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Genetic and phenotypic architecture of the ontogenetic determinants of severe mental illness (completed)

Mental illness is the largest contributor to years lived with disability worldwide.

About the project

Causal models implementing cognitive, biological, and genetic mechanisms are lacking, and identifying mechanisms is crucial to improve mental health care. Psychotic disorders are heritable, involving aberrant development of brain networks.

Objectives

In this large-scale multi-disciplinary and translational effort, we combine advanced multimodal fusion of brain imaging data, clinical information and genetics to (1) characterize the hierarchy of the structural and functional neuronal breakdown in psychosis, its developmental profiles and genetic modifiers, (2) develop multimodal classifiers to identify clinically predictive genotype-phenotype patterns, and (3) describe the genetic mapping and hierarchical clustering of the discriminative brain patterns based on phenotypic and genetic correlations to identify genetic pleiotropy between risk and sustainment of disease and brain networks in a lifespan perspective.

Outcomes

Our unique approach includes state-of-the art technology and tools for data integration, and builds on the joint efforts of a cross-disciplinary international team. Anecdotal observations and statistical evidence have suggested overlap between a range of traits and disorders. Novel biostatistical tools have finally enabled us to quantify the genetic correlations between traits using high-density genotype data, which have created an avenue for genetic dissection of complex traits, allowing for new discoveries and hypotheses. These methods provide a biostatistical platform for challenging historical conventions, paving the way toward a new nosology of complex disorders. We leverage these exciting new developments to propose a genetically informed hierarchical clustering of brain imaging and clinical traits, with a particular emphasis on neurodevelopmental markers. In addition to improving current brain-based models of mental illness, our genetic dissection provides novel clues about the fundamental architecture of the brain, the dynamic lifespan alterations, and the perturbations underlying neurodevelopmental disorders.

Financing

The project is financed by the Research Council of Norway (FRIMEDBIO - Young Researcher Talents) 2016 - 2020.

Cooperation

Department of Psychology and Norwegian Centre for Mental Disorders Research (NORMENT).

