Landrø, Nils Inge (2014). More rumination and less effective emotion regulation in previously depressed women with preserved executive functions. BMC Psychiatry. ISSN 1471-244X. 14(1). doi: 10.1186/s12888-014-0334-4. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

  • Landrø, Nils Inge; Harmer, Catherine; Blackwell, Simon E.; Bø, Ragnhild; Dawson, Gerry & Goodwin, Guy [Vis alle 16 forfattere av denne artikkelen] (2023). Combining antidepressants and attention bias modification in primary health care (DEPTREAT): Protocol for a pragmatic randomized controlled trial. Contemporary Clinical Trials. ISSN 1551-7144. 133. doi: 10.1016/j.cct.2023.107326.
  • Østergaard, Tom; Lundgren, Tobias; Rosendahl, Ingvar; Zettle, Robert D.; Jonassen, Rune & Harmer, Catherine [Vis alle 9 forfattere av denne artikkelen] (2023). Corrigendum: Acceptance and commitment therapy preceded by attention bias modification on residual symptoms in depression: a 12-month follow-up (Frontiers in Psychology, (2019), 10, (1995), 10.3389/fpsyg.2019.01995). Frontiers in Psychology. ISSN 1664-1078. 14. doi: 10.3389/fpsyg.2023.1233621.
  • Bø, Ragnhild; Kraft, Brage; Jonassen, Rune; Harmer, Catherine & Landrø, Nils Inge (2022). The effect of attentional bias modification on attentional bias change is related to increased emotional reactivity.
  • Hilland, Eva; Landrø, Nils Inge; Harmer, Catherine; Maglanoc, Luigi Angelo; Browning, Michael & Jonassen, Rune (2018). Attentional Bias Modification alters fMRI response towards negative stimuli in depression. .
  • Jonassen, Rune; Hilland, Eva; Harmer, Catherine; Berge, Torkil; Maglanoc, Luigi Angelo & Kraft, Brage [Vis alle 9 forfattere av denne artikkelen] (2017). Attentional Bias Modification reduces symptom severity in major depression: Preliminary analysis from an ongoing longitudinal RCT study. .
  • Jonassen, Rune; Hilland, Eva; Harmer, Catherine; Berge, Torkil; Maglanoc, Luigi Angelo & Kraft, Brage [Vis alle 9 forfattere av denne artikkelen] (2016). Attention bias modification reduces symptom severity in Major Depression. Preliminary analysis from an ongoing longitudinal RCT study.
  • Jonassen, Rune; Chelnokova, Olga V; Harmer, Catherine; Leknes, Siri & Landrø, Nils Inge (2014). A single dose of antidepressant alters eye-gaze patterns across face stimuli in healthy women.

Se alle arbeider i Cristin

Publisert 28. jan. 2014 09:05 - Sist endret 15. feb. 2016 13:29

Prosjekter