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Early-Onset Schizophrenia and ADHD

Clinical, Neurocognitive and Functional Outcome in Early-Onset Schizophrenia and Attention-Deficit/Hyperactivity Disorder: A 20-Year Follow-up Study.

About the project

This research project will develop new knowledge about the longitudinal course of the neurodevelopmental disorders Early Onset Schizophrenia (EOS) and Attention Deficit Hyperactivity Disorder (ADHD).  The project focuses on the association between clinical symptoms, neurocognition and functional outcome in these disorders, which often persist throughout the life span. We will study individuals with EOS compared to ADHD at three time points during a 20 year period. Prospective, longitudinal, multi-assessment studies of the same individuals across time are rare in the field and provide a unique opportunity to examine long-term changes. The current project has the longest follow-up time of neurocognition in individuals with EOS than any other study in the world. Further, EOS is rare and of substantial interest, since studies of these patients groups provide insight into the development of the disorder. By identifying early predictors of later disabilities, early treatments can alter morbidity and mortality. A better understanding of the longitudinal course has major clinical, scientific, and public health relevance. 


The overall aim is to explore the 20-year longitudinal course of clinical, neurocognitive and functional outcome in individuals with EOS and ADHD. We aim to identify possible predictive factors and how they interact in determining the longitudinal functional outcome.

  • Are the neurocognitive deficits stable from 13 to 20 year follow-up (i.e. similar to the 13-year follow up) or are there indications of a further progressive decline in adult years in individuals with EOS?
  • To what extent are baseline- and follow-up levels of neurocognition associated with the course of clinical symptoms, social dysfunction and other functional outcome measures in EOS and ADHD?
  • We will also investigate other issues such as the diagnostic stability, comorbid disorders and drug abuse, suicide, accidents, long-term morbidity, information about their living situation, education, employment and social network.


Extrastiftelsen (first 8 months) and Regional Psychosis Research Network 2015 - 2029.


The Regional Psychosis Research Network (Oslo University Hospital/Vestre Viken Hospital/Ahus/Hospital of Vestfold), NORMENT, Innlandet Hospital Trust.


Øie, M., Sundet, K., & Rund, B.R. (2010) Neurocognitive decline in early-onset schizophrenia compared to ADHD and normal controls: Evidence from a 13-year follow-up study.  Schizophrenia Bulletin, 36, 557-565.

Øie, M., Sundet, K., & Ueland, T. (2011) Neurocognition and functional outcome in early-onset schizophrenia and attention-deficit/hyperactivity disorder: A 13-year follow-up. Neuropsychology, 25 (1), 25-35.

Published Jan. 5, 2016 8:30 AM - Last modified Jan. 17, 2018 2:47 PM