Publications

  • Dahl, Andreas; Eilertsen, Espen Moen; Fernandez Rodriguez Cabello, Sara; Norbom, Linn B.; Tandberg, Anneli D. & Leonardsen, Esten [Show all 11 contributors for this article] (2024). Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions. Developmental Cognitive Neuroscience. ISSN 1878-9293. 65, p. 1–11. doi: 10.1016/j.dcn.2023.101339.
  • Maximov, Ivan & Westlye, Lars Tjelta (2023). Comparison of different neurite density metrics with brain asymmetry evaluation. Zeitschrift für Medizinische Physik. ISSN 0939-3889. doi: 10.1016/j.zemedi.2023.07.003. Full text in Research Archive
  • Slapø, Nora Berz; Jørgensen, Kjetil Nordbø; Elvsåshagen, Torbjørn; Nerland, Stener; Roelfs, Daniel & Valstad, Mathias [Show all 18 contributors for this article] (2023). Relationship between function and structure in the visual cortex in healthy individuals and in patients with severe mental disorders. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 332. doi: 10.1016/j.pscychresns.2023.111633. Full text in Research Archive
  • Icick, Romain; Shadrin, Alexey; Holen, Børge; Karadag, Naz; Lin, Aihua & Hindley, Guy [Show all 17 contributors for this article] (2022). Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings. Neuropsychopharmacology. ISSN 0893-133X. 47, p. 1883–1891. doi: 10.1038/s41386-022-01401-6.
  • Subramaniapillai, Sivaniya; Suri, Sana; Barth, Claudia; Maximov, Ivan; Voldsbekk, Irene & van der Meer, Dennis [Show all 13 contributors for this article] (2022). Sex- and age-specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort. Human Brain Mapping. ISSN 1065-9471. 43(12), p. 3759–3774. doi: 10.1002/hbm.25882. Full text in Research Archive
  • Beck, Dani; de Lange, Ann-Marie Glasø; Alnæs, Dag; Maximov, Ivan; Pedersen, Mads Lund & Leinhard, Olof Dahlqvist [Show all 20 contributors for this article] (2022). Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults. NeuroImage: Clinical. ISSN 2213-1582. 33. doi: 10.1016/j.nicl.2022.102949. Full text in Research Archive
  • Schindler, Louise S; Subramaniapillai, Sivaniya; Barth, Claudia; van der Meer, Dennis; Pedersen, Mads Lund & Kaufmann, Tobias [Show all 18 contributors for this article] (2022). Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women. NeuroImage: Clinical. ISSN 2213-1582. 36. doi: 10.1016/j.nicl.2022.103239. Full text in Research Archive
  • van der Meer, Dennis; Gurholt, Tiril Pedersen; Sønderby, Ida Elken; Shadrin, Alexey; Hindley, Guy Frederick Lanyon & Rahman, Zillur [Show all 18 contributors for this article] (2022). The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition. Communications Biology. ISSN 2399-3642. 5(1). doi: 10.1038/s42003-022-04237-4. Full text in Research Archive
  • Tesli, Natalia; Bell, Christina; Hjell, Gabriela; Fischer-Vieler, Thomas; Maximov, Ivan & Richard, Geneviève [Show all 14 contributors for this article] (2022). The age of violence: Mapping brain age in psychosis and psychopathy. NeuroImage: Clinical. ISSN 2213-1582. 36. doi: 10.1016/j.nicl.2022.103181. Full text in Research Archive
  • Tesli, Natalia; Rokicki, Jaroslav; Maximov, Ivan; Bell, Christina; Hjell, Gabriela & Gurholt, Tiril Pedersen [Show all 17 contributors for this article] (2021). White Matter Matters: Unraveling Violence in Psychosis and Psychopathy. Schizophrenia Bulletin Open. ISSN 2632-7899. 2(1). doi: 10.1093/schizbullopen/sgab026. Full text in Research Archive
  • Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi & Ellegaard, Maria [Show all 76 contributors for this article] (2021). 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01213-0. Full text in Research Archive
  • Sanders, Anne-Marthe; Richard, Geneviève; Kolskår, Knut-Kristian; Ulrichsen, Kristine Moe; Kaufmann, Tobias & Alnæs, Dag [Show all 11 contributors for this article] (2021). Linking objective measures of physical activity and capability with brain structure in healthy community dwelling older adults. NeuroImage: Clinical. ISSN 2213-1582. 31. doi: 10.1016/j.nicl.2021.102767. Full text in Research Archive
  • Roelfs, Daniel; Alnæs, Dag; Frei, Oleksandr; van der Meer, Dennis; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2021). Phenotypically independent profiles relevant to mental health are genetically correlated. Translational Psychiatry. ISSN 2158-3188. 11(1). doi: 10.1038/s41398-021-01313-x. Full text in Research Archive
