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Neuro-cognition and resilience in schizophrenia

A prospective longitudinal study of people with first - episode psychosis

Illustrasjonsfoto: ChIandra4U, Stock.xchng  

About the project

Schizophrenia  has a profound  impact on the person above and beyond symptoms. How persons with such a devastating mental illness  recover and the possible  predictors of positive clinical outcome has until recently been of limited interest to researchers. So far, there has been no study of resilience  and neurocognition as predictors  of remission and full recovery from schizophrenia. This is the first prospective longitudinal study on first-episode psychosis that examines neurocognition with a consensus cognitive  battery (MCCB) and resilience as  possible predictors of recovery during the early course  of illness and investigates the stability and rate of full recovery during a 10-year follow up  using consensus based definitions of remission and full recovery in schizophrenia.

Studying  persons with schizophrenia  who are in remission and/or in full recovery  will contribute to our understanding of prognosis  and  create hope among  patients and their relatives that recovery from schizophrenia is possible.

Background

The aim of this study is in accordance with the change in political and health policy to ensure that mental health services are recovery - orientated. Results from this study will therefore contribute to knowledge in an area of schizophrenia research which is of great interest to health policy makers.

Objectives

In this study we will investigate possible mechanisms  for remission and  full recovery  in schizophrenia, using  consensus based criteria.

The MATRICS Consensus Cognitive Battery – a consensus battery for neuropsychological assessment  is used to measure  neurocognitive function. In addition, standardized clinical instruments are used. 28 subjects are included in the study and are assessed  for the presence or absence of illness symptoms, level of neurocognitive function and resilience once a year  in a 10- year period.

A prospective longitudinal design is chosen because this is the best procedure  for investigating predictors of prognosis  in schizophrenia ensuring information about the course over time. Moreover, several assessments account for fluctuations or stability in functioning over time.

The results may  identify characteristics of persons who recovers and thereby generate increased knowledge of heterogeneity in schizophrenia and the  possibilities of recovery.

Financing

The project is supported  by grants  from The Faculty of Social Sciences, Department of Psychology, University of Oslo.

Cooperation

This is an on-going research project with national and international cooperation partners; The psychosis unit of  the Mental Health division, Vestre Viken Health Trust and the University of Boston and the University California Los Angeles (UCLA).

Published Nov. 5, 2012 3:03 PM - Last modified Oct. 20, 2016 9:07 AM