Maternal infection and obstetric complications in the pathogenesis of schizophrenia

– A follow-up of the MoBa study.

About the project

Increasing evidence indicates that schizophrenia has a neurodevelopmental etiology. Neurodevelopmental disorders begin early in life, with one possibility being that disturbed development is caused by infection during pregnancy.

Obstetric complications (OC) have also been related to schizophrenia.

Recently, prenatal factors have been examined with respect to causal links to the core features of neurocognitive deficits rather than to the disease itself.

Objectives

The present study will be the first one to link prenatal factors to a broad set of neurocognitive functions. The design is a prospective case-control study. The cohort will be derived from MoBa, consisting of 108,000 people. We expect the debut of 16-32 schizophrenia patients by the end of 2018.

Outcomes

Patients and healthy controls will be examined on serological tests, cytokines, OC and neuropsychological (NP) measures. Diagnoses will be established using SCID-I, according to the DSM-V criteria.

NP will be examined by the MCCB, in which a reference material exists. Serological tests and cytokines will be analyzed from plasma from the three blood samples taken in MoBa.

Background

The total study period will be more than 20 years.

In the first phase, which will last six years from November 2013, the focus will be on neurocognitive deficits in early-onset schizophrenia.

Sub-projects

Published Apr. 4, 2014 4:31 PM