  • Voldsbekk, Irene; Groote, Inge Rasmus; Zak, Nathalia; Roelfs, Daniël Thomas Heimen; Geier, Oliver & Due-Tønnessen, Paulina [Show all 14 contributors for this article] (2021). Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling. NeuroImage. ISSN 1053-8119. 226. doi: 10.1016/j.neuroimage.2020.117540. Full text in Research Archive
  • Pogosbekian, Eduard; Pronin, Igor N; Zakharova, Natalia; Batalov, A.I.; Turkin, A.M. & Konakova, T.A. [Show all 7 contributors for this article] (2021). Feasibility of generalised diffusion kurtosis imaging approach for brain glioma grading. Neuroradiology. ISSN 0028-3940. doi: 10.1007/s00234-020-02613-7. Full text in Research Archive
  • de Lange, Ann-Marie Glasø; Barth, Claudia; Kaufmann, Tobias; Maximov, Ivan; van der Meer, Dennis & Agartz, Ingrid [Show all 7 contributors for this article] (2020). Women's brain aging: effects of sex-hormone exposure, pregnancies, and genetic risk for Alzheimer's disease. Human Brain Mapping. ISSN 1065-9471. p. 1–10. doi: 10.1002/hbm.25180. Full text in Research Archive
  • Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung & Andreassen, Ole Andreas [Show all 8 contributors for this article] (2020). Maturation of cortical microstructure and cognitive development in childhood and adolescence: A T1w/T2w ratio MRI study. Human Brain Mapping. ISSN 1065-9471. 41(16), p. 4676–4690. doi: 10.1002/hbm.25149. Full text in Research Archive
  • Norbom, Linn Christin Bonaventure; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Doan, Nhat Trung & Moberget, Torgeir [Show all 10 contributors for this article] (2020). Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents. Translational Psychiatry. ISSN 2158-3188. 10(251). doi: 10.1038/s41398-020-00931-1. Full text in Research Archive
  • Tønnesen, Siren; Kaufmann, Tobias; de Lange, Ann-Marie Glasø; Richard, Geneviève; Doan, Nhat Trung & Alnæs, Dag [Show all 33 contributors for this article] (2020). Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multisample diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 5(12), p. 1095–1103. doi: 10.1016/j.bpsc.2020.06.014. Full text in Research Archive
  • Rokicki, Jaroslav; Wolfers, Thomas; Nordhøy, Wibeke; Tesli, Natalia; Quintana, Daniel & Alnæs, Dag [Show all 20 contributors for this article] (2020). Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders. Human Brain Mapping. ISSN 1065-9471. 42(6), p. 1714–1726. doi: 10.1002/hbm.25323. Full text in Research Archive
  • Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng & Alnæs, Dag [Show all 40 contributors for this article] (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry. ISSN 1359-4184. p. 1–8. doi: 10.1038/s41380-020-0664-1. Full text in Research Archive
  • Lund, Martina Jonette; Alnæs, Dag; Schwab, Simon; van der Meer, Dennis; Andreassen, Ole Andreas & Westlye, Lars Tjelta [Show all 7 contributors for this article] (2020). Differences in directed functional brain connectivity related to age, sex and mental health. Human Brain Mapping. ISSN 1065-9471. 41(15), p. 4173–4186. doi: 10.1002/hbm.25116. Full text in Research Archive
  • Richard, Geneviève; Petersen, Anders; Ulrichsen, Kristine Moe; Kolskår, Knut-Kristian; Alnæs, Dag & Sanders, Anne-Marthe [Show all 10 contributors for this article] (2020). TVA-based modeling of short-term memory capacity, speed of processing and perceptual threshold in chronic stroke patients undergoing cognitive training: Case-control differences, reliability, and associations with cognitive performance. PeerJ. ISSN 2167-8359. 8:e9948, p. 1–21. doi: 10.7717/peerj.9948. Full text in Research Archive
  • Anatürk, Melis; Kaufmann, Tobias; Cole, James H.; Suri, Sana; Griffanti, Ludovica & Zsoldos, Enikő [Show all 12 contributors for this article] (2020). Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25316. Full text in Research Archive
  • Beck, Dani; de Lange, Ann-Marie Glasø; Maximov, Ivan; Richard, Geneviève; Andreassen, Ole Andreas & Nordvik, Jan E. [Show all 7 contributors for this article] (2020). White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction. NeuroImage. ISSN 1053-8119. 224:117441, p. 1–14. doi: 10.1016/j.neuroimage.2020.117441. Full text in Research Archive
  • Ulrichsen, Kristine Moe; Alnæs, Dag; Kolskår, Knut-Kristian; Richard, Geneviève; Sanders, Anne-Marthe & Dørum, Erlend Solberg [Show all 11 contributors for this article] (2020). Dissecting the cognitive phenotype of post-stroke fatigue using computerized assessment and computational modeling of sustained attention. European Journal of Neuroscience. ISSN 0953-816X. 52(7), p. 3828–3845. doi: 10.1111/ejn.14861. Full text in Research Archive
  • de Lange, Ann-Marie Glasø; Anatürk, Melis; Suri, Sana; Kaufmann, Tobias; Cole, James H. & Griffanti, Ludovica [Show all 13 contributors for this article] (2020). Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study. NeuroImage. ISSN 1053-8119. 222. doi: 10.1016/j.neuroimage.2020.117292.
  • van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Shadrin, Alexey A.; Devor, Anna & Smeland, Olav Bjerkehagen [Show all 12 contributors for this article] (2020). Understanding the genetic determinants of the brain with MOSTest. Nature Communications. ISSN 2041-1723. 11:3512, p. 1–9. doi: 10.1038/s41467-020-17368-1.
  • van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Chen, Chi-Hua; Thompson, Wesley K. & O'Connell, Kevin S. [Show all 11 contributors for this article] (2020). Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area. Cerebral Cortex. ISSN 1047-3211. 30(10), p. 5597–5603. doi: 10.1093/cercor/bhaa146. Full text in Research Archive
  • Voldsbekk, Irene; Maximov, Ivan; Zak, Nathalia; Roelfs, Daniël Thomas Heimen; Geier, Oliver & Due-Tønnessen, Paulina [Show all 10 contributors for this article] (2020). Evidence for wakefulness-related changes to extracellular space in human brain white matter from diffusion-weighted MRI. NeuroImage. ISSN 1053-8119. 212. doi: 10.1016/j.neuroimage.2020.116682. Full text in Research Archive
  • Tesli, Natalia; van der Meer, Dennis; Rokicki, Jaroslav; Storvestre, Guttorm Breivik; Røsæg, Cato & Jensen, Arvid [Show all 14 contributors for this article] (2020). Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. doi: 10.1007/s00406-020-01098-y. Full text in Research Archive
  • Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag & Barch, Deanna M. [Show all 76 contributors for this article] (2020). The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-17376-1. Full text in Research Archive
  • Maglanoc, Luigi Angelo; Kaufmann, Tobias; Jonassen, Rune; Hilland, Eva; Beck, Dani & Landrø, Nils Inge [Show all 7 contributors for this article] (2019). Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.24802. Full text in Research Archive
  • Smith, Steve; Duff, Eugene; Groves, Adrian; Nichols, Thomas E.; Jbabdi, Saad & Westlye, Lars Tjelta [Show all 12 contributors for this article] (2019). Structural variability in the human brain reflects fine-grained functional architecture at the population level. Journal of Neuroscience. ISSN 0270-6474. 39(31), p. 6136–6149. doi: 10.1523/JNEUROSCI.2912-18.2019. Full text in Research Archive
  • Zak, Nathalia; Bøen, Erlend; Boye, Birgitte; Andreassen, Ole Andreas; Doan, Nhat Trung & Malt, Ulrik Fredrik [Show all 8 contributors for this article] (2019). Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II. Bipolar Disorders. ISSN 1398-5647. 21, p. 525–538. doi: 10.1111/bdi.12771. Full text in Research Archive
  • Schwarz, Emanuel; Doan, Nhat Trung; Pergola, Giulio; Westlye, Lars Tjelta; Kaufmann, Tobias & Wolfers, Thomas [Show all 38 contributors for this article] (2019). Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder. Translational Psychiatry. ISSN 2158-3188. 9(12). doi: 10.1038/s41398-018-0225-4. Full text in Research Archive
  • Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette & Agartz, Ingrid [Show all 84 contributors for this article] (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22(10), p. 1617–1623. doi: 10.1038/s41593-019-0471-7. Full text in Research Archive
  • Maximov, Ivan; Alnæs, Dag & Westlye, Lars Tjelta (2019). Towards an optimised processing pipeline for diffusion magnetic resonance imaging data: Effects of artefact corrections on diffusion metrics and their age associations in UK Biobank. Human Brain Mapping. ISSN 1065-9471. 40, p. 4146–4162. doi: 10.1002/hbm.24691. Full text in Research Archive
  • Moutal, Nicolas; Maximov, Ivan & Grebenkov, Denis (2019). Probing surface-to-volume ratio of an anisotropic medium by diffusion NMR with general gradient encoding. IEEE Transactions on Medical Imaging. ISSN 0278-0062. 38(11), p. 2507–2522. doi: 10.1109/TMI.2019.2902957.
  • Kremneva, Elena; Legostaeva, Ludmila; Morozova, Sofya; Sergeev, Dmitry; Sinitsyn, Dmitry & Iazeva, Elizaveta [Show all 11 contributors for this article] (2019). Feasibility of Non-Gaussian Diffusion Metrics in Chronic Disorders of Consciousness. Brain Sciences. ISSN 2076-3425. 9(5). doi: 10.3390/brainsci9050123. Full text in Research Archive
  • Quintana, Daniel; Rokicki, Jaroslav; van der Meer, Dennis; Alnæs, Dag; Kaufmann, Tobias & Còrdova Palomera, Aldo [Show all 9 contributors for this article] (2019). Oxytocin pathway gene networks in the human brain. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-08503-8. Full text in Research Archive
  • Richard, Geneviève; Kolskår, Knut-Kristian; Ulrichsen, Kristine Moe; Kaufmann, Tobias; Alnæs, Dag & Sanders, Anne-Marthe [Show all 12 contributors for this article] (2019). Brain age prediction in stroke patients: Highly reliable but limited sensitivity to cognitive performance and response to cognitive training. NeuroImage: Clinical. ISSN 2213-1582. 25, p. 1–11. doi: 10.1016/j.nicl.2019.102159. Full text in Research Archive
  • Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Còrdova Palomera, Aldo; Rokicki, Jaroslav & Moberget, Torgeir [Show all 30 contributors for this article] (2019). Brain heterogeneity in schizophrenia and its association with polygenic risk. JAMA psychiatry. ISSN 2168-6238. 76(7), p. 739–748. doi: 10.1001/jamapsychiatry.2019.0257.
  • Moberget, Torgeir; Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo & Norbom, Linn Christin Bonaventure [Show all 10 contributors for this article] (2019). Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence. Biological Psychiatry. ISSN 0006-3223. 86(1), p. 65–75. doi: 10.1016/j.biopsych.2019.01.019. Full text in Research Archive
  • Maximov, Ivan & Vellmer, Sebastian (2019). Isotropically weighted intravoxel incoherent motion brain imaging at 7T. Magnetic Resonance Imaging. ISSN 0730-725X. 57, p. 124–132. doi: 10.1016/j.mri.2018.11.007. Full text in Research Archive
  • Kolskår, Knut-Kristian; Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviéve´; Sanders, Anne-Marthe & Ulrichsen, Kristine Moe [Show all 10 contributors for this article] (2018). Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence. eNeuro. ISSN 2373-2822. 5(4), p. 1–13. doi: 10.1523/ENEURO.0092-18.2018. Full text in Research Archive
  • Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Bettella, Francesco; Djurovic, Srdjan & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2018). Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2018.0844.
  • Kelly, S; Jahanshad, Neda; Zalesky, A; P, Kochunov; Agartz, Ingrid & Alloza, C [Show all 158 contributors for this article] (2018). Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, p. 1261–1269. doi: 10.1038/mp.2017.170. Full text in Research Archive
  • Hibar, Derrek; Westlye, Lars Tjelta; Doan, Nhat Trung; Jahanshad, Neda; Cheung, J. W. & Ching, Christopher R K [Show all 123 contributors for this article] (2018). Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Molecular Psychiatry. ISSN 1359-4184. 23, p. 932–942. doi: 10.1038/mp.2017.73. Full text in Research Archive
  • Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Alnæs, Dag; Kaufmann, Tobias; Moberget, Torgeir & Rokicki, Jaroslav [Show all 9 contributors for this article] (2018). Probing brain developmental patterns of myelination and associations with psychopathology in youths using gray/white matter contrast. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2018.09.027. Full text in Research Archive
  • Maglanoc, Luigi Angelo; Landrø, Nils Inge; Jonassen, Rune; Kaufmann, Tobias; Còrdova Palomera, Aldo & Hilland, Eva [Show all 7 contributors for this article] (2018). Data-driven clustering reveals a link between symptoms and functional brain connectivity in depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022. 4(1), p. 16–26. doi: 10.1016/j.bpsc.2018.05.005. Full text in Research Archive
  • Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao & Glahn, David C. [Show all 151 contributors for this article] (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2018.04.023. Full text in Research Archive
  • Tønnesen, Siren; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo & van der Meer, Dennis [Show all 15 contributors for this article] (2018). White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging . Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-32355-9. Full text in Research Archive
  • Chen, Jiayu; Calhoun, Vince D.; Lin, Dongdong; Perrone-Bizzozero, Nora I.; Bustillo, Juan R. & Pearlson, Godfrey D. [Show all 29 contributors for this article] (2018). Shared genetic risk of schizophrenia and gray matter reduction in 6p22.1. Schizophrenia Bulletin. ISSN 0586-7614. 45(1), p. 222–232. doi: 10.1093/schbul/sby010.
  • Alnæs, Dag; Kaufmann, Tobias; Doan, Nhat Trung; Còrdova Palomera, Aldo; Wang, Yunpeng & Bettella, Francesco [Show all 9 contributors for this article] (2018). Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents. JAMA psychiatry. ISSN 2168-6238. 75(3), p. 287–295. doi: 10.1001/jamapsychiatry.2017.4277.
  • Liew, Sook-Lei; Anglin, Julia M.; Banks, Nick W.; Sondag, Matt; Ito, Kaori L. & Kim, Hosung [Show all 35 contributors for this article] (2018). A large, open source dataset of stroke anatomical brain images and manual lesion segmentations. Scientific Data. ISSN 2052-4463. 5. doi: 10.1038/sdata.2018.11. Full text in Research Archive
  • Còrdova Palomera, Aldo; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung & van der Meer, Dennis [Show all 12 contributors for this article] (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics. ISSN 1018-4813. 26(7), p. 1049–1059. doi: 10.1038/s41431-018-0134-2.
  • Kita, Kahori; Rokicki, Jaroslav; Furuya, Shinichi; Sakamoto, Takashi & Hanakawa, Takashi (2018). Resting‐state basal ganglia network codes a motor musical skill and its disruption from dystonia. Movement Disorders. ISSN 0885-3185. p. 1–9. doi: 10.1002/mds.27448.
  • Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra & Espeseth, Thomas [Show all 15 contributors for this article] (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry. ISSN 1359-4184. p. 1–16. doi: 10.1038/s41380-019-0358-8. Full text in Research Archive
  • van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir & Alnæs, Dag [Show all 54 contributors for this article] (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. ISSN 1359-4184. p. 1–13. doi: 10.1038/s41380-018-0262-7. Full text in Research Archive
  • Richard, Geneviève; Kolskår, Knut-Kristian; Sanders, Anne-Marthe; Kaufmann, Tobias; Petersen, Anders & Doan, Nhat Trung [Show all 13 contributors for this article] (2018). Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry. PeerJ. ISSN 2167-8359. doi: 10.7717/peerj.5908. Full text in Research Archive
  • Westlye, Lars Tjelta; Kaufmann, Tobias; Alnæs, Dag; Hullstein, Ingunn Riise & Bjørnebekk, Astrid (2017). Brain connectivity aberrations in anabolic-androgenic steroid users. NeuroImage: Clinical. ISSN 2213-1582. 13, p. 62–69. doi: 10.1016/j.nicl.2016.11.014.
  • Elvsåshagen, Torbjørn; Zak, Nathalia; Norbom, Linn Christin Bonaventure; Pedersen, Per Øystein Heiberg; Quraishi, Sophia H. & Bjørnerud, Atle [Show all 11 contributors for this article] (2017). Evidence for cortical structural plasticity in humans after a day of waking and sleep deprivation. NeuroImage. ISSN 1053-8119. 156, p. 214–223. doi: 10.1016/j.neuroimage.2017.05.027. Full text in Research Archive
  • Hellstrøm, Torgeir; Kaufmann, Tobias; Andelic, Nada; Søberg, Helene L.; Sigurdardottir, Solrun & Helseth, Eirik [Show all 8 contributors for this article] (2017). Predicting outcome 12 months after mild traumatic brain injury in patients admitted to a neurosurgery service. Frontiers in Neurology. ISSN 1664-2295. 8:125, p. 1–12. doi: 10.3389/fneur.2017.00125. Full text in Research Archive
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Published Aug. 17, 2016 12:47 PM - Last modified Mar. 21, 2023 4:25 PM

Participants

  • Lars Tjelta Westlye Universitetet i Oslo
  • Jaroslav Rokicki Universitetet i Oslo
  • Ivan Maximov Universitetet i Oslo
Detailed list of participants